JP3252192B2 - Antibacterial sheet and sanitary goods - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sheet having excellent antibacterial properties and a sanitary article having the sheet on its surface, particularly a body fluid absorbing material such as a sweat-absorbing pad, a sanitary napkin and a panty sheet. More specifically, the present invention relates to an antibacterial sheet containing a water-soluble extract derived from a plant containing a rosin aminated compound represented by an amine salt of abietic acid or pimaric acid, and a sanitary article having the same.

[0002]

2. Description of the Related Art Conventionally, various researches have been conducted on sanitary articles used for absorbing vaginal discharge, menstrual blood, sweat, urine, and other body fluids with the aim of improving water absorption, leakage prevention, stuffiness, and wearing feeling. Has been made.

[0003] On the other hand, such sanitary articles are displayed in stores and sold, so that they are often exposed to high temperature and humidity for a long period of time. In general, it is preferable that the sanitary ware itself maintain and exhibit antibacterial properties over a long period of time. In addition, hygiene products absorb body fluids during use and are placed under conditions suitable for bacterial growth,
Body fluids can spoil and produce foul odors and cause various infections.

[0004] However, antibacterial agents are generally highly irritating to the skin, so that if they are brought into direct contact with the skin for a long period of time, skin irritation becomes a problem.

From this point of view, proposals have been made to use various plant extracts as antibacterial agents that are highly safe for the human body, such as skin rash, and rosin, which is an extract of rosin, has attracted attention as one of them. I have.

[0006] However, such plant antibacterial agents generally have poor stability over time, and their antibacterial activity decreases under high temperature or high humidity. Therefore, they can be left under the high temperature and high humidity conditions such as storefronts described above, and Generally, it has been difficult to apply the method to a product packaged with a packaging material having no hiding effect. Further, since rosin is insoluble in water, it is necessary to impregnate a base cloth such as paper with a solution state containing 50% or more of ethanol, such as wet wipers described in JP-A-5-15467. However, it is difficult to stably hold and hold these fiber layers in a dry state over time, so that cloth or paper products with stable antibacterial performance using conventional rosin, especially moisture absorption and water absorption, can be used. It was not possible to prepare the desired product.

[0007]

DISCLOSURE OF THE INVENTION The present invention provides an antibacterial sheet which has a good yield of an antibacterial agent to a fiber layer, exhibits an antibacterial property continuously even under high temperature and high humidity conditions, and has little irritation to the skin. The purpose is to: Another object of the present invention is to provide a sanitary article having such an antibacterial sheet at least on a body fluid contact surface or a wearing surface, such as a sweat-absorbing pad, a sanitary napkin, and a panty sheet.

[0008]

DISCLOSURE OF THE INVENTION The present inventors have studied a method for improving the yield of rosin, a plant extract having inherently excellent antibacterial properties but difficult to be contained in fibers. When stacked, the rosin was aminated to form a water-soluble substance, and the water-soluble substance was processed into a fiber sheet to achieve the above object, whereby the antibacterial property of the rosin aminated compound was maintained for a long time under various temperature and humidity conditions. Was significantly maintained over time.
The present invention is based on such findings.

That is, the present invention is an antibacterial sheet comprising any one of the following embodiments.

(1) An antibacterial sheet having a plant-derived water-soluble extract containing a rosin aminated compound as an antibacterial agent.

(2) The antibacterial sheet according to (1), wherein the rosin aminated compound is at least one selected from the group consisting of dehydroabiethylamine, amine abietic acid and amine pimalate.

(3) The antibacterial sheet according to (1) or (2), wherein the plant-derived water-soluble extract contains a rosin aminated compound in a range of 5 to 20% by weight.

(4) The antibacterial sheet according to any one of (1) to (3), wherein a plant-derived water-soluble extract containing a rosin aminated compound is applied to a fiber sheet by gravure printing.

(5) The antibacterial sheet according to claim 4, comprising a plant-derived water-soluble extract containing a rosin aminated compound at a plate depth of 10 to 60 microns.

(6) The antibacterial sheet according to any one of (1) to (5), wherein the antibacterial property is maintained at 40 ° C. and a humidity of 75% for at least 5 weeks.

(7) The antibacterial sheet according to any one of (1) to (6), which has antibacterial activity against bacteria belonging to at least Escherichia coli, Staphylococcus and Candida.

Further, the present invention is a sanitary article comprising the antibacterial sheet according to any one of the above (1) to (7) on at least the body contact surface side surface. Examples of such sanitary articles include disposable sanitary articles selected from the group consisting of diaper sheets, panty sheets, sanitary napkins, masks, sweat-absorbing pattos, incontinence pads, bedwetting sheets, breast milk pads, medical sheets and diapers. it can.

In the present invention, the antibacterial property is a concept including an action of inhibiting the growth of microorganisms, that is, a bacteriostatic action.

[0019]

BEST MODE FOR CARRYING OUT THE INVENTION The antibacterial sheet of the present invention is characterized by containing a plant-derived water-soluble extract containing a rosin aminated compound as an antibacterial agent.

The plant-derived water-soluble extract containing a rosin aminated compound used in the present invention is obtained by subjecting a rosin obtained from pine roots to distillation to remove a turpentine oil component, and further subjecting a rosin obtained by a chemical treatment to partial extraction. It is prepared by subjecting a solid substance containing a rosin aminated compound to a water-soluble component by further extracting it with water.

The method of converting rosin into an amine salt is not particularly limited, and a method generally used in the art can be employed. The amine salt is not particularly limited, and includes a wide variety of monoamines and organic amine salts such as monoethanolamine salts, diethanolamine salts, and triethanolamine salts.

The method of water extraction is not particularly limited, but a more preferable example is a method of stirring and extracting with warm water at a temperature of about 40 ° C. for one to two days.

As a rosin used as a starting material, a resin obtained by purifying a resin acid contained in pine can be widely used. Any one of gum rosin, wood rosin, and tall oil rosin can be used. It is a wood rosin obtained by extracting a pine root strain, which has been passed for more than 10 years, into a chip and extracting the same with a solvent, followed by distillation to remove turpentine oil.

Specific examples of the rosin aminated compound include dehydroabiethylamine, amine abietic acid, and amine pimalate. These may be used alone or in combination of two or more.

The proportion of the rosin compound contained in the plant-derived water-soluble extract used in the present invention is not particularly limited, but is usually 0.5 to 90% by weight, preferably 1 to 50% by weight, more preferably 5% by weight. -20% by weight. The water-soluble extract may partially contain water-insoluble substances such as abietic acid and pimaric acid, as long as they exhibit water solubility as a whole.

The antibacterial sheet of the present invention comprises a fiber sheet containing the plant-derived water-soluble extract containing the rosin aminated compound as an antibacterial agent.

The fibrous sheet used in the present invention is not particularly limited, but may be a woven fabric, a knitted fabric, a nonwoven fabric (including a nonwoven fabric composed of a non-converged filament group or a short fiber group), or a pulp product such as paper. And a film-shaped or sheet-shaped molded product.

The fibers constituting such a fiber sheet are not particularly limited, and any fibers can be used. Specifically, for example, polyester fibers, polyamide fibers, acrylic fibers, polypropylene, polyethylene /
Synthetic fibers such as polyester composite fiber and polyethylene / polypropylene composite fiber; natural fibers such as cotton, wool, and hemp;
Or semi-synthetic fiber such as rayon fiber and acetate fiber,
And mixed fiber products of various fibers and mixed fiber products.
Preferably, polypropylene, polyethylene, polyester, polyethylene terephthalate, synthetic fibers such as ethylene vinyl acetate or composite fibers thereof are exemplified,
Specific examples include polyethylene / polyester (including polyethylene terephthalate) composite fibers, polyethylene / polypropylene composite fibers, and ethylene vinyl acetate / polypropylene composite fibers.

These synthetic fibers are not particularly limited by their cross-sectional structure and the like, but may be modified fibers, porous fibers, or the like.
It may have various structures as represented by porous water-absorbing fibers and the like.

The fiber sheet used in the present invention may be a single-layer sheet or film composed of the above-mentioned various components, or a multi-layered sheet or film composed of any different components.

The shape is not particularly limited as long as it is in the form of a sheet or a film, and may take the form of, for example, a mesh or a raised pattern (embossed pattern).

The antibacterial agent only needs to adhere at least to the fiber sheet. Therefore, the method of attaching the antibacterial agent is not particularly limited as long as the object can be achieved. Conventionally known printing methods, impregnation methods, Various methods such as a spray method, a pad method, and a coating method are widely employed. More specifically,
After treating the fiber sheet with a water-soluble extraction solution containing a rosin aminated compound by any of methods such as immersion, spraying, putting, and coating, the liquid sheet is drained if necessary, and then dried.

Preferably, a gravure printing method is used.

The gravure printing method is not particularly limited, but basically includes, as shown in FIG. 1, a roll 2 dipped in a solution 5 containing a plant-derived water-soluble extract containing a rosin aminated compound. The fiber sheet 1 which advances in the direction of the arrow by attaching the plant-derived water-soluble extract to the roller surface and engaging it with the roll 3
This is a method in which the water-soluble extract is applied by pressing the rolls 4 and 3 on top.

The conditions for gravure printing are not particularly limited, and can be appropriately selected depending on the material of the fiber sheet to be printed, the application, and the like. The plant-derived water-soluble extract containing the rosin aminated compound described above is added to a fiber sheet at a plate depth of 10 to 60.
It is preferably carried out under the condition that the content is contained at a micron, preferably 12 to 52 microns, more preferably 20 to 30 microns.

According to the antibacterial sheet containing a plant-derived water-soluble extract at such a depth, at least 40 ° C, 40 ° C against at least three species of Escherichia coli, Staphylococcus aureus and Candida.
Even when left under various conditions such as 75% at 75 ° C., 50 ° C., and 60 ° C. at 50 ° C., the antibacterial property can be maintained for at least 5 weeks.

The amount of the plant-derived water-soluble extract contained in the antibacterial sheet of the present invention varies depending on the purpose of use, the place of use, etc. of the antibacterial sheet.
Usually, it is 0.1-5% by weight, preferably 0.7-3% by weight, more preferably 1-2% by weight.

As long as the plant-derived water-soluble extract is contained in such a range, the application form of the plant-derived water-soluble extract is not particularly limited, and the plant-derived water-soluble extract may be coated on the entire fiber sheet, or may be dotted or wavy. It may be applied intermittently, such as in the form of a brush or a scum. This can be achieved by employing a roll 3 having a surface having irregularities corresponding to a dot-like or wavy-line-like pattern in the gravure printing method (FIG. 1).

The antibacterial sheet of the present invention may contain, in addition to the above-mentioned water-soluble extract, existing bactericides, deodorants, etc., as long as the effects of the present invention are not impaired. Can also.

According to the antibacterial sheet of the present invention, the antibacterial property is maintained for at least 5 weeks even under high temperature and high humidity in summer such as 40 ° C. and 75% humidity, as will be apparent from the examples described later. be able to. This means that the antibacterial sheet of the present invention and the product containing the sheet maintain stable antibacterial properties for a long period of time even when stored and left under high temperature and / or humid conditions. Show.

The antibacterial sheet of the present invention comprises at least Gram-negative facultative anaerobic bacilli such as Escherichia coli and bacteria belonging to the genus Staphylococcus, particularly Gram-positive cocci facultative anaerobic bacteria such as Staphylococcus aureus. It has excellent antibacterial properties against fungi belonging to the genus Candida, particularly pathogenic fungi such as Candida Albicans.

The antibacterial sheet of the present invention can be used on a skin contact side of a sanitary article or the like to reduce spoilage bacteria, bacteria,
Since the growth of Pseudomonas aeruginosa is suppressed, rot of body fluids such as menstrual blood can be suppressed to prevent the generation of offensive odors, and can also prevent bacterial infection and suppuration.

Furthermore, as shown in the experimental examples described below, the antibacterial sheet of the present invention containing a rosin aminated compound has low skin irritation and high safety to the human body.

The antibacterial sheet of the present invention having such properties may be stored and stored under high temperature and high humidity, and is required to have antibacterial and anti-irritant properties in an environment suitable for bacterial growth. For example, diaper sheets, panty sheets, sanitary napkins, masks, sweat-absorbing pats (adhesive pads), adhesive plasters, bed sheets, breast milk pads, incontinence pats, adhesive plasters, medical sheets (eg, disposable sheets for patients with disabilities) or diapers Sanitary goods, especially as a surface sheet of disposable sanitary goods.

From this viewpoint, the present invention provides a sanitary article having the above-mentioned antibacterial sheet.

The sanitary article of the present invention only needs to have the above antibacterial sheet at least on the body fluid contact surface, in other words, on the body contact surface side surface.

Examples of the sanitary articles include various kinds of sanitary articles that absorb vaginal discharge, menstrual blood, blood, sweat, urine, etc., as described above, and are preferably disposable sanitary articles.
Specifically, diapers, panty sheets, sanitary napkins,
It is a disposable body fluid absorbing material such as incontinence pads and medical sheets.

Such a sanitary article such as a bodily fluid absorbent may be one provided with the above-mentioned antibacterial sheet at least on the side to be worn on the body, and the other parts may adopt a conventionally known structure. As an example of a simple structure, the antibacterial sheet of the present invention as a topsheet, a water-impermeable synthetic resin sheet as a backsheet, and a sanitary article containing an absorbent between the topsheet and the backsheet are included.

[0049]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples, but the present invention is not limited to the Examples.

Example 1 14% by weight of a plant-derived water-soluble extract containing dehydroabiethylamine as a rosin aminated compound (to give a rosin aminated compound of 1.1% by weight) was applied with a basis weight of 35 g / m ^2.
Gravure printing was performed on the cotton non-woven fabric at a printing speed of 50 m / min using a plate having a plate depth of 20 microns. The obtained sheet was dried at 50 ° C. for about 8 seconds to prepare an antibacterial sheet of the present invention.

The antibacterial properties of the obtained antibacterial sheet were evaluated in accordance with the "Bacterial Counting Method" of the Evaluation Test Manual for Antibacterial and Deodorizing Processes of the Textile Sanitation Processing Council. The criteria for obtaining the SEK mark, which is the certification mark of the council, is the difference in the number of bacteria
1.6.

The details are as follows.

[Test bacterial strain] Staphylococcus aureus IFO 12732 Escherichia coli (Echerichia coli KPB 33) Candida albicans (Candida Albicans KPB 767) [Culture solution] Pre-culture solution: SCD agar medium (Staphylococcus aureus / E. Coli) Sabouroued Dextrose agar medium (Candida) Shaking culture and main culture: Brucella broth (Staphylococcus aureus / Escherichia coli) Sabouroued liquid Broth (Candida) [Test cloth] Test cloth: 0.2 g of the antibacterial sheet prepared above Control cloth: None 0.2 g of processed nonwoven fabric [Test method] One platinum loop of each of the above three strains was inoculated into a sterilized preculture solution, and cultured at 37 ° C for 24 hours. Next, one of the obtained colonies was transplanted to a culture medium for shaking culture, and cultured with shaking at 37 ° C. for 6 hours. The resulting culture broth was diluted 100 times, 1 to 5 × 10 ⁵ cells / ml for Staphylococcus aureus and Escherichia coli, for Candida adjusted to be 1 to 10 × 10 ³ cells / ml And a bacterial solution. Then, the test cloth was put into a vial having a capacity of about 10 to 20 ml, 0.2 ml of the bacterial solution was inoculated, and this was cultured at 37 ° C. for 18 hours. 20 ml of sterile physiological saline was put into a vial bottle and shaken up and down about 30 times to elute the bacterial solution into the physiological saline. The number of bacteria eluted in the physiological saline was measured, and the increase / decrease ratio, the increase / decrease value, and the difference between the increase / decrease values of the number of bacteria were calculated by the following formula.

[0054]

Embedded image

As a control, a similar test was performed using an unprocessed cloth.

Table 1 shows the number of viable bacteria and the difference between the increase and decrease in the number of bacteria after 0 hour and 18 hours of culture of various bacteria.

[0057]

[Table 1]

From Table 1, it can be seen that the antibacterial sheet of the present invention shows a difference in the number of increase / decrease in the number of bacteria against any of Staphylococcus aureus, Escherichia coli, and Candida, which is greater than 1.6, and that the growth of the bacteria is further suppressed From the above, it was found that the composition exhibited excellent antibacterial properties.

Experimental Example 1 An antibacterial sheet was prepared according to the method described in Example 1, and was subjected to 40 ° C./75% humidity, 40 ° C./0% humidity, and 50 ° C., respectively.
/ Humidity 60%, 50 ° C / humidity 0% for 5 weeks, and then according to the “Bacteria count method” described in Example 1.
The antibacterial properties of these antibacterial sheets were evaluated.

Table 3 shows the antibacterial properties of the antibacterial sheet left for 5 weeks at 40 ° C./75% humidity.

[0061]

[Table 2]

Table 4 shows the antibacterial properties of the antibacterial sheet left for 5 weeks at 40 ° C./0% humidity.

[0063]

[Table 3]

Table 5 shows the antibacterial properties of the antibacterial sheet left for 5 weeks at 50 ° C./60% humidity.

[0065]

[Table 4]

Table 6 shows the antibacterial properties of the antibacterial sheet which was allowed to stand at 50 ° C./0% humidity for 5 weeks.

[0067]

[Table 5]

From these results, it was found that the antibacterial sheet of the present invention suppressed the growth and proliferation of at least three kinds of bacteria, Staphylococcus aureus, Escherichia coli and Candida, and exhibited excellent antibacterial properties. In addition, it was found that the antibacterial action of the antibacterial sheet of the present invention was maintained for at least 5 weeks even when left under various temperature and humidity conditions. This means that the product having the antibacterial sheet of the present invention maintains stable antibacterial properties over time even when left under high temperature and / or high humidity conditions in a distribution channel or the like.

Experimental Example 2 An antibacterial sheet was prepared according to the method described in Example 1, and this sheet was attached to a window and exposed to sunlight. Four weeks after exposure to sunlight, the antibacterial properties of the antibacterial sheet of Escherichia coli and Staphylococcus aureus were evaluated in accordance with the "Bacteria count method" described in Example 1.

Table 7 shows the results.

[0071]

[Table 6]

As shown in Table 7, the antibacterial sheet of the present invention exhibited stable antibacterial properties even under sunlight exposure. Products with antimicrobial sheet Therefore, even when left under sunlight exposure, time stable described in Experimental Example 3 primary skin irritation test in Example 1, it can be seen to retain the antimicrobial An antimicrobial sheet was prepared according to the method, and the safety of the antimicrobial sheet on the skin was evaluated using a 24-hour closed patch test (n = 21) shown below. In the present invention, the skin irritation test and its determination method, except for the time of application of the test sample to the skin,
"Skin irritation disorder due to clothing"("Hygiene" 29-1, p2
-15, Tetsuro Sugai, 1985), and performed according to it.

<Test Method> (1) An antibacterial sheet having a diameter of 7 mm is attached to the upper arm using a skin sensitization test upper.

(2) The tape is peeled off 24 hours after application.

(3) Skin reaction is determined 60 minutes and 24 hours after peeling.

<Evaluation method of skin irritation> Among the judgments made 60 minutes and 24 hours after the antibacterial sheet tape was peeled off, the one with the highest degree of reaction was regarded as the degree of skin reaction of the subject. A score is given according to the criteria described in 8.
A quotient obtained by dividing the sum of the scores by the number of subjects is expressed as a percentage, and this is defined as a skin irritation index.

[0077]

[Table 7]

[0078]Contact, threshold of skin irritation index in clothing
Is based on the above document.Then, less than 10.0 Safety products 10.0 to 30.0 Allowable products 30.0 to 60.0 Need improvement60.0 or more Dangerous goods with large skin damage It has been established.

When evaluated according to the above evaluation criteria,
The skin irritation index of the antibacterial sheet of the present invention was 2.4, indicating that it was safe with little irritation to the skin.

[Brief description of the drawings]

FIG. 1 is a diagram showing an embodiment in which a solution containing a plant-derived water-soluble extract is applied to a fiber sheet.

[Explanation of symbols]

Reference Signs List 1 fiber sheet 2 roll 3 roll 4 roll 5 solution containing rosin aminated compound-containing plant-derived water-soluble extract

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification code FI A61F 13/49 D21H 21/36 13/53 A41B 13/02 B A61K 35/78 ADB A61F 13/18 381 ADZ D21H 21/36 ( 58) Field surveyed (Int.Cl. ⁷ , DB name) D06M 13/00-13/535 D21H 11/00-27/42

Claims (9)

(57) [Claims] 1. An antibacterial sheet comprising a plant-derived water-soluble extract containing a rosin aminated compound as an antibacterial agent. 2. The antibacterial sheet according to claim 1, wherein the rosin aminated compound is at least one selected from the group consisting of dehydroabiethylamine, amine abietic acid and amine pimarate. 3. The antibacterial sheet according to claim 1, wherein the plant-derived water-soluble extract contains rosin aminated compound in a range of 5 to 20% by weight. 4. The antibacterial sheet according to claim 1, wherein a plant-derived water-soluble extract containing a rosin aminated compound is applied to a fiber sheet by gravure printing. 5. The antibacterial sheet according to claim 4, comprising a plant-derived water-soluble extract containing a rosin aminated compound at a plate depth of 10 to 60 microns. 6. The antibacterial sheet according to claim 1, wherein the antibacterial property is maintained at 40 ° C. and a humidity of 75% for at least 5 weeks. 7. The antibacterial sheet according to claim 1, which has antibacterial properties against at least bacteria belonging to the genus Escherichia coli, Staphylococcus and Candida. 8. A sanitary article comprising the antibacterial sheet according to claim 1 on at least a body contact surface side surface. 9. A disposable hygiene article selected from the group consisting of diaper sheets, panty sheets, sanitary napkins, masks, sweat-absorbing pads, breast milk pads, bed sheets, incontinence pads, medical sheets and diapers. Sanitary goods as described.