JP3265111B2 - UV protective cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics, and more particularly to cosmetics for protecting against ultraviolet rays.

[0002]

2. Description of the Related Art It is a well-known fact in many literatures that ultraviolet rays have a great adverse effect on skin.
For example, it acts on the DNA of the cells that make up the skin to cleave the helical chain, induce skin cancer, cause inflammation even if it is minor, and cause pigmentation, which has many adverse effects. Across directions.

On the other hand, various cosmetics for protecting against ultraviolet rays have been developed. For example, cosmetics containing a masking agent such as titanium oxide or an ultraviolet absorber such as an aminobenzoate derivative or a benzophenone derivative can be exemplified.

[0004] However, the ultraviolet protection by the concealing agent has a drawback that when the concealing agent is added in an amount necessary for the protection of the ultraviolet light, the appearance is significantly whitened. Although this can be largely alleviated by reducing the particle size of the concealing agent, it has never been sufficient.

Further, the protection by the ultraviolet absorber has various problems related to the ultraviolet absorber, such as the safety of the ultraviolet absorber, the stability of the ultraviolet absorber, and the absorption limit of the ultraviolet absorber. Protecting the skin is almost impossible.

[0006]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a cosmetic which can be expected to sufficiently protect against ultraviolet rays without whitening.

[0007]

In view of the above, the present inventors have conducted intensive research on the formulation of cosmetics capable of protecting against ultraviolet rays without whitening.
By combining a flaky silica gel having an average size of 1 to 100 μm with a fine particle titanium oxide having an average particle size of 0.01 to 0.2 μm, excellent transparency is obtained, and The inventors have found that it is possible to provide a cosmetic which suppresses whitening and has an excellent protective effect from ultraviolet rays, and has completed the invention.

Here, regarding the average size of the flaky silica gel, it is calculated based on (the longest diameter of the flake + the shortest diameter of the flake) / 100 flakes.
Defined as the average of 2. The flaky silica gel used in the present invention has a small thickness with respect to the average size.
This ratio is preferably 10 to 50 times. This ratio is more preferably 20 to 30 times. Further, the average size is preferably 1 to 100 μm, particularly preferably 10 to 50 μm. This is because if the ratio of the average size to the thickness is too small or too large, the transparency of the flaky silica gel is impaired, and if the average size is too small, the transparency given to the system is small. This is because, if it is too large, the UV protection effect is impaired. Preparation of such silica gel, JP 6 No. 2 -12711, Sho 63 -
The method may be performed according to the manufacturing method described in Japanese Patent Application No. 66819, Japanese Patent Application No. 4-145011 or the like. SG flake (manufactured by Nippon Sheet Glass Co., Ltd.) is already commercially available as such flaky silica gel.

It is essential that the titanium oxide is fine particles, because whitening by the titanium oxide cannot be prevented unless the fine particles are fine particles. Here, the fine particles have an average particle size of 0.2.
It refers to particles of μm or less. The lower limit of the average particle size of titanium oxide is 0.01 μm. This is because if the average particle size is too small, mixing becomes difficult or handling for forming a dosage form becomes difficult. The titanium oxide may be of an anatase type or a rutile type, and may be a mixture of the two.

These flaky silica gel and fine particle titanium oxide may or may not be surface-treated. Examples of the surface treatment include baking treatment of polyhydroxymethylsiloxane, coating with silicone or oil and fat, coating with metal soap, and amino acid derivative. Processing.

The preferred amount of the flaky silica gel is 0.1.
If it is too small, the effect of contributing to transparency is too small, and if it is too large, the protective effect from ultraviolet rays is impaired. The most preferable compounding amount is 1 to 5% by weight, and 1/2 to 1% based on the titanium oxide amount of the fine particles.
/ 10 is preferred.

The amount of the fine particles of titanium oxide is 1-2.
0% by weight is preferable, and if it is less than 1%, a sufficient protective effect from ultraviolet rays cannot be obtained. If it exceeds 20% by weight, whitening becomes remarkable and the protective effect reaches a plateau. 3-10% by weight
Is most preferred.

The cosmetic of the present invention contains, in addition to these essential ingredients, optional ingredients widely used in various cosmetics, such as cream, emulsion, lotion, under makeup,
Various cosmetic dosage forms such as foundations, pressed powders, two-way cakes, lip colours, lip balms, etc. can be formulated using conventional methods.

Examples of these optional components include hydrocarbons such as liquid paraffin, petrolatum, and microcrystalline wax; esters of higher fatty acids and higher alcohols such as jojoba oil and carnauba wax; triglycerides such as olive oil, beef tallow, and castor oil; Higher alcohols, higher fatty acids, nonionic surfactants, anionic surfactants, cationic surfactants, soaps, iron oxide and ultramarine,
Colorants such as navy blue, organic pigments, powders such as kaolin, sericite, talc, mica, preservatives such as parabens, BH
Antioxidants such as T, various medicinal ingredients and the like.

Further, in order to enhance the protection effect from ultraviolet rays, an ultraviolet absorbent such as an aminobenzoic acid derivative or a benzophenone derivative may be added.

[0016]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, but it goes without saying that the present invention is not limited to these Examples. Hereinafter, all of the compounding ratios indicate parts by weight.

Example 1 Formulation Example (Lip Cream) An ultraviolet protective lip cream was prepared based on the following formulation. That is, after adding B to A and dispersing in a hole mill,
Was melted by heating at 90 ° C., poured into a mold and cooled to obtain a lip balm. (A) Glyceryl triisooctanoate 15 Cetyl isooctanoate 15 Liquid paraffin 15 Polymethylphenylsiloxane (100 cs.) 5 (B) Flaky silica gel (trade name: SG flake) 2 Fine particle titanium oxide (rutile type) 6 (C) microcrystalline wax 15 ceresin 7 lanolin 20

Example 2 Formulation Example (Lip Color ) An ultraviolet protection lip color was prepared based on the following formulation. That is, after B was added to A and dispersed by a ball mill, the component C was added and dissolved by heating at 90 ° C., poured into a mold and cooled to obtain a lip color . (A) Glyceryl triisooctanoate 15 Cetyl isooctanoate 15 Liquid paraffin 15 Polymethylphenylsiloxane (100 cs.) 5 (B) Flaky silica gel (trade name: SG flake) 1 Fine particle titanium oxide (rutile type) 4 Bengala 0.5 Red organic dye 0.5 Yellow iron oxide 2 (C) microcrystalline wax 15 Celesin 7 Lanolin 20

Example 3 Formulation Example (UV protection lip balm ) An UV protection lip balm was prepared based on the following formulation. That is, after adding B to A and dispersing in a ball mill,
Was melted by heating at 90 ° C., poured into a mold and cooled to obtain an ultraviolet protective lip cream . (A) glyceryl triisooctanoate 15 cetyl isooctanoate 13 liquid paraffin 13 polymethylphenylsiloxane (100 cs) 3 para-aminobenzoic acid isooctyl ester 2 (B) flaky silica gel (trade name: SG flake) 4 Fine particle titanium oxide (rutile type) 8 (C) microcrystalline wax 15 ceresin 7 lanolin 20

Example 4 Ultraviolet ray protection test Example 1 was performed using a Hartley white male guinea pig.
The ultraviolet protection effects of the cosmetics Nos. 1 to 3 were examined. That is, the back of the guinea pig was shaved, three 2 cm square sections were provided on the right and left, and a total of 6 sections were provided. A 0.05 g sample was applied on the right, and the specimen was irradiated with an SE lamp, which is an ultraviolet lamp, for 20 minutes.
At 4 hours, the skin reaction was observed according to the Japanese patch test standard. That is,-: no reaction, ±: false positive reaction, +: positive reaction, ++: reaction with edema. Table 1 shows the results.
This indicates that the ultraviolet protective cosmetic of the present invention has an excellent ultraviolet protective effect.

[0022]

[Table 1]

Example 5 Formulation Example (UV protection milky lotion) An ultraviolet protection milky lotion was prepared according to the formulation shown in Table 2 below. That is, A, B, and C were each heated to 80 ° C. to dissolve the respective components, D was dispersed in C, A and then B were added thereto, and the mixture was homogenized and cooled to obtain an emulsion. At the same time, Comparative Examples 1 to 3 were also prepared.

[0024]

[Table 2]

Example 6 Evaluation of the degree of whitening The emulsion of Example 5 and the emulsions of Comparative Examples 1 to 3 were evaluated for the degree of whitening using five professional beauty panels. That is, an appropriate amount of the sample is applied to the inner part of the upper arm, and the finished condition is significantly whitened, whitened, slightly whitened, and not whitened.
It was evaluated on a scale. Table 3 shows the results. It can be seen that the UV protective emulsion of the present invention is excellent in suppressing whitening. Therefore, it can be seen that the combination of silica gel on thin flakes and fine particle titanium oxide is excellent in suppressing whitening.

[0026]

[Table 3]

Example 7 UV protection test The cosmetics of Example 5 and Comparative Examples 1 to 3 were tested for UV protection effect using Hartley white male guinea pigs. That is, the back of the guinea pig was shaved, three 2 cm square sections were provided on the right and left, and a total of 6 sections were provided.
It was applied in an amount of 5 g each and irradiated with an SE lamp as an ultraviolet lamp for 20 minutes, and the skin reaction was observed 24 hours after the irradiation according to the Japanese patch test standard. That is,-: no reaction, ±: false positive reaction, +: positive reaction, ++: reaction with edema. Table 4 shows the results. This indicates that the ultraviolet protective cosmetic of the present invention has an excellent ultraviolet protective effect.

[0028]

[Table 4]

Example 8 Formulation Example (Ultraviolet Protective Lip Balm) An ultraviolet protective lip cream was prepared based on the following formulation. That is, after adding B to A and dispersing in a ball mill,
Was melted by heating at 90 ° C., poured into a mold and cooled to obtain an ultraviolet protective lip cream. (A) neopentyl glycol diisooctanoate 11 glycerol triisoiooctanoate 18 cetyl isooctanoate 9 liquid paraffin 11 (B) flaky silica gel (trade name: SG flake) 4 fine particle titanium oxide 20 (C) solid paraffin 12 micro Crystalline wax 15

Example 9 Ultraviolet Protection Test The lip balm of Example 8 was used to measure the Ultraviolet Protection Index (SPF) according to the FDA standard using white men and women.
The SPF value was 9.89. This indicates that the cosmetic of the present invention has an excellent ultraviolet protection effect.

[0031]

EFFECT OF THE INVENTION The cosmetic of the present invention is excellent in ultraviolet ray protection effect and does not whiten after use, which is very useful for protection of ultraviolet ray.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-6-87720 (JP, A) JP-A-4-145011 (JP, A) JP-A-63-166819 (JP, A) JP-A-62-1987 12711 (JP, A) JP-A-1-143821 (JP, A) JP-A-1-9803 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 7/00-7 / 50

Claims (1)

(57) [Claims] 1. A flaky silica gel having an average thickness of 0.1 μm to 2 μm and an average size of 1 to 100 μm (however,
Average thickness <average size) 0.1 to 10% by weight
And fine particle titanium oxide 1 having an average particle size of 0.01 to 0.2 μm
And a 20 wt%, and flaky silica gel amount fine
1/2 to 1/10 of the amount of titanium oxide particles
UV protection cosmetics characterized by the following .