EA042092B1 - TANK AND CONNECTING STRUCTURE TO PROVIDE COMMUNICATION BETWEEN TANK - Google Patents

Description

The present invention relates generally to the provision of fluid transferable communication (hereinafter referred to as fluid communication). In particular, the present invention relates to a container in accordance with the preamble of claim 1 of the claims and a connecting structure for providing fluid communication in accordance with the preamble of claims 17 and 33 of the claims, which also discloses the corresponding container systems, methods for preparing a mixture of substances and use of appropriate containers and connecting systems.

In the field of medicine, it is constantly required to transfer substances from one container to another. For example, mixtures of drugs and substances are formed in a mixing vial by first transferring the contents of one container, then the contents of another container into the mixing vial, plugging the mixing vial and forming the mixture by shaking.

In some cases, also related to the present invention, substances stored in different containers must be mixed under sterile conditions or conditions that exclude the ingress of foreign substances. The present invention also relates, in particular, to the creation of a sterile fluid communication preventing the ingress of foreign substances, such as pathogens.

In this part, WO 2013/104550 A, for example, discloses a kit for the preparation of a combination vaccine, in which two vials each have a membrane, and the kit includes a double needle to pierce the membranes and thereby ensure a permanent fluid connection between the vials. It has, however, been found that fluid bonding by means of a twin needle or the like involves a relatively high resistance to flow, which can slow down the transfer process between vials. There is also the possibility that the transfer will be partial, resulting in not reaching the required ratio of components in the mixture.

The object of the present invention is to provide a connection system, container system, method and application that will simplify or speed up the preparation of the mixture and / or provide versatility in compliance with sanitary requirements in the preparation of the mixture at the vaccination site.

This problem is solved by the capacity and the connecting system claimed in independent claims. Additional preferred features are the subject of dependent claims.

Namely, the present invention proposes a container having a connecting structure for providing fluid communication between the container and another container, and in the initial state, the connecting structure is sealed against the fluid in the opening area and can be opened to form a fluid connection and the opening area closed by another connecting structure. Moreover, the container contains a sealing device configured to continuously isolate the volume directly in contact with the opening area by interacting with another connecting structure during movement of the other connecting structure relative to the said connecting structure, moreover, these connecting structures are made with the possibility of mutual opening with the formation of a constant fluid connections and contain necks formed so that the neck of one of the connecting structures can pass into the neck of the other connecting structure.

The present invention also provides a connection system for providing fluid communication between containers, comprising at least two connection structures configured to form a fluid connection, namely a first connection structure and a second connection structure, each of which is sealed against fluid media in its original state and can be opened in the opening area to form a fluid bond. Moreover, the connecting system contains a sealing device configured to continuously isolate the volume directly in contact with the opening areas during the movement of the connecting structures relative to each other, moreover, these connecting structures are made with the possibility of mutual opening with the formation of a permanent connection in the fluid medium and contain necks , formed so that the neck of one of the first and second connection structures can pass into the neck of the other of the first and second connection structures.

In addition, the present invention proposes a connection system for providing fluid communication between containers, containing at least two connection structures configured to form a fluid connection, each of which contains an opening area, in the initial state sealed against the fluid , and each area of the opening is closed sterile or sterilizable. Moreover, the connecting structures are made with the possibility of mutual opening with the formation of a constant fluid connection, and the connecting structures contain necks formed so that the neck of one of the first and second connecting structures can pass into the neck of the other of the first and second connecting structures.

Below will be given additional details to more clearly disclose the features relevant to the present invention.

- 1 042092

The first feature of the present invention relates to a container with a connecting structure for establishing fluid communication of this container with another container, and in the initial state, the connecting structure is sealed against the fluid in the opening area and can be opened to form a fluid connection, and the opening area closed with a lid (closing means) in the form of a cap and/or other connecting structure.

It is also provided that the lid or other connecting structure is tightly (hermetically) held on the container, thus forming a sealed (hermetic) chamber, and the container contains a sealing device/means surrounding the opening area, which isolates the volume in direct contact with the opening area from the volume chamber separated from the dissection area.

Alternatively or additionally, it is envisioned that the container comprises a sealing device which continuously seals the volume enclosing the opening area by means of a lid or other connection structure when the lid or other connection structure is moved relative to said connection structure.

According to another feature that can be implemented independently, the present invention relates to a connection system for providing communication between containers in a fluid medium, containing at least two connection structures configured to form a communication fluid medium, namely the first connection structure and the second connection structure , each of which is initially fluid sealed and can be opened in the opening area to form a fluid bond.

Preferably, the connection structures form a sealed chamber and comprise a sealing device, whereby the sealing device separates the internal volume in direct contact with the opening areas from the external volume of the chamber, which is separated from the opening areas.

Alternatively or additionally, it is envisioned that the connection system comprises a sealing device that continuously seals off the volume in direct contact with the opening areas when the connection structures are displaced relative to each other.

As a result of double sealing by means of an additional chamber (separate or first volume) and a second volume surrounding the opening area, and/or sealing provided during movement, it is possible to achieve a more reliable sterile sealing or sealing of the opening area.

In another aspect, which can also be implemented independently, the present invention relates to a connection system for providing (permanent) fluid communication, preferably between containers, comprising at least two connection structures capable of providing fluid communication, each of which contains an opening area sealed in relation to the fluid in the initial state and, in particular, made in the form of a film, fragile, brittle and / or fragile, each opening area is closed sterilely or with the possibility of sterilization.

The advantage of such a double closure, namely the opening area and the shelter of the corresponding connection structure, is the possibility of complying with hygienic requirements during transport, storage and/or fluid bonding, even at the site of vaccination.

In another aspect, the invention may be used with a container system having at least two containers, preferably vessels, and a connection system according to the feature described above, each of the containers comprising at least one connection system connection structure to provide fluid communication between the containers. .

In this way, it is possible to form a fluid connection between the containers and ensure mixing of their contents.

According to another aspect, the invention can be used with a method of forming a fluid connection between connection structures and/or containers by means of connection structures that are fluidly connected in the initial state, the first connection structure being opened by another, second connection structure, by embedding the connection structures one in another and/or axial movement along a common axis.

In this way, it is also possible to achieve rapid formation of a reliable connection of the containers in the fluid medium and mixing of their contents.

According to another feature, the invention may provide for the use of a container system, the first container of which contains a first substance, in particular a first vaccine against a first disease, and the second container contains a second substance, in particular a second vaccine against a second disease different from the first, for preparing a mixture of substances, in in particular for the preparation of a combined vaccine for simultaneous immunization against various diseases, and the capacity

- 2 042092 connected to each other in a fluid medium by means of connecting structures, whereby the substances are mixed with each other, in particular to form a combined vaccine.

In this way, substances that are not compatible with one another, such as vaccines, can be hygienically mixed just prior to sharing and administration, saving time and reducing stress.

According to another feature, a container system can be used with two containers that are fluidly separated from each other in the initial state and between which a fluid connection can be formed by means of relative movement of the containers, the relative movement being prevented in the initial state by the latch.

It appears that the container system preferably has a recess in the form of a latch in which the latch can be inserted as a result of or during the relative movement.

As a result, separate parts are not required to enable unlocking and use. It has been found that tear-off tabs are sometimes swallowed by animals and can cause injury. The present invention provides convenient and safe operation.

According to another feature, a method for preparing a mixture of substances, preferably a combination vaccine, can be implemented, for which the substances are supplied separately from each other in two containers, for which a fluid bond can be formed by moving the containers relative to each other, preferably axial movement relative to a central axis or axes of symmetry of the container system.

It appears that there is a socket between the containers, a latch is placed or formed between the containers to block relative movement, and that the latch is activated and pushed into the socket by activation and relative movement. This ensures the convenience and safety of work.

The connection system is preferably applicable for creating a fluid connection between containers, in particular, having advantages, however, alternatively or as an addition, it can also be used for any other fluid connections or connections, for example, connection of a container with some other devices, or can be used independently of any containers.

The proposed connection system preferably contains at least or exactly two connection structures. Preferably, the connecting structures are formed in such a way that they are conjugated and/or coordinated with each other. The advantage of this approach is that fluid communication can only be achieved with connection structures that match each other. Preferably, mating and/or matching configurations of connection structures also have the advantage that the connection structures match each other so that fluid communication can be provided.

The connection structures are preferably in each case initially fluid-sealed. This allows the mixture to be prepared on demand or at the point of use, or to use containers each with coordinated connection structures, as well as to use them individually or independently of each other.

It is assumed that the connecting structures are made with the possibility of their mutual opening, and this mutual opening provides a continuous connection in a fluid medium.

Preferably, the first connection structure is configured to open the other, second connection structure. It is also preferred that the second connection structure be operable to open the first connection structure. This ensures the mutual opening of the connecting structures.

According to another feature, the connection system comprises several containers, each of which contains both one of the connection structures and an opening for withdrawal/removal.

According to another feature of the present invention, fluid communication can be provided by deforming at least one of the connection structures, preferably by destroying the opening area of the connection structures by deforming the connection structure outside the opening area.

It is contemplated, in particular, that each connection structure serves as a means, contains means, or is designed as a means for opening a corresponding other connection structure. Such means are preferably affixed or permanently attached to or integral with the respective connection structure. The advantage of this solution is the possibility of providing fluid communication without the use of a tool (apart from the actual connecting structures) and, in particular, ease of use. In particular, it is advantageous that no separate tool is required to move or operate separately from the connecting structures, so that the proposed connecting system is simple, inexpensive to manufacture, and also distinguished by reliability and strength.

Preferably, after establishing a fluid connection and/or mechanical connection of the connecting structures or containers, this connection and/or connection remains permanent and inseparable. Preferably, even partial mixing and/or penetration of foreign matter during or after fluid communication can be effectively prevented by this. Preferably, due to the permanent and/or permanent fluid connection, the use of a membrane (septum) or the like is not required to provide this fluid connection, even when sterility is desired. Therefore, relatively large openings, or openings with a large cross-section, can be obtained compared to a needle, which allows faster transfer and mixing of substances.

In the present invention, the connection is permanent in the sense that, in particular, the connection can only be opened again by damaging or destroying the structure, not by hand, and/or only by using a tool. A permanent connection is, in particular, a connection created by snap-on grips. However, other solutions are also possible.

Preferably, at least one, preferably both, of the connecting structures (each of them) contain an opening area, which is to be opened by the other of the connecting structures. It is particularly preferred that the opening region comprise or be formed using or by means of a film region, a rupture region, a reduced strength region, a wall thinning, a film, in particular a sealing film, a membrane, a membrane region and/or another structural part or region of the connecting structure providing opening under the influence of another connecting structure, in particular by destruction, breakthrough, tearing and / or separation of the opening area, without any other negative effect on the function or structure of the connecting structure. In particular, the (film) opening region is a mechanically weak or weakened part of the wall. The opening area may be destructible, fragile and/or brittle and/or may be a discontinuous area, form or include it. The advantage of using an opening region is that a hole with a relatively large passage cross-section can be created simply and quickly. This ensures rapid mixing and homogeneity of the mixture, even if the containers are at least mostly filled with liquid and/or solid matter.

The connecting structure or structures are designed or designed for a single and/or irreversible opening, in particular using or by means of the opening area or areas. The hole formed using or through or in the connection system is preferably not intended to be resealed.

In the present invention, the opening cannot be resealed or irreversibly opened in the sense that it can only be resealed using a special tool and/or replacing damaged parts or adding new parts. The ruptured seal film, as the preferred form of the opened tamper area, is preferably unrepairable and irreversibly torn according to the present invention, even though the ruptured seal film could theoretically be replaced and repaired using appropriate equipment.

The following is a more detailed discussion of the proposed connection system, with reference to two connection structures, the first connection structure and the second connection structure. This does not necessarily imply an opening sequence, but serves primarily to distinguish between connecting structures. Thus, in particular, it is possible to manufacture the second connection structure separately and independently from the first connection structure.

The connection structures are preferably different and/or have a different shape in order to expose another corresponding connection structure. This preferably uses different mechanisms to open different connecting structures, or connecting structures designed for this purpose.

The first connecting structure preferably contains the first opening area. The second connection structure preferably also includes an opening region, hereinafter referred to as a second opening region. This makes it possible to distinguish between them and preferably does not imply either consistency or the possibility of creating a second opening region without the first.

The second connection structure is preferably configured to open the first connection structure by tearing, cutting or destroying the first opening area. Alternatively, or additionally, the first connection structure is configured to open the second connection structure by tearing, cutting or destroying the second opening area. Thus, the connecting structures can provide mutual opening by tearing, cutting and/or destroying the opening area of another connecting structure by one connecting structure.

According to a particularly preferred feature of the present invention, which can also be implemented independently, the second opening area of the second connection structure can be pierced by the first connection structure. It is also preferred that the first opening area of the first connection structure can be pierced by means of the second connection structure.

- 4 042092

Alternatively or additionally, the first opening area of the first connection structure can be opened by deforming the first connection structure by the second connection structure, in particular by cracking, tearing, punching and / or separation of the first opening area, as a result of tensile stress caused by deformation.

Preferably, the connection system in the first embodiment firstly opens the opening area of the first connection structure by means of the second connection structure using a cutting element, followed by opening the second opening area of the second connection structure by piercing the second opening area with the first connection structure.

Preferably, the connection system in the second embodiment firstly opens the second opening area of the second connection structure by piercing the second opening area with the first connection structure, followed by opening the opening area of the first connection structure by deforming the first connection structure by means of the second connection structure.

These embodiments can be combined with each other, for example by first opening the opening area of the first connection structure with a second connection structure using a cutting element, followed by opening the second opening area of the second connection structure by piercing the second opening area with the first connection structure and then opening the opening area of the first connection structure using the second connection structure by deforming the first connection structure by the second connection structure.

The connecting structures can also mutually pierce each other and/or one of the connecting structures can pierce the other connecting structure, and the other connecting structure can open the first connecting structure by deforming.

The first and/or second connecting structure(s) preferably comprise (in each case) a neck. The neck can be made in the form of a constriction and/or a sleeve and/or a ring, or in the form of a pipe section, etc. The neck, in particular, is made with the possibility of transferring the fluid medium after opening.

The neck is preferably configured to create, form or enclose a fluid bond. To do this, the neck can be (in each case) closed in the initial state. In particular, the (corresponding) neck is closed off by means of the opening area, preferably so that it can be opened once and/or irreversibly and/or with sealing. The neck may have an open or outer edge, on which the opening area is preferably hermetically fixed, installed or formed.

The neck preferably surrounds the (corresponding) opening area. In particular, a part of the connecting structure containing the opening area is attached to the neck, for example, by means of a sealing film tightly covering the open edge of the neck. It is possible, although not necessary, for the opening to be located within the neck. In the present invention, the term surrounds, preferably means that the opening area or part of the (corresponding) connecting structure forming the opening area (in the initial state) is attached to the neck circumferentially or in some other way from all sides with fluid sealing.

Preferably, the second connection structure comprises a neck surrounding the opening area of this structure, while it is also preferred that the connection structure is pierced through this opening area. In this way, the second connecting structure can be opened.

Preferably, the opening area of the first connection structure is pierced by a neck and/or a separating, piercing or piercing element of the second connection structure. The opening or opening region of the second connection structure can therefore be designed as a means or tool for opening the first connection structure.

Alternatively or additionally, the second connection structure is configured to deform the neck of the first connection structure so that this deformation causes destruction, cracking, tearing and / or separation of the opening area of the first connection structure, in particular, by rotating the connection structures relative to each other. Alternatively or additionally, the first connection structure is configured to deform the neck of the second connection structure so that this deformation causes the destruction of the opening area of the second connection structure, in particular by rotating the connection structures relative to each other.

According to the concept described, it is fundamentally possible to functionally replace the first connecting structure with the second connecting structure.

Preferably, the neck of one first or second connection structures is made with

- 5 042092 the possibility of locating along the same axis with the neck of the other first or second connecting structures, preferably so that the opening area of the other first or second connecting structures could be broken through and / or another of the first and second connecting structures could be opened.

In particular, the connecting structures are therefore structures, each of which has a neck, also covered in each case by a plug containing an opening area, in particular a sealing film. In addition, the necks are formed different and complementary so that the neck of one of the connecting structures is able to destroy the opening area of the other connection structure. Thus, at least one of the connecting structures is exposed.

The connection system is preferably designed such that it is only necessary to open two connection structures or pierce two discontinuous sections of the connection structures to create a permanent fluid connection. Therefore, it is preferable that a permanent fluid connection is established immediately by opening both connecting structures, and if only one of the connecting structures is opened, or neither of the two connecting structures is opened, then hydraulic blocking or cut-off occurs.

In the present invention, permanent fluid communication means, in particular, that a passage is formed through which fluid can pass. Preferably, this passage is formed by mutual opening of the connecting structures.

In particular, it is preferable that both connecting structures contain necks that have a non-circular cross section and can be placed one inside the other and are made so that the rotation of the necks relative to each other leads to deformation of at least one of the necks so as to break through the opening area, surrounded by deformed necks or adjacent to deformed necks, in particular at least one inner opening area or one opening area related to the inner neck.

In particular, the tapering necks can be designed so that by pressing them into each other and rotating them relative to each other, preferably around, in particular, a common central axis, the outer side of the neck located inside comes into contact with the inside of the neck located outside so that that the resulting force changes the shape, or deforms, one or both necks. In particular, each neck may have an oval cross-section and/or may be pressed into the other with the same orientation, at least initially, in order to cause (mutual) deformation or change of shape during rotation. This can reduce the longitudinal dimension and/or increase the transverse dimension of the opening means with a corresponding tensile cracking, destruction, tearing and/or separation of the opening means, preferably at least the internal connecting structure, which leads to opening.

In particular, it is preferable that the opening area be made with the possibility of bending, indentation and/or stretching by deformation. In particular, the opening region is formed as a film or a sealing film which is capable of being torn apart when the neck on which the film is located or formed is deformed and the connecting structure is opened accordingly.

In accordance with another feature of the present invention, when the first connection structure approaches the second connection structure, only one of the first and second opening areas is first destroyed, in particular by piercing, and a permanent fluid connection is established only when the connection structures are further approached, by breaking the other from the first and second opening areas.

Preferably, there are at least two different possibilities for breaking open areas or break sections of different connecting structures, and thereby ensuring mutual opening of the connecting structures.

In the first variant, first, one connecting structure is pressed with its neck into another connecting structure, breaking through the opening area of the other connecting structure, after which the inserted connecting structure is deformed by rotating the connecting structures relative to each other, which leads to a rupture of their opening areas and, as a result, creating a permanent fluid connection.

In the second variant, one connection structure contains a cutting element, by means of which the opening area of the other connection structure is first broken through and thereby the opening is carried out. Only then is the neck of the other connection structure, the opening area of which has already been opened by the cutting member, pressed into the neck of the first connection structure, thereby causing the opening area of the first connection structure to break. At the same time, a permanent fluid connection is also formed as a result of mutual opening.

Common to these variants is that the neck of one connecting structure (hereinafter always referred to as the first connecting structure) is used to break through the opening area or to open the opening area of another connecting structure (hereinafter always referred to as the second connecting structure), preferably by pressing into the neck this other connecting structure.

According to another feature of the present invention, which can thus be implemented independently, the connection structures can be attached to one another, preferably permanently and/or snap-fitted. Preferably, the permanent connection of the connecting structure is carried out even before opening at least one of the first and second connecting structures. In particular, the connection structures are designed such that a permanent connection must first be made between the connection structures, and then a permanent fluid connection can be created.

Preferably, the connection structures have different connection positions with each other, in particular snap-in positions or blocking steps. The connection structures are preferably designed such that none or only one of the first and second connection structures can be opened when the first connection position is reached, and that permanent fluid communication and/or opening of the two connection structures is ensured when the other, second, connection position is reached. .

Thus, there may be at least two connection positions occupied one after the other when the connecting structures are pressed or inserted one inside the other. In the connection position, which is achieved first in time and/or distance, a permanent connection is created between the connecting structures, and a permanent fluid connection is created only in the second connection position. This prevents the connection structures from separating from one another after one or both of the connection structures have been opened. As a result, leakage and/or contamination can be prevented.

The connection system is preferably self-sealing after fluid bonding.

Preferably, the formation of a fluid connection by means of the proposed connection system, in particular, provides a passage for the fluid, hermetically sealed from the environment.

To form an airtight seal, preferably the at least one opening area acts as at least a sealant as a result of or after the formation of the fluid bond. In particular, a second connection structure may be used, comprising an opening area acting as a seal, a sealing lip, or the like, at least at the edges where it has been pierced by the mouth of the first connection structure. Alternatively or additionally, however, another sealant, in particular a sealing ring or a sealing lip, can be used.

According to another feature which can be implemented independently in this way, the present invention relates to a container system comprising containers, in particular vessels, each with a recess opening, in particular a baffle, which are further adapted to provide fluid communication independently of extraction holes. To this end, the connection structure is positioned, in particular preferably, on the side opposite the recess opening. It has been shown that for fluid communication of the container, in addition to the opening for the recess, or the device for the recess, for example a baffle, in particular, it is preferable to use a connecting structure located elsewhere, in particular in the case of a vessel, on the side opposite from the constriction of the vessel. . This allows for permanent fluid communication through the proposed connection system without compromising the function of the recess opening. The containers in this case remain suitable for use individually and independently of each other.

According to another feature that can be implemented independently in this way, the present invention relates to a container system with the proposed connection system, in which the first container contains the first connection structure, and the second container contains the second connection structure of the proposed connection system. In particular, it is preferable that at least one of the containers comprises a recess opening and, at a remote or opposite end from the recess opening, a connecting structure of the proposed connecting system. Thus, containers can be fluidly connected by means of the proposed connection system, in particular for mixing substances, while no blocking, for example, of standard openings for recessing or otherwise affecting them occurs.

Preferably, the first and second vessels each comprise an opening for a recess and, at the end remote or opposite from these openings, in particular on the respective base of the vessel, one of the proposed connection structures. As a result, the vessels can be fluidly connected to each other at the end remote from the recess opening by means of the proposed connection system.

As a result of the formation of the fluid connection, preferably a new combined container is obtained with a volume equal to the total volume of both containers and / or with two holes for

- 7 042092 notches. The advantage of this solution is that, theoretically, the containers can be used independently of each other by means of the corresponding openings for the recess, however, the contents of the containers can also be combined and mixed, due to the formation of a permanent fluid connection between the containers through the proposed connection system.

The container system may also comprise at least one container having a first connection structure at the first end and another second connection structure at the second, other, in particular opposite, end. Each of the two connecting structures is configured to form a fluid bond. The container may have, form and/or contain a volume in which the substance is or may preferably be contained. This allows more than two containers to be fluidly connected, or more than two different substances to be mixed. To this end, the container contains two connecting structures so that the other container can be fluidly connected at both ends by means of the proposed connection system. This container preferably forms an adapter between other containers of the container system, but it can also be used with only one additional container to create a fluid connection between it, and/or can also be manufactured separately and/or form an independent feature of the present invention.

According to another feature, which can be implemented independently in this way, the present invention relates to the use of the proposed container system, in which the first container contains the first substance, in particular the first vaccine against the first disease, the second container contains the second substance, in particular the second vaccine against the second disease different from the first one, the containers in each case having a recess opening and in each case containing, in addition to the corresponding recess opening, a connecting structure for providing fluid communication between the containers, for the preparation of a mixture of substances, in particular the preparation of a combined vaccine for simultaneous immunization against different diseases, while the containers are fluidly connected to each other by means of connecting structures so that the substances are mixed and, in particular, form a combined vaccine.

The proposed system of containers, in particular, is preferably used for the combined administration of drugs. In particular, it is possible to store vaccines, which are not very stable when combined, in separate containers, and to fluidly connect these containers before use by means of the proposed connection system, thereby ensuring a quick and efficient mixture formation without affecting the opening for the recess, for example, partitions. Alternatively, the respective vaccines can also be used separately from each other through the recess holes, if no fluid bond has been formed by the connection system.

The containers or vessels and/or connection structures in the present invention are preferably at least substantially dimensionally stable, rigid or partially rigid and/or at least predominantly formed from a plastic material or a plastic material containing, in particular, polyethylene, high density polyethylene (HDPE), low density polyethylene (LDPE) or polypropylene.

In the present invention, the term vessel preferably denotes a stopperable container for transporting and storing fluids, in particular liquids and fluid solids, such as powders. In the present invention, the vessel preferably has a diameter smaller than the height. The vessel in the present invention preferably has at least a substantially tapered end, also referred to as a vessel narrowing. The constriction of the vessel preferably has at its end an opening, in particular of a circular shape, which can be plugged and opened to extract the contents, also referred to as a withdrawal opening. The vessels in the present invention are preferably narrow-necked vessels and/or vials. In narrow-necked receptacles, the diameter or internal width of the recess opening is less than the average internal diameter of the storage space defined by the receptacle, preferably less than 70%, in particular less than 50%. However, other solutions are also possible.

In the present invention, the connection structure is preferably a device capable of providing a fluid connection and preferably a mechanical connection when forming a fluid connection. This is, in particular, a hydraulic connection, a flange, a connecting element, a fastening element, a detachable connection, a connection with a male/female element, in particular a plug connector, or parts thereof.

In the present invention, the connection structure may be a part/area of a container, in particular a vessel, or the connection structure (in each case) is attached to the container, in particular attached by a material, friction or interlocking connection. In particular, preferably the connecting structure is at least partially formed by or as an integral part of the container or vessel. Alternatively or additionally, the connection structure is adjacent to the container or vessel, or otherwise adapted to hydraulically attach or attach to the interior of the container or vessel.

- 8 042092

In the present invention, the connection structure is preferably fluid-tight when the leakage or passage of a fluid, in particular a liquid, is prevented, or when the leakage or passage of a fluid, in particular a liquid, is prevented by a fluid-tight seal, in particular a liquid.

In the present invention, the connecting structures are able to be inserted into each other, in particular, when a part or section of one of the connecting structures can be placed inside another connecting structure, or part or section. In particular, at least part of one of the connecting structures may be pressed, laid, inserted or otherwise inserted into the other or corresponding connecting structure. The connecting structures are inserted one into the other, in particular when they overlap in the radial direction at least partially, mainly or completely about a (common) axis of symmetry and/or a central axis, or the interior of one connecting structure is (completely) surrounded or enclosed ( along the radius) by the outer part of another connecting structure.

In the present invention, axial movement along a common axis is preferably a movement that is non-helical, non-rotational, at least mostly or exclusively linear and/or strictly axial, and/or a movement that does not require a complete rotation or reversal. The connection structures are preferably adapted to be built into one another, inserted into one another and/or at least substantially linearly fitted to one another to create a permanent and/or hydraulic connection.

In the present invention, opening, in particular, means providing access to the inside of the container, or vessel, or the volume formed by the container or vessel, by forming an opening, aperture, passage, slot, etc., in particular, so that entry and / or exit is provided. fluid, in particular liquid.

In the present invention, the opening area is, in particular, the area made with the possibility of opening, i.e. its design provides for the formation of an opening, opening, passage, slot, etc., or access for the fluid inside or into the volume located in the container. The opening area is preferably occluded and openable for fluid to pass through. The opening area may be a plugged slot, a plugged hole in a wall, a closed passage or plug, etc., which can be opened.

The opening area in the form of a film is preferably a part that is, in particular, a thin-walled or flat structure for forming a hole. The opening area in the form of a film is preferably an opening/area sealed or plugged with a film, membrane, flat, thin, breakable and/or weak structure.

In the present invention, a breakable structure is in particular a structure that can be broken through or pierced by an object, in particular a point, so that a connection from one (flat) side to the opposite side can be provided. Breakthrough preferably provides opening. In particular, the pierced area of the opening is destroyed during the rupture and remains permanently opened.

In the present invention, sealing indicates in particular that leakage and/or penetration of a substance is prevented by the sealing means.

In the present invention, self-closing indicates, in particular, that sealing is carried out without special means due to its own properties and/or automatically, fully automatically, simultaneously or without the need for additional actions.

In the present invention, sterile self-closing means, in particular, self-closing forming an insulating means against the entry of pathogens, for example bacteria or viruses, so that at least substantially the entry and/or leakage of bacteria is prevented. In particular, the sealant, the sealing gap and/or the contact pressure are chosen such that any possible leakages have a cross-section that blocks the passage of pathogens, such as bacteria or viruses.

In the present invention, moisture-proof refers to a seal that at least substantially prevents the entry or exit of fluids, in particular liquids.

In the present invention, gas-tight refers to a seal that at least substantially prevents the entry or exit of gases.

In the present invention, the physical structure means, in particular, a complex formation and/or structure and/or structure and/or an ordered combination of different structures, different materials, etc.

In the present invention, a layered structure, as well as a sandwich structure, a multilayer structure, in particular a composite structure, a composite material and/or a layered composite material, means, in particular, a structure containing various layers, which are preferably connected to each other and/or adjacent to each other, can be logically separated or delimited from each other, are arranged with flat sides facing each other or on top of each other, contain flat elements or parts that can differ in their physical or

- 9 042092 chemical properties.

In the present invention, at the edges or edge area refers, in particular, to the area remote from the center, middle or center of gravity, or to the area having an edge, edge, end or border, adjacent to them or facing them. In particular, it is part of a preferably planar structure at its annular edge, in particular surrounding or having an annular shape, etc.

In the present invention, the central part refers in particular to the part remote from the end, edge and/or edge and/or contains, surrounds or extends around the center, middle, central point or center of gravity.

In the present invention, the destruction of the opening area refers, in particular, to the irreversible change in the opening area, the effect on its former function as a seal, wall, sealing element and/or plug, or such that the former function is no longer performed, in particular as a result of mechanical impact, change of shape, deformation, tearing, separation or any other impact. The opening area may be opened and/or a fluid connection may thereby be established.

In the present invention, cutting through the opening area means, in particular, separating the material of the opening area from one side to the other, in particular the opposite side, and/or separating them and/or cutting them off by chopping, cutting, cutting or otherwise in any way way.

In the present invention, to remain intact means, in particular, the preservation of a pre-existing function. The intact opening area has and retains, in particular, the function or functions of closing, sealing and/or forming an insulating means to prevent the penetration or leakage of pathogens, fluids, liquids, gases, etc.

In the present invention, the fluid medium is preferably a substance having fluidity. The fluid, in particular, may use a fluid bond to flow. In particular, in the present invention, the fluid is a liquid, a slurry, a fluid solid, such as a powder or granular material, and/or a gas in liquid or gaseous form. In particular, preferably at least one of the substances is a liquid, in particular both or at least two substances.

In the present invention, fluid communication preferably means a structure/structure capable of passing a fluid medium, in particular a liquid, gas or fluid solid medium. In particular, it is a passage zone, a passage or a channel.

In the present invention, a fluid passage particularly means a means capable of passing a fluid, in particular a liquid, gas or solid fluid. In particular, it is a transit area, connection or channel, which is preferably (safely) isolated from the environment or from the side of the wall forming the passage, remote from the passage.

Preferably, in the present invention, the opening region is brittle if, in particular, due to its composition and/or design, it is suitable or intended for tearing near its elastic limit without plastic deformation or with little plastic deformation (brittle fracture).

In particular, the opening area has an elastic limit of less than 200 N/mm ² and/or a tensile strength of less than 100 N/mm ² , preferably less than 60 N/mm ² and/or a ratio of tensile strength and tensile strength of less than 1, preferably less than 0 .7 or 0.5. This can be achieved in particular by structuring and/or combining, combining or laminating different materials. The opening area can be formed by laminating several films, of which preferably one film contains aluminum, or consists of aluminum, or is a metal foil. In particular, the opening region is preferably at least partially metallic. Preferably, the opening area is formed by or from a composite material, which preferably has a flat or film layer of aluminum.

In the present invention, the weak area of the opening is preferably an area that has less mechanical strength than its surrounding parts, and/or which can be destroyed manually or by the application of force, in particular, in the form of a fractured section.

In the present invention, the expression outside the opening area means a region or part separated from the opening area, but which preferably directly or indirectly adjoins the opening area, in particular so that deformation in this area causes tension in the opening area.

In the present invention, deformable means preferably elastic or plastic deformable. The connecting structure(s) or necks are preferably characterized by elastic deformation, which causes plastic/irreversible deformation of the opening area. The connecting structure(s) or necks may, however, also exhibit plastic deformation/deformation.

In the present invention, parts or sections are considered to correspond to one another if, in particular, they have a similar and / or complementary design, when they are inserted one into the other, are similar to each other, are in the same position, have the same orientation

- 10 042092 structures of similar shape and / or are made with the possibility of interaction with each other to perform a function or action.

In the present invention, rotation towards each other means, in particular, the rotational movement of a part, preferably a connection structure or a container, or a vessel with a connection structure, relative to another part, preferably another connection structure or another container, or another vessel.

In the present invention, rotation opposite to each other means in particular the rotational movement of two parts, preferably a connection structure or container, or a vessel with a connection structure relative to another part, preferably another connection structure or another container, or another vessel, preferably in a different or opposite direction of rotation. .

In the present invention, a neck is, in particular, a section or part containing or forming an opening, the edge of the opening, opening or constricting, preferably with an opening at the end, or some other tubular part or passage, radially surrounded by a wall, ending with an opening, which is preferably open at end and/or forms an opening at at least one end.

In the present invention, the term thin-walled means, in particular, a structure, flat or planar in cross section, the average wall thickness of which is less than 2, 1.5, 1 mm and/or less than 0.5 or 0.3 mm, in particular less than 20 µm, in particular less than 150 µm.

In the present invention, the locking device is preferably part of the opening area, or at least partly forms the opening area. The closure device in this case, in particular, has a flat or planar shape or is a plugging plate. In this case, the locking device has, in particular, a material thickness greater than its longitudinal extension, preferably at least 2, 3, 4 or 5 times.

The locking device is preferably formed as a single unit, in particular as a single piece with a break section, in particular a thin section. The locking device together with the rupture section may form the opening area or part of it. Preferably, the rupture region forms a film-like, brittle and/or fragile part of the opening region, or makes the opening region film-like, brittle and/or fragile. For this reason, the fractured portion is preferably brittle enough to form a hole by tearing under mechanical force.

The connecting structure is preferably formed from a plastic material, in particular a thermoplastic material, in particular by injection molding. The opening area is advantageously formed by the locking device, in particular over more than 70%, 80%, 90% or 95% of its area. In this case, compared with the surface area of the locking device, the rupture section occupies an area of less than 10%, in particular less than 5%.

The locking device may have an S-shape in cross section along the main overall dimension. The locking device may have ribs or other reinforcing elements to increase rigidity. The locking device preferably has sufficient strength or rigidity to prevent it from being deformed or to be slightly deformed by the ruptured portion. As a result, the force acting on the rupture portion does not deform the closure device or deforms it only slightly, in particular by compression, thereby making it easier to destroy or rupture the rupture portion.

In the present invention, the rupture portion, in particular a thin delimited portion, is preferably a film-like, brittle and/or weak or brittle site or opening area, or a film-like, brittle and/or weak or brittle part of the opening area.

The rupture portion is preferably manufactured and designed to collapse or rupture under mechanical loading to form a hole. In particular, the rupture section interacts with the locking device, whereby the rupture section can be stretched relative to the closure device so that stresses, shear forces, etc., result in the destruction of the rupture section. Thus, the discontinuous section is or forms, in particular, an area of weakening or a part with a mechanically weakened structure compared to the surrounding sections.

The rupture portion is preferably formed wholly or partly in a circle on or within the neck or holder. The fracture site may be in the form of a rim or a diaphragm. In particular, the rupture section forms a connecting strip to the locking device, in particular from the holder or neck.

In the present invention, a chamber is preferably a structure or volume that is tightly sealed or sealed on all sides. The chamber, however, can in principle also be openable, for example by means of a connecting structure, or by opening a sealing structure, or the like.

In the present invention, volume or formed volume preferably means a region or (partially) chamber that is at least largely or completely surrounded. Term

- 11 042092 the scope can therefore be replaced if necessary by the term chamber or part of the chamber. Moreover, internal volume and external volume are distinguished; it is preferably contemplated that functionally the inner volume can be achieved by passing through the outer volume. Preferably, the outer volume surrounds the inner volume. This, however, is not absolutely necessary, since in other embodiments, the outer volume may form an antechamber to the inner volume. Preferably, the outer volume forms an externally insulated prechamber, while the inner volume is adjacent to and isolated from the outer volume, so that the outer volume shields the inner volume from the environment.

In the present invention, the container blank is a tubular structure with at least two openings, one of which is or is formed a recess hole, used later for opening and/or closing, or filling and/or retrieval. The other opening is temporary and plugged during the manufacturing process of the container, in particular preferably by sealed use or the introduction of a connection structure. The connection structure itself may form part of the container and further open the container in this area.

In the present invention, the container blank has an opening for insertion or installation of the connecting structure, preferably on the side opposite or away from the recess opening. However, other solutions are also possible. In addition, the container blank may also have only one opening for the insertion or installation of the connecting structure. In this case, the container obtained after assembly has only one opening in the form of an opening area of the connecting structure. The container blank preferably comprises a constriction-like portion having at least a substantially conically tapering portion or kink region merging into a narrow passage. The narrow passage in this case preferably forms or contains an opening for the recess.

In the present invention, the sealing portion is preferably an area configured and/or positioned to be sealed. In particular, such a part is a sealing lip, a sealing strip, etc. The sealing part may include a sealing surface formed by a surface area of the sealing part, and directly provides a sealing effect. In particular, the sealing effect is achieved by means of the sealing surfaces pressing against each other. To this end, the sealing surfaces are preferably pressed against one another under tension or pressure, for example in the form of a press fit or the like. The sealing surfaces are preferably formed from the material of the sealing part, or the surface of the sealing part. There are, however, other possibilities, such as the use of seals in the area of the sealing part.

In the present invention, the abutment part preferably cooperates with the opening or fracture area so that the opening of the opening area, or the destruction or tearing of the fracture section by means of a mixed mechanical support, a support from below, in particular, creating a support pressure or an opposite pressure, is excluded. In particular, this device removes or displaces mechanical stresses from fragile, fragile areas in order to block or prevent accidental opening. The support part is in particular designed to relieve stress from the fractured section.

In the present invention, the latch is preferably a means for preventing movements, in particular relative movements, of connecting structures and/or containers, or other influences that would or could lead to the opening of the opening of the opening. In particular, it may be a retaining ring or similar element to block the preferably axial movement of the connecting structures relative to each other and to allow such movement during activation or excavation. The latch preferably comprises a blocking part which, as an operating part or an operating section of the latch, directly locks, in particular movement, when actuated or removed.

In the present invention, the guiding device is preferably a mechanism or part of a mechanism, in particular a bayonet type, guiding the relative movement of the connecting structures relative to each other. By this movement, a bayonet connection is preferably effected. A bayonet connection, also known as a bayonet lock, is preferably a mechanical connection of at least two generally cylindrical and/or rotationally symmetrical parts, in particular with respect to a central axis or axis of symmetry.

Connection by means of guiding devices is carried out by pressing and turning. The parts are inserted into each other along the axis, and after they are inserted to the stop, they rotate relative to each other, interlocking engagement in the axial direction. This preferably creates a fluid bond.

The first guiding device for this purpose is preferably a slot, groove or other guiding device at least shaped as a substantially right angle, the first part of which extends along an axis or parallel to the central axis or axis of symmetry, and the adjacent part extends at least , mostly at right angles to the direction of the first part.

- 12 042092

The part extending behind the axially directed part preferably extends at least substantially in a plane perpendicular to the central axis of symmetry. The other or second guiding device and/or the guiding device associated with the first is preferably a pin, post, pad or other part corresponding to the first guiding device, in particular, the associated slot, groove or the like. In general, the guiding devices preferably form a sliding guide .

The fluid communication containers are preferably manufactured separately from each other. This ensures their universal applicability.

The features of the present invention mentioned above and described in the following partial description can also be implemented and have a beneficial effect individually and in various combinations.

Other details, advantages and properties of the present invention will be apparent from the claims and the following description of the preferred embodiments with reference to the drawings, in which: FIG. 1 shows a longitudinal section of a container system with the proposed connection system and with fluid communication implemented;

in fig. 2 shows a longitudinal section of the proposed connection system in the first embodiment, in the initial position;

in fig. 3 shows a longitudinal section of the proposed connection system in the first embodiment, in the first position of the connection;

in fig. 4 shows a longitudinal section of the proposed connection system in the first embodiment, in the second position of the connection;

in fig. 5 shows a longitudinal section of the proposed connection system in the second embodiment, in the initial position;

in fig. 6 shows a longitudinal section of the proposed connection system in the second embodiment, in the first position of the connection;

in fig. 7 shows a longitudinal section of the proposed connection system in the second embodiment, in the second connection position, with the connection structures oriented relative to each other;

in fig. 8 shows a longitudinal section of the proposed connection system in the second embodiment, in the second position of the connection, with the connection structures rotated relative to each other around a common axis;

in fig. 9 is a schematic plan view of a first vessel with a first connection structure for the proposed connection system of the second embodiment;

in fig. 10 is a schematic plan view of a second container with a second connection structure for the proposed connection system of the second embodiment;

in fig. 11 is a schematic cross-sectional view of the proposed connection system of the second embodiment taken along the line XI-XI in FIG. 7;

in fig. 12 is a schematic cross-sectional view of the proposed connection system of the second embodiment after the connection structures have been partially rotated relative to each other;

in fig. 13 is a schematic cross-sectional view of the proposed connection system of the second embodiment taken along the line XIII-XIII in FIG. 8;

in fig. 14 is a schematic longitudinal sectional view of a container with connection structures according to the first embodiment located on opposite sides;

in fig. 15 is a perspective view of a container with a second connection structure of the proposed connection system of the first embodiment;

in fig. 16 is a schematic longitudinal sectional view of the proposed container system with the proposed connection system according to the first embodiment in a shipping arrangement;

in fig. 17 is a schematic longitudinal sectional view of a first container with a first connection structure closed with a sterile or sterilizable lid;

in fig. 18 is a schematic longitudinal sectional view of the first container shown in FIG. 17, with the cover removed;

in fig. 19 is a schematic longitudinal sectional view of the first container supported in the lid shown in FIG. 17;

in fig. 20 is a schematic longitudinal sectional view of a second container with the closure partially removed;

in fig. 21 is a schematic longitudinal sectional view of the proposed container system showing the direction of movement to create a fluid connection through the proposed connection system;

in fig. 22 shows a schematic view of the longitudinal section of the container system in accordance with

- 13 042092 another embodiment in the connected state;

in fig. 23 is a schematic longitudinal sectional view of the container of the container system shown in FIG. 22, in the original state;

in fig. 24 is a schematic view of an enlarged detail of the container shown in FIG. 23;

in fig. 25 is a schematic longitudinal sectional view of the container shown in FIG. 23 with the lid removed;

in fig. 26 is a perspective view of the container shown in FIG. 23, from the side of its connecting structure;

in fig. 27 is a schematic longitudinal sectional view of another container of the container system shown in FIG. 22, in the original state;

in fig. 28 is a schematic view of an enlarged longitudinal section of the container shown in FIG. 27;

in fig. 29 is a schematic longitudinal sectional view of the container shown in FIG. 27, with cover removed;

in fig. 30 is a perspective view of the container shown in FIG. 27, from the side of its connecting structure;

in fig. 31 is a schematic longitudinal sectional view of the container system shown in FIG. 22, in the original state;

in fig. 32 is a schematic view of a fragment of a longitudinal section of the container system shown in FIG. 22, in the first connection position;

in fig. 33 is a schematic view of a fragment of a longitudinal section of the container system shown in FIG. 22, in the second connection position;

in fig. 34 is a schematic view of a fragment of a longitudinal section of the container system shown in FIG. 22, in the third connection position;

in fig. 35 is a schematic longitudinal sectional view of the container system, with the latch in the rest position;

in fig. 36 is a schematic view of a fragment of a longitudinal section of the container system shown in FIG. 35 with the latch actuated;

in fig. 37 is a schematic view of a fragment of a longitudinal section of the container system shown in FIG. 35, in the connection position;

in fig. 38 is a perspective view of the latch of the embodiment shown in FIG. 35, in the original position;

in fig. 39 is a schematic longitudinal sectional view of the container system with the proposed lock according to the second embodiment in the initial position;

in fig. 40 is a schematic view of a fragment of a longitudinal section of the container system shown in FIG. 39 with the latch actuated;

in fig. 41 is a schematic view of a fragment of a longitudinal section of the container system shown in FIG. 39, in the connection position; and in FIG. 42 is a perspective view of the latch of the embodiment shown in FIG. 39, in the original position.

In the description of the preferred embodiments given below with reference to the drawings, the same or corresponding reference numbers (with or without an apostrophe) are used for the same or similar components or parts, and similar or identical advantages and properties can be obtained even when not the description relating to them was repeated.

In FIG. 1 is a schematic sectional view of the proposed container system B with a first container B1 and a second container B2.

The container system B preferably comprises the proposed connection system 1. The connection system 1 is preferably configured to form a fluid connection 2, preferably between the first container B1 and the second container B2 of the container system B.

The connection system 1 preferably comprises a number of connection structures 3A, 3B, in particular a first connection structure 3A associated with the first container B1 of the container system B and a second connection structure 3B associated with the second container B2 of the container system B. Preferably, the first container B1 contains the first connection structure 3A and the second container B2 contains the second connection structure 3B and vice versa.

The containers B1, B2 are preferably used for storing the substances S1, S2, in particular for storing the first fluid and the second fluid and/or different vaccines. In particular, containers B1, B2 are completely or partially filled with one or more substances S1, S2 or vaccines. Alternatively or additionally, the container or containers B1, B2 may also contain and/or store other substances S1, S2, preferably in solid form. It is possible that only one substance S1, S2 will be a fluid medium, in particular a liquid. The solid substance S1, S2 can be presented as a solution or suspension with other substances S1, S2.

- 14 042092

The container system according to the invention is preferably used for the preparation of medicaments, in particular combination medicines, combination vaccines or the like. There are, however, other possible and preferred applications of the proposed container system B.

Preferably the first container B1 has a recess E1 or the second container B2 has a recess E2. In particular, preferably both or at least two containers B1, B2 of the proposed container system B each contain an opening E1, E2 for recess.

In the present invention, the withdrawal openings E1, E2 are preferably configured to dispense or withdraw the contents of the respective container B1, B2.

At least one and preferably several or all of the openings E1, E2 are preferably reusable or reusable, resealable, reusable, and/or contain a sealing element V1, V2 which preferably allows them to be opened and closed to receive discrete doses. This can be achieved by using a membrane.

Preferably, the extraction openings E1, E2 are closed or can be closed and/or are the main means for removing the substances S1, S2 from the containers B1, B2.

In the embodiment shown, at least one of the recess openings E1, E2 and in particular both of the recess openings E1, E2 are preferably covered with membranes. The membrane is a device with a rubber-like sealing element V1, V2, in particular a rubber stopper or an injection stopper, which is suitable for piercing with an injection needle to extract the contents, while the membrane automatically closes the (corresponding) opening E1, E2 for recess due to the ability to recover shape and size after deformation after removing the injection needle. The membrane, also referred to as a piercing membrane, preferably has a thin area, particularly in the center, suitable for puncturing when an injection liquid is withdrawn using an injection needle. The injection stopper or membrane is preferably secured to the vessel constriction or recess opening E1, E2 by means of a flanged cap, preferably made of aluminium.

Preferably one, both or all of the containers B1, B2 are injection ampoules or vials, for example so-called multi-dose containers, in particular for vaccinating several animals with one dose each.

Substances S1, S2 in containers B1, B2 in the form of powdered drugs, solutions or suspensions or vaccines can be transported in this form.

The containers B1, B2 may (each) may have a capacity of more than 10 ml, preferably more than 50, 100 or 200 ml, and/or less than 2 liters, preferably less than 1.5 or 1 liter, in particular less than 750 ml (each or after they are connected).

As shown in FIG. 1, the sealing element V1, V2 is preferably sealed to the corresponding recess opening E1, E2, preferably pressed, in particular by means of a pressure ring or a compression ring or a flanged cap. However, other technical solutions are also possible, such as bonding by adhesive, welding, injection molding or other methods.

It is certainly preferred that each container B1, B2 of the proposed container system B has a recess E1, E2, but not all containers B1, B2 of the container system B need to have a recess E1, E2.

Preferably, the use of openings E1, E2 for recessing on several containers B1, B2 allows the use of the corresponding substance S1, S2 from the corresponding container B1, B2, regardless of the use of the connection system 1. Preferably, the system B of the containers allows both the use of containers B1, B2 individually, and and use in conjunction with fluid communication 2 provided by connector system 1.

The containers B1, B2 are preferably fluidly connected to each other such that the fluid connection 2 between the volumes formed or contained by the containers B1, B2 provides a common interior space formed by the containers B1, B2 connected by the connecting system 1. Combined the internal space is particularly characterized in that a permanent fluid connection 2 is ensured by a hydraulic cross-section greater than 2 mm ² , preferably greater than 5 or 10 mm ² , in particular greater than 1, 2 or 3 cm ² , or there is no constriction between containers B1, B2 after formation of the fluid connection 2, having a size less than such a hydraulic cross section, or where the fluid connection 2 has at least such a hydraulic cross section.

The container or containers B1, B2 is or is preferably shaped like a vessel. In particular, preferably the containers B1, B2 (each) have a constriction F1, F2, forming or adjacent to the recess openings E1, E2. The taper F1, F2 can, starting from the end edge or recess opening E1, E2, include an expansion of the (hydraulic) cross section by more than 1.5 times, in particular by more than 2 or 2.5 times. However, the holes E1, E2 can also have a different design.

- 15 042092

Containers B1, B2 preferably have recess openings E1, E2 and connecting structures 3A, 3B on different, opposite, diametrically opposite sides, ends, axle ends and/or in the constriction area on the one hand, and in the base area on the other hand . Specifically, a recess hole E1, E2 is formed in the constriction F1, F2, and the connecting structure 3A, 3B is located in the base region or at the opposite end from the constriction F1, F2. A clear advantage of this solution is that when using the connection structures 3A, 3B, the hole(s) E1, E2 remain(s) available and its function is not disturbed.

The connection structures 3A, 3B are preferably not intended to be withdrawn, but only to establish a secure fluid connection 2 once or irreversibly, or not to be repeatedly closed.

The effect of the present invention is explained in particular by the preferred use for connecting containers B1, B2, in particular vessels. However, it is possible and preferable to use the proposed connection system 1 also in other areas, for example, to create a fluid connection of the container B1, B2 with other systems, for example, to quickly remove the substance S1, S2.

In FIG. 2 shows a longitudinal section of the proposed connection system 1 according to the first embodiment in the initial position or in the unconnected state.

In FIG. 3 shows a longitudinal section of the proposed connection system 1 according to the first embodiment in the first position of the connection, in which preferably the fluid connection has not yet been established, but one of the regions 4A, 4B has already been opened.

In FIG. 4 shows a longitudinal section of the proposed connection system 1 according to the first embodiment in the second connection position in which the fluid connection 2 is established. This position is also shown in Fig. 1.

The proposed connection system 1 preferably comprises several connection structures 3A, 3B, in particular preferably at least a first connection structure 3A and a second connection structure 3B, preferably configured to at least partially complement each other or match each other.

The first connection structure 3A preferably includes an opening area 4A. The second connection structure 3B preferably includes an opening area 4B.

Preferably, containers B1, B2 comprise opening areas 4A, 4B or areas 4A, 4B form part of or form part of a respective connection structure 3A, 3B associated with the respective container B1, B2.

Preferably, one or both of the opening areas 4A, 4B are areas or parts of the respective connecting structure 3A, 3B, configured to create a (lasting and irreversible) fluid connection 2, in particular by (irreversibly) destroying this structure. For this purpose, the region or regions 4A, 4B of the opening may have a (mechanically) weakened region or discontinuity, or may be designed as a weakened region or discontinuity. The opening regions 4A, 4B may have the same, similar or different design, in particular with respect to the thinned material and/or shape of the opening regions 4A, 4B.

In particular, the opening areas 4A, 4B are designed to be (mechanically) broken or pierced to form a fluid bond 2 . For this purpose, the area 4A, 4B in accordance with the present invention can be made with the possibility of its destruction, punching and/or tearing under mechanical action to ensure the formation of the connection 2 in fluid.

In the embodiment shown, the opening areas 4A, 4B are formed by film-like or membrane-like wall parts of the corresponding connecting structure 3A, 3B. In particular, one or more of the opening areas 4A, 4B is or are sealing films. As such, the opening regions 4A, 4B may also be formed by weakening the material forming the respective connection structures 3A, 3B and/or may be integrally formed with the respective connection structure 3A, 3B.

Regions 4A, 4B are preferably designed as wall parts of the (corresponding) connecting structure 3A, 3B. Regions 4A, 4B are preferably regions with a small wall thickness that have been weakened to some extent compared to adjacent regions. Preferably, the material thickness in the opening areas 4A, 4B is less than the material thickness of the adjacent areas, in particular the walls, of the (corresponding) connecting structure 3A, 3B. The (corresponding) opening areas 4A, 4B are therefore preferably thinner, more like a film and/or membrane compared to adjacent areas.

The area or areas 4A, 4B of the opening preferably contains or contain one or more discontinuous areas, in particular punches, thin areas, fragile areas or parts. In particular, the second connection structure 3B or its opening area 4B has a break section corresponding to the neck 5A of the first connection structure 3A. This contributes or contributes to the destruction or puncture of the opening area 4B of the second connecting structure 3B, even if, when using the neck 5A for this purpose, the separating force applied to the opening area 4B acts or is distributed over a larger area.

In the embodiment shown in FIG. 2-5, the opening areas 4A, 4B are each formed by sealing films which are welded, adhesively attached or otherwise firmly attached, in particular watertightly, to the respective connection structure 3A, 3B, preferably to its neck 5A, 5B.

In particular, it is preferred that the opening regions 4A, 4B are formed by a multilayer or plate material, in particular a plastic/metal composite film or a laminate. The opening regions 4A, 4B can, however, also be made differently, for example using several layers and/or a brittle or porous material, so as to have limited elasticity, whereby even with slight mechanical stress, the opening regions 4A, 4B are torn or destroyed in a different way.

The area or areas 4A, 4B of the opening are preferably made with the possibility of erosion under the influence of mechanical stresses, and the formation of a connection 2 in fluid. Preferably, the opening areas 4A, 4B comprise a material whose modulus of elasticity is greater than 2000 N/mm ² , preferably greater than 4000 N/mm ² , in particular greater than 6000 N/mm ² . Alternatively or additionally, the opening regions 4A, 4B may have a tensile strength of less than 100 N/mm ² , preferably less than 80 N/mm ² , more preferably less than 60 N/mm ² . Elastic modulus and tensile strength can be determined according to EN ISO 6892-1, ISO 6892, ASTM E 8, ASTM E 21, DIN 50154, DIN 50125 and/or ISO 527, ASTM D 63.

It is also preferred that the opening area or areas have a material thickness of less than 100 µm, preferably less than 70 µm, in particular less than 50 µm and/or more than 5 µm, in particular more than 10 µm.

The first connection structure 3A, 3A' preferably comprises first, in particular film-like opening areas 4A, 4A', and/or the second connection structure 3B, 3B' preferably comprises a second, in particular film-like opening area 4B, 4B' . Preferably, this simultaneously ensures effective sealing of the 14 respective connecting structures 3A, 3A', 3B, 3B' and a safe and easy opening of the respective regions 4A, 4A', 4B, 4B'.

The first connection structure 3A, 3A' is preferably configured to open the second connection structure 3B, 3B' by piercing or destroying the second opening area 4B, 4B'. Alternatively or additionally, the second connection structure 3B, 3B' is preferably configured to open the first connection structure 3A, 3A' by piercing or destroying the first opening area 4A, 4A'. This allows the fluid bond 2 to be formed manually or without the use of a tool. The interior volumes of the containers B1, B2, B3 are preferably connectable by means of the connecting structures 3A, 3A', 3B, 3B' without any additional fixtures or tools.

Preferably, to create the fluid connection 2, the opening area 4B, 4B' of the second connection structure 3B, 3B' may be cut through by the first connection structure 3A, 3A', and preferably the first opening area 4A, 4A' of the first connection structure 3A, 3A' may be cut through by the second connection structure 3B, 3B', in particular by its cutting member 7. Thus, the fluid bond can be formed by mutual punching or piercing.

The connection structures 3A, 3A', 3B, 3B' preferably have necks 5A, 5A', 5B, 5B' formed such that the neck 5A, 5A', 5B, 5B' of one first or second connection structures 3A, 3A', 3B , 3B' can be aligned with the neck 5A, 5A', 5B, 5B' of another first or second connection structure 3A, 3A', 3B, 3B', whereby the opening area 4A, 4A', 4B, 4B' can preferably be cut the other first or second connection structures 3A, 3A', 3B, 3B' and/or the other first or second connection structures 3A, 3A', 3B, 3B' can be opened.

The opening region 4A preferably comprises a neck 5A and/or the opening region 4B comprises a neck 5B. The necks 5A, 5B preferably define the boundaries of the opening regions 4A, 4B. The necks 5A, 5B may be integrally formed with the respective connection structures 3A, 3B or form part of their wall. Preferably, the necks 5A, 5B have open edges or are formed as sleeves or constrictions, the respective opening areas 4A, 4B are preferably surrounded or limited by the respective necks 5A, 5B. The necks 5A, 5B, or their open edges, preferably abut or delimit the opening areas 4A, 4B, or vice versa. In particular, the preferably open edge of the respective necks 5A, 5B forms a (circular) fastening part for the opening region 4A, 4B, which in particular preferably has the form of a film or is formed by a film.

The container system B according to another feature of the present invention, which can also be implemented independently, comprises a lid (closing means) 6 adapted to hold one of the containers B1, B2, in particular by acting as a support for it. Preferably, the lid 6 may alternatively or additionally serve, in particular, as a sterile protective cover for one of the containers B1, B2 and/or one of the connection structures 3A, 3B. The following is a more detailed discussion of this feature.

The connection structure 3A, 3B and the method of formation by fluid coupling thereof are discussed in more detail below in the first embodiment shown in FIG. 2-5.

In the first embodiment, the first connection structure 3A is configured to open the opening area 4B of the second connection structure 3B. In particular, it is preferable that the neck 5A of the first joint structure 3A is adapted to be inserted or pressed into the neck 5B of the joint structure 3B so that the opening area 4B of the second joint structure 3B is exposed during the insertion or pressing.

In the embodiment shown, the first connection structure 3A, 3A' or the first neck 5A, 5A' is preferably a male connection and/or the second connection structure 3B, 3B' or the second neck 5B, 5B' is preferably a female connection, in particular , forming a fluid bond.

In particular, it is provided that one end or open edge of the neck 5A has an outer circumferential edge that can be placed inside the inner circumferential edge of the neck 5B.

Preferably, the outer circumferential edge of the neck 5A of the first joint structure 3A corresponds to or is similar to the inner circumferential edge of the neck 5B of the second joint structure 3B, or vice versa. In particular, the neck 5A of the first connection structure 3A has an outer diameter, at least across or at the transition to the opening area 4A, smaller than the inside diameter of the neck 5B of the second connection structure 3B, preferably at least at the end edge or at the transition to the area 4B autopsy. In the embodiment shown in FIG. 2-5, the neck 5A, 5B is preferably tapered and/or at least substantially circular in cross section.

In the present invention, unless otherwise indicated, a cross section is a section or a sectional image at right angles to the longitudinal axis or axis 9 of symmetry of the corresponding container B1, B2 and/or the corresponding connecting structure 3A, 3B.

The second connection structure 3B of the first embodiment preferably comprises a cutting element 7 which is preferably configured to pierce, cut, cut or generally destroy the opening region 4A of the first connection structure 3A. In particular, the cutting element 7 comprises a piercing device, a point, a blade, a wedge or, in general, a cutting and/or cutting device.

The cutting element 7 is preferably positioned and/or attached to the opening area 4B of the second connection structure, in particular directly. The cutting element 7 is preferably located on the outside of the second connection structure 3B, or on the side or outside remote from the interior of the container 3B. The cutting element 7 is preferably positioned such that when the connecting structure 3B or the cutting element 7 approaches the opening area 4A of the first connection structure, the cutting element 7 exerts a force on the opening area 4A, which leads to the destruction and opening of the opening area 4A, preferably without opening or destroying the area 4B opening the second connecting structure 3B.

Specifically, the cutting member 7 is a device for concentrating the force acting on the opening region 4A or distributing the counter force acting on the second joint structure 3B or the opening region 4A so that the opening region 4B of the second joint structure 3B remains intact when the region 4A of the opening is opened upon destruction by the cutting element 7.

In an embodiment (not shown), the cutting element 7 is located on the inside of the connection structure, on the inside or inside the interior of the container B1 or (when viewed from the outside) is located behind the opening area 4B of the second connection structure 3B. Preferably, the opening area 4A, 4A' of the first connection structure 3A is destroyed by the cutting element 7 when the neck 5A is pushed into the neck 5B of the second connection structure 3B. For this purpose, a cutting element 7 is used, which is located, in particular, directly (inside or on the side remote from the first connection structure 3A) behind the opening area 4B of the second connection structure 3B.

Preferably, the cutting element 7 is fixedly positioned or fixed on the second connecting structure 3B, in particular (immediately) on, in front of or behind the opening area 4A.

In FIG. 2 shows the proposed connection system 1 in the initial position, where the opening areas 4A, 4B of the containers B1, B2 are closed or sealed. In particular, they are (in each case) bottle-shaped vessels or containers B1, B2, in which the lower opening areas 4A, 4B are closed in the initial position.

As indicated by the arrow 8 indicating movement, the first connection structure 3A and the second connection structure 3B can be moved towards each other or pushed into one another. For this purpose, the connecting structures 3A, 3B are preferably moved along the axis

- 18 042092 towards each other about the central axis or axis 9 of symmetry. The central axis or symmetry axis 9 is preferably the central axis or symmetry axis 9 of the neck or parts 5A,

5B and/or the opening area or areas 4A, 4B, and/or the container or containers B1, B2.

The containers B1, B2, the connection structures 3A, 3B, the opening areas 4A, 4B and/or the openings 5A, 5B can in this case be formed essentially symmetrical about a central axis or axis 9 of symmetry. The axisymmetric and rotationally symmetrical design of the necks 5A, 5B is preferred because it allows the use of the connecting structures 3A, 3B regardless of their angular position. Theoretically, however, other solutions are also possible, in particular those in which the necks 5A, 5B are rotationally asymmetric or non-circular and preferably a guide is provided, which is configured to determine the angular position of the connecting structures 3A, 3B relative to the central axis or axis 9 of symmetry. This will be discussed in more detail in connection with the second embodiment.

As seen in FIG. 3, as the connecting structures 3A, 3B move closer to each other, the cutting element 7 is applied to the opening area 4A, preferably by the tip 7A, and as the connecting structures 3A, 3B are further moved towards each other, it is forced through the opening area 4A, 4B. Thus, the opening area 4A is destroyed or the connecting structure 3A and/or the container B1 is opened.

The connecting structures 3A, 3A', 3B, 3B' are preferably designed to be separate and/or independent from each other in the initial position (see also FIGS. 16 and 17). This also makes it possible to use both together and separately cavities or containers B1, B2, B3, which are connected or can be connected to the connecting structures 3A, 3A', 3B, 3B'.

In the initial position, the connecting structures 3A, 3A', 3B, 3B' are preferably not connected and are fluidly separated from each other. As a result of the formation of the fluid bond 2, the connecting structures 3A, 3A', 3B, 3B' are displaced to the connection position in which the fluid bond is formed.

The fluid connection 2 between the containers B1, B2, B3 is preferably formed at least when it becomes possible to move between the containers B1, B2, B3 masses or substances S1, S2, S3 enclosed in these containers, under the action of gravity and/or mixing with each other.

The fluid connection 2 is in particular provided by a channel or passage through which fluids S1, S2, S3, in particular liquids, can flow.

The connecting structures 3A, 3A', 3B, 3B' can preferably only be used once and/or can be opened irreversibly; the fluid bond 2 is preferably permanent and/or irreversible.

The connection system 1 is preferably configured to form a connection without the possibility of disconnection and separation, in particular with the formation of an inseparable connection even before at least one of the connection structures 3A, 3A', 3B, 3B' has been opened. This prevents the loss of substances and, importantly, prevents the process of partial mixing.

The connecting structures 3A, 3A', 3B, 3B' preferably include retainers 10A, 10B to create a permanent connection, which form a permanent connection between the connecting structures 3A, 3A', 3B, 3B' by inserting one into the other and/or passing one through the other during axial movement along their common axis. In particular, the latches 10A, 10B comprise snap hooks or snap hooks. It is thus possible to ensure that the connection cannot be released manually and/or without being damaged or destroyed.

The connecting structures 3A, 3A', 3B, 3B' can preferably be connected to each other without the possibility of separation or separation by interlocking and/or frictional engagement, in particular by snap-fitting. In particular, by inserting one into the other and/or inserting one into the other during axial movement along a common axis, various connection positions, in particular locking positions, can be realized.

In particular, one of the connecting structures 3A, 3A', 3B, 3B' comprises snap-on means, in particular one or more snap-on protrusions, located on the parts located one behind the other along the axis. Preferably, the snap-on means of one of the connection structures are arranged such that one or more mating snap-on means of the other connection structure 3A, 3A', 3B, 3B', in particular one or more slots or notches, snap onto each other to form an engagement by being surrounded by one the other and/or inserting one into the other during axial movement along a common axis. This ensures that a permanent or non-separable connection, or connection position, is achieved.

The connection structures 3A, 3A', 3B, 3B' are preferably configured to obtain a permanent and inseparable connection when a first connection position is reached in which none or only one of the first or second connection structures 3A, 3A', 3B, 3B' is open or has been open. In this case, the fluid connection 2 in this first blocking position is preferably not yet formed or not completely formed.

When, after the first connection position, by location or time, another, second, connection position is preferably reached, a permanent fluid connection 2 is formed and/or the opening of the two connecting structures 3A, 3A', 3B, 3B'.

By pushing together the first connection structure 3A, 3A' and the second connection structure 3B, 3B', preferably only one first or second opening region 4A, 4A', 4B, 4B' is first destroyed, in particular by piercing, and only after as the connecting structures 3A, 3A', 3B, 3B' are moved closer or rotated relative to each other or pressed into one another, a permanent fluid bond 2 is formed due to the destruction of the other first or second opening regions 4A, 4A', 4B, 4B' .

Preferably, the connection system 1 has a first connection position in which the connection structures 3A, 3B are permanently connected to each other, preferably by a snap connection. To this end, the connecting structures 3A, 3B may have latches 10A, 10B corresponding to each other, which form a permanent connection between the connecting structures 3A, 3B when they come close together.

In the embodiment shown, the latches 10A, 10B are formed by corresponding or mating cutouts, snap-in projections, etc. In particular, separate snap-in projections are formed on one of the connecting structures 3A, 3B, and in particular, annular beads and/or cutouts are formed on the other of the connecting structures. structures 3A, 3B, through the interaction of which a blocked connection is provided between the connecting structures 3A, 3B.

Particularly preferably, the latches 10A, 10B are designed to permanently connect the connecting structures 3A, 3B to each other in the first connection position, but allow further movement of the connecting structures towards each other.

Moreover, the latches 10A, 10B are preferably configured to maintain the next, second connection position, in which the connection structures 3A, 3B move more tightly or are pressed deeper into each other than in the first connection position. In particular, several snap positions are preferably provided, in which, in the first snap position, the connecting structures 3A, 3B are already permanently connected to each other. The proposed connection system 1 is shown in this first connection position in FIG. 3.

In the first connection position, one of the connection structures 3A, 3B may already be opened. Alternatively or additionally, the first connection position can also be characterized in that a permanent connection has indeed been made between the connecting structures, but none of the regions 4A, 4B has yet been opened or is in the process of being opened.

In the embodiment shown in FIG. 3, in the first connection position, the first connection structure 3A is connected to the second connection structure 3B by a permanent snap-lock connection, and the first opening area 4A has already been opened or destroyed by the cutting element 7.

In FIG. 4 shows the connection system 1 according to the invention in a second connection position, in particular the following snap-in position, in which the connection structures 3A, 3B are moved further apart and/or pushed further into each other, in particular at least substantially completely in comparison with the first connection position. In the second connection position, the first opening area 4A of the first connection structure 3A was opened by the second connection structure 3B, and furthermore, the opening area 4B of the second connection structure 3B was opened by the first opening means 3A.

In order to open the second connection structure 3B using or by means of the first connection structure 3A, preferably the neck 5A of the first connection structure 3A is forced through the opening area 4B of the second connection structure 3B, thereby destroying this opening area 4B. Preferably, this is done when the connecting structures 3A, 3B are shifted from the first connection position to the second connection position.

The latches 10A, 10B are preferably designed to prevent (axial) moving away from each other of the connecting structures 3A, 3B located in the first connection position and in the second connection position. It is therefore envisaged in particular that the connection structures 3A, 3B are movable to the second connection position from the first connection position, but not in the opposite direction. It is also preferred that the connection structures 3A, 3B in the second connection position (see FIG. 4) cannot be moved back to the first connection position.

Preferably, in the first connection position, the connecting structures 3A, 3B abut against each other, partly creating a tight connection. This prevents leakage of substances S1, S2.

According to a feature of the present invention, which can also be implemented independently, during or as a result of opening the opening area 4B of the second connection structure 3B, a seal against the environment is formed by the neck 5A of the first connection structure 3A. Specifically, the opening area 4B of the second joint structure 3B forms a sealing system using the neck 5B of the second joint structure 3B. Alternatively or additionally, the necks 5A, 5B can seal by pressing against each other, while the opening area 4B creates a sealing effect or seals, in particular at the edges and/or in the transition zone to the neck 5B. However, other solutions are also possible, such as the use of an additional or separate rubber seal, sealing lip or the like.

The connection structures 3A, 3B or the connection system 1 are preferably formed or formed without the use of threads. It has been found that known systems using threads to move a cutting tool to open containers are more prone to defects and cost more to create a hole or fluid connection. Preferably, the connection structures 3A, 3B of the present connection system can be connected to each other by a simple linear or axial movement and/or by displacement directly towards each other (without the need for any additional rotation of several revolutions relative to each other). This provides the advantage of speed and convenience in forming the bond 2 in fluid.

It is also an advantage of the connection system 1 according to the invention that it contains one or more connection positions, in particular preferably locking positions. This, in particular, has the advantage over a locking thread that a permanent connection can be created between the connecting structures 3A, 3B. On the other hand, when using a threaded connection, disassembly and contamination are possible.

Theoretically, however, it is possible to combine the features of the present invention with connection structures 3A, 3B that are connected or capable of being connected by interlocking threads, or in which the fluid connection 2 can be formed by interlocking threads and rotational movement relative to each other.

In FIG. 5-13 are illustrations of the proposed connection system 1 according to the second embodiment. Only special features and differences from the embodiments described above will be considered, therefore, the above remarks will also apply as an addition to the second embodiment, unless otherwise specifically indicated or obvious to a person skilled in the art.

In FIG. 5 shows the start position of the first connection structure 3A' and the second connection structure 3B' according to the second embodiment. In the second embodiment, preferably none of the connecting structures 3A', 3B' has a cutting element. In particular, the joint system 1 according to the second embodiment does not have cutting tools, cutting mechanisms and/or sharp-edged protrusions or opening parts thereof.

In the second embodiment, the necks 5A' and 5B' of the connecting structure 3A', 3B' are preferably made rotationally non-symmetrical, or non-circular, or oval about the central axis or axis 9 of symmetry. Preferably, the necks 5A, 5B are configured to correspond to each other and/or be similar to each other with respect to a circular line, so that they can be located one inside the other and/or one can be pressed into the other. Moreover, the description of the necks 5A, 5B in the first embodiment can be used as additional information.

In FIG. 6 shows the connection structures 3A', 3B' in the first connection position, where they are connected to each other, preferably permanently. This can be used clamps 10A, 10B, as described above.

The connecting structure 3A', 3B' preferably comprises regions 4A', 4B' corresponding to or resembling opening regions 4A, 4B of the first embodiment. In the first connection position shown in FIG. 6, regions 4A', 4B' abut each other or are directly adjacent to each other. In contrast, in the first connection position, the opening area 4B' of the second connection structure 3B' can, however, also already be opened, as shown above with reference to FIG. 7.

In order to open or penetrate the second opening region 4B', the neck 5A' of the first connection structure 3A' is forced through the opening region 4B' of the second connection structure 3B', as described above when considering the opening of the region 4B in the first embodiment. Preferably, the opening area 4B', in particular the sealing film or the film-like part of the second connection structure 3B', is destroyed or opened, in particular by pressing a part of the first connection structure 3A' through the opening area 4B' so that the opening area 4B' is opened. or the film or film-like portion forming the opening region 4B' is pierced or broken. The result is shown in Fig. 7, which shows how, as a result of reaching the second connection position, the second connection structure

- 21 042092

3B' is opened in the manner described.

Unlike the first embodiment, the method of forming the fluid bond 2 in the second embodiment starts with the step of opening the second connection structure 3B' by means of the neck 5A' or destroying the opening area 4B' of the second connection structure 3B' using the neck 5A'.

In the second embodiment, it is also provided that the connecting structures 3A', 3B' are rotatable relative to one another or about a (common) central or symmetry axis 9 in their connected state, in particular in the second connection position. As a result, preferably, in particular, another of the connection structures 3A', 3B' is opened, i.e. the first connection structure 3A', as described in detail below with reference to FIG. 8-13.

According to one aspect, it is preferable that the first region 4A, 4A' of the first connection structure 3A, 3A' can be deformed by means of the second connection structure 3B, 3B'. Regions 4A, 4A', 4B, 4B' can also be mutually opened by mutual deformation. Opening by deformation preferably does not require any cutting edges or cutting elements, which is an advantage in terms of simplifying the manufacturing process and saving materials.

The second connection structure 3B, 3B' is preferably openable to the first connection structure 3A, 3A', in particular the second connection structure 3B, 3B' is preferably openable to the region 4A, 4A' of the first connection structure 3A, 3A' by deforming the first connection structure. designs 3A, 3A'.

In particular, according to this feature, it is preferred that the deformation be initiated by turning the connecting structures relative to each other, in particular about a common axis 9, and/or opening the opening regions 4A, 4A' of the first connecting structure 3A, 3A'.

The connecting structures 3A, 3A', 3B, 3B' preferably have non-circular, in particular oval or at least substantially elliptical, corresponding parts, which can be inserted one into the other and/or cause deformation and/or opening when their rotation relative to each other.

The deformation preferably creates tensile stresses in the opening region 4A, 4A' at least substantially radial or transverse with respect to the central axis or axis 9 of symmetry or along the opening region of the opening region 4A, 4A', whereby the opening region is torn, broken or separated and /or area 4A, 4A' is opened.

At the same time, the second connection structure 3B, 3B' can have, in particular, a film-like, fragile and/or weak area 4B, 4B', preferably in this case the first connection structure 3A, 3A' is operable to open the second connection structure. 3B, 3B'. In particular, the first connection structure 3A, 3A' is configured to open the second connection structure 3B, 3B' by tearing the opening area 4B, 4B' of the second connection structure 3B, 3B'.

The first connecting structure 3A, 3A' preferably comprises a neck 5A, 5A' adjacent to the opening area 4A, 4A' or surrounding the opening area 4A, 4A', wherein the neck 5A, 5A' is deformable such that the area 4A, 4A' openings can be opened by deformation.

The neck 5A, 5A' preferably has the form of a diaphragm, constriction, wall, thin wall, or it has elasticity and/or flexibility, and/or the neck 5A, 5A' is more elastic, more resilient and/or stronger than the region 4A, 4A' opening, which is preferably opened by deformation of the neck 5A, 5A' and area 4A, 4A' opening, in particular by tearing, breaking or separation.

The second connection structure 3B, 3B' is preferably configured to deform the neck of the first connection structure 3A, 3A' such that this deformation causes the region 4A, 4A' of the first connection structure 3A, 3A' to open.

The neck 5A, 5A', 5B, 5B' preferably has a non-circular, in particular oval, at least substantially elliptical, and/or polygonal shape in cross section, while the second connecting structure 3B, 3B' has a corresponding transverse section so that the rotation of the connecting structures 3A, 3A', 3B, 3B' relative to each other causes deformation and/or opening of the first connecting structure 3A, 3A' in their opening areas 4A, 4A'.

Both connecting structures 3A, 3A', 3B, 3B' preferably have necks 5A, 5A', 5B, 5B', which can be located oriented one inside the other or can be pushed into one another, while the rotation of the connecting structures 3A, 3A', 3B, 3B' or the necks 5A, 5A', 5B, 5B' relative to each other causes the first and preferably the second neck 5A, 5A', 5B, 5B' to deform.

The connecting structures 3A, 3A', 3B, 3B' may be connected to each other by a bayonet connection, or they may have connectors or guides 18A, 18B configured to form a bayonet type connection. For this purpose, the necks 5A, 5A', 5B, 5B' can be

- 22 042092 are first pushed or have the possibility of being pushed into each other (only) in the axial direction, and only after that they can be rotated or are able to be rotated relative to each other, while the fluid connection 2 is not formed until they rotated relative to each other. The guides 18A, 18B can then be designed to provide a bayonet connection. For this purpose, a guide is used, passing (only) along the axis, adjacent to (only) a radial guide.

Preferably by turning the connection structures 3A', 3B' relative to each other, while the neck 5A' of the first connection structure 3A' is placed in the neck 5B' of the second connection structure 3B', the opening area 4A' of the first connection structure 3A' is subjected to mechanical stress, in particular, by stretching when the neck 5A' of the first connection structure 3A' is deformed to such an extent that it breaks.

In order to make the opening mechanism of the first opening area 4A' of the first connection structure 3A' of the second embodiment more clear, FIG. 9 and 10 are plan views of the connection structure 3A', 3B'. The second connection structure 3B' shown in FIG. 9 preferably has a neck 5B' similar in shape and/or outline to the neck 5A' of the first connection structure 3A' shown in FIG. 10, but having large dimensions, diameters, longitudinal extent and/or transverse extent (at right angles to the central axis or axis 9 of symmetry).

In particular, the second connection structure 3B' includes an inner circular edge 15 shown in dotted line in the plan view of FIG. 9, similar in shape to, corresponding to, and/or configured to, the outer circumferential edge 16 of the neck 5A' so that the outer circumferential edge 16 can fit into the inner circumferential edge 15. Preferably, the maximum diameter of the inner circumferential edge 15 is greater than the maximum diameter of the outer circumferential edge 16 and/or the minimum diameter of the inner circumferential edge 15 is greater than the minimum diameter of the outer circumferential edge 16, preferably more than 2 or 3% and/or less than 40%, preferably less than 30%, more preferably less than 20, 15 or 10%. This ensures that the openings 5A', 5B' can be easily inserted one into the other and, at the same time, the opening of the opening area 4A' of the first connection structure 3A' is secure.

The necks 5A', 5B' may preferably be located inside each other or pressed into one another with some clearance. With this arrangement of the necks 5A', 5B', a gap 17 or gap is formed (at least partially) between the inner circular edge 15 and the outer circular edge 16.

In the embodiment shown, which relates in particular to the preferred embodiment, the necks 5A', 5B' each have an oval cross section, in particular at least substantially elliptical. Theoretically, however, other shapes are possible, for example at least substantially square or polygonal shapes. Theoretically, it is preferable that the extent of the cross section in the direction of the main axis or the maximum extent in the secondary axial direction (central or transverse or perpendicular to the main axial direction) exceeds the minimum extent of the cross section by more than 1.2 times, preferably 1.3 times, in particular 1 .5 times and/or at least or at least substantially 2 times. This ensures a sufficiently strong deformation during rotation of the connecting structures relative to each other, so that a reliable opening of the opening area 4A' of the first connecting structure 3A' can be carried out.

In FIG. 11-13, the connection structures 3A', 3B' are shown in different angular positions relative to each other, preferably in a second connection position.

Preferably, the connecting structures 3A', 3B' can be rotated around a (common) central axis or symmetry axis 9 by more than 45° and/or less than 200°, in particular less than 135° and/or at least substantially 90°. °, in its (permanently) connected state or with the necks 5A', 5B' inserted into each other. This ensures that one or both necks 5A', 5B' are deformed and the opening area 4A', 4B' is opened, in particular the area 4A' of the first connection structure 3A'.

In the embodiment shown in FIG. 8, the necks 5A', 5B' are similar, in particular with respect to a circular line spaced radially from the central axis or axis 9 of symmetry, in particular so that after the first neck 5A' has been inserted or pressed into the second neck 5B', they enter one another freely or with a gap, or at least partially abut directly against each other, in particular, at least at two points located opposite each other relative to the central axis or axis 9 of symmetry, and/or at least 20 %, preferably at least 50% corresponding to the circular line.

Due to the rotationally asymmetric or non-circular shape of the necks 5A, 5B, the rotation indicated by the rotation arrows 11 generates a force that deforms the first connection structure 3A', in particular its neck 5A'. In the embodiment shown, the necks 5A', 5B' have an oval cross section. In particular, this results in an advantage, since rotation of the necks 5A', 5B' relative to each other with sliding without blockages, with at least continuous deformation of the neck 5B' of the second connecting structure 3B' during the rotation of the connecting structures 3A' , 3B' relative to each other. However, other rotationally asymmetric or non-circular cross-sections are possible, such as rectangular, polygonal, triangular, etc.

In FIG. 12 shows a schematic cross-section of the connection system 1, in particular in the second position of the connection, where the necks 5A', 5B' are shown in a position rotated by 45° relative to each other. The respective necks 5A', 5B' act on each other with forces so as to cause the neck 5B' of the second connection structure 3B' to deform, and preferably at the same time, in particular, the neck 5A' of the first connection structure 3A' to deform accordingly. As shown by broken lines 12, deformation of the neck 5B' results in tensile stresses and/or compressive stresses on the opening region 4B' and preferably results in tearing or opening.

In FIG. 13 is a schematic sectional view of the proposed connection system 1, where the first connection structure 3A' has been rotated by at least substantially 90° relative to the second connection structure 3B'. Compared to the 45° rotation shown in FIG. 12, the increased angle of rotation of the connecting structures 3A', 3B' relative to each other increases the stress or pressure and/or tensile stress on the opening area 4B' so that the opening area 4B' is torn, destroyed, separated (along the edges) or opened by some in a different way.

The connection system 1 according to the second embodiment preferably comprises a guide 18A, 18B (cf. FIGS. 9 and 10) for connecting the connection structures 3A', 3B' in an angular orientation position, or for determining the angular position during their connection. In particular, a sliding guide or the like is used, whereby the connecting structures 3A', 3B' or the necks 5A', 5B' can only be inserted, placed or pressed into each other at certain angular positions (with respect to the central axis or axis 9 of symmetry) , preferably such that the necks 5A', 5B' have the same orientation.

The necks 5A', 5B' have the same orientation, in particular when the main axes, longitudinal axes, transverse axes, ends, corners and/or similar features coincide with each other, at least mainly, in particular, so that the first the neck 5A' can be pushed into the second neck 5B' at least substantially without any deformation of the neck 5A', 5B'.

The guides 18A', 18B' are preferably designed such that in the (second) connection position, either after the connection structures 3A', 3B' have been attached, or after the necks 5A', 5B' have been inserted or pressed into each other, it is possible to rotation relative to each other, in particular about a central axis, or axis 9 of symmetry. In particular, the guide 18A, 18B includes a groove or part extending along an axis or parallel to the central axis or symmetry axis 9 and further has a radially extending part, resulting in the rotational movement described above. However, other solutions are also possible.

Features of the first and second embodiments can also be combined with each other. Thus, in addition, the second connection system 3B, 3B' may comprise a cutting element 7, which at least partially opens the opening area 4A, 4A' of the first connection structure 3A, 3A', when the connection structures 3A, 3A', 3B, 3B' are placed alone. inside the other. Further, the necks 5A, 5A' can be used for opening, in particular for punching, the opening area 4B' of the second connecting structure 3A, 3B'. Rotation of the connecting structures 3A, 3A', 3B, 3B' relative to each other about the central axis, or axis 9 of symmetry further leads to the deformation of one or both necks 5A, 5A', 5B, 5B'. This leads to tension in the region or regions 4A, 4A', 4B, 4B' of the opening. In this way, disruption and/or rupture of the opening region or regions 4A, 4A', 4B, 4B' can preferably be effected, whereby the fluid connection 2 can be improved or the hydraulic cross section of the fluid connection 2 can be increased.

The connecting structures 3A, 3A', 3B, 3B' are preferably designed to open and/or complement and/or match each other, whereby a permanent fluid connection 2 can be formed.

The connection structures 3A, 3A', 3B, 3B' are preferably designed so that when the fluid connection 2 is created, a hydraulic cross section of more than 0.5 cm ² , preferably more than 1 cm ^{2 ,} is formed. This ensures fast and complete mixing.

The connecting structures 3A, 3A', 3B, 3B' are preferably adapted for axial insertion into each other, embedding into each other and/or formed without the use of threads. This ensures quick and easy formation of the bond 2 in fluid.

By forming the fluid connection 2, a passage is thereby preferably formed between the containers B1, B2, B3, which are hermetically isolated from the environment. This prevents the penetration of foreign substances and microbes.

The second connection structure 3B, 3B' is preferably openable to the first connection structure 3A, 3A' by breaking through the first opening area 4A, 4A' and/or the first connection structure 3A, 3A' is openable to the second connection structure 3B, 3B' by breaking through the second opening area 4B, 4B'. Due to the mutual destruction of the regions 4A, 4A', 4B, 4B', it is possible to form an irreversible bond 2 in a fluid having a sufficiently large diameter to ensure rapid mixing.

The connection system 1 is preferably self-sealing by forming a fluid bond 2, in which, in particular, at least one of the opening regions 4A, 4A', 4B, 4B' has a sealing property due to the formation of a fluid bond 2, or after this, so that the permanent fluid connection 2 forms a passage isolated from the environment. Preferably, the formation of the fluid connection 2 forms a fluid passage isolated from the environment, in particular watertight, impervious to microbes and/or gases.

To this end, one of the opening areas 4A, 4A', 4B, 4B' or a device that forms the corresponding opening area, after punching or otherwise damaging its insulating properties, for example a sealing edge, can pass between the connecting structures 3A, 3A', 3B , 3B' and thereby seal the connecting structures 3A, 3A', 3B, 3B' from or relative to each other.

The connection system 1 is preferably self-sealing in the sense of being sterile or sterilizable by forming a fluid connection 2. In particular, the formation of a fluid bond 2 forms a seal that prevents the penetration of microbes.

Preferably, for sealing the connecting structures 3A, 3A', 3B, 3B' relative to each other, a sealing gasket, in particular a sealing ring or a sealing lip, is used.

In particular, preferably for sealing the fluid connection 2 preferably with respect to the environment or for sealing the fluid passage, at least one opening area 4A, 4A', 4B, 4B', preferably the second area 4B, 4B', acts as a seal in the result of the formation of communication 2 on the fluid medium or after that.

In particular, it is contemplated that at least one opening area 4A, 4A', 4B, 4B', preferably the second opening area 4B, 4B', has a sealing property, or acts as a seal at least at the edges, or forms an o-ring or the sealing lip when the fluid bond 2 has been formed. Alternatively or additionally, it can be assumed that at least one opening area 4A, 4A', 4B, 4B', preferably a second opening area 4B, 4B', seals into the connecting structure 3A, 3A', 3B, 3B', preferably into the first or corresponding connection structure, in particular its neck 5A, 5A', 5B, 5B', when it has been pierced by the neck 5A, 5A', 5B, 5B' to form a fluid connection 2.

Preferably, at least one opening region 4A, 4A', 4B, 4B', preferably at least one opening region 4A, 4A', 4B, 4B' is designed to suppress cracking around the edges and/or form a seal, and/or it uses a material of construction, or a layered structure, in the edge region, as opposed to the central region, so that the edge region has greater strength and/or acts as a sealant after the edge region is opened.

The containers B1, B2, B3 of the proposed container system B in the initial state are preferably made separately from each other and can be used separately and/or fluidly separated from one another. In the initial state, the connection structures 3A, 3A', 3B, 3B' are each preferably fluid-sealed independently of one another. Once a fluid connection 2 has been formed between the containers B1, B2, B3, these containers are preferably connected without the possibility of separation and release.

In FIG. 14 shows another container B3 which may also constitute or form part of the container system B. The container system B preferably comprises a container B3. This container has two different, corresponding and/or complementary connection structures 4A, 4A', 4B, 4B'. As a result, this container B3 can serve as an adapter between other containers B1, B2 and/or can be connected to different containers B1, B2 and/or can mix more than two substances S1, S2, S3.

The container B3 contains both first and second connecting structures 3A and 3B on different, preferably opposite, sides. The container B3 thus contains the first connecting structure 3A, 3A' on the first side and the second of the connecting structures 3B, 3B' on the second side remote from the first side. This container is preferably free of recess holes E1, E2.

Moreover, the other container B3 is configured to form a fluid connection 2 on both sides by means of the proposed connecting system 1. The other container B3 may contain or cover an additional, different, substance S3 different from the previous substances S1, S2, in particular dry or sublimated substance (lyophilizate).

Several containers B3 can be connected to each other and to the first and/or second container

- 25 042092

B2, B2. More than three substances S1, S2, S3 can be mixed in this way and/or a combination of more than three containers B1, B2, B3 can be formed and/or more than three containers B1, B2, B3 can be fluidly connected to each other .

As already shown with reference to FIG. 1, the proposed connection system 1 is preferably used for fluid connection of bottle-shaped vessels or containers B1, B2, in particular for pharmacology. In particular, it is preferred that the opening areas 4A, 4A', 4B, 4B' are designed to be airtight and sterile for transport.

In FIG. 15 is a schematic perspective view of the first connection structure 3A with the cutting element 7 located on the opening area 4A. In the embodiment shown in FIG. 15, the cutting element 7 has 4 or (dashed) three bars, but may also have more bars 19. The bars 19 are preferably wedge-shaped, at least partially or at the edges, or have cutting edges spaced from the opening area 4A. The cutting element 7 preferably has a tip 20 directed away from the opening area 4A. Tip 20 preferably abuts rods 19 or vice versa. By means of the tip 20 and/or the rods 19, shear forces can be increased and destruction or perforation of the opening area 4B can be effected. However, other alternative embodiments of the cutting element 7 are theoretically possible.

In the embodiment shown, the cutting element 7 preferably has lug-shaped connecting parts 21 connecting to the opening area 4B. They can be configured to apply or distribute the force generated by the cutting element 7, in particular the tip 20 or the rods 19, on the opening area 4A. Alternatively or additionally, the fittings 21 may be used and positioned such that when the fittings 3A, 3B are pushed into each other, the neck 5B presses against or near the fittings 21, whereby shear forces acting on on area 4B of the opening. This facilitates the opening of the opening area 4A.

The cutting element 7 is preferably positioned and/or configured to pierce, cut, cut or destroy the opening region 4A, 4A' of the first connection structure 3A, 3A'.

The cutting element 7 is preferably located and/or attached to the opening area 4A, 4A' of the second connecting structure 3B, 3B', in particular directly. Alternatively or additionally, the cutting element 7 is configured to concentrate the force acting on the opening area 4A, 4A' and/or distribute the force or counter force acting on the area 4B, 4B', so that the opening area 4B of the second connecting structure 3B, 3B' remained intact when the opening area 4A, 4A' was opened by destroying it with the cutting element 7.

According to another aspect, it is assumed that the cutting element 7 comprises one or more connecting parts 21 to which or to which the cutting element 7 is connected, preferably by material bonding, to the opening area 4A, 4A', 4B, 4B'.

The connecting parts 21 preferably form break sections for the opening areas 4B, 4B' of the second connecting structure 3B, 3B'. Preferably, the connecting parts 21 are arranged so as to correspond to the first connecting structure 3A, 3A', in particular its neck 5A, 5A'. Moreover, the connection parts 21 are preferably designed such that the forces acting on the opening area 4B, 4B' of the second connection structure 3B, 3B' are concentrated by the first connection structure 3A, 3A'. This facilitates the destruction and/or opening of the region 4B, 4B' of the second connection structure 3B, 3B' by means of the first connection structure 3A. 3A', in particular its necks 5A, 5A'.

In FIG. 16 shows a proposed container system in transport position or orientation. The containers B1, B2, B3 are preferably releasably connected to each other for transport, due to the fact that the part or constriction F1, F2 of the vessel of the container B1, B2, B3, forming an opening for the recess, is adapted to be held by the holding device of the cover 6 in the form of a cap.

The first container B1 preferably has a lid 6, or the first connection structure 3A, 3A' is closed by a lid 6. The second container B2 is inserted into and/or held by the lid 6, preferably in or through the area of its recess opening E2 or by its constriction F2 of the vessel. By this method or by some other means of the container B1, B2, the container systems can form a set or combination combining the containers B1, B2 with each other. This advantageously makes it possible to avoid unintended combinations of containers B1, B2 or substances S1, S2.

The lid 6 can preferably be held on the first container B1 and is configured to hold both the opening region E1, E2 or the vessel constriction F1, F2 of the first container B1 and the second container B2. The lid 6 thus has a triple function, namely providing a (sterile) shelter, forming a transport combination and as a support. The latter function will be discussed next.

In FIG. 17 shows the first vessel B1 in longitudinal section, the first connection

- 26 042092 structure 3A is closed, preferably sterile, with a lid 6. The lid 6 can be held on the container B1 with the possibility of its removal by means of or using one of the clamps 10A,

10B, or any other means on tank B1.

One or both of the opening areas 4A, 4A', 4B, 4B' are preferably sterile sealed from the environment with a lid 6 in the form of a cap. The (other) opening area 4A, 4A', 4B, 4B' is preferably sterile or sterilizable isolated from the environment by a removable, detachable, tear-off and/or film closure 14.

A double occlusion may be formed by the respective opening areas 4A, 4A', 4B, 4B' and an appropriate sterile or sterilizable cover. In this way, a sterile or sterilizable or sterile-sealed area or space or cavity can be formed between the sterile or sterilizable cover and the corresponding connection structure 3A, 3A', 3B, 3B'.

The sterile or sterilizable cover is preferably removable. This makes it possible to create a (sufficiently) sterile fluid connection 2 through the connection system 1 by removing the covers and using the opening areas 4A, 4A', 4B, 4B' located in the sterile zone to form the fluid connection 2.

In the embodiment shown, the cap 6 forms a sterile seal for the first opening areas 4A, 4A' and/or the occlusion 14 forms a sterile seal for the second opening area 4B, 4B' by means of a sealed or welded or otherwise tightly applied film. Theoretically, however, sterile protection can also be provided by other means, for example by replacing the film with a cap or (screw) closure, optionally with a sealing gasket or similar, and/or by making the cap 6 without retaining means or with another retaining device.

In the present invention, sterility means, in particular, at least mainly protection against microbes or antiseptic protection.

The sterile or sterilizable shelter is preferably a device designed to prevent the entry of microbes, in particular by forming a germ-tight barrier.

From a manufacturing point of view, the sterile or sterilizable cover is preferably tightly attached or connected to the respective connection structure 3A, 3A', 3B, 3B' so as to create a germ-tight barrier.

A shelter is sterilizable when materials are used, or a sterile or sterilizable shelter contains or is made of materials that are suitable for using at least one sterilization method for killing germs known in the art. For example, such materials can be sterilized by one of the known sterilization methods without damaging them or losing their barrier function against microbial penetration. Known methods of sterilization include irradiation, in particular with gamma rays or an electron beam, gas disinfection, hot air treatment or autoclave sterilization. Preferably, the connection structures 3A, 3A', 3B, 3B' are also sterile or sterilizable.

The opening areas 4A, 4A', 4B, 4B' are preferably made independently of one another or separately from one another in the initial state and/or are sterile or sterilizable closed separately from each other. This ensures the possibility of separate use of containers B1, B2, B3.

Between the opening areas 4A, 4A', 4B, 4B' and the sterile or sterilizable cover or sterile cover means, in particular the lid 6 and/or the closure 14, a sterilized, sterilizable and/or sterile-sealed space or with a seal is preferably formed providing air tightness or microbial protection.

According to another feature of the present invention, which can also be implemented independently, said space houses, attaches and/or retains a substance, in particular an active substance, a vaccine and/or an activating drug. In particular, the substance is located in this space in a lattice structure and/or is held by the cutting element 7.

According to a preferred feature, the cutting element 7 or another part of one of the connecting structures inside the space can be dissolved, made soluble and/or form a suspension. In this way, after the fluid bond 2 is formed, the substance from said space can become part of the mixture of substances S1, S2, S3.

The substance located in the space can be dissolved and/or can be made soluble and/or suspended on the connecting structure 3A, 3A', 3B, 3B' or opening area 4A, 4A', 4B, 4B' by one of the substances S1 , S2, S3.

According to a preferred feature, a lyophilizate (sublimated preparation) is dried or otherwise applied to the opening area. The lyophilisate, as well as one or more substances S1, S2, S3 may contain a vaccine, an active substance and/or an activating preparation for the preparation

- 27 042092 vaccines or combined vaccines. Thus, once the fluid bond 2 is formed, the substance located in said space can form a substance mixture component, in particular a combination vaccine.

The sterile sealing means, in particular the closure 6 and/or the closure 14, can preferably be removed or detached, in particular manually or without the use of a tool, so that the opening areas 4A, 4A', 4B, 4B' become accessible for forming the connection 2 by fluid environment.

One of the containers B1, B2, B3 preferably has, on the side remote from the opening E1, E2 for recess, a removable cover 6 in the form of a cap, which in the initial position closes the connecting structures 3A, 3A', 3B, 3B', preferably with sterility.

The lid 6 in the form of a cap preferably comprises a holding device for an opening E1, E2 for recessing or constricting the vessel F1, F2. The holding device, in particular the seat 13, is preferably adapted to hold a part of the container B1, B2, B3, in particular the vessel constriction F1, F2, forming the opening E1, E2, E3 for the recess.

The lid 6 preferably comprises a support part whose shape resembles a flange and/or corresponds to or mates with the kink region of the container B1, B2 adjacent to the recess opening E1, E2.

In the embodiment shown, the lid 6 preferably comprises a seat 13 adapted to receive and/or retain, preferably by means of a locking or snap-on engagement, a constriction F1, F2 of the container or containers B1, B2.

The lid 6 is preferably designed as a holder or stand for the container or containers B1, B2. For this purpose, the recess E1, E2 or the constriction F1, F2 can preferably be inserted into the lid 6. In particular, the socket 13 is adapted to grip and/or snap and/or releasably hold the container or containers B1, B2, preferably in areas of holes E1, E2 for notching and/or narrowing F1, F2. This ensures reliable operation as a support or stand and/or for holding or forming a set or combination of containers B1, B2, in particular the vessels of the container system B.

The lid 6 preferably serves as a base or support surface for one of the containers B1, B2, in particular the first container B1, if its opening area 4A is closed by the lid 6. The seat 13 can be located on the bottom in the initial position and/or accessible from the outside. This provides the additional advantage that the containers B1, B2 can be placed one above the other by placing the first container B1, containing the lid 6 with the seat 13, on the second container B2 in such a way that its opening E2 for recess or constriction F2 is pressed in the socket 13 and is preferably held, in particular by snapping and/or gripping. In this way, a set can be obtained in which the containers B1, B2 are connected to each other in a separable way, thereby preventing incorrect packaging and erroneous mixing of substances when using the connection system 1.

When using the proposed connection system 1, it can be assumed that first the cover 6 is separated or removed from the first container B1 (see Fig. 18).

As shown by way of example in FIG. 19, then the first container B1 (or alternatively the second container B2) is preferably inserted with the recess hole E1, E2 or the constriction F1, F2 or part thereof into the seat 13 of the lid 6. To this end, the lid 6 can be fitted with the hole of the seat 13 oriented upwards in the operative position, wherein the recess E1, E2 or the constriction F1, F2 is pressed at least partially from above into the seat 13 in the operative position. Theoretically, however, it is also possible to insert the container B1, B2 into the socket 13 in other positions. Preferably, the cover 6 is then used as a holder or support or stand in the working position. In this case, the first connecting structure 3A or its opening area 4A in the working position is accessible from above.

The lid 6 can be used as a support for the containers B1, B2, B3 if the containers B1, B2, B3 are held by the retaining device or the seat 13 by the part forming the recess E1, E2 or the constriction F1, F2.

The lid 6 thus preferably forms a holder or stand for the container B1, B2 held by the lid. The double function of the lid saves space and material and additionally allows the lid 6 to be used as a holder or stand, preventing contamination of the connecting structures 3A, 3A', 3B, 3B'.

The lid 6 preferably has the form of a cap and, in the initial position or during transport, forms an airtight seal with the connecting structure 3A, 3A', 3B, 3B', so as to create a sterile or sterilizable seal.

The lid 6 preferably comprises a seat 13 and a support part for holding onto the connecting structure 3A, 3A', 3B, 3B' from different sides, in particular opposite sides. The support part may have an area attached or attached, with the possibility of detachment to the connecting structure 3A, 3A', 3B, 3B' by means of a gripping and/or snap-on element. To this end, the cover 6 in the support part and the connecting structure 3A, 3A', 3B, 3B' can have complementary or corresponding structures.

The lid 6 is preferably made of plastic and contains plastic. The lid 6 is preferably a thermoformed or injection molded piece and/or a molded piece made of sheet material. The lid 6 preferably has a wall thickness of more than 1 mm and/or less than 2 mm. However, other technical solutions are also possible.

In the embodiment shown, the closure 6 is generally shaped as a W or U in longitudinal section with a recess at the curvature of the U which forms the seat 13. As such, however, the closure 6 may also be shaped differently to realize the dual function of a sterile closure, with one side, and the supporting device, on the other.

In FIG. 20 shows a second container B2 in which the opening area 4B is covered, in particular by a sterile closure 14, in particular by a removable plug, a film, a sealing film, etc. Preferably, the closure 14 is removable, in particular by being torn off to use the connection system 1 according to the invention. The closure 14 may have a tongue for this purpose.

At least one of the connection structures 3A, 3A', 3B, 3B', in particular the second connection structure 3B, 3B', in the embodiment shown preferably has a socket for another one of the connection structures 3A, 3A', 3B, 3B', which may preferably be formed by a coupling (docking ring) 22 or alternatively or additionally by any other means. The sleeve 22 can help to fasten the connecting structures 3A, 3A', 3B, 3B' in each other, guide their movement as necessary and/or protect the connecting structures 3A, 3A', 3B, 3B' from the side. Preferably, the sleeve includes device latches 10A, 10B, or portions thereof.

Preferably, one of the connection structures 3A, 3A', 3B, 3B', in particular the second connection structure 3B, 3B', is surrounded by a sleeve 22 in the (first and/or second) connection position.

The sleeve 22 preferably serves to lead (respectively) another connecting structure 3A, 3A', 3B, 3B' into it or to form a socket and/or a guide, in this case preferably a linear guide in the direction of the central axis or axis 9 of symmetry.

In the embodiment shown, the sleeve 22 is located on the second connecting structure 3B, 3B' or on the second container B2. Alternatively or additionally, the sleeve 22 can also be arranged around the first connection structure 3A, 3A' of the first container B1.

The sleeve 22 is preferably fixedly, rigidly and/or non-rotatably connected to the associated connecting structures 3A, 3A', 3B, 3B', preferably by means of a locking engagement, in particular with a snap and/or frictional engagement, in particular by being gripped and/or secured by a material, in particular by adhesive bonding or injection moulding, but alternatively also integrally with one of the connection structures 3A, 3A', 3B, 3B' or containers B1, B2.

Sleeve 22 preferably protrudes beyond the necks 5A, 5A', 5B, 5B' and/or projects at least partially parallel to them or in the same direction, preferably forming a socket or linear guide for the other one of the connecting structures 3A, 3A' , 3B, 3B'.

The sleeve 22, or the socket which may be formed by it, preferably at least partially comprises guides 18A, 18B, in particular a groove, a guide pin, etc.

The open edge of the sleeve 22 preferably forms an abutment for those of the connection structures 3A, 3A', 3B, 3B' that it does not surround in the separated state of the connection structures 3A, 3A', 3B, 3B', and/or for the container B1 attached to her. Preferably, in the second connection position, the connecting structures 3A, 3A', 3B, 3B' abut against each other in the region of the abutment.

The sleeve 22 is preferably closed, in particular sterile, at one end or on the open side by a closure 14, in particular by a hermetically attached film.

In FIG. 21 shows, as a particular example, how containers B1, B2 can be fluidly connected to each other by means of the connection system 1 proposed. 3B, 3B' is placed on top of the first connection structure 3A, 3A'. In the embodiment shown, the first connection structure 3A, 3A' protrudes into the socket formed by the sleeve 22.

Next, the opening areas 4A, 4A', 4B, 4B' are opened. By means of a combination of connecting structures 3A, 3B, which form in particular the base regions of bottle-shaped vessels or containers B1, B2, a fluid connection 2 can be formed, as previously shown with reference to FIG. 2-8. In FIG. 21 shows the first embodiment, however, what has been said also applies to the second embodiment and the combination of embodiments.

In accordance with another feature of the present invention, which can be implemented independently, the connection system 1 or the connection structures 3A, 3A', 3B, 3B' are sized to suit specific containers.

In particular, the proposed container system B contains containers B1, B2, B3 of different sizes, volumes and/or specific quantities of the substance S1, S2, S3 to obtain the desired mixture proportions.

- 29 042092

For this, it is preferable that the connecting structures 3A, 3A', 3B, 3B' have such mechanical characteristics that containers B1, B2, B3 with compatible contents can be connected, and containers B1, B2, B3 with incompatible contents or containers B1, B2 , B3, the use of which would result in a mixture with an unacceptable fluid bonding ratio, had connecting structures 3A, 3A', 3B, 3B' mechanically incompatible with each other.

In particular, it is preferable that the connecting structures 3A, 3A', 3B, 3B' can be made to match with each other, in particular according to the lock and key principle. This can be done using guides 18A, 18B, guide grooves, diameters, etc., with or without compatibility with each other.

The features of the present invention described with reference to FIGS. 16-21 may take precedence both by themselves and in various combinations, in particular, in whole or in part, or with respect to some details in the course of explanations. In particular, the cover 6 is preferably removed and used as a holder or stand before the second connection structure 3B is opened or unsealed, in particular by removing the blockage 14.

Moreover, in FIG. 16-21 show the connection structures 3A, 3B of the first embodiment. Instead, however, it is possible to use the connection structures 3A', 3B' of the second embodiment or a combination of the first connection structure 3A, 3A' and the second connection structure 3B, 3B'. The previous descriptions of the features apply here as well.

The fluid bond 2 may alternatively or additionally be obtained by deformation. In this case, the cutting element 7 is optional, and the sleeve 22 preferably has a non-circular cross section, whereby when the connecting structures 3A, 3B, 3A', 3B' are rotated relative to each other, the fluid connection 2 is formed by shaping or deformation. For the sake of clarity, the description of the corresponding operations will not be repeated here.

Other features of the present invention, which may be implemented alone or in combination with each other and/or may be implemented in conjunction with the features and features of the present invention described above and are preferred, will be described in more detail below.

A feature of the present invention, which can be implemented independently, or in combination with one or more previously described features, relates to a connection system 1 for forming a fluid connection 2, preferably between containers B1, B2, B3, the connection system 1 comprising at least at least two connection structures 3A, 3A', 3B, 3B', configured to form a fluid connection 2, namely the first connection structure 3A, 3A' and the second connection structure 3B, 3B', which in the initial state are each fluid tight. media and each are sealed independently of one another, while the connecting structures 3A, 3A', 3B, 3B' can be inserted one into the other and / or adapted to be inserted one into the other, preferably by at least linear and / or axial movement along a common axis, through which at least one of the connecting structures 3A, 3A', 3B, 3B' can be opened.

In particular, the fluid connection 2 is formed during said introduction. The advantage of this method is that the fluid connection 2 is formed quickly and reliably, in particular without the need for repeated rotation of the connecting structures 3A, 3A', 3B, 3B' along several helical turns or threads.

The insertion of the connecting structures 3A, 3A', 3B, 3B' one into the other also makes it possible to move together the connecting structures 3A, 3A', 3B, 3B' oriented with each other with respect to the position of rotation about the (common) axis of symmetry or central axis 9, which , particularly preferably if the openings 5A, 5A', 5B, 5B' of the connection structures 3A, 3A', 3B, 3B' are not circular in cross section, or if at least one of the connection structures 3A, 3A', 3B is opened , 3B' is performed by deforming and resulting stretching of the opening region 4A, 4A', 4B, 4B'.

A feature of the present invention, which can also be implemented independently or in combination with one or more of the features discussed above, relates to a connection system 1 for forming a fluid connection 2 preferably between containers B1, B2, B3, the connection system 1 comprising at least at least two connection structures 3A, 3A', 3B, 3B' configured to form a fluid connection 2, namely the first connection structure 3A, 3A' and the second connection structure 3B, 3B', which are fluid-sealed in the initial state , wherein the first connection structure 3A, 3A', having in particular a film-like, brittle and/or fragile region 4A, 4A', 4B, 4B', can be deformed outside the region 4A, 4A', 4B, 4B' opening, and is made so that the deformation causes the opening of the first connecting structure 3A, 3A', 3B, 3B' in the areas 4A, 4A', 4B, 4B' opening.

A feature of the present invention, which can also be implemented independently or in

- 30 042092 combinations with one or more of the features discussed above, refers to one or more containers B1, B2, B3 or vessels, which in each case contain connecting structures 3A, 3A,

3B, 3B'.

A feature of the present invention, which can also be implemented independently or in combination with one or more of the features discussed above, relates to a connection system 1 for forming a fluid connection 2 preferably between containers B1, B2, B3, wherein the connection system 1 has at least at least two connecting structures 3A, 3A', 3B, 3B', configured to form a fluid connection 2, each of which contains an opening area 4A, 4A', 4B, 4B' closed for the passage of fluid in the initial state, in in particular by means of a film or characterized by brittleness, brittleness and/or fragility, while the areas 4A, 4A', 4B, 4B' of the opening each have a sterile or sterilizable plug.

In particular, the opening or formation of the fluid bond 2 is achieved in this case due to the fact that the area 4A, 4A' of the first connection structure 3A, 3A' is or forms a discontinuous area, so that the deformation of the first connection structure 3A, 3A', in particular, by tension leads to tearing or destruction of the area 4A, 4A' of the opening. This has the advantage, in particular, that no point or other cutting element is required to effect the opening. The cutting elements 7 usually need to have sharp edges and be rigid in order to open the opening area 4A, 4A', 4B, 4B'. As a result, due to the absence of such a cutting element, softer materials can be used in production and/or production will be simpler. As has already been shown above, a combination of the features described above using the cutting element 7 is also possible, while the advantage and present feature is the enlargement and expansion of the opening or fluid connection 2.

The advantage of sterile or sterilizable opening area plugs 4A, 4A', 4B, 4B' is that they allow the formation of a fluid bond 2 while preventing the entry of microbes or other foreign matter, particularly in the pharmaceutical/medical field. Alternatively or additionally, the sterile or sterilizable end caps of the regions 4A, 4A', 4B, 4B' allow the containers B1, B2, B3 with the connection structure 3A, 3A', 3B, 3B' to be used separately from each other in the environment and optionally in combinations with each other.

One feature of the present invention, which can also be implemented independently or in combination with one or more of the features discussed above, relates to a container system B with at least two containers B1, B2, B3, preferably vessels, and a connection system 1, the containers B1, B2, B3 for forming a fluid connection 2 between the containers B1, B2, B3 in each case contain at least one connecting structure 3A, 3A', 3B, 3B' of the connecting system 1.

However, the use of the proposed connection system 1 for connecting containers B1, B2, B3 proved to be preferable, in particular because it is possible to form a permanent and/or irreversible fluid connection 2 between containers B1, B2, B3, thereby guaranteeing complete mixing of the contents containers B1, B2, B3.

Another feature of the present invention, which can also be implemented independently or in combination with one or more of the features discussed above, relates to a container system B with at least two containers B1, B2, B3, preferably vessels, each of which contains holes E1, E2 for recess, preferably each sealed with a membrane, while preferably the containers B1, B2, B3 contain on the side opposite the respective hole E1, E2 for recess, in particular at the base of the respective vessel, the connecting structure 3A, 3A', 3B, 3B' to form a fluid connection 2 between the tanks B1, B2, B3 and/or are configured to form a fluid connection 2 between the tanks B1, B2, B3.

The use of two containers B1, B2, B3, each containing a recess E1, E2 and a connecting structure 3A, 3A', 3B, 3B', is particularly advantageous since the containers B1, B2, B3 can also be used separately from each other. from each other, but at the same time, in the case of joint use, a fluid connection with a relatively large cross section can be formed by means of connecting structures 3A, 3A', 3B, 3B' for fast or accelerated mixing of the contents of containers B1, B2, B3.

Another feature of the present invention, which can also be implemented independently or in combination with one or more of the features discussed above, relates to a method for forming a fluid connection 2 between the connecting structures 3A, 3A', 3B, 3B' and/or containers B1, B2, B3 by means of the connection structures 3A, 3A', 3B, 3B', whereby in the initial state the connection structures 3A, 3A', 3B, 3B' are fluid-sealed in each case, the first connection structure 3A, 3A' is opened by another, second, connection structure 3B, 3B', and the second connection structure 3B, 3B' is opened by the first connection structure 3A, 3A', whereby a permanent fluid connection 2 is formed between the connection structures 3A, 3A', 3B, 3B'.

This provides corresponding advantages, ie, in particular, the rapid and reliable formation of a fluid bond 2 or mixing of the substances S1, S2, S3.

Another feature of the present invention, which can also be implemented independently or in combination with one or more of the features discussed above, relates to the use of a container system B, in which the first container B1 contains the first substance S1, in particular the first vaccine against the first disease, and the second container B2 contains a second substance S2, in particular a second vaccine against a second disease, different from the first, for preparing a mixture of substances, in particular for preparing a combined vaccine for simultaneous immunization against different diseases, moreover, containers B1, B2, B3 are connected to each other in a fluid environment by means of connecting structures 3A, 3A', 3B, 3B' so that the substances are mixed with each other, in particular to form a combined vaccine.

The advantage of using the proposed connection system 1 or container system B for the preparation of a combination vaccine is, for example, that the vaccines can be used individually or in combination as needed. The proposed connection system 1 or container system B provides the flexibility to make a decision on the spot regarding the separate administration of substances S1, S2 or vaccines or in combination. This avoids stressing the animals with an unnecessarily large number of individual injections, or avoiding the need to always vaccinate with a combination vaccine, even if vaccination with one of the vaccines administered is not required, in the presence of appropriate immunity. Due to this, the invention allows to reduce the consumption of materials and the cost of vaccination.

Another feature of the present invention, which can also be implemented independently or in combination with one or more of the features discussed above, relates to a method for forming a fluid connection 2 between the connecting structures 3A, 3A', 3B, 3B' and/or containers B1, B2, B3 by means of the connection structures 3A, 3A', 3B, 3B' of the connection system 1, in which preferably the sterile covering means, in particular the lid and/or plug 14, are removed from the opening areas 4A, 4A', 4B, 4B' in each case, the still closed exposed areas 4A, 4A', 4B, 4B' of the opening are opened to form a fluid bond 2.

Another feature of the present invention, which can also be implemented independently or in combination with one or more of the features discussed above, relates to a method for forming a fluid connection 2 between the connecting structures 3A, 3A', 3B, 3B' and/or containers B1, B2, B3 by means of the connection structures 3A, 3A', 3B, 3B', whereby in the initial state the connection structures 3A, 3A', 3B, 3B' are fluid-tight in each case, the first connection structure 3A, 3A' being opened the other, second, connection structure 3B, 3B', and the second connection structure 3B, 3B' is opened by the first connection structure 3A, 3A', thereby forming a permanent fluid connection 2 between the connection structures 3A, 3A', 3B, 3B'.

According to another feature that can be implemented independently, the present invention relates to a set with two suggested containers B1, B2, B3 or containers B1, B2, B3, which can be fluidly connected to each other by means of a connecting system 1 so that a mixture of substances S1, S2, S3 contained in containers B1, B2, B3 can be formed. This prevents mixing of other, incompatible substances S1, S2, S3.

In the present invention, a kit is, in particular, a combination and/or system containing a first container B1 and a second container B2, which form the components of the kit. The set may also contain a third container B3 and/or other containers and components.

The components of the kit are preferably supplied as a kit, in particular in a general package or in a similar manner. However, the components can also form an arbitrary combination for sharing. The supply of common or connecting components may be provided, for example, a general set of operating instructions, recommendations for working with components, textual information on one or more of the components of the kit, or others.

Preferably, the containers B1, B2, B3 form a set in a fixed form with each other, in particular by means of a lid 6 or a socket 13.

Containers B1, B2, B3 are preferably intended for the preparation of a combined vaccine for simultaneous immunization against different diseases, preferably due to the possibility of forming fluid communication of containers B1, B2, B3 with each other through connecting structures 3A, 3A', 3B, 3B', so that substances S1, S2, S3 contained in containers B1, B2, B3 are mixed with each other to form a combined vaccine, while, in particular, substances S1, S2, S3 can be extracted through openings E1, E2 to extract independently of one another and subsequently used, in particular, before or without the formation of the fluid bond 2 .

Preferably, at least one of the containers B1, B2, B3 comprises openings E1, E2 for recess, preferably sealed with a membrane, while the container B1, B2, B3 is preferably configured to be formed on the side remote from the opening E1, E2 for recess 32 042092 in particular, at the bottom of the vessel, fluid connections 2 between the vessels B1, B2. B3 and/or contains a connecting structure 3A, 3A', 3B, 3B'.

The containers B1, B2, B3 are preferably fluidly connected to each other by means of connecting structures 3A, 3A', 3B, 3B', so that the substances are mixed, preferably forming a combined vaccine.

According to another feature that can be implemented independently, the present invention relates to the use of the connection system 1, set or system B of the containers proposed in the invention for the preparation of drugs or the supply of drugs to live animals, preferably mammals, and / or for medical use. .

According to another feature that can be implemented independently, the present invention relates to the use of the connector system 1, set or system B of the containers proposed in the invention for the preparation of a vaccine and/or the supply of a vaccine, in particular for immunization against the disease(s) of swine circovirus disease. (PCVD) and/or enzootic pneumonia (EP) or infection with porcine circovirus and/or infection with a bacterium strain of mycoplasma, in particular Mycoplasma hyopneumoniae, preferably for immunization against diseases of porcine circovirus disease (PCVD) and/or enzootic pneumonia (EP) or infections with porcine circovirus and/or infections with a bacterium strain of mycoplasma, in particular mycoplasma hyopneumoniae.

To do this, the first proposed container B1 contains the first reagent as the first substance S1, and the second proposed container B2 contains the second reagent as the second substance S2. The reagents may be vaccines against various diseases, or isolated substances may contain vaccines against various diseases.

In particular, it is preferred that the first reagent contains only the first of the components of the mycoplasma vaccine or mycoplasma antigen or circovirus vaccine or circovirus antigen (and optionally other substances). The first reagent may thus comprise either a mycoplasma vaccine or one or more mycoplasma antigens, or alternatively a circovirus vaccine or one or more circovirus antigens. The first reagent is preferably stored separately from the second reagent, in particular if the reagents are not stable when stored together for a long time. The second reagent preferably contains only another of the components of the mycoplasma vaccine, or one or more mycoplasma antigens or circovirus vaccine, or one or more circovirus antigens (and optionally other substances). If the first reagent contains a mycoplasma vaccine or one or more mycoplasma antigens, then the second reagent contains a circovirus vaccine or one or more circovirus antigens, or vice versa.

The mycoplasma vaccine may contain attenuated and/or inactivated bacteria, bacterial fragments, or recombinant portions of mycoplasma hyopneumonia, but at least one or more mycoplasma hyopneumonia antigens. Preferably, the Mycoplasma hyopneumonia antigen is derived from the Mycoplasma hyopneumonia J strain or the inactivated Mycoplasma hyopneumonia bacteria is the J strain. Moreover, the mycoplasma vaccine may be one of the following vaccines, or the mycoplasma hyopneumonia antigen may be the antigen or antigens contained in one of the following vaccines: Ingelvac® MycoF1ex (Boehringer Ingelheim Vetmedica Inc., St. Joseph, Missouri, USA), Porcillis M. hyo, Myco Silencer® BPM, Myco Silencer® BPME, Myco Silencer® ME, Myco Silencer® M, Myco Silencer® Once, Myco Silencer® MEH (all manufactured by Intervet Inc., Millsbrough, USA), Stellamune Mycoplasma (Pfizer Inc., New York, NY, USA), Suvaxyn Mycoplasma, Suvaxyn M. Hyo, Suvaxyn MH-One (all formerly Fort Dodge Animal Health, Overland Park, Kansas, USA (now Pfizer Animal Health).

The circovirus vaccine may contain an attenuated and/or inactivated porcine circovirus, preferably type 2, in particular ORF2 type 2 protein. In particular, it is preferred to use the recombinantly expressed porcine circovirus type 2 ORF2 protein, preferably expressed in cell culture and obtained from this culture in laboratory conditions. Examples of ORF2 proteins of porcine circovirus type 2 are described inter alia in international patent application WO 2006-072065. These examples have shown, in particular, their advantages for effective vaccination. In addition, the circovirus vaccine may be one of the following vaccines, or the circovirus antigen may be the antigen or antigens contained in one of the following vaccines: Ingelvac®CircoFLEX (Boehringer Ingelheim Vetmedica Inc., St. Joseph, Missouri, USA), CircoVac® ( Merial SAS, Lyon, France), CircoVent (Intervet Inc., Millsbrough, Delaware, USA) or Suvaxyn PCV-2 One Dose® (Fort Dodge Animal Health, Kansas City, Kansas, USA).

The circovirus vaccine, if it contains the ORF2 protein, preferably contains 2 to 150 μg, preferably 2 to 60 μg, more preferably 2 to 50 μg, more preferably 2 to 40 μg, more preferably 2 to 30 μg, more preferably 2 to 25 μg, more preferably 2 to 20 μg, more preferably 4 to 20 μg, more preferably 4 to 16 μg, of ORF2 protein per dose administered. The circovirus vaccine is preferably prepared or formulated such that 1 ml of the vaccine corresponds to a single dose. In particular, the circovirus vaccine may contain

- 33 042092 ORF2 protein in an amount greater than 2 μg/ml, preferably greater than 4 μg/ml and/or less than 150 μg/ml, preferably less than 60, 50, 40, 30, 25 μg/ml, in particular less than 20 μg/ml . This contributes to the reliability of vaccine administration.

The mycoplasma vaccine, if it contains inactivated mycoplasma bacteria, preferably inactivated hyopneumonia mycoplasma bacteria, preferably contains from 103 to 10 ⁹ colony forming units (CFU), preferably from 10 ⁴ to 10 ⁸ CFU, more preferably from 105 to 106 CFU per administered dose, and the corresponding CFU value is corrected before bacteria are inactivated. The mycoplasma vaccine is preferably prepared or formulated such that 1 ml of the vaccine corresponds to a single dose. In particular, the mycoplasma vaccine may contain more than 103 cfu/ml, preferably more than 104 cfu/ml, in particular more than 105 cfu/ml and/or less than 10 ⁹ cfu/ml, preferably less than 10 ⁸ cfu/ml, in particular less than 10 ⁷ cfu/ml or less than 106 cfu/ml of inactivated mycoplasma bacterium, preferably inactivated mycoplasma hyopneumonia bacterium, in particular before inactivating the bacteria.

At least one of the reagents and/or the vaccine or combination vaccine may contain an adjuvant, preferably a polymeric adjuvant, in particular a carbomer. Preferably, at least or exactly one of the two reagents, preferably both reagents, contains an amount of adjuvant from 500 μg to 5 mg, preferably from 750 μg to 2.5 mg, more preferably about 1 mg of adjuvant per administered dose. The reagents are preferably prepared or formulated so that 1 ml of the respective reagent corresponds to a single dose. The use of an adjuvant, preferably a polymeric adjuvant, such as a carbomer, for example, has advantages in terms of the effectiveness of the immunization or the duration of its action. However, the use of alternative and/or additional adjuvants cannot be ruled out.

According to another feature of the present invention, the first and/or the second and/or the combination of the first and second containers B1, B2, B3 with an established fluid connection 2 can be configured for use in or with an injection device and/or used with it . In particular, it is the injection device that can be used repeatedly, such as a syringe gun, a needleless syringe and/or a self-filling syringe, similar to those used for vaccination, for example, large herds of animals.

The set or system B of containers according to the invention may comprise or be associated with such an injection device. In particular, the recess hole E1, E2 or another hole, flange or other connecting or plugging element of at least one of the containers B1, B2 and/or both containers B1, B2 can be made with the possibility of direct use in the injection device or together with him. Moreover, the recess device, opening, flange, or other connecting or plugging element can be configured to be connected specifically to a specific injection device. This can reduce the likelihood of misuse, in particular the administration of incorrect amounts of the active substance or incorrect routes of administration.

A feature of the present invention, which can be implemented independently, also relates to an injection device with a plug-in combination of at least two proposed containers B1, B2, B3, fluidly connected to each other by means of connecting structures 3A, 3A', 3B, 3B', proposed in the present invention. In particular, a mixture of substances S1, S2, S3 is formed by fluid connection 2 from containers B1, B2, B3 and an injection device is prepared for injection of a mixture of substances S1, S2, S3.

The following is a description of other features of the present invention with reference to other embodiments with a detailed consideration of only the differences and special features in comparison with the previously discussed embodiments. These features may therefore be combined with the previously discussed features and vice versa, unless specifically excluded. In addition, reference will be made to the previously given explanations and definitions.

The embodiment discussed below with reference to FIG. 22 et seq. preferably refers to the above-described embodiment in which the first connection structure 3A' is deformable outside the opening area 4A' and is configured such that the deformation causes the opening of the opening area 4A' by the first connection structure 3A'. Details will be clear from a consideration of FIG. 5-13 and explanations to them.

In accordance with a feature of the present invention, which can be implemented independently, the first connection structure 3A' preferably comprises a rigid, inflexible and/or dimensionally stable closure device 23, in particular a plugging plate. The locking device 23 is preferably sealed to the holder 25 by means of a weak break section 24, in particular a section of reduced thickness. In this way, an opening area 4A' of the first connecting structure 3A' can be formed with or through the locking device 23 and/or the rupture section 24.

The features discussed above in connection with the brittleness of the opening region 4A', in particular with respect to material thickness and other factors, may advantageously be applied to the rupture

- 34 042092 section 24 or transferred to it. The difference lies in particular in that the opening area 4A' of the first connection structure 3A' additionally comprises a locking device 23 which stabilizes or reinforces the opening area 4A' in the central part or the part surrounded by a film-like, brittle, fragile and/or fragile area in the form of a discontinuous section 24.

The holder 25 preferably corresponds to the neck 5A' of the first connection structure 3A' and/or the neck 5A' comprises a holder 25. The corresponding explanations relating to the neck 5A' can therefore also be applied to the holder 25 as an alternative or addition. If necessary, the holder 25 can therefore be completely defined by the neck 5A' or completely or partially formed by it, or vice versa.

In particular, it is preferred that the holder 25 is deformably movable relative to the locking device 23 so that the first connection structure 3A' can be opened by tearing the rupture portion 24. It has been found that through the use of the locking device 23 and the appropriate concentration applied due to deformation force to the frangible area (breaking section 24) surrounding the locking device 23, it is possible to achieve in particular a secure and easier opening by means of deformation.

Fig. 22 gives an overview of a container system B in which the containers B1, B2 are fluidly connected to each other by means of connection structures 3A', 3B'. To this end, the first connection structure 3A' or its opening area 4A' and the second connection structure 3B' or its opening area 4B' are shown in each case opened.

Further explanations additionally use references to FIGS. 23-25, where in Fig. 23 shows a longitudinal section of the first container B1 with the first connection structure 3A' in its original state with the opening area 4A' closed. In FIG. 24 shows an enlarged fragment of a part of the locking device 23 and the holder 25 with a break section 24 between them. In the shown embodiment according to FIG. 23, the opening area 4A' is closed preferably with a lid (closing means) 26 in the form of a cap. Cover 26 has been removed in the embodiment shown in FIG. 25. In FIG. 26 is a perspective view of the first connection structure 3A' as part of the first container B1 without the lid 26.

The closure 23 is preferably shaped and/or held by the rupture portion 24 in such a way that the closure 23 tilts when the holder 25 is deformed.

Preferably, the fracture section 24, or the surface or plane 27 formed or formed by the fracture section 24, is inclined with respect to the central axes or axes 9 of symmetry. This ensures or facilitates the pushing, rotation and/or further tilting of the locking device 23 during opening or prevents the locking device 23 from blocking relative to the holder 25.

During opening, the locking device 23 may slide over the holder 25 as a result of deformation of the holder 25, in particular during tilting or tilting.

The holder 25 preferably includes a frame 28 or has a frame structure. The locking device 23 is preferably inclined relative to the frame 28 in the initial state. As a result, the frame 28 and the locking device 23 are each partially offset from each other, whereby the offset immediately adjacent to the fracture portion 24 can form this area or area of the offset. The offset is preferably in the opposite direction on opposite sides. The advantage of having an offset is that during the deformation of the holder 25, the locking device 23 can slide along the frame 28 or tuck behind it. This simplifies the opening process, since the locking device 23 is prevented from blocking the deformation of the holder 25, and as a result, the opening of the opening area 4A' is simplified.

Preferably, in particular as a result of the stepped displacement of the frame 28 relative to the edge of the locking device 23 near the breaking section 24 and/or as a result of the inclination of the locking device 23 and/or the breaking section 24 relative to the central axis 9 during the deformation, the shearing action of the locking device is made possible or achieved. 23 with respect to the frame 28. This shearing action makes it possible to apply a strong mechanical load to the breaking portion 24 in accordance with the degree of deformation of the holder 25, in particular by creating tensile or shear stresses, which makes it easier to cut or tear the breaking portion 24. In general, this provides a convenient and secure opening of the opening area 4A' of the first connecting structure 3A'.

In accordance with another feature of the present invention, the locking device 23 is formed in the form of an inclined platform, starting from the breaking section 24, located on its edge. This can be achieved by increasing the thickness of the material, preferably with respect to the surface or plane 27 defined by or passing through the discontinuous section 24. Alternatively or additionally, the locking device 23 is formed in the form of an inclined platform starting from the displacement area. In this way, it is possible to tilt the locking device 23 more and more as the deformation of the holder 25 increases. The inclined part of the locking device 23 can slide along the holder 25 and thereby increase its inclination.

- 35 042092

The locking device 23 itself preferably includes reinforcement elements 29, which in the present embodiment are shown in the form of ribs or other elements of added material or material thickenings that increase mechanical strength. These reinforcing elements 29 may be formed around the edge of the closure 23 or may be in the form of a slope starting from the tearing section 24 at the edge, in particular so that the slope of the closure 23 increases as the deformation increases.

As seen in particular in the perspective view of FIG. 26, the holder 25 preferably has a non-circular shape in a plane not perpendicular to the central axis or axis of symmetry 9, in particular an oval shape, as mentioned above with respect to FIG. 5-13. This is also applicable as an alternative or in addition to the break section 24 and/or the edge surrounding the locking device 23 or a similar edge adjacent to the break section 24 and/or the frame 28.

The fractured section 24, in particular the thin dotted section, is preferably so weak that the deformation of the holder 25 may cause the fractured section 24 to break and, as a result, the connecting structure 3A' to be opened.

In the embodiment shown, the fracture portion 24 is only 10 microns thick, preferably less than 300 microns, more preferably less than 200 microns or less than 150 microns. The distance between the holder 25 and the closure 23 sealed by the break section 24 is preferably less than 3 mm, more preferably less than 2 or 1 mm, in the embodiment shown less than 0.5 mm. It is also preferred that the distance between the closure device 23 and the holder 25, or the length of the rupture section 24, does not exceed or slightly exceeds the corresponding values over the entire area surrounding the closure device 23. The rupture section 24 preferably has at least a substantially constant length. and/or the thickness of the material along that length around the closure 23. The rupture portion 24 thus preferably surrounds the closure 23 at least substantially completely.

The holder 25 is preferably deformable upon insertion of a deforming device 30 of at least substantially conjugated shape and subsequent rotation of the holder 25 relative to the deforming device 30 about a central axis and/or axis 9 of symmetry. In particular, the holder 25 is deformable in the radial direction about and/or in the direction of the central axis and/or the symmetry axis 9 .

In FIG. 27 shows a cross section of the second container B2 with the second connection structure 3B', and FIG. 28 shows an enlarged fragment of the section. In FIG. 29 shows the second container B2 with the lid 6 removed, and FIG. 30 is a perspective view of the second connection structure 3B'.

The deforming device 30 is particularly preferably formed by the second connection structure 3B', in particular its neck 5B'. Appropriate explanations can be used here with respect to FIG. 5-13 and the following explanations regarding the second connection structure 3B' of the embodiment shown in FIG. 22 and beyond.

The holder 25 of the first connection structure 3A' is preferably in the form of a constriction, a sleeve and/or a tube with a flexible deformable wall 31 and is in particular formed by such a wall. In the embodiment shown in FIG. 22 et seq., the wall 31 preferably forms an at least substantially conical surface converging to the frame 28, which in the present case may form the neck 5A'. Theoretically, however, other solutions are possible.

It is also preferred that the holder 25, in particular the frame 28, have a piercing and/or cutting edge 32 or another cutting element 7. The piercing and/or cutting edge 32 is preferably attached to the frame 28, formed by the frame 28, in particular as a single piece. and/or casting. The piercing and/or cutting edge 32 is preferably formed at least as a whole by an axially extending strip, preferably having a point.

The piercing and/or cutting edge 32 is preferably adapted to open the second connection structure 3B', in particular by piercing or piercing through the piercing and/or cutting edge 32 the area 4B' of opening the second connection structure 3B'. Preferably, during the axial movement of the connecting structures 3A', 3B' towards each other, the opening area 4B' of the second connecting structure 3B' is firstly pierced by the piercing and/or cutting edge 32, which protrudes axially outward relative to the opening region 4A', in particular with respect to the locking device 23, and only then can the opening area 4A' of the first connection structure 3A' be opened by rotating the connection structures 3A', 3B' relative to each other as described above. Compared to the embodiment described with reference to FIG. 5-13, in the present case, the holder 25 or the neck 5A' is configured to pierce the opening area 4B' of the second connection structure 3B'. For more information on this issue, you can use the previous discussion.

In the present embodiment, in comparison with the previous embodiment, the piercing and/or cutting edge 32 is located on the neck 5A', which is also possible in the previous embodiment and is preferable in order to simplify the opening of the opening region 4B' of the opening of the second connection

- 36 042092 thread design 3B'.

In the present embodiment, the opening area 4B' of the second connection structure 3B' is closed off in particular by a closure device 33 that is at least substantially rigid and has stable geometrical dimensions and/or plate shape, in particular a plugging plate or disc, which is preferably hermetically sealed. to the neck 5B, in particular via the break section 34. Other constructions are also theoretically possible, such as those described with reference to FIG. 7. However, the use of a locking device 33, similar to sealing the first connection structure 3A' with the locking device 23, makes it easier to open the second connection structure 3B' in the opening area 4B'.

The piercing and/or cutting edge 32 preferably corresponds in its orientation and location to the fracture section 34 of the second joint structure 3B', so that the approach of the joint structures 3A', 3B' to each other causes the piercing and/or cutting edge 32 to act on the fracture section. 34, whereby the fracture portion 34 can be cut starting from the starting point of application of the piercing/cutting edge 32. Preferably, the joint structures 3A', 3B' are respectively oriented towards each other.

The frame 28 and/or the piercing and/or cutting edge 32 preferably has a rounded and/or bevelled portion so that when the piercing and/or cutting edge 32 impacts the fractured portion 34, the fractured portion 34 is partially preserved, whereby the intact portion of the fractured portion is preferably section 34 continues to keep the locking device 33 pressed against the neck 5B' after opening, in particular in analogy with the film hinge. This ensures that the locking device 33 does not come off and prevents blocking of one of the recess holes E1, E2.

In the shown embodiment, in the initial state, the locking device 33 has an orientation coinciding with the orientation of the neck 5B', at least substantially perpendicular to the central axis or axis 9 of symmetry. Of course, oblique alignment is also possible, as is the case with the locking device 23 in the first connection structure 3A', but this is not strictly necessary, since the second connection structure 3B' is preferably opened by the piercing and/or cutting edge 32 rather than by deformation. necks 5B'.

The neck 5B' preferably has a sufficiently strong structure and positional stability, so that when the connecting structures 3A', 3B' are rotated after insertion into each other, deformation occurs at least mainly or in any case predominantly in the region of the necks 5A' or in holder 25. However, some deformation of the neck 5B' and/or the deforming device 30 of the second connection structure 3B' is also possible.

In accordance with another aspect of the present invention, (each) container(s) B1, B2 is or are formed from a container blank BR1, BR2 and respective connection structures 3A', 3B'. The same can also be applied to the previous embodiment.

In the embodiment shown, container blanks BR1, BR2 are portions of an upper container or vessel, configured to be connected to respective connection structures 3A', 3B' at or opposite the side or end away from the recess hole E1, E2. In particular, they are container blanks BR1, BR2 without bases, the resulting open areas being closed during production by means of respective connecting structures 3A', 3B' to form the corresponding container B1, B2.

The container blanks BR1, BR2 in this case, in particular, are structures with a recess E1, E2 and another open part, which can be closed by a corresponding connecting structure 3A', 3B'.

Preferably, the corresponding connection structure 3A', 3B' is firmly attached to the wall of the container blank BR1, BR2 by material bonding, particularly preferably by welding, adhesive bonding, injection molding or some other method. The connection structures 3A', 3B' can therefore be used in containers B1, B2 of any type, or can also be used independently of the containers B1, B2, for example, to connect the container B1, B2 in fluid to another structure, for example a pipe, connector, etc. However, it is particularly preferred to connect the containers B1, B2, B3 to each other.

Preferably, the (corresponding) connection structure 3A', 3B' is adapted to be attached to the container blank BR1, BR2 to form the container B1, B2. It is also preferred that the container blank BR1, BR2 has a wall 35A', 35B' with an open edge 36A', 36B' forming a socket for the connection structure 3A', 3B' into which the corresponding connection structure 3A', 3B' and hermetically connected to the workpiece BR1, BR2 containers.

According to another aspect, the present invention relates to a connection system 1 having a first connection structure 3A' comprising a holder 25 and a rupture portion 24, and a second connection structure 3B' comprising a deforming device 30 corresponding to the holder 25, wherein the connection structures 3A', 3B' can be hermetically inserted into each other, and when the connecting structures 3A', 3B' rotate relative to each other as a result of the deformation of the holder 25 by the deforming device 30, the first connecting structure 3A' can be opened to form a fluid connection 2.

According to another feature that can be implemented independently, the present invention further relates to one or more containers B1, B2, B3, in particular vessels (each) having connection structures 3A', 3B' in accordance with the present invention, preferably at the side or end , remote from the opening of the container or opening E1, E2 for recess, other connecting structure 3A', 3B' or base.

According to another feature that can be implemented independently, the present invention also relates to a container system B with at least two containers B1, B2, B3, in which the first container B1 contains the first connection structure 3A', and the second container B2, B3 contains the second a connection structure 3B' corresponding to the first connection structure 3A'.

The connecting structures 3A', 3B' are preferably made in accordance with the above description. In particular, it is preferable for the first connection structure 3A' to have a piercing and/or cutting edge 32, through which the second connection structure 3B' can be opened.

Alternatively or additionally, the second connection structure 3B' comprises a neck 5B' or a deforming device 30 for opening the first container B1 by means of the first connection structure 3A' by deforming the holder 25 or the neck 5A'.

It is also preferable that the connection structures 3A', 3B' provide for the formation of a fluid connection 2 by mutual opening, when the first connection structure 3A' opens the second connection structure 3B', and the second connection structure 3B' opens the first connection structure 3A', thereby forming most bond 2 by fluid.

According to another feature of the present invention, which can be implemented independently, the connecting structures 3A', 3B' are used in the preparation of a mixture of substances, preferably drugs, in particular a vaccine or combination vaccine, to form a bond 2 in a fluid medium and/or to mix starting materials or substances S1, S2, which were stored separately.

The present invention also relates to a method, which can be carried out independently, of manufacturing one of the connection structures 3A', 3B' or the connection system 1 and/or the container B1, B2, B3, in which the locking device 23, 33, the rupture section 24, 34 and the holder 25 or neck 5A', 5B' are injection molded in one operation. This is advantageous in terms of manufacturing reliability of the fracture portion 24, 34.

In carrying out the method, in the presence of an open end blank BR1, BR2, in particular a vessel blank with a recess opening E1, E2, in addition to the open end, it is also preferable that the open end is hermetically sealed by a separately manufactured connecting structure 3A', 3B'.

The connecting structure 3A', 3B' preferably comprises a sleeve or tube part 37A', 37B', radially outwardly enclosing (respectively) the connecting structure 3A', 3B' and corresponding to the wall 35A', 35B' of the respective capacity B1, B2 or blank BR1 , BR2 containers for introduction into it and attachment to the workpiece BR1, BR2 containers.

Another feature of the present invention, which can also be implemented independently, relates to the principle of sealing, based on the combination with each other of the connecting structures 3A', 3B', or one of the connection structures 3A', 3B' with preferably a cover 6, 26 in the form of a cap .

A container B1, B2, B3 is proposed, having a connecting structure 3A', 3B', for forming a fluid connection 2 of the container B1, B2, B3 with another container B1, B2, B3. In the initial state, the connection structure 3A', 3B' can be fluidly sealed in the opening area 4A', 4B' and can be opened to form a fluid connection 2. The opening area 4A', 4B' is closed by a cap 6, 26 and/or another connecting structure 3A', 3B'. This feature therefore applies in particular to the container system B of the individual container B1, B2, B3 or its connection structure combined with the cap-like lid 6, 26 and/or the (corresponding) connection structure 3A', 3B' .

According to another feature, which can also be implemented independently, it appears that the cover 6, 26 or other connecting structure 3A', 3B' is hermetically held on the proposed container B1, B2, B3, thereby forming a sealed chamber 38A, 38B, 38C. Moreover, the proposed container B1, B2, B3 contains a sealing device 39 surrounding its opening area 4A', 4B', which seals the volume 40A, 40B, 40C of the chamber 38A, 38B, 38C in direct contact with the opening area 4A', 4B' . In particular, it is preferable that the sealing device 39 seals the inner volume 40A, 40B, 40C from the outer volume 41A, 41B, 41C of the chamber 38A, 38B, 38C. This makes it possible to close the opening area 4A', 4B', in particular by double sealing. As a result, the effectiveness of protection against the penetration of substances, in particular microbes, is increased.

As a result, in particular, foreign matter may enter the interior space 40A, 40B,

- 38 042092

40C, only passing through the outer volume 41A, 41B, 41C. The sealing device 39 is preferably mechanically separated from the environment by an external seal in the form of a cover 6, 26, so that any force acting on the cover 6, 26 can affect the tight seal of the outer volume 41A, 41B, 41C, but the inner volume 40A, 40B , 40C remains sealed even in this case, preferably with airtightness, in particular with protection against the penetration of microbes and bacteria. In this way, a sterile environment can be guaranteed on the opening area 4A', 4B'.

Alternatively or in addition, the sealing device 39 seals the internal volume 40A, 40B, 40C surrounding the opening area 4A', 4B' by means of a cover 6, 26 or other connection structure 3A', 3B' when the cover 6 is continuously moved. , 26 or another connection structure 3A', 3B' relative to the connection structure 3A', 3B' of the proposed container B1, B2, B3. In this way, during the insertion of the connecting structures 3A', 3B' one into the other and/or during the assembly or removal of the cover(s) 6, 26, the area 4A', 4B' can be protected from the penetration of foreign substances, in particular microbes.

In particular, it is preferable to combine the two features, i. e. form a chamber 38A, 38B, 38C, which is divided by a sealing device 39 into an inner volume 40A, 40B, 40C and an outer volume 41A, 41B, 41C, the sealing device 39 being configured to prevent foreign matter, in particular microbes, from entering the inner volume 40A , 40B, 40C during, in particular, the axial movement of the cover 6, 26 or other connecting structure 3A', 3B'.

The sealing device 39 preferably includes sealing parts 42A, 42B, 43A, 43B corresponding to each other, with the first sealing part 42A, 42B associated with the connecting structure 3A', 3B', and the second sealing part 43A, 43B located on the cover 6, 26 and /or on another connecting structure 3A', 3B', in particular formed in one piece with it.

The sealing parts 42A, 42B, 43A, 43B preferably comprise sealing surfaces 44A, 44B, 45A, 45B corresponding to each other, which abut tightly against each other when the cover 6, 26 is placed on the connection structure 3A', 3B' or the connection structures 3A ', 3B' are nested inside each other.

Sealing surfaces 44A, 44B, 45A, 45B preferably have a similar cross-sectional shape (perpendicular to the central axis or axis 9 of symmetry) and/or have circular and/or rotational symmetry about a common axis of symmetry and/or central axis 9.

Preferably, the sealing surfaces 44A, 44B, 45A, 45B are designed and/or matched so that the cover 6, 26 and/or other connection structure 3A', 3B' can be rotated relative to the container B1, B2, B3.

Preferably, one of the connection structures 3A', 3B' comprises a sealing surface 44A, 44B that matches both the sealing surface 44A, 44B of the other connection structure 3A', 3B' and the sealing surface 45A, 45B of the cover 6, 26 corresponding to the connection surface 3A ', 3B'. The sealing device 39 can thus be formed on the basis of the connection structure 3A', 3B' either with the corresponding cover 6, 26 or with another connection structure 3A', 3B'. In this way it is possible to form a seal over the lid 6, 26 during transport and over the other connection structure 3A', 3B' during use using the same means or repeated use of the same means.

Another feature of the present invention, which can be implemented independently, relates to a connection system 1 for forming a fluid connection 2 between containers B1, B2, B3 and/or container B3, a connection system 1 or container B3, having at least two connection structures 3A', 3B' configured to form a fluid connection 2, namely a first connection structure 3A' and a second connection structure 3B', each of which is fluid-sealed in the initial state or isolated from the container B1, B2 for fluid , B3 and can be opened in the area 4A', 4B' opening to form a connection 2 in fluid.

According to another feature, the connecting structures 3A', 3B' form a chamber 38C and contain a sealing device 39, while the volume 40C directly in contact with the opening areas 4A', 4B' is isolated from the volume 41C of the chamber 38C separated from the areas 4A', 4B' opening by means of a sealing device 39.

Alternatively or additionally, the connection system 1 comprises a sealing device 39 which seals without interruption the volume 40C in direct contact with the opening areas 4A', 4B' when the connection structures 3A', 3B' are moved relative to each other.

It is also preferred if the connection structure 3A', 3B' has at least two positions for connection to one another, which it occupies in sequence in time and space when the connection structures are pressed or inserted into each other. In the first connection position, a permanent connection is formed between the connecting structures 3A', 3B', and the fluid connection 2 is or can only be formed in the second connection position. Further details can be found in the description relating to the embodiments discussed above.

In particular, it is preferred that the sealing device 39 isolate or plug the internal volume 40C without interruption at the first connection position, at the second connection position and between the first and second connection positions, and/or isolate or separate the internal volume 40C from the external volume 41C without interruption.

Other elements of the connection system 1 associated with the sealing device 39 have been discussed above, in particular with regard to the sterile or sterilizable shelter, with reference to, for example, FIG. 16, 17 and 20 and/or in connection with the proposed container B1, B2, B3 with the sealing device 39.

Other features of the present invention, which can also be implemented independently, relate to a connection structure 3A', 3B' and/or a container B1, B2, B3 having this connection structure 3A', 3B', wherein the opening area 4A', 4B' of the connection structures 3A', 3B' is fluid sealed in the initial state and can be opened to form a fluid connection 2. According to this feature, the connection structure 3A', 3B' comprises a lid 6, 26, which can preferably be snap-fitted to the container B1, B2, B3 or the connection structure 3A', 3B' and/or be cap-shaped and/or removable and which covers the opening area 4A', 4B'.

According to this feature, the lid 6, 26 preferably comprises a support portion 46 corresponding to the opening area 4A', 4B' and directly or so closely pressed against the opening area 4A', 4B' that the force FS acting on the opening area 4A', 4B' in direction of the base portion 46 is absorbed by contacting at least part of the opening area 4A', 4B' with the base portion 46 so that opening of the opening area 4A', 4B' is prevented.

In the embodiment shown in FIG. 23, the cover 26 closes the connecting structure 3A' in a suitable manner. The support part 46A in this case directly adjoins the closure device 23. When the force FS acts on the closure device 23 from inside the container B1, for example, when the container B1 opens in the region of the lid 26 in case of overturning or the like, and as a result, the substance S1 in the container , suddenly acts with a force FS on the opening area 4A', in particular on the locking device 23, the locking device 23 can be supported by the bearing part 46A, while the force FS is in any case partially absorbed by being intercepted and/or deflected by the bearing part 46A. In this case, the opening area 4A' is protected against accidental opening, in particular as a result of impact or overturning.

This mechanism of operation is preferred, as illustrated in FIG. 27, where the support portion 46B of the cap 6 is combined with a tamper-evident area 4B' or a closure device 33. In addition, the described tamper-evident protection provided by the bearing portion 46A, 46B can also be applied to previous embodiments and features by appropriate replacement of the cap 6 or occlusion. 14 with a cover 6, 26 having a support portion 46A, 46B.

The support portion 46 is preferably at least substantially held, or may be held, on the wall of the vessel B1, B2, B3 and/or on the connection structure 3A', 3B'. In this case, it is possible to deflect the force FS acting on the support portion 46A, 46B. In particular, it is preferred that the support portion 46A is at least substantially rigidly connected to the mouthpiece 5A', 5B' or holder 25 by means of a connecting structure 3A', 3B' and/or a container B1, B2, B3 due to its design. or by mechanical means.

In this case, the opening area 4A', 4B' is preferably held on the container B1, B2, B3 or on the wall of the container B1, B2, B3 by means of the neck 5A' or holder 25 and the support part 46A, 46B is held at least basically rigidly on the same container B1, B2, B3 or on the same wall of the container B1, B2, B3. Thus, the force FS acting on the opening area 4A', 4B' or the closure device 23, 33 towards the support portion 46A, 46B or out of the interior volume of the container can be absorbed and deflected through or by the rupture portion 24, 34 or not. only through or by means of the breaking section 24, 34. By relieving the load from the breaking section 24, 34, in the event of any forces FS, the connecting structure 3A', 3B' is prevented from being unintentionally opened.

The supporting part 46A, 46B preferably corresponds to and/or is adjacent to the closure device of the corresponding opening area 4A', 4B', in particular to the corresponding closure device 23, 33. The support portion 46A, 46B may form a flat portion formed and/or mounted at least substantially parallel and/or respectively to the lateral surface of the locking device 23, 33 facing the support portion 46A, 46B. It is also preferred that movement of the closure device 23, 33 towards the support portion 46A, 46B results in a planar engagement and/or contact that counteracts tilting of the closure device, in particular due to impact or flip forces on the closure device.

- 40 042092

The support portion 46A, 46B is preferably formed by the base of the recess 47 or seat 13 of the lid 6, 26, which is accessible from the outside when installed or attached to the container B1, B2, B3 or the connection structure 3A', 3B'. Additional information related to socket 13 is also given in the description of the previous embodiments. In particular, it can be provided that the seat 13, the recess 47 or the cavity corresponds to the hole E1, E2 for the recess or the constriction F1, F2 of the vessel of the container B1, B2, B3, so that it can be placed in the seat 13, the recess 47 or the cavity, in particular for transport and/or as a support.

The lid 6 preferably includes rib-like reinforcing elements 48, preferably helping to support or increase the strength of the support portion 46B. Alternatively, or additionally, the reinforcing elements 48 are associated with a narrowing F1, F2 of the vessel in order to accommodate, hold and/or strengthen it. As such, lid 26 may also include corresponding or similar reinforcing elements 48, even though they are not shown in this embodiment.

The support portion 46A, 46B is preferably supported by an oblique or at least substantially conical strip 49 preventing movement or deformation in axial directions or directions along or parallel to the central axis and/or axis 9 of symmetry.

It is also preferred that the lid 6, 26 be sealed onto the container and/or the connection structure 3A', 3B' using a sealing device 39. The sealing device 39 preferably seals the side of the support portion 46A, 46B facing the area 4A', 4B' autopsy. Alternatively or additionally, the sealing device 39 is located on the wall of the container B1, B2, B3 if used in addition to the sealing and/or snap-fitting of the lid 6, 26. Thus, the chamber 38A, 38B, the internal volume 40A, 40B and/ or volumes 40A, 40B, 41A, 41B, separated from one another, may be formed inside the lid(s) 6, 26, which are attached or may be attached to the container B1, B2, B3 or the connecting structure 3A', 3B'.

According to another feature that can be implemented independently, the present invention also relates to a lid 6, 26 in the form of a cap and/or its combination with a connecting structure 3A', 3B' to form a fluid connection 2, in particular between containers B1 , B2, B3, and the cover 6, 26 has a side wall 50A, 50B and a base 51A, 51B adjacent to the side wall 50A, 50B.

On the side wall 50A, 50B there is a holding device for releasably holding the cover 6, 26 with a blocking and/or frictional engagement. In particular, these are one or more areas made with the possibility of sealing and/or attaching in another way by blocking and/or friction connection of one or more, preferably one female connection to the container B1, B2, B3, in particular without interruptions, in the form of a bent edges or by other means.

Preferably, the base 50 includes a socket 13, a recess 47 or a cavity, into which a bottle-shaped opening E1, E2 can be inserted for a recess in the form of a container B1, B2, B3.

Alternatively or additionally, the region of the base of the seat 13, the recess 47 or the cavity facing the opening of the lid 6, 26, comprises a flat support portion 46A, 46B to support the opening region 4A', 4B' of the connecting structure 3A', 3B', container B1, B2, B3 or parts thereof.

Alternatively or additionally, the base 51A, 51B of the lid 6, 26 comprises a female tape seal portion 43A, 43B configured to form multiple sealed volumes 40A, 40B, 40C, 41A, 41B, 41C and/or divide the chamber 38A, 38B and/or provide support for the base 51A, 51B.

The support portion 46A, 46B is preferably supported or strengthened, in particular by rib-like reinforcing elements 48, preferably such that the lid 6, 26 becomes rigid in order to deflect the force FS acting on the support portion 46A, 46B into the container wall B1, B2, B3.

According to another feature, which can also be implemented independently, the invention relates to the use of a lid 6, 26 in the form of a cap, containing the support part 46A, 46B, which is located immediately adjacent to or with such a small gap from the opening area 4A', 4B' of the container B1 , B2, B3, that the force FS acting on the area 4A', 4B' in the direction of the bearing part 46A, 46B is absorbed by the planar contact of at least part of the opening region 4A', 4B' with the bearing part 46A, 46B to protect against accidental opening under the influence of external forces, preferably accelerations, in particular as a result of impact or overturning of the container B1, B2, B3, which is connected or can be connected to the cover 6, 26 and/or the connection structure 3A', 3B' provided for the container B1, B2, B3 or forming part of it.

With reference to FIG. 31 to 34, with reference to the present embodiment, it is once again explained how the containers B1, B2, B3 are connected to each other by the first and second connection structures 3A', 3B' shown as an example in FIG. 26 and 30 to form 2 in fluid. This procedure corresponds, at least in general, to the procedure already described with reference to FIG. 5-13, or vice versa.

- 41 042092

Preferably, the covers 6, 26 are first removed, thereby exposing the connecting structures 3A', 3B'. Cover 6 can be used as a stand.

Then, the connecting structures 3A', 3B' are moved closer together along the axis and inserted one into the other, as shown by way of example in FIG. 31-33.

In FIG. 32 illustrates a preliminary, optional step of a snap connection in the first connection position, in which the connection structures 3A', 3B' or their opening areas 4A', 4B' are still plugged, however the connection structures 3A', 3B' or the containers B1, B2, The B3 are already attached to each other, in particular by a locking engagement, in particular by a non-removable one. The details of this step are given in the respective explanations for the previously described embodiments.

In FIG. 33 shows how the first connection structure 3A opens the opening area 4B' of the second connection structure 3B', in this case preferably by means of a piercing and/or cutting edge 32 or some other cutting element 7. To do this, the piercing or cutting edge 32 acts axially on a rupture section 34 which holds the locking device 33. As the movement continues, the rupture section 34 is dissected, in particular cut, by means of a piercing and/or cutting edge 32 or is torn. This results in an initial opening of the opening region 4B' of the second connecting structure 3B'.

In the next step, the connecting structures 3A', 3B' or containers B1, B2, B3 are rotated relative to each other about a common central axis or axis 9 of symmetry, as a result of which the holder 25 or the neck 5A' of the first connecting structure 3A' is deformed and as a result also opens opening area 4A' of the first connection structure 3A', as shown in FIG. 22 and 34 in the final opening position.

The connecting structures 3A', 3B' are preferably capable of being connected to each other by a bayonet-type connector in which at least mainly or exclusively axial movement along the central axis or axis 9 of symmetry, after the connecting structures 3A', 3B' have been pushed in one inside the other, complemented by a rotational movement of the connecting structures 3A', 3B' relative to each other around the central axis or axis 9 of symmetry.

Said bayonet movement is preferably guided by the connecting structures 3A', 3B'. In particular, as shown, for example, in perspective views of the first connection structure 3A' in FIG. 26 and the second connection structure 3B' in FIG. 30, there are corresponding guides or guides 18A, 18B which preferably direct the bayonet movement described above. In particular, the first connecting structure comprises a guide or guide 18A in the form of a strip, which preferably extends at least in a plane or along a plane perpendicular to the central axis or axis 9 of symmetry. The guide or guide 18B of the second connection structure 3B' preferably has a conjugated, preferably complementary, structure. It may include a guide slot into which a guide device or guide 18A may be received to direct the movement.

The guides or guides 18A, 18B can also be configured to be pre-aligned with respect to the central axis or symmetry axis 9 when the connecting structures 3A', 3B' are pushed towards each other. This alignment is preferably carried out in such a way that the oval-shaped openings 4A', 4B', for example, in the embodiments shown correspond to each other or are arranged in the same orientation relative to each other.

The guide means or guides 18A, 18B are preferably configured to prevent rotation of the connection structures 3A', 3B' about a central axis or axis of symmetry 9 by interlocking engagement during movement of the connection structures 3A', 3B' towards each other. Once the connection structures 3A', 3B' have been inserted one into the other, in particular opening the opening area 4B' of the second connection structure 3B', the guide devices 57A, 57B allow the connection structures 3A', 3B' to rotate relative to each other around common central axis or axis 9 of symmetry. This rotation leads to the aforementioned deformation of the neck 5A' or the holder 25 of the first connection structure 3A' and, consequently, to the opening of the opening area 4A' of the first connection structure 3A', thereby forming the fluid connection 2.

The guides or guides 18A, 18B preferably also make it possible to block the relative position of the connecting structures 3A', 3B' in the axial direction, i.e. in the direction of the central axis or axis 9 of symmetry, in particular by interlocking engagement by means of or after turning the connecting structures 3A', 3B' relative to each other.

Alternatively, or in addition, locking means can be used which prevent reverse rotation. This ensures that once the fluid connection 2 has been established, the connecting structure 3A', 3B' cannot be separated again, which in particular ensures that the fluid connection 2 is sterile.

- 42 042092

According to another feature, which can also be implemented independently, the present invention relates to a container system B with two containers B1, B2, B3, B4, which are fluidly separated from each other in the initial state and are fluidly connected to each other. the other by moving the containers B1, B2, B3, B4 relative to each other, while in the initial state the latch 52 blocks, in particular, partial and/or initially axial movement of the containers B1, B2, B3, B4 or their connecting structures 3A' , 3B' relative to each other.

In the embodiment shown in FIG. 35, the first container B1 is shown as an example with an additional container B4 and a latch 52. The additional container B4 in the embodiment shown has only one possible access opening, which is formed by the second opening device 4B'. However, other solutions are also possible, for example, using the containers B2, B3 described earlier.

In FIG. 35 shows the latch 52 in the initial state in which the containers B1, B2 are not attached to each other. In this initial state, the latch 52 prevents the containers B1, B4 from moving relative to each other, which is necessary to open or create a connection between the containers B1, B4. In this case, the latch 52 stands as a spacer between the containers B1, B4, preventing axial movement of the containers relative to each other.

In FIG. 36 is an enlarged view of a fragment of the embodiment shown in FIG. 35 in which the latch 52 is activated or activated. In this state, the containers B1, B4 can move relative to each other so that a fluid bond 2 can be formed. To this end, it is particularly preferred that the opening areas 4A, 4B, 4A', 4B' are opened by means of the connecting container 3A, 3A', 3B, 3B' described above, by means of an initial axial or intermediate movement and then a rotational movement of the containers. B1, B4 relative to each other.

In FIG. 37 is an enlarged view of a fragment of the embodiment shown in FIG. 35 in the state after the relative movement has occurred.

In FIG. 38 shows the latch 52 in a perspective view.

For the present feature, it is preferable that the containers B1, B4 can be connected to each other by means of the proposed connection structures 3A', 3B'. In principle, however, other connection methods can be considered.

The container system B preferably comprises a seat 53, in particular a pocket for the latch 52, into which the latch 52 can be inserted, in particular by pressing as a result of or during relative movement.

In the embodiment shown, in order to open the second connection structure 3B', in particular the connection structures 3A', 3B' are moved axially relative to each other. This relative axial movement is initially prevented by the latch 52 and can be allowed by this latch 52.

The socket 53 is preferably located behind the wall 35A', 36A' of one of the containers B1, B4 and/or behind the annular and/or tubular part 37A', 37B' of one of the connection structures 3A', 3B' when viewed from the outside. In the embodiment shown, this wall is the wall of the container B1, which preferably forms a tubular or annular extension of the wall of the container B1 delimiting the inner chamber, in particular co-axial with it.

In the illustrated embodiment, the seat 53 is formed between the wall 35A', 36A' or sleeve 37A, 37B and the neck 5A', 5B' or opening area 4A', 4B' of the container B1. Alternatively or additionally, however, the same may apply to other containers B2, B3, B4.

The container system B is preferably designed such that, during or as a result of or after activation, the latch 52 can protrude into the seat 53 in the axial direction or can have a common central axis and/or symmetry axis 9 of the container system B with it.

It is also preferable that the latch 52 be located in the initial position between the edges 36A', 36B' of the containers B1, B2, B3, B4 or the connection structures 3A', 3B', which are in particular opposed to each other or correspond to each other so that the edges 36A', 36B' abut against each other through the latch 52.

The latch 52 is preferably at least partially subject to deformation, as a result of which relative movement becomes possible. In particular, by actuating the latch 52, the blocking engagement can be broken so that the containers B1, B2, B3, B4 no longer bear on each other, which ensures their mutual movement.

In the embodiment shown, the latch 52 has an annular or annular shape, in particular is made in the form of a ring, in particular a retaining ring, or contains such a ring, which is at least partially deformable or deformable at certain places for separation. This, however, is not essential and can also be achieved in some other way, although the use of a ring has advantages in terms of fabrication and assembly.

The retainer 52 preferably comprises at least one blocking element 54, preferably in the form of a flap or a tab, or so formed. In the initial position, the blocking element 54 prevents the connecting structures 3A', 3B' from moving relative to each other due to the blocking engagement. Moreover, the blocking element 54 is preferably deformable and/or indentable so as to release the blocking and allow mutual movement.

In the illustrated embodiment, the blocking element 54 or blocking elements 54 comprises (at) an edge 55 forming a blocking engagement and having the ability to move and deform at least mainly in the radial direction (relative to or in the direction of the central axis or axis 9 of symmetry) for unlocking. In particular, the blocking member 54 is integrally molded with the latch 52 at one end and/or has a petal shape.

The socket 53 preferably corresponds in shape to the latch 52 or vice versa, and may thus contain a cavity or pocket or be formed by a cavity or pocket, which, in particular, also have an annular or annular shape associated with the shape of the latch 52. The cavity or pocket preferably contains an opening, facing the latch 52 or to the connecting structure 3A', 3B' located opposite the socket 53.

The retainer 52 is preferably formed from a plastic material, in particular a thermoplastic material. The latch 52 may be a plastic ring. Blocking elements 54 preferably have the property of elastic deformation. Alternatively, release of the blockage may also be effected by plastic deformation of the blocking elements 54.

In the initial state, the latch 52 is preferably located between the containers B1, B2, B3, B4 in such a way that movement in the axial direction relative to the central axis and/or axis 9 of symmetry of the system B of the containers is blocked, and due to the partial deformation of the latch 52 radially in the direction of the central axis and/or axis 9 of symmetry of the container system B, the relative movement can be unlocked.

The retainer 52 preferably cannot be removed and/or removed. Instead, the latch 52 is placed in the seat 53 during or after activation and thus does not form a separate part that must be disposed of separately, which simplifies the use of the system and its operational reliability.

In the embodiment shown, the latch 52 is rotatable, in particular mounted rotatably about a central axis and/or axis 9 of symmetry. The retainer 52 is held on the tapered portion and/or by interlocking engagement on the container system B.

According to another feature that can be implemented independently, the invention relates to a method for preparing a mixture of substances, in particular a vaccine, in which the starting substances in the form of the first substance S1 and the second substance S2 are supplied separately from each other in two containers B1, B2, B3, B4, which have the possibility of fluid connection, carried out by moving the containers B1, B2, B3, B4 relative to each other, preferably by axial movement relative to the central axis and/or the axis of symmetry of the system B of the containers.

Preferably, the process uses a socket 53 and a latch 52 located or formed between the containers B1, B2, B3, B4, blocking the movement of the containers B1, B2, B3, B4 relative to each other in the initial state. In the process, the latch 52 is activated and it slides into the seat 53 as a result of this activation and/or relative movement.

In the embodiment shown, the latch 52 is located, for example, between the first container B1 and the fourth container B4. However, theoretically, these containers can also be replaced by containers of a different type, in particular as described previously. Thus, during the formation of the socket 53, the latch 52 could theoretically also be in the first connection position according to FIG. 32 in the same manner as in the embodiment shown in FIG. 22-33.

In FIG. 37 shows an enlarged view of the area containing the latch 52 and the socket 53, in which relative movement has already taken place. As a result, the latch 52 or the locking elements 54 have each been pushed partially or at least substantially into the seat 53. In particular, the lip 55 has been pushed into the seat 53. Preferably, this prevents the latch 52 from entering another locking engagement. In the embodiment shown, the latch 52 is located in the socket 53 between the tubular protrusion or wall apron 35A' of the first container B1 and the first connection structure 3A'.

In FIG. 38 is a separate schematic perspective view of the inventive latch 52. This clearly shows lobe-shaped blocking elements 54 formed like film hinges, or hinged to the latch 52 by means of a film hinge connection. In the embodiment shown in FIG. 39, the axis of rotation of the locking element 54 is located at least substantially in the plane formed by the latch 52.

In FIG. 39 is a schematic sectional view of a container system B with a retainer according to the second embodiment. The second embodiment is functionally similar to the first embodiment and therefore other details can be learned from the description relating to the previous embodiment with reference to FIG. 35-38. Therefore, only the differences from the previously described embodiments will be discussed below.

In FIG. 39 shows the container system B or latch 52 in the initial or locked position. In this position, the blocking element 54 acts between the containers B1, B4 so that they bear on each other and thus prevent relative movement.

In FIG. 40 shows the container system B with the latch 52 activated when relative movement has become possible. To this end, the blocking element or elements 54 are deformed or displaced so that they or the latch 52 can be placed in the seat 53, in particular by pressing them there.

In FIG. 41 shows the container system B during or after a relative movement, or part thereof, during or as a result of which the latch 52 was pushed into the seat 53.

In FIG. 42 shows separately the latch 52 of the second embodiment in a perspective view. One or more blocking elements 54 are in the form of petals. The blocking elements 54 in the initial state protrude at least generally tangentially along the circumferential line of the latch 52 or container B1, B4. In other words, the locking element 54 can be bent about one or more axes extending at least substantially parallel to the central axis or symmetry axis 9 and/or can be deformed by twisting it into a shape that matches the shape of the socket 53 or provides relative displacement. .

The goal in both embodiments is to unlock by shaping and/or placing the locking element in a position in which the latch 52 is mated with the socket 53 and in which relative movement is possible so that the latch can be pressed into the socket 53 as a result of or during relative movement.

In the embodiments according to FIG. 35-42, the latch 52 is made in the form of a separate part, not connected to the connecting structures 3A, 3A', 3B, 3B' and/or containers B1, B2. In this case, if necessary during the assembly process, the latch 52 can be placed between the connecting structure 3A, 3A', 3B, 3B' or containers B1, B2.

Alternatively or additionally, it is possible that the latch 52 is formed by the container B1, B4 and/or the connecting structure 3A, 3A', 3B, 3B' or has a fixed and/or permanent connection with them.

In this case, the socket 53 and the latch 52, in particular one or more of the blocking elements 54, are preferably located opposite each other on different containers B1, B4 or connection structures 3A, 3A', 3B, 3B'. Due to this, the latch 52 and/or one or more of the blocking elements 54 can be moved into the seat 53 during or after the activation of the latch 52.

The latch 52, in particular one or more of the blocking elements 54, may be connected to the container B1, B4 or the connecting structure 3A, 3A', 3B, 3B' by positive blocking, friction connection and/or adhesion, or may be formed in the form one with them. In particular, it is preferred that the latch 52 and/or the locking elements 54 are matched, inserted and/or formed in the same operation with the container B1, B4 or the connection structure 3A, 3A', 3B, 3B', in particular , by injection molding. It is possible, however, that the latch 52 is held on the container B1, B2 or the connection structure 3A, 3A', 3B, 3B' by a snap fastener or other means.

The blocking elements 54 are preferably held on the container B1, B2 and/or the connecting structure 3A, 3A', 3B, 3B' in analogy to a film hinge. Alternatively, or additionally, blocking elements 54 may be deformable and/or secured. This ensures that the locking elements 54 work without separately releasing the latch 52. In this case, the locking elements 54 can be configured as shown in FIG. 38 and/or 42 or otherwise.

According to another feature that can be implemented independently, the present invention relates to the use of connecting structures and/or containers for mixing viscous liquids, in particular vaccines, preferably having a dynamic viscosity at 23°C and a shear rate gradient of 1s ^-1 (in particular measured in a Brookfield RVT type viscometer with No. 4 spindle), greater than 1.5 or 2 Pa-s, preferably greater than 4 Pa-s, in particular greater than 6 or 10 Pa-s and/or less than 100 Pa-s, in in particular less than 70 Pa-s, preferably less than 50 Pa-s, and/or in the range from 1 to 100 Pa-s, in particular from 2 to 70 Pa-s, preferably from 5 to 50 Pa-s. The above viscosities within the scope of the present invention can be determined, in particular, by a method in accordance with EN ISO 2884-1:2006. When working with viscous fluids, in particular, the use of large hydraulic minimum cross-sections of the connections gives an advantage over known designs.

Features of the present invention may be used in combination with each other. In particular, the features of the embodiments described with reference to FIGS. 1-20 can also be used, respectively, in the embodiments described with reference to FIGS. 21-37 and vice versa.

- 45 042092

For example, features relating to the sealing device 39 and/or the support portion 46A, 46B may also be present in the cover 6 of the embodiments of FIG. 1-20. Caps 6, 26 can provide, in particular, repeated or multi-stage sterile and/or sterilizable sealing, while the features discussed with reference to FIG. 17 can be combined with the features regarding the sealing device 39 described with reference to FIG. 22-34. Alternatively, or additionally, the features relating to opening using deformation discussed with reference to FIG. 6-15 can be combined with features related to the locking device 33 and vice versa. These examples clearly show that there are numerous preferred combinations of features that may form the subject of the present invention, even if these combinations are not explicitly described.

Reference number designations.

fluid connection system

FOR, FOR' the first connecting structure

ZV, ZV' second connecting structure

4A, 4A' opening area of the first connecting structure

4B, 4B' opening area of the second connecting structure

5A, 5A' neck of the first connecting structure

5B , 5B' neck of the second connecting structure closing means (lid) cutting element arrow indicating movement central axis, or axis of symmetry

10A, 10B retainer rotation direction arrow rupture line socket blockage inner annular edge outer annular edge gap

18A guide of the first connecting structure

18B guide of the second connecting structure rod tip connecting part coupling locking device (of the first connecting structure) breaking section (of the first connecting structure) holder closing means (lid) plane frame reinforcing element

- 46 042092

thirty deforming device 31 wall 32 piercing and/or cutting edge 33 locking device (second connecting structure) 34 discontinuous section (of the second connecting structure)

35A', 35B'wall (tanks/blanks)

36A', 36B'edge (tanks/blanks)

37A', 37B' coupling and/or tubular part

38A-38C camera 39 sealing device 40A-40C internal volume 41A-41C external volume 42A-42C sealing part 43A-43C sealing part 44A, 44B sealing surface 45A, 45V sealing surface 46A, 46B bearing part 47 deepening 48 reinforcing element 49A, 49B band 50A, 50V side wall 51A, 51B base 52 retainer 53 nest 54 blocking element 55 edge IN container system IN 1 first container AT 2 second container VZ third container AT 4 additional capacity BR1 container preparation BR2 container preparation E1 opening for the extraction of the first container E2 opening for the extraction of the second container F1 narrowing of the vessel of the first container F2 constriction of the vessel of the second container FS force S1 substance in the first container S2 substance in the second container S3 substance in the third container VI sealing element of the first container V2 sealing element of the second container

CLAIM

Claims (36)

1. A container (B1, B2, B3) having a connecting structure (3A', 3B') to provide fluid communication (2) between a container (B1, B2, B3) and another container (B1, B2, B3), moreover, in the initial state, the connecting structure (3A', 3B') is sealed against the fluid in the area (4A', 4B') of the opening and can be opened to form a connection (2) along the fluid medium and the area (4A', 4B') opening is closed by another connecting structure (3A', 3B'), characterized in that it is - 47 042092 holds a sealing device (39) configured to continuously isolate the volume (40A, 40B, 40C) directly in contact with the opening area (4A', 4B') by interacting with another connecting structure (3A', 3B') during the movement of another connecting structure (3A', 3B') relative to the mentioned connecting structure (3A', 3B'), moreover, these connecting structures (3A', 3B') are made with the possibility of mutual opening with the formation of a permanent connection (2) fluid and contain necks (5A, 5B, 5A', 5B') formed so that the neck (5A, 5B, 5A', 5B') of one of the connecting structures (3A', 3B') can pass into the neck ( 5A, 5B, 5A', 5B') of another connection structure (3A', 3B'). 2. Container according to claim 1, characterized in that the sealing device (39) continuously seals off the volume (40A, 40B, 40C) in a sterile or sterilizable manner. 3. The container according to claim 1 or 2, characterized in that the sealing device (39) contains the sealing parts (42A, 42B, 43A, 43B) corresponding to each other, and the first sealing part (42A, 42B) is connected to the connecting structure ( 3A', 3B'), and the second sealing part (43A, 43B) is located on another connecting structure (3A', 3B'). 4. Container according to claim 3, characterized in that the first sealing part (42A, 42B) is integrally formed with the connecting structure (3A', 3B'). 5. Container according to claim 3 or 4, characterized in that the second sealing part (43A, 43B) is integrally formed with another connection structure (3A', 3B'). 6. Container according to one of the preceding claims, characterized in that the sealing parts (42A, 42B, 43A, 43B) correspond to each other so that, abutting against each other, they isolate the opening area (4A', 4B'). 7. Container according to claim 6, characterized in that the sealing parts (42A, 42B, 43A, 43B) isolate the region (4A', 4B') in a sterile or sterilizable manner. 8. Container according to one of the preceding claims, characterized in that the sealing parts (42A, 42B, 43A, 43B) provide relative movement, tightly abutting each other. 9. The container according to claim 8, characterized in that the sealing parts (42A, 42B, 43A, 43B) provide relative movement in the axial direction. 10. Container according to claim 8 or 9, characterized in that the sealing parts (42A, 42B, 43A, 43B) provide relative movement, sliding along each other with a sealing fit. 11. Container according to one of the preceding claims, characterized in that the first and/or second sealing part (42A, 42B, 43A, 43B) is formed in the form of a sleeve, a strip and/or a pipe section. 12. A container according to one of the preceding claims, characterized in that one of the sealing parts (42A, 42B, 43A, 43B) is flexible, reversibly deformable and/or resilient, stretching under the pressure of the sealing parts (42A, 42B, 43A, 43B) on top of each other and/or in tension with respect to another of the sealing portions (42A, 42B, 43A, 43B). 13. The container according to claim 12, characterized in that the other sealing part (42A, 42B, 43A, 43B) is formed by a strip or sleeve and/or forms a counterstop with a sealing surface against which the sealing part (42A, 42B, 43A, 43B). 14. A container according to claim 13, characterized in that the strip or sleeve is at least substantially rigid. 15. Container according to one of the preceding claims, characterized in that the sealing parts (42A, 42B, 43A, 43B) have sealing surfaces (44A, 44B, 45A, 45B) corresponding to each other, which fit tightly to each other, and the sealing the surfaces (44A, 44B, 45A, 45B) are similar in cross section and/or round and/or rotationally symmetrical with respect to a common axis of symmetry and/or central axis (9). 16. A container according to one of the preceding claims, characterized in that the connecting structures (3A', 3B') are made with the possibility of conjugated mutual opening. 17. Connecting system (1) to provide communication (2) in fluid between containers (B1, B2, B3), containing at least two connecting structures (3A', 3B') configured to form a connection (2) along fluid medium, namely the first connecting structure (3A') and the second connecting structure (3B'), each of which is sealed against the fluid in the initial state and can be opened in the opening area (4A', 4B') to form a connection ( 2) by fluid, characterized in that it contains a sealing device (39) configured to continuously isolate the volume (40C) in direct contact with the areas (4A', 4B') of the opening, during the movement of the connecting structures (3A', 3B') relative to each other, and these connecting structures (3A', 3B') are made with the possibility of mutual opening with the formation of a permanent connection (2) in the fluid medium and contain necks (5A, 5B, 5A', 5B'), formed so that the neck (5A, 5B, 5A', 5B') of one of the first and second connection structures (3A', 3B') can pass into the neck (5A, 5B, 5A', 5B') of the other of the first and second connection structures structures (3A', 3B'). 18. The connection system according to claim 17, characterized in that the connection structures (3A', 3B') have at least two connection positions, which they occupy one after the other in time - 48 042092 and / or by location, when the connecting structures (3A', 3B') are pushed or pushed into one another, and in the first position of the connection between the connecting structures (3A', 3B') a permanent connection is formed, and the connection (2) by fluid is formed only when the second connection position is reached, while in the first connection position, in the second connection position and between the first and second connection positions, the sealing device (39) continuously closes the internal volume (40C) and/or continuously separates the internal volume (40C) from the external volume (41C). 19. The connection system according to claim 17 or 18, characterized in that the sealing device (39) comprises sealing parts (42A, 42B, 43A, 43B) corresponding to each other, the first sealing part (42A, 42B) being connected to one of connecting structures (3A', 3B'), and the second sealing part (43A, 43B) is connected to another of the connecting structures (3A', 3B'). 20. The connection system according to claim 19, characterized in that the first sealing part (42A, 42B) is integrally formed with one of the connection structures (3A', 3B'). 21. A connection system according to claim 19 or 20, characterized in that the second sealing part (43A, 43B) is integrally formed with the other of the connection structures (3A', 3B'). 22. Connection system according to one of claims 17 to 21, characterized in that the sealing parts (42A, 42B, 43A, 43B) correspond to each other so that they overlap the opening area (4A', 4B') against each other . 23. The connection system according to claim 22, characterized in that the sealing parts (42A, 42B, 43A, 43B) isolate the region (4A', 4B') in a sterile and/or sterilizable manner. 24. A coupling system according to one of claims 17 to 23, characterized in that the sealing parts (42A, 42B, 43A, 43B) provide relative movement while firmly abutting each other. 25. Connecting system according to claim 24, characterized in that the sealing parts (42A, 42B, 43A, 43B) provide relative movement in the axial direction. 26. The connection system according to claim 24 or 25, characterized in that the sealing parts (42A, 42B, 43A, 43B) provide relative movement, sliding along each other with a sealing fit. 27. A connection system according to one of claims 17 to 26, characterized in that the first and/or second sealing part (42A, 42B, 43A, 43B) is formed in the form of a sleeve, a strip and/or a pipe section. 28. The connection system according to one of claims 17 to 27, characterized in that one of the sealing parts (42A, 42B, 43A, 43B) is flexible, reversibly deformable and/or resilient, stretching under the pressure of the sealing parts (42A, 42B, 43A, 43B) on top of each other and/or in tension relative to another sealing portion (42A, 42B, 43A, 43B). 29. The connecting system according to claim 28, characterized in that the other sealing part (42A, 42B, 43A, 43B) is formed by a strip or sleeve, which forms a counterstop with a sealing surface (44A, 44B, 45A, 45B), to which it fits snugly one of the sealing parts (42A, 42B, 43A, 43B). 30. A connection system according to claim 29, characterized in that the strip or sleeve is at least substantially rigid. 31. The connection system according to any one of claims 17 to 30, characterized in that the sealing parts (42A, 42B, 43A, 43B) comprise sealing surfaces (44A, 44B, 45A, 45B) corresponding to each other, which fit snugly against each other. to each other, wherein the sealing surfaces (44A, 44B, 45A, 45B) have a similar cross-sectional shape and/or a round shape and/or are rotationally symmetrical about a common axis of symmetry and/or a central axis (9). 32. A connection system according to one of claims 17 to 31, characterized in that the connection structures (3A', 3B') are designed to open mutually in parallel. 33. Connecting system (1) for providing fluid communication (2) between containers (B1, B2, B3), containing at least two connecting structures (3A, 3B, 3A', 3B') configured to form a connection (2) by fluid, each of which contains the area (4A, 4B, 4A', 4B') of the opening, in the initial state sealed against the fluid, and each area (4A, 4B, 4A', 4B') of the opening is closed sterile or with the possibility of sterilization, and the connecting structures (3A, 3B, 3A', 3B') are made with the possibility of mutual opening with the formation of a permanent connection (2) in the fluid medium and the connecting structures (3A, 3B, 3A', 3B' ) comprise necks (5A, 5B, 5A', 5B') formed such that the neck (5A, 5B, 5A', 5B') of one of the first and second connection structures (3A, 3B, 3A', 3B') can pass into the neck (5A, 5B, 5A', 5B') of the other of the first and second connection structures (3A, 3B, 3A', 3B'). 34. The connection system according to claim 33, characterized in that the area (4A, 4B, 4A', 4B') of the opening has the form of a film with brittleness, brittleness and/or fragility. 35. The connection system according to claim 33 or 34, characterized in that the first connection structure (3A, 3A') is made with the possibility of opening it by perforating the first opening area (4A, 4A') and/or the first connection structure (3A, 3A ') is configured to open the second connecting structure (3B, 3B') by perforating the second opening area (4B, 4B'). - 49 042092 36. The connecting system according to one of claims 33-35, characterized in that the necks (5A, 5B, 5A', 5B') are formed so that by inserting the neck (5A, 5B, 5A', 5B') of one of the first and second connecting structures (3A, 3B, 3A', 3B') into the neck (5A, 5B, 5A', 5B ') another from the first and second connection structures (3A, 3B, 3A', 3B') opening area (4A, 4B, 4A', 4B') another from the first and second connection structures (3A, 3B, 3A', 3B' ) can be perforated and/or opened.