CA2063580C - Receptor assay for fk-506 - Google Patents

Receptor assay for fk-506 Download PDF

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Publication number
CA2063580C
CA2063580C CA002063580A CA2063580A CA2063580C CA 2063580 C CA2063580 C CA 2063580C CA 002063580 A CA002063580 A CA 002063580A CA 2063580 A CA2063580 A CA 2063580A CA 2063580 C CA2063580 C CA 2063580C
Authority
CA
Canada
Prior art keywords
protein
binding
binding protein
daltons
molecular mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002063580A
Other languages
English (en)
French (fr)
Other versions
CA2063580A1 (en
Inventor
Steven J. Soldin
Edmund W. Palaszynski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Research Institute
Original Assignee
Childrens Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Research Institute filed Critical Childrens Research Institute
Publication of CA2063580A1 publication Critical patent/CA2063580A1/en
Application granted granted Critical
Publication of CA2063580C publication Critical patent/CA2063580C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493—Immunosupressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002063580A 1990-05-09 1991-05-07 Receptor assay for fk-506 Expired - Fee Related CA2063580C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52107490A 1990-05-09 1990-05-09
US521,074 1990-05-09
PCT/US1991/003114 WO1991017439A1 (en) 1990-05-09 1991-05-07 Receptor assay for fk-506

Publications (2)

Publication Number Publication Date
CA2063580A1 CA2063580A1 (en) 1991-11-10
CA2063580C true CA2063580C (en) 2002-11-19

Family

ID=24075229

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002063580A Expired - Fee Related CA2063580C (en) 1990-05-09 1991-05-07 Receptor assay for fk-506

Country Status (5)

Country Link
EP (1) EP0482189A1 (https=)
JP (1) JP3240135B2 (https=)
AU (1) AU657096B2 (https=)
CA (1) CA2063580C (https=)
WO (1) WO1991017439A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763590A (en) * 1991-10-11 1998-06-09 Vertex Pharmaceuticals, Inc. Isolation of an Mr 52,000 FK506 binding protein and molecular cloning of a corresponding human cDNA
WO1993025533A1 (en) * 1992-06-05 1993-12-23 Abbott Laboratories Methods and reagents for the determination of immunosuppressive agents
US5457182A (en) * 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6
ES2249986B1 (es) * 2004-07-02 2007-02-01 Universidad Complutense De Madrid Sintesis de derivados fluorescentes de tacrolimus (fk506) y su uso en la caracterizacion de la interaccion de fk506 con proteinas de union a fk506.
US7642059B2 (en) * 2005-09-07 2010-01-05 Roche Diagnostics Operations, Inc. Single receptor assays for immunosuppressive drugs
US9658218B2 (en) 2012-05-07 2017-05-23 Siemens Healthcare Diagnostics Inc. Determination of total analyte concentration
WO2013168876A1 (ko) 2012-05-11 2013-11-14 가톨릭대학교 산학협력단 이식 후 면역 상태를 모니터링 하는 키트 및 이를 이용한 면역 상태의 모니터링 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641889B1 (fr) * 1989-01-18 1991-03-29 Schlumberger Prospection Procede de representation graphique polychrome du pendage des couches geologiques
EP0379342B1 (en) * 1989-01-19 1994-10-05 Merck & Co. Inc. New FK-506 cytosolic binding protein
WO1991004321A1 (en) * 1989-09-25 1991-04-04 President And Fellows Of Harvard College Receptor for fk-506
AU2803692A (en) * 1991-10-11 1993-05-03 Vertex Pharmaceuticals Incorporated Isolation of an mr 52,000 fk506 binding protein and molecular cloning of a corresponding human cdna

Also Published As

Publication number Publication date
WO1991017439A1 (en) 1991-11-14
AU657096B2 (en) 1995-03-02
EP0482189A4 (https=) 1994-03-30
JPH05502101A (ja) 1993-04-15
AU8186491A (en) 1991-11-27
EP0482189A1 (en) 1992-04-29
JP3240135B2 (ja) 2001-12-17
CA2063580A1 (en) 1991-11-10

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