JP3201816B2 - External preparation for skin - Google Patents
External preparation for skinInfo
- Publication number
- JP3201816B2 JP3201816B2 JP04137392A JP4137392A JP3201816B2 JP 3201816 B2 JP3201816 B2 JP 3201816B2 JP 04137392 A JP04137392 A JP 04137392A JP 4137392 A JP4137392 A JP 4137392A JP 3201816 B2 JP3201816 B2 JP 3201816B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- extract
- lactic acid
- external preparation
- acid bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- Cosmetics (AREA)
Description
【0001】[0001]
【産業上の利用分野】本発明は皮膚の老化防止に有用
な、過酸化脂質生成抑制効果を有する皮膚外用剤に関す
る。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin having an effect of inhibiting the production of lipid peroxide, which is useful for preventing skin aging.
【0002】[0002]
【従来の技術】従来、外用剤、ことに皮膚化粧料に各種
薬効作用を有する成分を処方し、美容効果に優れた化粧
料を提供する試みは数多くなされているところである
が、なかでも、抗酸化作用を有する成分は、皮膚表皮に
於ける過酸化脂質の生成を抑制し、皮膚の老化防止等に
有効であり、美容効果も期待できるので、関心がもた
れ、各種化粧料への応用の試みも行われている。2. Description of the Related Art There have been many attempts to provide various cosmetically effective ingredients to external preparations, especially skin cosmetics, to provide cosmetics having excellent cosmetic effects. The oxidizing component suppresses the production of lipid peroxide in the skin epidermis, is effective in preventing skin aging, and can be expected to have a cosmetic effect. Has also been done.
【0003】そこで、各種抗酸化作用を有する物質の検
索、皮膚老化防止の効果に関する検討等が行われている
が、本発明者らは、先に、乳酸菌の発酵液中に、抗酸化
作用があることを見出した。さらに、当該乳酸菌発酵液
はビタミンE類との組合せで抗酸化作用が増強されるこ
とを見出し、これを応用した化粧料について開示してい
る(特公昭60−46084号)。[0003] Therefore, various substances having an antioxidant action have been searched, and studies on the effect of preventing skin aging have been carried out. However, the present inventors first found that the fermented solution of lactic acid bacteria had an antioxidant action. I found something. Furthermore, they have found that the lactic acid bacteria fermented liquid has enhanced antioxidant action in combination with vitamin Es, and disclosed a cosmetic using the same (Japanese Patent Publication No. 60-46084).
【0004】また、一方で、安全性の面で、優れている
と考えられる各種生薬成分についての検討も行われてお
り、ある種の生薬成分が抗酸化作用もしくはこれに類似
の効果を有していることが知られている(特開昭59−
73509号、特開昭60−214721号、特開平3
−81227号等)。[0004] On the other hand, various crude drug components considered to be excellent in terms of safety have also been studied, and certain crude drug components have an antioxidant action or an effect similar thereto. (Japanese Patent Application Laid-Open No.
73509, JP-A-60-214721, JP-A-Hei 3
No. 81227).
【0005】[0005]
【発明が解決しようとする課題】しかしながら、乳酸菌
の発酵液由来の抗酸化物質にしても、生薬由来の抗酸化
物質にしても、効果が比較的緩やかであり、必ずしも効
果の点で満足できないものであり、さらに効果増強の工
夫が望まれていた。However, the effect of the antioxidant derived from the fermented liquor of lactic acid bacteria or the antioxidant derived from crude drugs is relatively slow, and is not always satisfactory in terms of effect. Therefore, a device for enhancing the effect has been desired.
【0006】[0006]
【課題を解決するための手段】本発明者は、この観点か
ら、乳酸菌発酵液由来の抗酸化物質と生薬由来の抗酸化
物質の組合せについて検討を行った結果、乳酸菌の発酵
液と、オウゴンエキス及び/またはカンゾウの有機溶媒
抽出エキスとを組み合わせることにより、更にビタミン
E類を配合することにより、優れた抗酸化作用が発揮さ
れ、また、皮膚外用剤として使用するとき、皮膚の過酸
化脂質の生成を抑制し、さらに、紫外線照射時の皮膚の
着色も抑制することを見出し、本発明を完成した。From this viewpoint, the present inventor studied a combination of an antioxidant derived from a fermented lactic acid bacterium solution and an antioxidant derived from a crude drug. And / or combination with extract of liquorice in organic solvent, and further blended with vitamin Es, exerts excellent antioxidant effect. Also, when used as an external preparation for skin, the lipid peroxide of skin It has been found that the formation is suppressed and the coloring of the skin upon irradiation with ultraviolet rays is also suppressed, and the present invention has been completed.
【0007】すなわち、本発明は、オウゴンエキス及び
カンゾウの有機溶媒抽出エキスから選ばれる少なくとも
1種の生薬エキス、乳酸菌発酵液、並びにビタミンE類
を含有することを特徴とする皮膚外用剤を提供するもの
である。[0007] That is, the present invention provides an external preparation for skin characterized by containing at least one kind of crude drug extract selected from the extract of organic radish and organic extract of licorice, fermented lactic acid bacteria, and vitamin Es. Things.
【0008】本発明に用いられる乳酸菌発酵液とは、特
公平2−24247号公報にも、製法の一例が開示され
ているが、獣乳を主成分とする培養基に乳酸菌を接種し
て乳酸発酵を行い、得られた培養物より、乳清を分取し
て得られるものである。その液をそのまま、あるいは必
要に応じて減圧下に加熱して香気成分を蒸発して除去す
る等の処理を行って用いることができる。The lactic acid bacteria fermented liquid used in the present invention is disclosed in Japanese Patent Publication No. 2-24247, one example of a production method of which is described below. And whey is fractionated from the resulting culture. The liquid can be used as it is or, if necessary, by heating it under reduced pressure to evaporate and remove fragrance components.
【0009】乳酸発酵に用いる乳酸菌は通常の乳酸菌飲
料、発酵乳などを製造する場合に通常使用されている乳
酸菌、例えばラクトバチルス・アシドフィルス、ラクト
バチルス・ブルガリクス、ラクトバチルス・カゼイ、ス
トレプトコッカス・サーモフィルス等が使用可能であ
る。The lactic acid bacteria used for lactic acid fermentation are lactic acid bacteria commonly used for producing ordinary lactic acid bacteria beverages and fermented milk, such as Lactobacillus acidophilus, Lactobacillus bulgaricus, Lactobacillus casei, Streptococcus thermophilus. Etc. can be used.
【0010】培養基として用いる獣乳は、人乳、牛乳、
山羊乳などいずれでも良く、さらにこれらの獣乳の脱脂
乳または粉乳等からの還元乳であっても良い。The animal milk used as a culture medium is human milk, milk,
Any milk such as goat milk may be used, and reduced milk from skim milk or powdered milk of these animal milks may be used.
【0011】本発明に用いるオウゴンエキスとは、シソ
科コガネバナの植物体の熱水もしくはエタノール等の有
機溶媒による抽出物である。特に、抽出方法に制限はな
いが、例えば、水・エタノールの混合溶媒で抽出し、抽
出液の濾液に冷水を加えて、析出物を濾取することによ
って得られる。また、カンゾウエキスとは、日本薬局方
記載のマメ科植物カンゾウのエタノール等の有機溶媒に
よる抽出物である。同じく特に、抽出方法に制限はない
が、例えば、無水エタノールによる抽出物をさらに酢酸
エチルで抽出して、油溶性画分として得られるものがあ
る。これらのオウゴンエキス及びカンゾウエキスは、各
々単独で用いても、これらを併用してもよい。The pentagon extract used in the present invention is an extract of plants of the Labiatae family Scutellaria using hot water or an organic solvent such as ethanol. The extraction method is not particularly limited. For example, it is obtained by extracting with a mixed solvent of water and ethanol, adding cold water to the filtrate of the extract, and collecting the precipitate by filtration. The licorice extract is an extract of a legume licorice plant described in the Japanese Pharmacopoeia with an organic solvent such as ethanol. Similarly, although there is no particular limitation on the extraction method, for example, there is one obtained by extracting an extract with anhydrous ethanol with ethyl acetate and obtaining an oil-soluble fraction. These Orgonum extract and Licorice extract may be used alone or in combination.
【0012】本発明皮膚外用剤には、乳酸菌発酵液を培
養液換算で0.1〜40重量%、特に1〜20重量%配
合するのが好ましい。また、オウゴンエキスまたはカン
ゾウエキスは固形物換算でそれぞれ0.00005〜1
重量%、特に0.0001〜0.05重量%配合するの
が好ましい。The skin preparation for external use of the present invention preferably contains a fermented lactic acid bacterium in an amount of 0.1 to 40% by weight, especially 1 to 20% by weight, in terms of a culture solution. The gogon extract or licorice extract is 0.00005 to 1 in terms of solid matter.
% By weight, particularly preferably 0.0001 to 0.05% by weight.
【0013】また、本発明皮膚外用剤は、上記成分に加
えビタミンE類を配合することにより、さらに優れた皮
膚の過酸化脂質生成抑制効果及び紫外線照射時の着色抑
制効果が得られる。このようなビタミンE類としては、
dl−α−トコフェロール、dl−α−トコフェロール脂肪
酸エステル、dl−α−トコフェロールニコチン酸エステ
ル等が挙げられる。これらのビタミンE類は、1種また
は2種以上を混合して用いることができ、本発明化粧料
中に0.00001〜5重量%、特に0.0005〜3
重量%配合するのが好ましい。Further, the skin external preparation of the present invention can further provide an excellent effect of inhibiting the formation of lipid peroxides on the skin and an effect of suppressing coloring upon irradiation with ultraviolet rays by adding vitamin Es to the above components. As such vitamin Es,
dl-α-tocopherol, dl-α-tocopherol fatty acid ester, dl-α-tocopherol nicotinic acid ester and the like. These vitamin Es can be used alone or as a mixture of two or more kinds.
It is preferable to mix by weight%.
【0014】また、これら以外に本発明の効果を損なわ
ないかぎり、各種成分を配合することができる。即ち、
色素や、香料、保存剤、安定剤、ビタミンE以外の脂溶
性ビタミン、油脂類、保湿剤等が配合可能である。In addition to these, various components can be blended as long as the effects of the present invention are not impaired. That is,
Pigments, fragrances, preservatives, stabilizers, fat-soluble vitamins other than vitamin E, oils and fats, humectants, and the like can be blended.
【0015】本発明の皮膚外用剤は、頭髪化粧料を含む
各種化粧品はもちろんのこと、医薬部外品、医薬品、ト
イレタリー製品類等皮膚に塗布するものならどの様なも
のにも適用することができるし、形態もクリーム状のも
の、液体状のもの、乳液状のもの等特に制限されない。The external preparation for skin of the present invention can be applied not only to various cosmetics including hair cosmetics, but also to any quasi-drugs, pharmaceuticals, toiletry products, etc. as long as they are applied to the skin. It can be made, and the form is not particularly limited, such as cream, liquid, and emulsion.
【0016】[0016]
【実施例】以下、実施例により、本発明を詳細に説明す
る。Hereinafter, the present invention will be described in detail with reference to examples.
【0017】製造例1 乳酸菌発酵液の製造;脱脂粉乳3重量部に精製水97重
量部を加え、加熱殺菌後ストレプトコッカス・サーモフ
ィルスのスターターを接種して37℃にて24時間培養
した。培養終了後、濾過により透明な乳酸菌発酵液を得
た。Production Example 1 Production of lactic acid bacteria fermentation broth; 3 parts by weight of skim milk powder, 97 parts by weight of purified water were added, sterilized by heating, inoculated with a starter of Streptococcus thermophilus, and cultured at 37 ° C. for 24 hours. After completion of the culture, a clear lactic acid bacteria fermented liquid was obtained by filtration.
【0018】製造例2 日本薬局方オウゴン1kgに精製水6lを加え、50〜6
0℃に加温した後、無水エタノール14lを加えて1昼
夜浸漬する。ろ過して不溶物を除き、ろ液に、大過剰の
精製水を加えて生ずる析出物をろ取し、乾燥し、オウゴ
ンエキスを黄色〜黄緑色の粉末として100g得た。Production Example 2 Purified water (6 L) was added to 1 kg of Japanese pentagon in Japanese pharmacopoeia.
After heating to 0 ° C., 14 liters of absolute ethanol is added and immersed for 24 hours. Filtration was performed to remove insolubles, and a large excess of purified water was added to the filtrate, and the resulting precipitate was collected by filtration and dried to obtain 100 g of a pentagon extract as a yellow-yellow-green powder.
【0019】製造例3 カンゾウ(甘草)の根1kgに無水エタノール10lを加
え、還流下で5時間抽出を行う。得られたエタノール抽
出液を一担減圧下に濃縮し、この濃縮物に酢酸エチル1
lを加えて還流下で5時間抽出を行う。不溶物をろ過で
除き、ろ液を濃縮し、乾燥することにより、カンゾウエ
キスを黄かっ色〜赤かっ色の粉末として30g得た。Production Example 3 10 kg of absolute ethanol is added to 1 kg of licorice root (licorice), and the mixture is extracted under reflux for 5 hours. The obtained ethanol extract was concentrated under reduced pressure, and ethyl acetate was added to the concentrate.
l and extract under reflux for 5 hours. The insolubles were removed by filtration, and the filtrate was concentrated and dried to obtain 30 g of licorice extract as a yellowish brown to reddish brown powder.
【0020】処方例1:(化粧水) 下記の成分を常法により混合し、化粧水を製造した。 乳酸菌発酵液 25(重量%) 酢酸−dl−α−トコフェロール 0.2 オウゴンエキス(製造例2) 0.01 カンゾウエキス(製造例3) 0.01 エタノール 5 グリセリン 5 1,3−ブチレングリコール 5 メチルパラベン 0.05 ポリオキシエチレンソルビタンモノオレート 0.5 カルボキシビニルポリマー 0.1 ヒアルロン酸ナトリウム 0.01 香料 0.05 精製水 残部Formulation Example 1 (Lotion) The following components were mixed by a conventional method to prepare a lotion. Lactic acid bacteria fermented liquid 25 (% by weight) Acetic acid-dl-α-tocopherol 0.2 Ougon extract (Production example 2) 0.01 Licorice extract (Production example 3) 0.01 Ethanol 5 Glycerin 5 1,3-butylene glycol 5 Methyl paraben 0.05 polyoxyethylene sorbitan monooleate 0.5 carboxyvinyl polymer 0.1 sodium hyaluronate 0.01 fragrance 0.05 purified water balance
【0021】処方例2:(乳液) 下記の成分を常法により混合し、乳液を製造した。 乳酸菌発酵液 30(重量%) 酢酸−dl−α−トコフェロール 1 オウゴンエキス(製造例2) 0.05 ステアリン酸 2 セタノール 1 ワセリン 5 流動パラフィン 10 ポリオキシエチレンソルビタンモノオレート 2 ソルビタンモノステアレート 2 ブチルパラベン 0.05 1,3−ブチレングリコール 5 カルボキシメチルセルロース 0.1 水酸化ナトリウム 0.05 メチルパラベン 0.1 香料 0.05 精製水 残部Formulation Example 2: (Emulsion) The following components were mixed by a conventional method to produce an emulsion. Lactic acid bacteria fermentation liquid 30 (% by weight) Acetic acid-dl-α-tocopherol 1 Ougone extract (Production Example 2) 0.05 Stearic acid 2 Cetanol 1 Vaseline 5 Liquid paraffin 10 Polyoxyethylene sorbitan monooleate 2 Sorbitan monostearate 2 Butyl paraben 0.05 1,3-butylene glycol 5 carboxymethyl cellulose 0.1 sodium hydroxide 0.05 methyl paraben 0.1 fragrance 0.05 purified water balance
【0022】処方例3:(クリーム) 下記の成分を常法により混合し、クリームを製造した。 乳酸菌発酵液 10(重量%) dl−α−トコフェロール 0.001 カンゾウエキス(製造例3) 0.05 ステアリン酸 4 セタノール 2 ワセリン 5 流動パラフィン 10 ホホバ油 5 ポリオキシエチレンベヘニルエーテル 3 ソルビタンモノステアレート 3 1,3−ブチレングリコール 2 ブチルパラベン 0.05 メチルパラベン 0.1 水酸化ナトリウム 0.05 香料 0.05 精製水 残部Formulation Example 3 (Cream) The following ingredients were mixed by a conventional method to produce a cream. Fermented solution of lactic acid bacteria 10 (wt%) dl-α-tocopherol 0.001 Licorice extract (Production Example 3) 0.05 Stearic acid 4 Cetanol 2 Vaseline 5 Liquid paraffin 10 Jojoba oil 5 Polyoxyethylene behenyl ether 3 Sorbitan monostearate 3 1,3-butylene glycol 2 butyl paraben 0.05 methyl paraben 0.1 sodium hydroxide 0.05 fragrance 0.05 purified water balance
【0023】抗酸化効果に関する試験例1:(紫外線照
射によるヒト皮膚における過酸化脂質生成抑制効果、及
び皮膚の色変化に及ぼす影響) 〔試験方法〕上記処方例1で製造した化粧水について試
験を行い、対照群(塗布・非照射、未塗布・照射、未塗
布・非照射)との比較を行った。成人男子2名につい
て、背部の皮膚を試験の対象とした。まず、1名につき
背部の4か所を選択し、被検スペース(未塗布・非照射
1点、塗布・非照射1点、未塗布・照射1点、塗布・照
射1点の計4か所)とする。ここに、紫外線照射前日よ
り、各サンプルを塗布(2回/日、午前と午後)し、つ
いで紫外線照射装置(Black light)で、約
3500〜4000mWで1時間、紫外線を照射した。
照射後、各照射部位について、テープストリップ法に
て、角層・皮脂をサンプリングし、過酸化脂質の量を測
定、比較した。結果を表1に示す。Test Example 1 on Antioxidant Effect (Inhibition of Lipid Peroxide Production in Human Skin by Irradiation of Ultraviolet Ray and Effect on Skin Color Change) [Test Method] A test was conducted on the lotion prepared in Formulation Example 1 above. The comparison was performed with a control group (coated / non-irradiated, uncoated / irradiated, uncoated / non-irradiated). The skin on the back was tested for two adult males. First, four places on the back are selected for each person, and the space to be tested (one uncoated / non-irradiated point, one coated / non-irradiated point, one uncoated / irradiated point, one applied / irradiated point) ). From the day before the UV irradiation, each sample was applied (twice / day, morning and afternoon), and then UV light was irradiated for 1 hour at about 3500 to 4000 mW by a UV light irradiator (Black light).
After irradiation, the stratum corneum and sebum were sampled by the tape strip method for each irradiated site, and the amount of lipid peroxide was measured and compared. Table 1 shows the results.
【0024】[0024]
【表1】 [Table 1]
【0025】また、各点の皮膚の着色についても、色差
計で照射前、照射後に測定を行い、その変化ΔEについ
て、未塗布・照射部位を100%とし、比較した。結果
を表2に示す。The coloration of the skin at each point was also measured before and after the irradiation with a color difference meter, and the change ΔE was compared with the uncoated / irradiated portion as 100%. Table 2 shows the results.
【0026】[0026]
【表2】 [Table 2]
【0027】以上の結果より、本発明皮膚外用剤は、紫
外線照射による皮膚の過酸化脂質量の増加及び皮膚の着
色を抑制する作用が極めて顕著であることがわかる。From the above results, it can be seen that the external preparation for skin of the present invention has extremely remarkable effects of increasing the amount of lipid peroxide in the skin and suppressing the coloring of the skin by ultraviolet irradiation.
【0028】抗酸化効果に関する試験例2:(ラット皮
膚ホモジネートに於ける過酸化脂質生成抑制効果) 各成分の過酸化脂質の生成抑制に対する効果について、
ラットの皮膚ホモジネートを用いて試験した。すなわ
ち、体重約290gのWister系雄性ラットの皮膚
を採取し、冷生理食塩水を加えて、ポリトロンにて処理
して2%皮膚ホモジネートとした。シャーレ中に、皮膚
ホモジネート8ml、精製水1mlエタノール1mlを加えた
反応系を作り、これに、各被検サンプル(乳酸菌発酵液
10%、酢酸トコフェロール0.1%、オウゴンエキス
0.001%、カンゾウエキス0.0002%、これら
4者の混合物及び無添加コントロール群の6点)を添加
した。30分間、室温に放置後、紫外線(UV−A)を
30分間照射した。次いで、それぞれの検体中の過酸化
脂質の生成量を大石らのTBA法(最新医学,vol3
3,p660,1978年参照)により定量した。結果
を表3に示す(無添加群の生成量を基準とした時の抑制
の割合で表わした。)Test Example 2 for Antioxidant Effect: (Effect of Inhibiting Lipid Peroxide Production in Rat Skin Homogenate) Regarding the effect of each component on inhibiting the production of lipid peroxide,
The test was performed using rat skin homogenate. That is, the skin of male Wister rats weighing about 290 g was collected, added with cold physiological saline, and treated with Polytron to obtain a 2% skin homogenate. A reaction system was prepared by adding 8 ml of skin homogenate, 1 ml of purified water and 1 ml of ethanol in a Petri dish, and each test sample (lactic acid bacteria fermented solution 10%, tocopherol acetate 0.1%, gongon extract 0.001%, licorice) 0.0002% of the extract, a mixture of the four, and a control group without the addition (6 points) were added. After leaving at room temperature for 30 minutes, ultraviolet rays (UV-A) were irradiated for 30 minutes. Next, the amount of lipid peroxide produced in each sample was determined by the OBA et al.
3, p660, 1978). The results are shown in Table 3 (represented by the percentage of suppression based on the amount of production in the non-added group).
【0029】[0029]
【表3】 [Table 3]
【0030】[0030]
【発明の効果】本発明により、優れた抗酸化作用及び過
酸化脂質抑制作用を有する皮膚外用剤が提供可能となっ
た。また、本発明皮膚外用剤は、特に皮膚の老化防止効
果、美容効果に優れた化粧料として有用である。Industrial Applicability According to the present invention, it has become possible to provide a skin external preparation having an excellent antioxidant action and lipid peroxide-suppressing action. Further, the external preparation for skin of the present invention is particularly useful as a cosmetic having an excellent antiaging effect on skin and an excellent cosmetic effect.
フロントページの続き (72)発明者 小山 隆子 東京都港区東新橋1丁目1番19号 株式 会社ヤクルト本社内 (72)発明者 市岡 稔 東京都港区東新橋1丁目1番19号 株式 会社ヤクルト本社内 (56)参考文献 特開 平3−81227(JP,A) 特開 昭59−73509(JP,A) 特開 平2−111710(JP,A) 特開 平2−36113(JP,A) 特開 昭63−23809(JP,A) 特開 昭60−214721(JP,A) 特開 平1−256587(JP,A) 特開 昭59−4432(JP,A) 特開 平5−70334(JP,A) 特公 昭60−46084(JP,B2) (58)調査した分野(Int.Cl.7,DB名) A61K 7/00 - 7/50 Continued on the front page (72) Inventor Takako Koyama 1-1-19 Higashi-Shimbashi, Minato-ku, Tokyo Yakult Honsha Co., Ltd. (72) Inventor Minoru Ichioka 1-1-19 Higashi-Shimbashi, Minato-ku, Tokyo Yakult Co., Ltd. In-house (56) References JP-A-3-81227 (JP, A) JP-A-59-73509 (JP, A) JP-A-2-111710 (JP, A) JP-A-2-36113 (JP, A) JP-A-63-23809 (JP, A) JP-A-60-214721 (JP, A) JP-A-1-256587 (JP, A) JP-A-59-4432 (JP, A) JP-A-5-205 70334 (JP, A) JP 60-46084 (JP, B2) (58) Fields investigated (Int. Cl. 7 , DB name) A61K 7/ 00-7/50
Claims (1)
抽出エキスから選ばれる少なくとも1種の生薬エキス、
乳酸菌発酵液、並びにビタミンE類を含有することを特
徴とする皮膚外用剤。Claims: 1. A herbal extract selected from the organic solvent extract of Orgonum extract and the extract of Licorice,
An external preparation for skin, comprising a fermented solution of lactic acid bacteria and vitamin Es.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP04137392A JP3201816B2 (en) | 1992-02-27 | 1992-02-27 | External preparation for skin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP04137392A JP3201816B2 (en) | 1992-02-27 | 1992-02-27 | External preparation for skin |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05238925A JPH05238925A (en) | 1993-09-17 |
JP3201816B2 true JP3201816B2 (en) | 2001-08-27 |
Family
ID=12606621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP04137392A Expired - Lifetime JP3201816B2 (en) | 1992-02-27 | 1992-02-27 | External preparation for skin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP3201816B2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU746946B2 (en) * | 1997-03-21 | 2002-05-09 | Shiseido Company Ltd. | Immunopotentiators |
JP2002519312A (en) * | 1998-06-30 | 2002-07-02 | エイボン プロダクツ インコーポレーテッド | Skin whitening composition |
KR19980072119A (en) * | 1998-07-24 | 1998-10-26 | 서정인 | Plant extract composition with natural antioxidant capacity |
JP4197091B2 (en) * | 2000-12-27 | 2008-12-17 | 花王株式会社 | Cosmetics |
KR100720655B1 (en) * | 2005-11-01 | 2007-05-21 | (주) 이지함 | Crude drug composition showing anti-oxidative a nd anti-tumor activity |
BRPI1100062A2 (en) | 2011-07-01 | 2016-08-02 | Shiseido Co Ltd | platelet-derived growth factor bb production promoter, and mesenchymal stem cell production accelerator, stem cell stabilizer and dermal regenerator comprising the same |
KR101470347B1 (en) * | 2012-12-31 | 2014-12-10 | 재단법인 전남생물산업진흥원 | A Composition Comprising the Fermentate of Scutellariae Radix extract for protecting liver damage |
-
1992
- 1992-02-27 JP JP04137392A patent/JP3201816B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH05238925A (en) | 1993-09-17 |
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