JP3246153U - Tablet-shaped candy with the ability to improve bone density and joint function - Google Patents

Abstract

The present invention provides a tablet-shaped candy containing SGF skeletal growth factor that has the function of improving bone density. [Solution] SGF skeletal growth factor is a physiologically active polypeptide substance prepared from constituent materials such as cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide, and improves animal bone minerals. It is a new type of food-based basic bone health supplement that is prepared from raw materials and processed through processes such as decolorization, deodorization, and removal of non-collagen impurities by applying biological enzyme cutting technology. [Selection diagram] Figure 1

Description

The present invention relates to the technical field of health foods, and particularly to SGF skeletal growth factor having the function of improving bone density and a method for producing the same.

Skeletal diseases, especially bone and joint diseases, not only limit the movement and activities of patients, but also cause serious damage to people's overall health and pose a heavy socio-economic burden. As the world's aging problem becomes more and more severe, the incidence/prevalence of bone-related diseases in the elderly group also increases day by day, and various bone diseases greatly affect the quality of life of the elderly group. posed a serious threat to the overall health of the elderly. Pre-existing bone and joint diseases are more likely to occur in the elderly, but in recent years, research reports have shown that the age at which related bone and joint diseases occur is getting earlier each year. Osteoarticular diseases due to inappropriate intervention may further develop, intensify joint pain, cause associated activity impairment, and eventually lead to the development of disability. Therefore, developing adaptive and individualized prevention and treatment strategies is imperative to early intervention and control of bone and joint diseases, and thus to alleviate the health and economic burden of the population. There is also a constant rush to find effective treatments to alleviate bone degeneration, improve joint flexibility, and control bone pain.

Currently, clinical treatment for skeletal diseases mainly involves drug treatment other than surgery. Medications commonly used in clinical practice are those using paracetamol and non-steroidal anti-inflammatory drugs. Among them, non-steroidal anti-inflammatory drugs are the main therapeutic agents for treating affected bones and joints. However, non-steroidal anti-inflammatory drugs have many drawbacks, such as they can cause gastrointestinal ulcers and can cause problems such as kidney failure and dehydration, so they are currently not used to treat skeletal diseases. It became clear that drug safety and efficacy needed to be improved.

In order to solve the problem that the safety and efficacy of drugs for treating skeletal system diseases need to be improved, embodiments of the present application provide SGF skeletal growth factors with the ability to improve bone density.

The embodiment of the present application is an SGF skeletal growth factor that is realized in this way and has the function of improving bone density, and the raw material of the SGF skeletal growth factor is:
Contains cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt and chitosan oligosaccharide.

Preferably, the SGF skeletal growth factor comprises the following weight percentages of ingredients:
Cartilage collagen peptides 1-40%, bovine bone collagen peptides 1-50%, milk mineral salts 8-60%, and chitosan oligosaccharides 0.01-1%.

Preferably, the SGF skeletal growth factor comprises the following weight percentages of ingredients:
20% cartilage collagen peptides, 29.98% bovine bone collagen peptides, 50% milk mineral salts, and 0.02% chitosan oligosaccharides.

Preferably, the raw material for the SGF skeletal growth factor further comprises:
Contains sorbitol, crystalline cellulose, bovine bone peptide and magnesium stearate.

Preferably, the SGF skeletal growth factor comprises the following weight percentages of ingredients:
Cartilage collagen peptide 1-20%, bovine bone collagen peptide 1-30%, milk mineral salt 8%, chitosan oligosaccharide 0.7%, sorbitol 25%, crystalline cellulose 7%, bovine bone peptide 0-20% and Magnesium stearate 1.3%.

Preferably, the SGF skeletal growth factor comprises the following weight percentages of ingredients:
Cartilage collagen peptide 23%, bovine bone collagen peptide 26%, milk mineral salt 8%, chitosan oligosaccharide 0.7%, sorbitol 25%, crystalline cellulose 7%, bovine bone peptide 9% and magnesium stearate 1.3 %.

Embodiments of the present application further provide a method for producing SGF skeletal growth factor having the function of improving bone density,
preparing a raw material based on the constituent materials of the SGF skeletal growth factor having the function of improving bone density;
Crushing cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt and chitosan oligosaccharide;
After sufficiently mixing the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide, the mixture is put into a granulating device for granulation, followed by drying and tableting. Obtaining SGF skeletal growth factor with the ability to improve bone density.

Preferably, the method for producing SGF skeletal growth factor having the function of improving bone density comprises:
preparing a raw material based on the constituent materials of the SGF skeletal growth factor having the function of improving bone density;
Crushing cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide and magnesium stearate;
After thoroughly mixing the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide, and magnesium stearate, the mixture is put into a granulation device and granulated. The method includes the steps of performing granulation processing, drying, and tableting processing, that is, obtaining SGF skeletal growth factor with the function of improving bone density.

Preferably, the relative humidity of the environment during the tableting process is controlled to 60% or less.

Preferably, after the granulation process, the obtained granules are sized using a 12 to 18 mesh sieve.

Preferably, the sized material is dried at 60° C. until the moisture content of the granules becomes 5% or less.

Preferably, after the grinding process, the ground material is passed through an 80-100 mesh sieve.

The embodiments of the present application further provide a tablet-shaped candy having the function of improving bone density and joint function, and the tablet-type candy having the function of improving bone density and joint function have the function of improving bone density. Includes SGF skeletal growth factor with

Embodiments of the present application provide SGF skeletal growth factor with the ability to improve bone density, which is prepared by component materials such as cartilage collagen peptide, bovine bone collagen peptide, milk mineral salts and chitosan oligosaccharides. Bone health through a new type of food that is an active polypeptide substance made from animal bone minerals and prepared through processes such as decolorization, deodorization, and removal of non-collagen impurities by applying biological enzyme cleavage technology. As a basic supplement, there is no risk of surgery, no side effects of drug treatments such as non-steroidal anti-inflammatory drugs, and compared to other drug treatments and other supplements, the SGF skeletal growth factor provided by this application It can significantly improve the related symptoms of patients with this disease and improve their quality of life and health status.

In addition, compared to existing collagen on the market, the SGF skeletal growth factor provided by the present application has a more remarkable improvement effect on elderly osteoporotic patients, and has a remarkable bone formation activation effect on elderly osteoporotic patients. It can significantly reduce alkaline phosphatase levels in patients, improve bone density, and better control related discomfort in patients, making it a safe and effective solution to potentially treat total bone and joint diseases. . Especially in the face of the advent of an aging society, this will make a great contribution to lowering the number of total skeletal patients and increasing the overall level of human health.

In addition, the tablet-shaped candy that has the function of improving bone density and joint function provided by the embodiments of the present application does not require heating and boiling, can effectively retain nutritional components, and the tablet-shaped candy has the ability to improve bone density and joint function. Easy to carry, compared to commercial skeletal growth factor titanium powder products that need to be drunk with water, its edible is more convenient, easier to digest and absorb after eating, tastes better, and meets the current market needs. It suits.

In order to make the objectives, technical solutions and advantages of the present application more clear, the present application will be described in more detail by combining specific examples below. It is to be understood that the specific examples described herein are used only to illustrate the present application and not to limit the present application.

Embodiments of the present application provide SGF skeletal growth factors based on cartilage collagen peptides, bovine bone collagen peptides, milk mineral salts and chitosan oligosaccharides.

Here, cartilage collagen peptide is a novel protein hydrolyzate produced from edible proteins through enzymatic decomposition, separation, purification, etc. Cartilage collagen peptides differ depending on their relative molecular weight distribution, and are divided into cartilage collagen peptides (relative molecular weight less than 1000) and food-derived polypeptides (relative molecular weight 1000 or more). Cartilage collagen peptide relieves bone pain by increasing the content of synovial cell mucus, participates in the absorption and release of skeletal calcium, and promotes skeletal neovascularization by regulating skeletal metabolism and growth. promotes bone density, strengthens bone strength, prevents osteoporosis, plays the role of protecting the gastric mucosa, can achieve anti-allergic effects, and is expected to prevent skin aging. It can be expected to have a moisturizing effect on the skin to some extent.

Bovine bone collagen peptide is a refined powdered oligopeptide made from bovine bone as the main raw material, and is a raw material for a new type of nutritious health food. Bovine bone collagen peptide is effective in beauty care and calcium supplementation. Bovine bone collagen peptide is mainly collagen extracted from bovine bones, mainly type I collagen, and is a collagen peptide obtained through enzymatic decomposition, separation and purification of collagen in bovine bones. Yes, this collagen is easily digested and absorbed by the human body, has anti-hypertension, bone health protection, antibacterial, antioxidant and immunomodulation effects, and can effectively increase skin elasticity and strengthen bone strength. be able to.

Milk mineral salt is made from whey, from which components such as protein and lactose have been removed. Milk mineral salt contains abundant minerals and various trace elements necessary for human skeletal regeneration, promotes healing and growth of the human skeletal structure, increases bone density, and locks in nutrients for the musculoskeletal system. In addition, when ingested by the human body, milk mineral salts can increase the ion content and regulate the ion balance in the body.

Chitosan oligosaccharide is the only positively charged alkaline oligosaccharide among the natural sugars known to mankind, and it strengthens cartilage new generation and repair ability, improves cartilage elasticity, pressure resistance and wear resistance, and improves bone structure. It has the effect of nourishing and lubricating the joints.

1 is an external view of a tablet-shaped candy according to an embodiment of the present invention, in which (a) is a front view, (b) is a side view, and (c) is a perspective view.

Examples of some embodiments of the present application are provided below, but are not intended to limit the scope of the present application.

Although the numerical values shown in the examples below are as accurate as possible, those skilled in the art will appreciate that they are not absolutely accurate, and due to unavoidable measurement errors and experimental manipulation problems, each number may be a divisor. I understand that it should be understood as

(Example 1)
In this example, the SGF skeletal growth factor with the function of improving bone density contains the following weight percentages of raw materials:
Cartilage collagen peptide 23%, bovine bone collagen peptide 21%, milk mineral salt 8%, chitosan oligosaccharide 0.7%, sorbitol 25%, crystalline cellulose 7%, bovine bone peptide 14% and magnesium stearate 1.3 %.

preparing raw materials based on the constituent materials of the SGF skeletal growth factor having the function of improving bone density;
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide, and magnesium stearate are crushed and processed through an 80-100 mesh sieve, and when crushing is not necessary. directly to the mixing process,
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salts, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide and magnesium stearate until the ingredients are uniformly mixed; Then, the uniformly mixed material is put into a granulation equipment for granulation treatment, the manufactured particles are sieved through a 12-18 mesh sieve, and the sized material is dried at 60°C for 2 hours. , the granule water content was controlled to be less than 5%, the environmental relative humidity was controlled to be less than 60%, and the material was processed into tablets, that is, the SGF skeletal growth factor with the function of improving bone density was obtained.

(Example 2)
In this example, the SGF skeletal growth factor with the function of improving bone density contains the following weight percentages of raw materials:
Cartilage collagen peptide 26%, bovine bone collagen peptide 28%, milk mineral salt 8%, chitosan oligosaccharide 0.7%, sorbitol 25%, crystalline cellulose 7%, bovine bone peptide 4% and magnesium stearate 1.3 %.

preparing raw materials based on the constituent materials of the SGF skeletal growth factor having the function of improving bone density;
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide, and magnesium stearate are crushed and processed through an 80 to 100 mesh sieve, and when crushing is not necessary. directly to the mixing process,
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salts, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide and magnesium stearate until the ingredients are uniformly mixed; Then, the uniformly mixed material is put into a granulation equipment for granulation treatment, the manufactured particles are sieved through a 12 to 18 mesh sieve, and the sized material is dried at 60°C for 2 hours. , the granule water content was controlled to be less than 5%, and the environmental relative humidity was controlled to be less than 60%, and the material was processed into tablets, that is, the SGF skeletal growth factor with the function of improving bone density was obtained.

(Example 3)
In this example, the SGF skeletal growth factor with the function of improving bone density contains the following weight percentages of raw materials:
Cartilage collagen peptide 23%, bovine bone collagen peptide 26%, milk mineral salt 8%, chitosan oligosaccharide 0.7%, sorbitol 25%, crystalline cellulose 7%, bovine bone peptide 9% and magnesium stearate 1.3 %.

preparing raw materials based on the constituent materials of the SGF skeletal growth factor having the function of improving bone density;
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide, and magnesium stearate are crushed and processed through an 80-100 mesh sieve, and when crushing is not necessary. directly to the mixing process,
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salts, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide and magnesium stearate until the ingredients are uniformly mixed; Then, the uniformly mixed material is put into a granulation equipment for granulation treatment, the manufactured particles are sieved through a 12-18 mesh sieve, and the sized material is dried at 60°C for 2 hours. , the granule water content was controlled to be less than 5%, the environmental relative humidity was controlled to be less than 60%, and the material was processed into tablets, that is, the SGF skeletal growth factor with the function of improving bone density was obtained.

(Example 4)
In this example, the SGF skeletal growth factor with the function of improving bone density contains the following weight percentages of raw materials:
Cartilage collagen peptide 31%, bovine bone collagen peptide 24%, milk mineral salt 8%, chitosan oligosaccharide 0.7%, sorbitol 25%, crystalline cellulose 7%, bovine bone peptide 3% and magnesium stearate 1.3 %.

preparing raw materials based on the constituent materials of the SGF skeletal growth factor having the function of improving bone density;
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide, and magnesium stearate are crushed and processed through an 80-100 mesh sieve, and when crushing is not necessary. directly to the mixing process,
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salts, chitosan oligosaccharide, sorbitol, crystalline cellulose, bovine bone peptide and magnesium stearate until the ingredients are uniformly mixed; Then, the uniformly mixed material is put into a granulation equipment for granulation treatment, the manufactured particles are sieved through a 12-18 mesh sieve, and the sized material is dried at 60°C for 2 hours. , the granule water content was controlled to be less than 5%, the environmental relative humidity was controlled to be less than 60%, and the material was processed into tablets, that is, the SGF skeletal growth factor with the function of improving bone density was obtained.

The SGF skeletal growth factor products prepared in Examples 1 to 4 were quality tested, and the test results are shown in Table 1 below.

(Example 5)
In this example, the tablet-shaped candy 10 having the function of improving bone density and joint function contains the following weight percentages of raw materials:
Cartilage collagen peptide 10%, bovine bone collagen peptide 29.94%, milk mineral salt 60%, chitosan oligosaccharide 0.06%.

Prepare raw materials based on the constituent materials of the tablet-shaped candy 10 having the function of improving bone density and joint function,
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide are crushed and processed through an 80-100 mesh sieve, and if crushing is not necessary, directly go to the mixing process.
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide until the materials are evenly mixed, and then put the uniformly mixed materials into the granulation equipment. The produced particles are sieved through a 12 to 18 mesh sieve for granulation, and the sized material is dried at 60°C for 2 hours until the moisture content of the granules is less than 5% and the relative humidity of the environment is The content was controlled until it was 60% or less, and the material was tableted, that is, 2.5 g/tablet of tablet-shaped candy 10 was obtained.

(Example 6)
In this example, the tablet-shaped candy 10 having the function of improving bone density and joint function contains the following weight percentages of raw materials:
Cartilage collagen peptide 15%, bovine bone collagen peptide 24.98%, milk mineral salt 60%, chitosan oligosaccharide 0.02%.

Prepare raw materials based on the constituent materials of the tablet-shaped candy 10 having the function of improving bone density and joint function,
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide are crushed and processed through an 80-100 mesh sieve, and if crushing is not necessary, directly go to the mixing process.
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide until the materials are evenly mixed, and then put the uniformly mixed materials into the granulation equipment. The produced particles are sieved through a 12 to 18 mesh sieve for granulation, and the sized material is dried at 60°C for 2 hours until the moisture content of the granules is less than 5% and the relative humidity of the environment is The content was controlled until it was 60% or less, and the material was tableted, that is, 2.5 g/tablet of tablet-shaped candy 10 was obtained.

(Example 7)
In this example, the tablet-shaped candy 10 having the function of improving bone density and joint function contains the following weight percentages of raw materials:
Cartilage collagen peptide 20%, bovine bone collagen peptide 29.98%, milk mineral salt 50%, chitosan oligosaccharide 0.02%.

Prepare raw materials based on the constituent materials of the tablet-shaped candy 10 having the function of improving bone density and joint function,
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide are crushed and processed through an 80-100 mesh sieve, and if crushing is not necessary, directly go to the mixing process.
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide until the materials are evenly mixed, and then put the uniformly mixed materials into the granulation equipment. The produced particles are sieved through a 12 to 18 mesh sieve for granulation, and the sized material is dried at 60°C for 2 hours until the moisture content of the granules is less than 5% and the relative humidity of the environment is The content was controlled until it was 60% or less, and the material was tableted, that is, 2.5 g/tablet of tablet-shaped candy 10 was obtained.

(Example 8)
In this example, the tablet-shaped candy 10 having the function of improving bone density and joint function contains the following weight percentages of raw materials:
Cartilage collagen peptide 30%, bovine bone collagen peptide 15.98%, milk mineral salt 54%, chitosan oligosaccharide 0.02%.

Prepare raw materials based on the constituent materials of the tablet-shaped candy 10 having the function of improving bone density and joint function,
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide are crushed and processed through an 80-100 mesh sieve, and if crushing is not necessary, directly go to the mixing process.
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide until the materials are evenly mixed, and then put the uniformly mixed materials into the granulation equipment. The produced particles are sieved through a 12 to 18 mesh sieve for granulation, and the sized material is dried at 60°C for 2 hours until the moisture content of the granules is less than 5% and the relative humidity of the environment is The content was controlled until it was 60% or less, and the material was tableted, that is, 2.5 g/tablet of tablet-shaped candy 10 was obtained.

(Example 9)
In this example, the tablet-shaped candy 10 having the function of improving bone density and joint function contains the following weight percentages of raw materials:
Cartilage collagen peptide 40%, bovine bone collagen peptide 14.95%, milk mineral salt 45%, chitosan oligosaccharide 0.05%.

Prepare raw materials based on the constituent materials of the tablet-shaped candy 10 having the function of improving bone density and joint function,
Cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide are crushed and processed through an 80-100 mesh sieve, and if crushing is not necessary, directly go to the mixing process.
Thoroughly mix the crushed cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide until the materials are evenly mixed, and then put the uniformly mixed materials into the granulation equipment. The produced particles are sieved through a 12 to 18 mesh sieve for granulation, and the sized material is dried at 60°C for 2 hours until the moisture content of the granules is less than 5% and the relative humidity of the environment is The content was controlled until it was 60% or less, and the material was tableted, that is, 2.5 g/tablet of tablet-shaped candy 10 was obtained.

Table 2 shows the blending ratios of the tablet-shaped candies 10A to E samples prepared in Examples 5 to 9 above.

A food sensation experiment was conducted on the tablet-shaped candy samples 10A to 10E prepared in Examples 5 to 9 above, that is, the samples were evaluated in a balanced random order based on the requirement of ordering experiment in the food sensation experiment. The results were submitted to the government and evaluated by an evaluation expert, who ordered the samples with the five different blending ratios, statistically analyzed the results, and calculated the rank sum, which is shown in Table 3.

According to the Friedman test method, a statistic of F=31.093, a<0.01 was calculated, indicating that the difference is very significant.

According to the Kramer test method, when the number of evaluation experts is 15 and the number of samples is 5, the critical values are shown in Table 4.

First, we tested whether there were significant differences between the top samples. Since the rank sum RC of sample C is 24, which is smaller than the upper minimum value, and RE=67, which is larger than the upper maximum value, it is determined that there is a significant difference between the samples.

Next, it is examined whether there is a significant difference between the lower samples, RE=67, which is greater than the lower maximum value 58, RA=57, RB=36, RD=41, all of which are in the lower range. It is within. RC=24, which is smaller than the minimum value at the bottom. As a result, the five samples can be divided into three groups, namely, sample C alone is one set, sample A, sample B, and sample D are one set, and sample E is one set.

According to the Kramer test method, it was concluded that Sample C had the best texture, followed by Sample A, Sample B, Sample D, and finally Sample E. From this, the tablet-shaped candy 10 manufactured with the sample C formulation adopted in the present application is not only easy to eat, but also has high nutritional value and the best texture, and is recognized in the market.

A clinical test was conducted on the SGF skeletal growth factor prepared in Example 3 above, specifically as follows:
Clinical data and 52 elderly patients with osteoporosis were selected. We excluded those who had used drugs that affect bone metabolism such as estrogen, anticoagulants, calcitonin, and bisphosphonates within the past 3 months, and we excluded those who had used drugs that affect bone metabolism, such as estrogen, anticoagulants, calcitonin, and bisphosphonates. Those with endocrine and other bone diseases were excluded, and those with moderate to severe hepatic and renal insufficiency and severe heart disease were excluded.

Grouping/Intervention Method: Fifty-two study subjects were randomly divided into an intervention group and a control group using a completely random grouping method, and a 6-month follow-up treatment was conducted. The intervention group received one tablet of SGF skeletal growth factor once daily during the follow-up period, and the control group received two tablets of commercially available collagen three times daily during the follow-up period. All subjects were required to take the medication regularly under the same medication conditions.

Data collection: Before taking medication, the subjects' alkaline phosphatase and bone density status were collected from laboratory test data. An on-site follow-up was conducted 6 months after taking the medication. The alkaline phosphatase and bone density status of the subjects will be collected again through laboratory test data, and the effects of drug treatment will be determined by comparing the changes in related bone indicators before and after taking the drug and the data differences between the control group and the intervention group.

Data analysis: All study data were input into SPSS software for statistics, and the data were subjected to t-test or chi-square test, and P<0.05 indicates that the difference is statistically significant.

Results of the clinical trial showed that among 52 elderly patients with osteoporosis, the intervention group consisted of 15 men (57.7%) and 11 women (42.3%), ages 56-82 years old, average (72.7%). The patient's average medical history was (5.24±1.41) years. The control group consisted of 16 men (61.5%) and 10 women (38.5%), age 57-80 years, mean (71.2±2.41) years, mean medical history (5.13±1. 62). There was no statistical significance when comparing the differences between the two groups in terms of age, gender, medical history, etc. (P<0.05).Detailed results are shown in Table 5.

There were significant changes in alkaline phosphatase and bone density in the intervention group before and after treatment (P<0.05), and there were no significant differences in the two indicators before and after treatment in the control group (P<0.05). . There is no statistical significance in the index difference between the pre-treatment intervention group and the control group, and the post-treatment intervention group clearly improved, and the difference is statistically significant (P<0.05).Detailed results are in Table 6 Shown below.

From the above, the SGF skeletal growth factor that has the function of improving bone density provided by the embodiments of the present application is a physiological growth factor prepared with constituent materials such as cartilage collagen peptide, bovine bone collagen peptide, milk mineral salt, and chitosan oligosaccharide. Bone health through a new type of food that is an active polypeptide substance made from animal bone minerals and prepared through processes such as decolorization, deodorization, and removal of non-collagen impurities by applying biological enzyme cleavage technology. As a basic supplement, there is no risk of surgery, no side effects of drug treatments such as non-steroidal anti-inflammatory drugs, and compared to other drug treatments and other supplements, the SGF skeletal growth factor provided by this application It can significantly improve the related symptoms of patients with this disease and improve their quality of life and health status.

In addition, compared to existing collagen on the market, the SGF skeletal growth factor provided by the present application has a more remarkable improvement effect on elderly osteoporotic patients, and has a remarkable bone formation activation effect on elderly osteoporotic patients. It can significantly reduce alkaline phosphatase levels in patients, improve bone density, and better control related discomfort in patients, making it a safe and effective solution to potentially treat total bone and joint diseases. . Especially in the face of the advent of an aging society, this will make a great contribution to lowering the number of total skeletal patients and increasing the overall level of human health.

In addition, the tablet-shaped candy 10 that has the function of improving bone density and joint function provided by the embodiment of the present application does not require heating and boiling, can effectively retain nutritional components, and can be used as a tablet-shaped candy. 10 is easy to carry, compared to the commercial skeletal growth factor titanium powder products that need to be drunk with water, its consumption is more convenient, easier to digest and absorb after consumption, and tastes better, which is the best in the current market. meets the needs of

The above-mentioned examples only represent some embodiments of the present invention, and although the description thereof is more specific and detailed, they cannot therefore be understood as a limitation on the scope of the present invention. It should be pointed out that a person skilled in the art, which falls within the protection scope of the present invention, can make several modifications and improvements without departing from the concept of the present invention. Therefore, the scope of protection of the patent for the present invention shall conform to the scope of the attached claims.

10 Tablet-shaped candy

Claims (6)

It is a tablet-shaped candy that has the ability to improve bone density and joint function.
The tablet-shaped candy that has the function of improving bone density and joint function contains SGF skeletal growth factor that has the function of improving bone density, and the raw materials for the SGF skeletal growth factor include cartilage collagen peptide, bovine bone. A tablet-shaped candy containing collagen peptide, milk mineral salt, and chitosan oligosaccharide, which has the function of improving bone density and joint function. The tablet-shaped candy having the function of improving bone density and joint function as claimed in claim 1, wherein the SGF skeletal growth factor contains the following weight percent of raw materials.
Cartilage collagen peptides 1-40%, bovine bone collagen peptides 1-50%, milk mineral salts 8-60%, and chitosan oligosaccharides 0.01-1%. The tablet-shaped candy having the function of improving bone density and joint function as claimed in claim 1, wherein the SGF skeletal growth factor contains the following weight percent of raw materials.
20% cartilage collagen peptides, 29.98% bovine bone collagen peptides, 50% milk mineral salts, and 0.02% chitosan oligosaccharides. The tablet-shaped candy having the function of improving bone density and joint function as claimed in claim 2, wherein the SGF skeletal growth factor contains the following weight percent of raw materials.
20% cartilage collagen peptides, 29.98% bovine bone collagen peptides, 50% milk mineral salts, and 0.02% chitosan oligosaccharides. The raw material for the SGF skeletal growth factor further includes:
The SGF skeletal growth factor of claim 1 comprising sorbitol, microcrystalline cellulose, bovine bone peptide and magnesium stearate comprises the following weight percent ingredients: A tablet-shaped candy having the described function of improving bone density and joint function. The tablet-shaped candy having the function of improving bone density and joint function as claimed in claim 5, wherein the SGF skeletal growth factor contains the following weight percent of raw materials.
Cartilage collagen peptide 1-31%, bovine bone collagen peptide 1-30%, milk mineral salt 8%, chitosan oligosaccharide 0.7%, sorbitol 25%, crystalline cellulose 7%, bovine bone peptide 0-20% and Magnesium stearate 1.3%.

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