JP3240135B2 - Ｆｋ―５０６のレセプター分析法 - Google Patents
Ｆｋ―５０６のレセプター分析法Info
- Publication number
- JP3240135B2 JP3240135B2 JP51172191A JP51172191A JP3240135B2 JP 3240135 B2 JP3240135 B2 JP 3240135B2 JP 51172191 A JP51172191 A JP 51172191A JP 51172191 A JP51172191 A JP 51172191A JP 3240135 B2 JP3240135 B2 JP 3240135B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- binding
- labeled
- cyclosporin
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000013212 standard curve analysis Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52107490A | 1990-05-09 | 1990-05-09 | |
| US521,074 | 1990-05-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05502101A JPH05502101A (ja) | 1993-04-15 |
| JP3240135B2 true JP3240135B2 (ja) | 2001-12-17 |
Family
ID=24075229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51172191A Expired - Fee Related JP3240135B2 (ja) | 1990-05-09 | 1991-05-07 | Ｆｋ―５０６のレセプター分析法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0482189A1 (https=) |
| JP (1) | JP3240135B2 (https=) |
| AU (1) | AU657096B2 (https=) |
| CA (1) | CA2063580C (https=) |
| WO (1) | WO1991017439A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101459227B1 (ko) | 2012-05-11 | 2014-11-12 | 가톨릭대학교 산학협력단 | 이식 후 면역 상태를 모니터링 하는 키트 및 이를 이용한 면역 상태의 모니터링 방법 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763590A (en) * | 1991-10-11 | 1998-06-09 | Vertex Pharmaceuticals, Inc. | Isolation of an Mr 52,000 FK506 binding protein and molecular cloning of a corresponding human cDNA |
| WO1993025533A1 (en) * | 1992-06-05 | 1993-12-23 | Abbott Laboratories | Methods and reagents for the determination of immunosuppressive agents |
| US5457182A (en) * | 1994-02-15 | 1995-10-10 | Merck & Co., Inc. | FK-506 cytosolic binding protein, FKBP12.6 |
| ES2249986B1 (es) * | 2004-07-02 | 2007-02-01 | Universidad Complutense De Madrid | Sintesis de derivados fluorescentes de tacrolimus (fk506) y su uso en la caracterizacion de la interaccion de fk506 con proteinas de union a fk506. |
| US7642059B2 (en) * | 2005-09-07 | 2010-01-05 | Roche Diagnostics Operations, Inc. | Single receptor assays for immunosuppressive drugs |
| US9658218B2 (en) | 2012-05-07 | 2017-05-23 | Siemens Healthcare Diagnostics Inc. | Determination of total analyte concentration |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641889B1 (fr) * | 1989-01-18 | 1991-03-29 | Schlumberger Prospection | Procede de representation graphique polychrome du pendage des couches geologiques |
| EP0379342B1 (en) * | 1989-01-19 | 1994-10-05 | Merck & Co. Inc. | New FK-506 cytosolic binding protein |
| WO1991004321A1 (en) * | 1989-09-25 | 1991-04-04 | President And Fellows Of Harvard College | Receptor for fk-506 |
| AU2803692A (en) * | 1991-10-11 | 1993-05-03 | Vertex Pharmaceuticals Incorporated | Isolation of an mr 52,000 fk506 binding protein and molecular cloning of a corresponding human cdna |
-
1991
- 1991-05-07 CA CA002063580A patent/CA2063580C/en not_active Expired - Fee Related
- 1991-05-07 EP EP91912612A patent/EP0482189A1/en not_active Withdrawn
- 1991-05-07 WO PCT/US1991/003114 patent/WO1991017439A1/en not_active Ceased
- 1991-05-07 JP JP51172191A patent/JP3240135B2/ja not_active Expired - Fee Related
- 1991-05-07 AU AU81864/91A patent/AU657096B2/en not_active Ceased
Non-Patent Citations (2)
| Title |
|---|
| Ｎａｔｕｒｅ，Ｖｏｌ．３４１（１９８９）ｐ．７５５−７５７ |
| Ｎａｔｕｒｅ，Ｖｏｌ．３４１（１９８９）ｐ．７５８−７６０ |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101459227B1 (ko) | 2012-05-11 | 2014-11-12 | 가톨릭대학교 산학협력단 | 이식 후 면역 상태를 모니터링 하는 키트 및 이를 이용한 면역 상태의 모니터링 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991017439A1 (en) | 1991-11-14 |
| AU657096B2 (en) | 1995-03-02 |
| CA2063580C (en) | 2002-11-19 |
| EP0482189A4 (https=) | 1994-03-30 |
| JPH05502101A (ja) | 1993-04-15 |
| AU8186491A (en) | 1991-11-27 |
| EP0482189A1 (en) | 1992-04-29 |
| CA2063580A1 (en) | 1991-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |