JPH08276952A - Vial container - Google Patents

Abstract

PURPOSE: To provide a vial container that is produced at low cost while being available for easy sorting in accordance with types of materials on disposal by burning, and to prevent a plug thereof from loosening or coming off during transportation. CONSTITUTION: A needle-sticking window part 12 is formed at the top board of a protector 11 to be put on a bottle mouth 19a of a bottle container 19, and a plug body 15 for hermetically sealing a space between the internal face of the top board and the upper face of the bottle mouth is fitted into the inside of the cylindrical part of the protector 11, and a holding means 17 that holds the protector 11 in two positions of a half-plugged freezing/drying position and a full-plugged sealing position by being engaged respectively with the outer peripheral edge on the upper side of a bottle mouth flange 19b and the outer peripheral edge on the lower side of the bottle mouth flange 19b is provided at the inside of the cylindrical part. A vent 20 that connects the inside of the bottle container 15 with the open air when the protector is in the half-plugged freezing/drying position is provided at the cylindrical part of the protector 11.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to improvements in vial containers.

[0002]

2. Description of the Related Art In a conventionally known vial container, as shown in FIG. 20, a protector 1 made of an aluminum material is formed with a breaking portion 3 surrounded by an easy breaking line 2 such as a score. An engaging projection 5 formed on the inner surface of a synthetic resin lid body (hereinafter referred to as a flip-off cap) 4 is fixed to the breaking portion 3 with an eyelet structure, while the stopper portion 6a is vented to the inside of the protector 1. A rubber stopper 6 having a notch 7 formed therein is fitted, and the drug in the vial bottle 8 is freeze-dried in a half stopper position in which the rubber stopper 6 is fitted in a bottle mouth 8a of the vial bottle 8 in a floating manner. After freeze-drying, the rubber stopper 6 was completely sealed, and the bottom of the protector 1 was wound by a winding machine. In use, as shown in the figure, the breaking portion 3 is broken through the flip-off cap 4, the exposed upper portion of the rubber stopper 6 is sterilized, and a needle of a syringe is pierced through this portion to remove distilled water or the like. A liquid is poured into a vial 8 to dissolve a freeze-dried drug, and this drug solution is poured into a syringe or the like for administration.

[0003]

The conventional vial container has the following problems. (A) The vial container is composed of four types of glass, aluminum, synthetic resin, and rubber material, and it is necessary to separate the respective materials at the time of waste incineration processing, which requires much time and labor. (B) Keep the aluminum protector in the hopper,
During the process of crushing the vial via the feeder with this protector, aluminum scraps may be generated during the retention rolling in the hopper, and the aluminum scraps may contaminate the flip-off cap. (C) The rubber stopper may float up and fall off during transportation to the freeze-drying device. (D) It is difficult to inspect the bottle mouth because the vial mouth corresponding to the winding part of the aluminum protector is opaque. (E) When the lid is removed and the fractured part is exposed, a shearing part of aluminum is generated around the fractured part, and absorbent cotton for sterilization is caught and left on this, which hinders the sterilization of the exposed part of the upper surface of the rubber plug. You

It is an object of the present invention to provide a vial container at a low cost, which is extremely easy to sort by materials at the time of waste incineration processing, and on the other hand, in which there is no fear that the stopper will rise or fall during transportation.

[0005]

The structure of the present invention for solving the problems of the prior art is such that the top wall portion of the protector fitted in the bottle mouth of the bottle container is closed by an opening or a sealing means for facilitating needle passing. And a stopper body for sealing between the inner surface of the top wall and the upper surface of the bottle mouth is fitted in the tubular portion of the protector, and the inner surface of the tubular portion has an upper surface of the bottle mouth collar portion. A locking means for engaging the outer peripheral edge portion to hold the protector in the half-stopper freeze-drying posture and to engage the outer peripheral edge of the lower surface of the bottle mouth flange portion in the two postures of the full stopper stopper sealing posture. Provided, on the other hand, in the tubular portion of the protector in the half-drying freeze-drying posture, provided with a vent for communicating the inside of the bottle container with the outside air, the plug has a thick sheet-like packing structure, In the stopper, insert a stopper part that has a ventilation notch to be inserted and fitted into the bottle mouth. In the lower half of the inner surface of the cylinder part, another locking means is formed on the inner surface of the cylindrical part to prevent the cap body from being lifted up by engaging with the outer peripheral edge of the lower surface of the bottle mouth collar part when the protector is in the half-stopper freeze-drying posture. The protector, which is provided in the bottle mouth of the bottle container, is formed with a needle passage window portion closed by an opening or a sealing means for facilitating needle passage, and the ceiling portion is provided in the tubular portion of the protector. A stopper that seals between the inner surface of the wall and the upper surface of the bottle mouth is fitted, and the protector is held in the half-stopper freeze-drying position by engaging the inner peripheral surface of the cylindrical portion with the outer peripheral edge of the upper surface of the bottle mouth collar. In addition, a locking means for engaging with the outer peripheral edge of the lower surface of the bottle mouth collar portion to hold the two stopper sealing postures is provided. On the other hand, the protector cylinder portion in the half stopper stopper freeze-drying posture is provided with In addition to forming a ventilation path whose lower end communicates with the outside air in the thick part of the cylinder, The inner wall surface of the cylindrical portion corresponding to the upper end of the ventilation passage of (1) is provided with an air vent, and the inside of the bottle container is communicated with the outside air through the air vent during the half-stopper freeze-drying posture. The sheet-like packing structure of (1), the stopper is integrally formed with a stopper portion having a ventilation notch to be inserted and fitted into the bottle mouth, and when the protector is in the half-stopper freeze-drying posture, Another locking means for engaging the outer peripheral edge of the lower surface of the portion to prevent the plug body from rising is provided on the lower side of the inner surface of the tubular portion, and a sealing means for opening or facilitating needle passage on the top wall is provided. At least half-stroke the protector, which has a closed needle-through window part and is fitted with a stopper that seals between the inner wall of the top wall and the upper surface of the bottle mouth, into the tube portion. It can be held in two positions: a freeze-drying position for the stopper and a sealing position for all stoppers. The protector is provided with an air vent for communicating the inside of the bottle container with the outside air in a state where the protector is fitted with a screw and the half-stopper freeze-drying posture is maintained with respect to the protector bottle mouth.

[0006]

With the locking means having the ridge structure or the screw structure, it is possible to prevent the protector from rising and falling during transport to the freeze-drying means and to ensure the sealing after freeze-drying. Lyophilization of the drug can be effectively performed by the communication means between the vent provided on the inner surface of the cylindrical body constituting the protector and the inside of the vial container. Since non-combustible metals such as aluminum are not used at all, the work of separating the materials is omitted in the waste incineration process.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, details of embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a vertical sectional front view showing a half-plug stopper freeze-drying posture of the first embodiment, FIG. 2 is a vertical sectional front view showing a full stopper plug sealing posture of the first embodiment, and FIG. 3 is a second embodiment. FIG. 4 is a vertical sectional front view showing a half-plug stopper freeze-drying posture, FIG. 4 is a vertical sectional front view showing a full stopper stopper sealing posture of the second embodiment, and FIG. 5 is an enlarged cross-sectional view of a main part of the second embodiment. ~ Fig. 8 is a sectional view of the protector, Fig. 9
Fig. 10 is a vertical sectional front view showing a half-stopper freeze-drying posture of the third embodiment, Fig. 10 is a vertical sectional front view showing a full-stopper sealing posture of the third embodiment, and Fig. 11 is a half-stopper of the fourth embodiment. FIG. 12 is a vertical sectional front view showing a stopper freeze-drying posture, FIG. 12 is a vertical sectional front view showing a full stopper sealing posture of the fourth embodiment, and FIGS. 13 to 15 are vertical sectional front views showing another embodiment of the protector. FIG. 19 is a sectional view showing still another embodiment of the protector.

The structure of the first embodiment will be described with reference to FIGS. 1 and 2. Reference numeral 11 shown in FIG. 1 is a protector made of a synthetic resin material, and a needle passing window portion 12 is provided in the central portion of the ceiling wall constituting the protector 11. Form and protector 11
A seal 13 for closing the needle passing window portion 12 is attached to the upper surface of the ceiling wall. On the surface of the sticker 13, a display (not shown) for identifying the drug name, content, etc. is printed. Further, as shown in FIG. 1, a plug body 15 made of rubber or a synthetic resin material integrally formed with a vent cutout 14 so as to abut against the inner surface of the ceiling wall is provided in the cylindrical portion constituting the protector 11. The flange portion 15b of the thickness a formed integrally with the plug body 15 by fitting is engaged with a small ridge 16 integrally formed on the peripheral surface of the tubular portion of the protector 11, and 15 is prevented from falling off. Further, on the inner peripheral surface of the cylindrical portion of the protector 11, two parallel protrusions 17 and 18 are integrally formed below the protrusion 16 at required intervals, and a vial bottle is provided between the protrusions 17 and 18. 19
By sandwiching the collar portion 19b formed on the bottle mouth 19a of the container, the half-stopper freeze-drying posture of the protector 11 is maintained as shown in FIG. Protector 1 like this
1 is in a half-stroke freeze-drying posture, a vial bottle 19 is provided in the protector tube portion between the ridges 16 and 17.
A ventilation port 20 is provided for communicating the inside of the container with the outside air. Further, the protrusions 18 in the lowermost stage prevent the protector 11 from rising and falling in conjunction with the lifting of the plug body 15, and the protrusions 17 in the next stage prevent inadvertent lowering of the protector 11. This is to ensure that the stopper freeze-drying posture can be maintained. The plug 1
5, the thickness a of the collar 15b and the distance b between the ridges 16 and 17
Is the sum of the inside of the top wall of the protector 11 and the next ridge 1
7 is slightly larger than the distance L from the upper edge. With this dimensional condition, as shown in FIG. 2, after the drug is freeze-dried, the top surface of the protector 11 is pressed by a top plate (not shown) provided in the freeze-drying chamber, and the stopper 15 is in the full stopper sealing posture, that is, the stopper. Body 1
Compress the collar 15b of No. 5 and bring it into close contact with the upper surface of the bottle mouth 19a,
This is intended to improve the sealing performance when both are sandwiched and supported between the top wall of the protector 11 and the ridge 17 of the next stage.

Next, the details of the second embodiment shown in FIGS. 3 and 4 will be described. In this embodiment, the plug 15 having the plug 15a shown in FIGS. 1 and 2 is used as the sheet packing 21. For the purpose of improving the sealing property, the sheet-like packing 21 has a bottle opening 19
It is also possible to use a plurality of ring-shaped seal projections 22 integrally formed on the peripheral upper and lower surfaces which abut on the peripheral upper surface of a. Further, instead of the seal protrusion 22, the bottle mouth 1
A plurality of ring-shaped seal projections (not shown) on the upper surface of 9a
Can be integrally formed. The other structure is the same as that of the embodiment shown in FIGS. 1 and 2 described above, and the detailed description is omitted by giving the same symbols to the same components.
The seal ridge 22 can also be applied to the embodiment shown in FIG.

FIGS. 6 to 8 show the protector 11 used in the first and second embodiments. Whether or not a plurality of laterally elliptical vent holes 20 are provided at equal intervals as shown in FIG. Alternatively, as shown in FIG.
A plurality of air vents 20 are provided at equal intervals, or a plurality of circular vents 20 are provided at equidistant intervals as shown in FIG. 8, and particularly if the total area of the vents 20 is within a range suitable for freeze-drying. ,
There is no particular focus on its shape or number.

The third embodiment shown in FIGS. 9 and 10 will be described in detail. In the embodiment shown in FIGS. 1 and 2 described above, the protector 11 is held in a freeze-dried posture in a half stoppered state and in a sealed posture in a fully stoppered state, and a plurality of ridges 17 formed on the inner surface of the protector 11, However, in this embodiment, the female screw 23b formed on the inner surface of the cylindrical portion of the protector 11 is screwed into the male screw 23a formed on the outer peripheral portion of the collar portion 19b of the bottle mouth 19a. Is. The same applies to the fourth embodiment shown in FIGS. 11 and 12. The same structural parts as those shown in FIGS. 1 and 3 are designated by the same reference numerals, and detailed description thereof will be omitted. still,
In the embodiment shown in FIGS. 1 and 3, a large number of protectors 11 can be displaced from the half-stopper freeze-drying position to the full-stopper sealing position by pressing the top plate provided in the freeze-drying chamber.
In the embodiment shown in FIGS. 10 and 12, the disk is pressed while the protector 11 is in contact with the disk (not shown) that is being driven by rotation, or the vial 19 is pushed up and brought into contact with the disk. The protector 11 is screwed and is displaced from the half-stopper freeze-drying posture to the full-stopper sealing posture.

13 to 15, details of another embodiment of the protector 11 will be described. In this embodiment, instead of the seal 13 shown in FIGS. 1, 3, and 9 described above, a seal film 24 that allows a thin syringe needle to easily penetrate the needle passage window portion 12 is formed.
As shown in FIG. 13, the seal film 24 is formed on the uppermost portion of the needle window portion 12 to flatten the upper surface of the protector 11, or as shown in FIG.
The seal film 24 may be provided at the bottom of the needle window portion 12, or as shown in FIG.
It is integrally formed in the middle part of 2. In order to facilitate breakage of the seal film 24, an easy opening means such as a scorer (not shown) is provided on the seal film 24 portion in contact with the peripheral edge of the needle passing window portion 12, and the seal film 24 is pressed with a fingertip. It is also possible to make it possible to break the score portion cleanly and easily.

Next, referring to FIG. 16 to FIG.
The details of another embodiment will be described. 16 and 17, a ventilation path 25 having a slit structure, the lower end of which communicates with the outside air, is formed on the entire circumference of the thick wall portion of the tubular portion that constitutes the protector 11.
Inner wall surface 11a of the cylindrical portion corresponding to the upper end of the air passage 25
In addition, a plurality of vent holes 20a are formed at appropriate intervals. Further, as shown in FIG. 18, a columnar reinforcing portion 26 for closing the ventilation passage 25 is provided between the ventilation openings 20a to prevent the deformation of the tubular portion due to the formation of the ring-shaped ventilation passage 25. is there. FIG. 19 shows that the ventilation passages 27 having a cylindrical structure are formed at appropriate intervals in the thick wall portion of the cylindrical portion.
On the inner wall surface 11a of the cylindrical portion corresponding to the upper end of the
Is provided. It is desirable that the upper limit of the air passages 25 and 27 be up to the portion corresponding to the protrusion 16 as shown in FIG. 16 in view of the strength of the protector tubular portion.

[0014]

As described above, according to the structure of the present invention, the following effects can be obtained. (A) With a simple structure, it is possible to secure the half-stopper freeze-drying posture and the full-stopper sealing posture of the protector, and it is possible to completely prevent the protector from rising and falling off during transportation to the freeze-drying warehouse, thus improving work processing efficiency. Can be improved. (B) Since the vial container is made of three materials of glass, synthetic resin, and rubber, the waste incineration process becomes extremely easy as compared with the conventional case. (C) Since the protector is made of a synthetic resin material as compared with the prior art that uses an aluminum protector, no waste is generated during retention in the hopper and the like, and the protector is easy to manage. (D) Aeration between the vial and the outside air during lyophilization can be completely ensured, and proper and uniform lyophilization can be performed.

[Brief description of drawings]

FIG. 1 is a vertical sectional front view showing a freeze-drying posture of a half stopper according to a first embodiment.

FIG. 2 is a vertical cross-sectional front view showing a fully stoppered sealing posture of the first embodiment.

FIG. 3 is a vertical sectional front view showing a half-stopper freeze-drying posture of the second embodiment.

FIG. 4 is a vertical cross-sectional front view showing a fully stoppered sealing posture according to a second embodiment.

FIG. 5 is an enlarged sectional view of a main part of the second embodiment.

FIG. 6 is a sectional view of a protector.

FIG. 7 is a sectional view of a protector.

FIG. 8 is a cross-sectional view of a protector.

FIG. 9 is a vertical sectional front view showing a freeze-drying posture of a half stopper according to a third embodiment.

FIG. 10 is a vertical cross-sectional front view showing a full stopper sealing posture according to a third embodiment.

FIG. 11 is a vertical sectional front view showing a freeze-drying posture of a half stopper according to a fourth embodiment.

FIG. 12 is a vertical cross-sectional front view showing a full stopper sealing posture according to a fourth embodiment.

FIG. 13 is a vertical sectional front view showing another embodiment of the protector.

FIG. 14 is a vertical sectional front view showing another embodiment of the protector.

FIG. 15 is a vertical sectional front view showing another embodiment of the protector.

FIG. 16 is a sectional view showing still another embodiment of the protector.

FIG. 17 is a sectional view showing still another embodiment of the protector.

FIG. 18 is a sectional view showing still another embodiment of the protector.

FIG. 19 is a sectional view showing still another embodiment of the protector.

FIG. 20 is an exploded vertical sectional front view of a conventional vial container.

[Explanation of symbols]

 11 protector 11a inner wall surface of cylinder 12 needle window 13 seal 14 ventilation notch 15 plug 15a plug 15b collar 16 ridge 17 ridge 18 ridge 19 vial 19a bottle mouth 19b collar 20 vent 20a vent 21 Sheet-like packing 22 Seal ridge 23a Male screw 23b Female screw 24 Seal film 25 Ventilation path 26 Reinforcement part 27 Ventilation path

Front page continuation (72) Hideo Miura Inventor Hideo Miura 2-7-12 Ginza, Chuo-ku, Tokyo Sankyo Co., Ltd.

Claims (7)

[Claims] 1. A needle passing window portion closed by an opening or a sealing means for facilitating needle passing is formed in a ceiling wall portion of a protector fitted to a bottle mouth of a bottle container, and the protector is provided in a cylindrical portion of the protector. A stopper that seals between the inner surface of the top wall and the upper surface of the bottle mouth is fitted, and the protector is placed in a half-stopper freeze-drying position by engaging the inner peripheral surface of the cylindrical portion with the outer peripheral end of the upper surface of the bottle mouth collar. Locking means is provided for holding and holding the two stopper postures of the stopper stopper by engaging with the outer peripheral edge of the lower surface of the bottle mouth collar portion, while the tubular portion of the protector in the half stopper stopper freeze-drying posture is provided. A vial container characterized in that a vent hole is provided for communicating the inside of the bottle container with the outside air. 2. The vial container according to claim 1, wherein the stopper has a thick sheet-like packing structure. 3. The stopper is integrally formed with a stopper having a vent cutout to be inserted and fitted into the bottle mouth, and when the protector is in the half-stopper freeze-drying position, the outer circumference of the lower surface of the bottle mouth flange is formed. 2. The vial container according to claim 1, wherein another locking means for engaging the end and preventing the stopper body from being lifted up is provided on the lower side of the inner surface of the cylindrical portion. 4. A needle passing window part closed by an opening or a sealing means for facilitating needle passing is formed in a ceiling wall part of a protector fitted to a bottle mouth of a bottle container, and the protector is provided in a cylindrical part of the protector. A stopper that seals between the inner surface of the top wall and the upper surface of the bottle mouth is fitted, and the protector is placed in a half-stopper freeze-drying position by engaging the inner peripheral surface of the cylindrical portion with the outer peripheral end of the upper surface of the bottle mouth collar. Locking means is provided for holding and holding the two stopper postures of the stopper stopper by engaging with the outer peripheral edge of the lower surface of the bottle mouth collar portion, while the tubular portion of the protector in the half stopper stopper freeze-drying posture is provided. An air passage whose lower end communicates with the outside air is formed in the thick wall portion of the tubular portion, and an air vent is provided on the inner wall surface of the tubular portion corresponding to the upper end of this air passage, and the half-stopper freeze-drying is performed through the air vent. The via is characterized in that the inside of the bottle container is made to communicate with the outside air when the user is in a posture. Le container. 5. The vial container according to claim 4, wherein the stopper has a thick sheet-like packing structure. 6. The stopper body is integrally formed with a stopper portion having a ventilation notch to be inserted and fitted into a bottle mouth, and when the protector is in the half-stopper freeze-drying position, the outer periphery of the lower surface of the bottle mouth collar portion. 5. The vial container according to claim 4, wherein another locking means for engaging the end and preventing the stopper body from being lifted up is provided on the lower side of the inner surface of the cylindrical portion. 7. A plug window that forms an opening or a needle passing window portion closed by a sealing means for facilitating needle passage on the top wall, and fits a plug body that seals between the inner surface of the top wall and the upper surface of the bottle mouth in the cylindrical portion. The protector that has been put on is screwed onto the bottle mouth of the bottle container so that it can hold at least two postures, that is, a half-stopper freeze-drying posture and a full-stopper sealing posture. A vial container characterized in that a vent hole for communicating the inside of the bottle container with the outside air is provided in the cylindrical portion of the protector while the stopper is kept in the freeze-drying posture.