WO2004014276A1 - Disposable absorbent articles with skin health and odor control additives - Google Patents
Disposable absorbent articles with skin health and odor control additives Download PDFInfo
- Publication number
- WO2004014276A1 WO2004014276A1 PCT/US2003/020515 US0320515W WO2004014276A1 WO 2004014276 A1 WO2004014276 A1 WO 2004014276A1 US 0320515 W US0320515 W US 0320515W WO 2004014276 A1 WO2004014276 A1 WO 2004014276A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- skin
- article
- skin health
- health treatment
- treatment additive
- Prior art date
Links
- 239000002250 absorbent Substances 0.000 title claims abstract description 64
- 230000002745 absorbent Effects 0.000 title claims abstract description 64
- 239000000654 additive Substances 0.000 title claims abstract description 44
- 230000036559 skin health Effects 0.000 title claims abstract description 36
- 238000011282 treatment Methods 0.000 claims abstract description 33
- 230000000996 additive effect Effects 0.000 claims abstract description 32
- 229930003231 vitamin Natural products 0.000 claims abstract description 7
- 235000013343 vitamin Nutrition 0.000 claims abstract description 7
- 239000011782 vitamin Substances 0.000 claims abstract description 7
- 229940088594 vitamin Drugs 0.000 claims abstract description 7
- 102000004190 Enzymes Human genes 0.000 claims description 19
- 108090000790 Enzymes Proteins 0.000 claims description 19
- 206010021639 Incontinence Diseases 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 12
- 230000000903 blocking effect Effects 0.000 claims description 10
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 6
- 239000003974 emollient agent Substances 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 3
- 150000003752 zinc compounds Chemical class 0.000 claims description 3
- 229940050168 zinc lactate Drugs 0.000 claims description 3
- 239000011576 zinc lactate Substances 0.000 claims description 3
- 235000000193 zinc lactate Nutrition 0.000 claims description 3
- 239000011787 zinc oxide Substances 0.000 claims description 3
- 229960001296 zinc oxide Drugs 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 abstract description 6
- 208000004210 Pressure Ulcer Diseases 0.000 abstract description 5
- 208000017520 skin disease Diseases 0.000 abstract description 5
- 206010052428 Wound Diseases 0.000 abstract description 4
- 208000027418 Wounds and injury Diseases 0.000 abstract description 4
- 230000036961 partial effect Effects 0.000 abstract description 4
- 206010040880 Skin irritation Diseases 0.000 abstract description 2
- 230000036556 skin irritation Effects 0.000 abstract description 2
- 231100000475 skin irritation Toxicity 0.000 abstract description 2
- 150000003626 triacylglycerols Chemical class 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 51
- 229940088598 enzyme Drugs 0.000 description 16
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 12
- 239000000463 material Substances 0.000 description 11
- 235000019645 odor Nutrition 0.000 description 11
- 210000002700 urine Anatomy 0.000 description 10
- 239000002085 irritant Substances 0.000 description 9
- 231100000021 irritant Toxicity 0.000 description 9
- 239000004599 antimicrobial Substances 0.000 description 8
- 230000004888 barrier function Effects 0.000 description 8
- 108010046334 Urease Proteins 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 6
- 229910021529 ammonia Inorganic materials 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 210000003608 fece Anatomy 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 5
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 5
- -1 polypropylene Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 230000036983 biotransformation Effects 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 3
- 108090001060 Lipase Proteins 0.000 description 3
- 102000004882 Lipase Human genes 0.000 description 3
- 239000004367 Lipase Substances 0.000 description 3
- 229920001057 Silicone quaternary amine Polymers 0.000 description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 229940067596 butylparaben Drugs 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000019421 lipase Nutrition 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- 229960002216 methylparaben Drugs 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- 239000011719 vitamin A Substances 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 241000640882 Condea Species 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 206010012442 Dermatitis contact Diseases 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 206010046543 Urinary incontinence Diseases 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 2
- 208000010247 contact dermatitis Diseases 0.000 description 2
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 2
- 229960001083 diazolidinylurea Drugs 0.000 description 2
- WQOXQRCZOLPYPM-UHFFFAOYSA-N dimethyl disulfide Chemical compound CSSC WQOXQRCZOLPYPM-UHFFFAOYSA-N 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
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- 102000004169 proteins and genes Human genes 0.000 description 2
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- 210000001519 tissue Anatomy 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 description 1
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- TZZGHGKTHXIOMN-UHFFFAOYSA-N 3-trimethoxysilyl-n-(3-trimethoxysilylpropyl)propan-1-amine Chemical compound CO[Si](OC)(OC)CCCNCCC[Si](OC)(OC)OC TZZGHGKTHXIOMN-UHFFFAOYSA-N 0.000 description 1
- OYDCCWNLILCHDJ-ZZXKWVIFSA-N 4-(sulfooxy)-cinnamic acid Chemical compound OC(=O)\C=C\C1=CC=C(OS(O)(=O)=O)C=C1 OYDCCWNLILCHDJ-ZZXKWVIFSA-N 0.000 description 1
- 102000000496 Carboxypeptidases A Human genes 0.000 description 1
- 108010080937 Carboxypeptidases A Proteins 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 206010072064 Exposure to body fluid Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 101000583175 Homo sapiens Prolactin-inducible protein Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- XPJVKCRENWUEJH-UHFFFAOYSA-N Isobutylparaben Chemical compound CC(C)COC(=O)C1=CC=C(O)C=C1 XPJVKCRENWUEJH-UHFFFAOYSA-N 0.000 description 1
- CMHMMKSPYOOVGI-UHFFFAOYSA-N Isopropylparaben Chemical compound CC(C)OC(=O)C1=CC=C(O)C=C1 CMHMMKSPYOOVGI-UHFFFAOYSA-N 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 102000002704 Leucyl aminopeptidase Human genes 0.000 description 1
- 108010004098 Leucyl aminopeptidase Proteins 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 102100030350 Prolactin-inducible protein Human genes 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
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- 239000002671 adjuvant Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- NGPTYCZGBCGWBE-UHFFFAOYSA-N decanoic acid hexadecanoic acid octadecanoic acid octanoic acid propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCC(O)=O.CCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O NGPTYCZGBCGWBE-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
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- 229960004698 dichlorobenzyl alcohol Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
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- 150000002148 esters Chemical class 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
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- 230000002550 fecal effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 150000001469 hydantoins Chemical class 0.000 description 1
- ZSAQFJAMTOPNDX-UHFFFAOYSA-N imidazolidine-2,4-dione;styrene Chemical class O=C1CNC(=O)N1.C=CC1=CC=CC=C1 ZSAQFJAMTOPNDX-UHFFFAOYSA-N 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
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- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 208000014674 injury Diseases 0.000 description 1
- 229940113094 isopropylparaben Drugs 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
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- 230000007774 longterm Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 229960005040 miconazole nitrate Drugs 0.000 description 1
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- OYDCCWNLILCHDJ-UHFFFAOYSA-N p-sulfooxy cinnamic acid Natural products OC(=O)C=CC1=CC=C(OS(O)(=O)=O)C=C1 OYDCCWNLILCHDJ-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
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- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
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- 238000012549 training Methods 0.000 description 1
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- 239000012588 trypsin Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
Definitions
- the invention relates to disposable absorbent articles containing skin health treatment additives and odor control additives.
- These disposable absorbent articles contain discreet localized deposits of a skin health treatment additive applied to the various layers of the article that will come into contact with the skin of a wearer.
- these disposable absorbent articles are useful as garments for incontinent adults for protecting the skin from irritating body fluids and fecal enzymes that may cause contact dermatitis and subsequent skin breakdown.
- the skin is a natural barrier to the penetration of foreign substances.
- the stratum corneum is the superficial cornified layer of the skin which provides a barrier to water evaporation and reduces the permeation of undesirable molecules from the external environment.
- the stratum corneum consists of dead cells called comeocytes, that are embedded in a lipid-rich matrix of fatty-acids, ceramides, and cholesterols. This structure of comeocytes embedded in lipids is thought to provide many of the barrier properties of the skin. Substances deposited on the skin must traverse this structure through a tortuous path to gain access to the underlying viable layers of the skin.
- Skin inflammation occurs when substances that are irritating to the skin are able to penetrate this barrier and initiate an elaborate cascade of immunological events once they contact the skin cells in the viable epidermis and der is layers. As the skin barrier is compromised, the skin is subject to inflammatory events from percutaneous absorbtion of irritants through the stratum corneum.
- Skin barrier function can be compromised by a variety of insults that cause inflammation.
- Insults to the skin can include, but are not limited to, environmental irritants, mechanical abrasion, continuous tissue load pressure, exposure to body fluids and waste, and exposure to chemicals.
- environmental irritants for example, physical and chemical treatments, abrasion, tape stripping, ultrasonics, electrical fields, enzymes, solvents, surfactants, and elevated ambient humidity are known to diminish skin barrier function.
- Bodily fluids and wastes may contain skin irritants in the form of enzymes such as proteases, ureases and lipases. Enzymes found in feces cleave the epidermis, dermis, and stratum corneum proteins and lipids and cause the breakdown of the natural barrier of the skin.
- Bacterial ureases on the skin convert the urea from urine to ammonia on the skin, causing an alkaline pH and leading to irritation of the skin. Prolonged exposure of the skin to these enzymes is thought to be a major cause of skin damage that leads to subsequent skin breakdown and contact dermatitis. In addition, the care of skin in individuals with ostomies is difficult due to the frequent contact of digestive enzymes with the skin surrounding the ostomy site. These enzymes can degrade the skin surface and cause severe skin breakdown and the development of partial thickness wounds.
- a number of approaches are known for protecting the skin against the action of skin irritants and subsequent skin breakdown.
- Examples include protective apparel, skin protectant formulations, and anti-inflammatory compositions.
- Protective apparel garments may prevent irritants from contacting the skin, or may be used to prevent (ftssemination of irritants from bodily fluids to the surrounding environment, for example, diapers or adult incontinence garments.
- barrier materials prevents movement of moisture and air and therefore, proliferates an environment in which skin may be kept in contact with the irritants and increase the damage.
- Disposable absorbent products currently find widespread use in many applications. For example, in the infant and child care areas, diapers and training pants have generally replaced reusable cloth absorbent articles.
- Other typical disposable absorbent products include feminine care products such as sanitary napkins or tampons, adult incontinence products, and health care products such as surgical drapes or wound dressings.
- a typical disposable absorbent product generally comprises a composite structure including a top sheet, a back sheet, and an absorbent structure between the top sheet and back sheet. These products usually include some type of fastening system for fitting the product onto the wearer.
- Disposable absorbent products are typically subjected to one or more liquid insults, such as exposure to urine, menses, blood, and feces during use.
- the outer cover back sheet materials of the disposable absorbent products are typically made of liquid-insoluble and liquid impermeable materials, such as polypropylene films, that exhibit a sufficient strength and handling capability so that the disposable absorbent product retains its integrity during use by a wearer and does not allow leakage of the liquid insulting the product.
- These products are used for incontinent adults, especially bed-ridden or incapacitated individuals.
- the combination of skin contact with urine and feces, and the lack of air flow in garments consisting of these disposable absorbent articles can contribute to the irritation of skin leading to the development of partial and full thickness wounds and pressure ulcers.
- An additional area of concern to care recipients and care givers alike is the effective management of odors arising from urinary incontinence.
- Soiled clothes, bedding, and disposable incontinence garments and pads can generate malodorous compounds such as isovaleric acid and other short chain organic acids, trimethylamine, ammonia, and a wide range of sulfides including dimethyl disulfide and dimethyl sulfide.
- the natural flora on the skin surface contain bacterial ureases which are responsible for the biotransformation of urea from urine into ammonia which is the most noticeable malodor in acute care, long term care and home based caregiver settings.
- the organisms most frequently associated with the develoment of the above cited malodorous compounds are Klebsiella pneumoniae, Eschericia coli, and Proteus mirabilis. Other species present as normal flora can include a vast variety of gram negative and positive bacteria and fungi.
- the dominant offensive malodors arising from urine biotransformation and urine decomposition are sulfurous compounds and ammonia.
- malodorous compounds has been shown to be delayed for several hours during the effective wear period of the garment (5-8 hours) by the application of a wide range of anti-microbial compounds including mild cosmetic preservatives such as methylparaben, ethylparaben, or butylparaben.
- mild cosmetic preservatives such as methylparaben, ethylparaben, or butylparaben.
- sparingly water soluble and water insoluble compounds which are thought to impact the normal flora of the skin in a minimal way since they are not carried by the moisture of urine on the pad to the skin surface. Maintaining the normal flora is an important consideration in the management of healthy skin. Concerns about the development of resistant strains of bacteria has brought about the need for effective management of incontinence odors without aggressing the normal flora of the care recipient.
- the invention relates to disposable absorbent articles comprising skin health treatment additives. More particularly, the invention relates to disposable absorbent adult incontinence articles comprising discreet localized deposits of a skin health treatment additive applied to the layer of the article that will come into contact with the skin of a wearer and odor control additives.
- the disposable absorbent articles comprise a liquid permeable top sheet, an absorbent structure, a liquid impermeable back sheet, and a skin health treatment additive, wherein the skin health treatment additive is applied consistently and uniformly to the top sheet in a discreet area of a regional zone corresponding to the sacral-coccyx area of the spine.
- a disposable absorbent article of the present invention comprises a top sheet having an inner surface oriented toward an interior of the absorbent article and an outer surface oriented toward an epidermal surface of a wearer of the article, an absorbent structure, a liquid impermeable back sheet, and a skin health treatment additive applied to the surface of the article that will come into contact with the skin of the wearer.
- the absorbent structure can be positioned between the top sheet and the back sheet.
- a fluid acquisition layer can be added to the disposable absorbent article.
- the skin health additive can be applied consistently and uniformly to the surface of the top sheet in an area that will come into contact with the sacral and coccyx area of the wearer.
- Non-migrating antimicrobials including, but not limited to, polychlorinated hydantoins such as n-halamine from HaloSource and silicone quaternary amines, from Aegis Environmental in Medland, MI, are especially suited for odor control management in urinary incontinence of the frail elderly who are at risk for the development of antibiotic resistant strains of bacteria.
- suitable odor control additives can include a chelating agent such as disodium EDTA in the range of 2%, an insoluble chlorinated hydantoin styrene bead in the range of 1.5-2.5%, a partially neutralized acrylic acid absorbent material coated with a silicone quaternary amine and present in 8-10%, a sparingly soluble anti-microbial such as methylparaben in the range of 0.5-1.0%, an anti-bioadhesion material such as zosteric acid present at 2-3%, a pH controlling organic acid such as malic acid present at 0.3-0.8%, a fluffed cellulose which has been pretreated with water soluble antimicrobials such as diazolidinyl urea at 0.5-0.8%, or combinations thereof.
- a chelating agent such as disodium EDTA in the range of 2%
- an insoluble chlorinated hydantoin styrene bead in the range of 1.5-2.5%
- the skin health treatment additive comprises at least one skin replenishing compound.
- the skin health treatment additive can comprise anti- inflammatory compounds, topical antibiotics, vitamins, enzyme blocking compounds, or combinations thereof.
- Skin replenishing compounds include, but are not limited to emollients.
- Emollients are natural or synthetic compounds that soften, sooth, coat, lubricate or moisturize the skin.
- Emollients include, but are not limited to, fats, waxes, polar lipids, . triglycerides, and esters.
- Emollients can be siloxane, silicone, or polysolixane based, or combinations thereof.
- Emollients suitable for the present invention include Huls Softisan 378 triglyceride wax, obtained from Condea Chemie/Condea Vista of Houston, TX.
- the skin health treatment additives of the present invention can comprise vitamins to help treat skin that has been irritated.
- Vitamins that are suitable for the present invention include, but are not limited to, vitamins A, C, and E.
- the skin health treatment additive of the present invention can comprise oil soluble vitamin C, vitamin A, and vitamin E.
- Barnett BVOSC is a vitamin C commercially available from Barnet Products
- Retinyl Palmitate is a suitable vitamin A
- Tocopherol Acetate is a suitable vitamin E, both commercially available from Roche, Nutley, NJ.
- Vitamins can be present in amounts ranging from about 0.1% to about 0.5% of the composition.
- Enzyme blocking compounds prevent skin irritation by blocking the ureases, and proteases or enzymes in feces and urine that can cause the breakdown of the natural protective barrier of the skin.
- Enzyme blocking compounds suitable for the present invention include any compound having inhibitory activity against proteolytic and/or lipolytic enzymes including, but not limited to, lipase, carboxypeptidase A, chymotrypsin, urease, elastase, trypsin, and leucine aminopeptidase.
- Enzyme blocking compounds suitable for the present invention can include, but are not limited to, any zinc compound. Suitable zinc compounds include, but are not limited to, zinc oxide, zinc sulfate or zinc lactate. Disodium EDTA is also a suitable enzyme blocking compound.
- compositions will often be formulated to contain one or more preservatives.
- Preservatives that are suitable for the present invention include, but are not limited to isopropylparaben, isobutylparaben, and butylparaben.
- disodium EDTA is a preservative adjuvant which is a chelating agent that can bind and inactivate ureases, lipases and other enzymes.
- Disposable absorbent articles suitable for the present invention can comprise a composite structure including a top sheet, a back sheet, and an absorbent structure between the top sheet and the back sheet.
- the article can further comprise a fluid acquisition layer.
- the liquid impermeable back sheet comprises a liquid repellent or water-barrier polymer material.
- the water-barrier material commonly used includes polymer materials, such as polyethylene film or copolymers of ethylene and other polar and non-polar monomers.
- the purpose of the water-barrier layer is to minimize or prevent absorbed liquid that may, during use, exude from the absorbent component and soil the user or adjacent clothing or environment.
- the water-barrier layer also has the advantage of allowing greater utilization of the absorbent capacity of the product and must exhibit a sufficient strength and handling capability so that the disposable absorbent product retains its integrity during use by the wearer.
- the absorbent structure between the top sheet and back sheet can be any biocompatible absorbent material comprising natural or synthetic components.
- the structure can comprise fibers, woven or non-woven materials, a web, a sponge, a matrix, fluffed cellulose superabsorbent material, or any combination thereof.
- the top sheet comprises any biocompatible natural or synthetic material that will feel soft against the skin of the wearer, allow moisture and air to transpire, and not cause allergic or toxic reactions by the skin.
- Disposable absorbent articles suitable for the present invention include those disclosed in U.S. Patent Nos. 6,306,782, 6,197,237, and 5,952,088 assigned to Kimberly Clark Worldwide, which are incorporated herein by reference.
- the absorbent structure can comprise partially neutralized acrylic acid polymers in a fluffed cellulose matrix comprising enzyme blocking and odor control chemicals such as disodium EDTA, zinc lactate, zinc chloride, zinc oxide, and zinc sulfate evenly dispersed in the absorbent layer matrix.
- the odor control chemicals comprise 1.5-2.5% of the total weight of the product.
- the absorbent matrix can comprise an antimicrobial to minimize the development of odors arising from the biotransformation of lipids, apocrine sweat, and proteins by bacteria on the skin or from body fluids.
- Suitable antimicrobials include but are not limited to, methylparaben, ethylparaben, butylparaben, diazolidinyl urea, imidazolidinyl urea, miconazole nitrate, 2- Bromo-2-Nitropropane-l, 3-Diol, dichlorobenzyl alcohol, DMDM Hydantoin and Iodopropynyl Butylcarbamate crystals, or non-leaching antimicrobials such as a n- halamine, or silicone quaternary amines. These antimicrobials can be used alone or in compatible mixtures. The amount of these will range from 0.25-2.5% of the total weight of the product.
- the absorbent matrix can comprise a pH regulating organic acid such as malic, citric, tartaric, mandellic, lactic, aleic or glycolic acid.
- a pH regulating organic acid such as malic, citric, tartaric, mandellic, lactic, aleic or glycolic acid.
- the addition of these acids should be in sufficient quantity to maintain an optimum skin pH of 4.2-4.8.
- the amount added should be titrated so as not to interfere with the absorbency of the partially neutralized acrylic acid super absorbent particles contained in the absorbent layer. The amount may range from 0.3-0.6% of the total weight of the product.
- the lowered pH is regarded to minimize the effect of skin damaging enzymes in feces and the bacterial urease biotransformation of urea in urine to ammonia.
- the backsheet or the layer furthermost from the body can be a bilayer component composed of an extruded polyurethane foam with a breathable polyethylene outer layer.
- This layer will serve to cushion the sacral-coccyx area of the spine and allow air circulation to minimize the buildup of humidity as the garment is worn.
- this layer can be inserted into an area of the article which will correspond to the region of the sacral-coccyx area of the spine commonly known as the tailbone.
- the preferred shape of this insert is a rectangle of 5x7 inches.
- the packaging in which the disposable article is distributed is made from a water-barrier, specifically water-resistant, material.
- Water-resistivity is necessary to prevent the degradation of the packaging from environmental conditions and to protect the disposable articles therein.
- a formula for a skin health additive for a disposable absorbent article is prepared by combining the following ingredients by any method known in the art:
- the resulting anhydrous formula is heated to obtain a fluid homogenous state (from about 70°C to about 90°C) and applied to the absorbent article.
- the coating can be applied by suitable methods apparent in the art including, but not limited to, spray application, slot coating, bead coating, rotary silk screening processes, evaporative coating, extrusion, or any combination thereof.
- the skin health treatment additive can be applied in a geometric pattern or a random pattern. A uniform and consistent coating with the skin health treatment additive is thought to provide maximum protection to the skin.
- the coated area can be in the geometric form of a circle, oval, square, rectangle, triangle, or combination, that is positioned on the top sheet of the article in a discreet location that would contact the skin of the sacral/coccyx anatomical region, or tailbone, of the wearer.
- the coated area is in the form of an elongated oval.
- the skin health additive can be applied in a criss-cross continuous pattern that allows indentations or fluid intake holes in the fluid acquisition skin contact layer.
- the skin health additive can be applied to the innermost skin contact layer.
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003281944A AU2003281944A1 (en) | 2002-08-08 | 2003-06-26 | Disposable absorbent articles with skin health and odor control additives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/215,961 | 2002-08-08 | ||
US10/215,961 US6855134B2 (en) | 2002-08-08 | 2002-08-08 | Disposable absorbent articles with skin health and odor control additives |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004014276A1 true WO2004014276A1 (en) | 2004-02-19 |
Family
ID=31494976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/020515 WO2004014276A1 (en) | 2002-08-08 | 2003-06-26 | Disposable absorbent articles with skin health and odor control additives |
Country Status (3)
Country | Link |
---|---|
US (1) | US6855134B2 (en) |
AU (1) | AU2003281944A1 (en) |
WO (1) | WO2004014276A1 (en) |
Cited By (1)
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WO2012070225A1 (en) * | 2010-11-26 | 2012-05-31 | Unicharm Corporation | Absorbent article |
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JP3979959B2 (en) * | 2003-04-10 | 2007-09-19 | 住友精化株式会社 | Water absorbent resin composition |
WO2006020213A2 (en) * | 2004-07-19 | 2006-02-23 | Bruce Fine | Superabsorbent pad |
US7163529B2 (en) * | 2004-12-15 | 2007-01-16 | Kimberly-Clark Worldwide, Inc. | Absorbent article having disposal wings with odor absorbency |
US8138106B2 (en) | 2005-09-30 | 2012-03-20 | Rayonier Trs Holdings Inc. | Cellulosic fibers with odor control characteristics |
US20080200890A1 (en) * | 2006-12-11 | 2008-08-21 | 3M Innovative Properties Company | Antimicrobial disposable absorbent articles |
US7883495B2 (en) | 2007-05-24 | 2011-02-08 | First Quality Retail Services, Llc | Disposable absorbent article and polymer film having odor control and/or skin health agents |
US20090030391A1 (en) * | 2007-07-25 | 2009-01-29 | John Lee Hammons | Absorbent article |
US20090155325A1 (en) * | 2007-12-14 | 2009-06-18 | Kimberly-Clark Worldwide, Inc. | Formulation and products for promoting skin cleanliness and health |
CN101909667B (en) * | 2008-01-10 | 2015-04-22 | 爱乐康株式会社 | Adhesive agent for skin, adhesive sheet for skin and face plate of ostomy appliance |
US9533479B2 (en) * | 2008-09-18 | 2017-01-03 | Medline Industries, Inc. | Absorbent articles having antimicrobial properties and methods of manufacturing the same |
US9717818B2 (en) * | 2009-05-08 | 2017-08-01 | Medline Industries, Inc. | Absorbent articles having antimicrobial properties and methods of manufacturing the same |
US20120070480A1 (en) | 2010-09-17 | 2012-03-22 | 3M Innovative Properties Company | Antimicrobial disposable absorbent articles |
US20130165880A1 (en) | 2010-09-17 | 2013-06-27 | David T. Amos | Antimicrobial disposable absorbent articles |
US9238348B2 (en) | 2010-10-08 | 2016-01-19 | Kimberly-Clark Worldwide, Inc. | Method of manufacture of article for delivering health-benefit agent |
US8552251B2 (en) | 2010-10-08 | 2013-10-08 | Kimberly-Clark Worldwide, Inc. | Article with health-benefit agent delivery system |
US8785714B2 (en) | 2011-02-28 | 2014-07-22 | Celanese International Corporation | Alkali neutralizing acquisition and distribution structures for use in personal care articles |
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Also Published As
Publication number | Publication date |
---|---|
US6855134B2 (en) | 2005-02-15 |
AU2003281944A1 (en) | 2004-02-25 |
US20040030315A1 (en) | 2004-02-12 |
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