JP3081953B2 - Vial container - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an improvement in a vial container.

[0002]

2. Description of the Related Art As shown in FIG. 20, a conventionally well-known vial container has a break portion 3 surrounded by an easy break line 2 such as a score on the upper surface of a protector 1 made of an aluminum material. An engaging projection 5 formed on the inner surface of a synthetic resin lid (hereinafter, referred to as a flip-off cap) 4 is fixed to the broken portion 3 by an eyelet structure, while the stopper 6 a is vented into the protector 1. A rubber stopper 6 formed with a notch 7 is fitted therein, and the medicine in the vial bottle 8 is freeze-dried in a half stoppering posture in which the rubber stopper 6 is fitted to the vial opening 8a of the vial bottle 8 in a floating manner, After freeze-drying, the rubber stopper 6 is completely sealed, and the skirt of the protector 1 is fastened by a winder. In use, as shown in the figure, the breaking portion 3 is broken through the flip-off cap 4, the exposed upper part of the rubber stopper 6 is sterilized, and a needle of a syringe is pierced into this portion to remove distilled water or the like. The liquid is injected into the vial 8 to dissolve the drug to be lyophilized, and the drug solution is poured into a syringe or the like for administration.

[0003]

The conventional vial container has the following problems. (A) The vial container is composed of four types of glass, aluminum, synthetic resin, and rubber material, and it is necessary to separate the respective materials at the time of waste incineration, which requires a lot of time and labor. (B) retaining the aluminum protector in the hopper,
In the process of inflating the protector on the vial via the feeder, aluminum chips may be generated during stagnation rolling in the hopper, and the aluminum chips may contaminate the flip-off cap. (C) During transportation to the freeze-drying device, there is a possibility that the rubber stopper rises and falls off. (D) Since the vial opening corresponding to the tightened portion of the aluminum protector is opaque, it is difficult to inspect the opening of the vial. (E) When the lid is removed to expose the fractured portion, a shearing portion of aluminum is formed around the fractured portion, and absorbent cotton for sterilization remains on the portion, which hinders sterilization of the exposed portion of the rubber stopper upper surface. You.

[0004] It is an object of the present invention to provide a low-cost vial container that can be easily separated by a material at the time of waste incineration and that does not cause the plug to rise or fall off during transportation.

[0005]

Means for Solving the Problems The configuration of the present invention to solve the problems of the prior art, if that is fitted to the bottle mouth of the bottle container
In the top wall of the protector made of a synthetic resin material , an opening or a needle passage window closed with a sealing means for easy passage of needles is formed, and the inner wall of the top wall and the upper surface of the bottle opening are formed in the cylindrical portion of the protector. vias allowed fitting the plug body for sealing the
In the container, the inner surface of the cylindrical portion of the protector is engaged with the upper outer peripheral edge and the lower outer peripheral edge of the bottle flange to hold the protector in a half-plug-freeze-drying position; Locking means for engaging the outer peripheral end of the lower surface of the container to maintain the two positions of the entire stoppered sealing position, while connecting the inside of the bottle container and the outside air to the cylindrical portion of the protector in the half stoppered freeze-drying position. Providing a vent, forming the plug into a thick sheet-shaped packing structure, and integrally forming a plug having a vent notch inserted and fitted into the bottle, in the plug, When the protector is half-plugged in a freeze-drying posture, another locking means is provided on a lower portion of the inner surface of the cylindrical portion so as to engage with the outer peripheral end of the lower surface of the bottle mouth flange to prevent the plug body from floating, made of synthetic resin which is fitted to the bottle mouth of the container <br/> protector An opening or a needle passing window portion closed by a sealing means for easy needle passing is formed in the wall portion, and a plug body for sealing between the inner surface of the top wall and the upper surface of the bottle opening is fitted into the cylindrical portion of the protector. In a succulent vial container
On the inner surface of the cylindrical portion of the protector, the upper outer peripheral edge and the lower peripheral edge of the bottle mouth flange are engaged to hold the protector in a half-stopping freeze-drying posture, and the lower peripheral edge of the bottle mouth flange is held. Is provided to hold the two positions of the entire stopper sealing posture, while the lower end of the protector in the half stopper freeze-drying position communicates with the outside air at the thick portion of the cylinder. A vent is formed on the inner wall surface of the cylindrical portion corresponding to the upper end of the vent, and the inside of the bottle container is communicated with the outside air during the half-stopper freeze-drying posture through the vent. That the plug body has a thick sheet-like packing structure, and that the plug body is integrally formed with a plug portion having a vent notch to be inserted and fitted into a bottle opening, and the stopper is half-plugged. In the freeze-drying posture, the stopper engages with the outer peripheral edge of the lower surface of the bottle mouth flange. Is lifted to ash provided on the inner surface lower portion of the cylindrical portion of the alternative locking means for preventing the.

[0006]

With the ridge structure or the screw structure locking means, it is possible to ensure that the protector corresponding to the middle of the transportation to the freeze-drying means is prevented from rising and falling off, and that the seal after the freeze-drying is sealed. The freeze-drying of the drug can be effectively performed by the communicating means between the vent provided on the inner surface of the cylindrical body constituting the protector and the inside of the vial container. Since non-combustible metals such as aluminum are not used at all, material separation work is omitted in waste incineration.

[0007]

Next, details of an embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a longitudinal sectional front view showing a half stoppered freeze-drying posture of the first embodiment, FIG. 2 is a longitudinal sectional front view showing a completely stoppered sealing posture of the first embodiment, and FIG. FIG. 4 is a vertical sectional front view showing a half stoppered freeze-drying posture, FIG. 4 is a vertical sectional front view showing a completely stoppered sealing posture of the second embodiment, FIG. 5 is an enlarged sectional view of a main part of the second embodiment, FIG. FIG. 8 to FIG. 8 are cross-sectional views of the protector, FIG. 9 is a vertical sectional front view showing a half stoppered freeze-drying posture of the third embodiment, FIG. 10 is a vertical front view showing a full stopper sealing posture of the third embodiment, FIG. 11 is a longitudinal sectional front view showing a half stoppered freeze-drying posture of the fourth embodiment, FIG. 12 is a longitudinal sectional front view showing a completely stoppered sealing posture of the fourth embodiment, and FIGS. FIGS. 16 to 19 are longitudinal sectional front views showing an embodiment, and FIGS. 16 to 19 are sectional views showing still another embodiment of the protector.

The structure of the first embodiment will be described with reference to FIGS. 1 and 2. Referring to FIG. 1, numeral 11 denotes a protector made of a synthetic resin material. Form and protector 11
A seal 13 for closing the needle passing window 12 is attached to the upper surface of the ceiling wall. On the surface of the seal 13, a display (not shown) for identifying a medicine name, a content and the like is printed. In addition, as shown in FIG. 1, a plug 15 made of rubber or a synthetic resin material having a vent cutout 14a integrally formed with a plug 15a so as to contact the inner surface of the ceiling wall is provided in the cylindrical portion constituting the protector 11, as shown in FIG. The lower peripheral edge of the flange portion 15b having a thickness a integrally formed with the plug 15 is engaged with a small ridge 16 integrally formed on the peripheral surface of the cylindrical portion of the protector 11. 15 is prevented from falling off. On the inner peripheral surface of the cylindrical portion of the protector 11, two parallel ridges 17, 18 are integrally formed at required intervals below the ridges 16, and a vial bottle is provided between the two ridges 17, 18. 19
By interposing and sandwiching the flange portion 19b formed in the bottle opening 19a, the half-plug freeze-drying posture of the protector 11 is maintained as shown in FIG. Thus, protector 1
1 is in a half-punch freeze-drying posture, and a vial bottle 19 is inserted into the protector cylinder between the ridges 16 and 17.
Is provided with a vent 20 for communicating the inside of the device with the outside air. The lowermost ridge 18 prevents the protector 11 from rising and falling off in conjunction with the lifting of the plug 15, and prevents the protector 11 from being inadvertently lowered by the next ridge 17. The stopper freeze-drying posture can be reliably maintained. The plug 1
5, the thickness a of the flange 15b and the distance b between the ridges 16 and 17
Is the inner surface of the top wall of the protector 11 and the next ridge 1
7 is slightly larger than the distance L from the upper edge. Under the dimensional conditions, as shown in FIG. 2, after freeze-drying the medicine, the upper surface of the protector 11 is pressed by a top plate (not shown) provided in the freeze-drying chamber, and the stopper 15 is completely closed and sealed, that is, the stopper is closed. Body 1
5, the flange 15b is compressed and brought into close contact with the upper surface of the bottle opening 19a,
The sealing performance when both are sandwiched and supported between the top wall of the protector 11 and the next ridge 17 can be improved.

Next, the second embodiment shown in FIGS. 3 and 4 will be described in detail. In this embodiment, the plug body 15 having the plug portion 15a shown in FIGS. In order to improve the sealing property, the sheet-like packing 21 is
The one in which a plurality of ring-shaped seal protrusions 22 are integrally formed on the upper and lower peripheral edges abutting on the upper peripheral surface of a may be used. Also, instead of this seal ridge 22, the bottle mouth 1
A plurality of ring-shaped seal protrusions (not shown) on the upper surface of 9a
Can be integrally formed. The other configuration is the same as that of the embodiment shown in FIGS. 1 and 2 described above, and the detailed description is omitted by attaching the same reference numerals to the same components.
The seal ridge 22 is applicable to the embodiment shown in FIG.

FIGS. 6 to 8 show a protector 11 used in the first and second embodiments. As shown in FIG. 6, a plurality of horizontally elliptical vents 20 are provided at equal intervals. Alternatively, as shown in FIG.
Or a plurality of circular vents 20 are provided at regular intervals as shown in FIG. 8, particularly if the total area of the vents 20 is within a range suitable for freeze-drying. ,
We do not care about the shape and number.

The third embodiment shown in FIGS. 9 and 10 will be described in detail. In the embodiment shown in FIGS. 1 and 2 described above, the holding of the freeze-drying posture of the protector 11 in the half-plugged state and the holding of the sealed posture in the fully-plugged state are performed on the inner surface of the protector 11 by a plurality of ridges 17, In this embodiment, the female screw 23b formed on the inner surface of the cylindrical portion of the protector 11 is screwed with the male screw 23a formed on the outer peripheral portion of the flange 19b of the bottle opening 19a. It is. The same applies to the fourth embodiment shown in FIGS. The same components as those shown in FIGS. 1 and 3 are denoted by the same reference numerals, and detailed description is omitted. still,
In the embodiment shown in FIGS. 1 and 3, a large number of protectors 11 can be displaced from the half stoppered freeze-drying position to the entire stoppered sealing position by pressing the top plate provided in the freeze dryer.
In the embodiment shown in FIGS. 10 and 12, the disk is pressed down while the protector 11 is in contact with the disk (not shown) being driven to rotate, or the vial 19 is pushed up and brought into contact with the disk. The protector 11 is screwed in, and is displaced from the half-plug-freeze-drying position to the full-plug-sealing position.

Another embodiment of the protector 11 will be described in detail with reference to FIGS. In this embodiment, instead of the seal 13 shown in FIGS. 1, 3 and 9 described above, a seal film 24 that allows easy penetration of a thin syringe needle into the needle passage window 12 is used.
As shown in FIG. 13, the sealing film 24 is formed at the uppermost portion of the needle window 12 to flatten the upper surface of the protector 11, or as shown in FIG.
The seal film 24 may be provided at the lowermost part of the needle window 12 or, as shown in FIG.
2 is formed integrally with the intermediate portion. In order to facilitate the breaking of the seal film 24, an easy opening means such as a score (not shown) is applied to the seal film 24 in contact with the periphery of the needle passing window portion 12, and the seal film 24 is pressed with a fingertip. It is also possible to cleanly and easily break the score part.

Next, referring to FIGS.
Another embodiment will be described in detail. FIG. 16 and FIG. 17 show that a ventilation passage 25 having a slit structure whose lower end communicates with the outside air is formed all around the thick portion of the cylindrical portion constituting the protector 11,
A cylindrical inner wall surface 11a corresponding to the upper end of the ventilation path 25
In addition, a plurality of ventilation holes 20a are formed at appropriate intervals. Further, as shown in FIG. 18, a reinforcing portion 26 of a column for closing the ventilation passage 25 is provided between the ventilation openings 20a to prevent deformation of the cylindrical portion due to the formation of the ring-shaped ventilation passage 25. is there. FIG. 19 shows a case in which cylindrical air passages 27 are formed at appropriate intervals in a thick portion of a cylindrical portion.
A vent 20a is formed on the inner wall surface 11a corresponding to the upper end of the cylinder.
Is provided. The upper limit of the ventilation passages 25 and 27 is preferably up to a portion corresponding to the ridge 16 as shown in FIG. 16 in view of the strength of the protector tube.

[0014]

According to the configuration of the present invention as described above,
The following effects can be obtained. (A) With a simple configuration, the half-stopper freeze-drying position of the protector and the entire stopper-sealing position can be ensured, and the protector can be completely prevented from rising and falling during transportation to the freeze-drying cabinet, and work processing efficiency. Can be improved. (B) Since the vial container is made of three materials of glass, synthetic resin, and rubber, the waste incineration becomes extremely easy as compared with the conventional case. (C) Since the protector is made of a synthetic resin material as compared with the conventional technology using an aluminum protector, there is no generation of debris while staying in a hopper or the like, and the management of the protector is easy. (D) Ventilation between the vial and the outside air during freeze-drying can be completely ensured, and freeze-drying can be performed accurately and uniformly.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional front view showing a half-stopper freeze-drying posture of a first embodiment.

FIG. 2 is a vertical sectional front view showing the entire stopper sealing posture of the first embodiment.

FIG. 3 is a longitudinal sectional front view showing a half stoppered freeze-drying posture of a second embodiment.

FIG. 4 is a vertical sectional front view showing a completely stoppered sealing posture of a second embodiment.

FIG. 5 is an enlarged sectional view of a main part of the second embodiment.

FIG. 6 is a cross-sectional view of the protector.

FIG. 7 is a cross-sectional view of the protector.

FIG. 8 is a cross-sectional view of the protector.

FIG. 9 is a longitudinal sectional front view showing a half stoppered freeze-drying posture of the third embodiment.

FIG. 10 is a longitudinal sectional front view showing a completely stoppered sealing posture of the third embodiment.

FIG. 11 is a longitudinal sectional front view showing a half stoppered freeze-drying posture of the fourth embodiment.

FIG. 12 is a vertical sectional front view showing the entire stopper-sealing posture of the fourth embodiment.

FIG. 13 is a vertical sectional front view showing another embodiment of the protector.

FIG. 14 is a longitudinal sectional front view showing another embodiment of the protector.

FIG. 15 is a longitudinal sectional front view showing another embodiment of the protector.

FIG. 16 is a sectional view showing still another embodiment of the protector.

FIG. 17 is a sectional view showing still another embodiment of the protector.

FIG. 18 is a sectional view showing still another embodiment of the protector.

FIG. 19 is a sectional view showing still another embodiment of the protector.

FIG. 20 is an exploded vertical sectional front view of a conventional vial container.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 11 Protector 11a Inner wall surface of cylinder part 12 Needle passage window part 13 Seal 14 Vent notch 15 Plug body 15a Plug part 15b Flange part 16 Protrusion 17 Protrusion 18 Protrusion 19 Vial bottle 19a Bottle 19b Flange 20 Vent 20a Vent DESCRIPTION OF SYMBOLS 21 Sheet-like packing 22 Seal ridge 23a Male screw 23b Female screw 24 Seal film 25 Air passage 26 Reinforcement part 27 Air passage

──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Hideo Miura 2-7-12 Ginza, Chuo-ku, Tokyo Sankyo Co., Ltd. (56) References JP-A-63-135641 (JP, U) JP-A-49- 52949 (JP, U) Jikken 47-6703 (JP, Y1) Special Table Hei 3-505320 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) B65D 35/44-35 / 54 B65D 39/00-55/16

Claims (6)

(57) [Claims] 1. A synthetic resin to be fitted to a bottle mouth of a bottle container.
In the top wall of the protector made of a material , an opening or a needle passing window portion closed by a sealing means for easy passing of needles is formed, and a space between the inner surface of the top wall and the upper surface of the bottle opening is sealed in the cylindrical portion of the protector. Vial container fitted with a stopper
In the inner surface of the cylindrical portion of the protector, the upper surface outer peripheral edge and the lower surface outer peripheral edge of the bottle mouth flange are engaged to hold the protector in a half-plug freeze-drying posture, and the lower surface of the bottle mouth flange A locking means is provided for engaging with the outer peripheral end to maintain the two positions of the entire stoppered sealing position, and a vent port for communicating the inside of the bottle container and the outside air to the cylindrical portion of the protector in the half stoppered freeze-drying position. A vial container comprising: 2. The vial container according to claim 1, wherein the plug body has a thick sheet-like packing structure. 3. A stopper having a vent notch inserted and fitted into a bottle mouth is integrally formed with the stopper, and an outer periphery of a lower surface of a bottle mouth flange is provided when the protector is in a half-plug freeze-drying posture. 2. The vial container according to claim 1, wherein another locking means which engages with the end to prevent the plug body from floating is provided on a lower portion of the inner surface of the cylindrical portion. 4. A synthetic resin to be fitted in a bottle mouth of a bottle container.
In the top wall of the protector made of a material , an opening or a needle passing window portion closed by a sealing means for easy passing of needles is formed, and a space between the inner surface of the top wall and the upper surface of the bottle opening is sealed in the cylindrical portion of the protector. Vial container fitted with a stopper
In the inner surface of the cylindrical portion of the protector, the upper surface outer peripheral edge and the lower surface outer peripheral edge of the bottle mouth flange are engaged to hold the protector in a half-plug freeze-drying posture, and the lower surface of the bottle mouth flange A locking means is provided for engaging the outer peripheral end to maintain the two positions of the entire stoppered sealing position. On the other hand, the lower end of the thick portion of the cylindrical portion of the protector in the half stoppered freeze-drying position is open air. And a ventilation port is provided on the inner wall surface of the cylindrical portion corresponding to the upper end of the ventilation path, so that the inside of the bottle container can communicate with the outside air through the ventilation port during the half-stopping freeze-drying posture. A vial container characterized in that: 5. The vial container according to claim 4, wherein said plug body has a thick sheet-like packing structure. 6. A stopper having a vent notch inserted and fitted into a bottle opening is formed integrally with the stopper, and an outer periphery of a lower surface of a bottle opening flange is provided when the protector is in a half-stopping freeze-drying posture. 5. The vial container according to claim 4, wherein another locking means which engages with the end to prevent the plug body from floating is provided on a lower portion of the inner surface of the cylindrical portion.