JPH10101124A - Vial container - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a vial container at a low cost, which is extremely easily classified based on materials on disposing and incinerating treatment and which prevents the plug from floating up or dropping out during transportation and secures ventilation on freeze-drying. SOLUTION: In a vial container in which a vent means connecting the inside and outside of the bottle container 20 is provided between a synthetic resin protector 11 forming a needle insertion aperture 12 closed by a seal means 13 of opening or easily inserting needle and the bottle container 20 on which the protector is fitted, and a hermetically sealing plug 15 between the top wall of the protector 11 and the bottle mouth 20a is fitted at the inside face of the top wall of the protector, and a fixing means 18 retaining the fully plugged and hermetically sealed posture of the corresponding protector 11 after freeze- drying by fitting to the lower peripheral edge of the bottle mouth collar, at the inside face of the cylindrical part constituting the protector 11, the vent means comprises a vertical groove 17 formed at the cylinder inside face of the protector.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an improvement in a vial container.

[0002]

2. Description of the Related Art As shown in FIG. 29, a vial container generally known in the art generally includes an easy-to-break line 2 such as a score on an upper surface of a protector 1 made of an aluminum material.
Is formed, and an engaging protrusion 5 formed on the inner surface of a synthetic resin lid (hereinafter, referred to as a flip-off cap) 4 is fixed to the broken portion 3 by an eyelet structure.
A rubber stopper 6 having a ventilation notch 7 formed in a stopper part 6a is fitted into the protector 1, and the rubber stopper 6 is fitted into a vial 8a of the vial 8 in a floating manner. The medicine inside is freeze-dried. After freeze-drying, the rubber stopper 6 is completely sealed, and the skirt of the protector 1 is fastened by a winder. In use, as shown in the figure, the breaking portion 3 is broken through the flip-off cap 4, the exposed upper part of the rubber stopper 6 is sterilized, and a needle of a syringe is pierced into this portion to remove distilled water or the like. The liquid is injected into the vial 8 to dissolve the drug to be lyophilized, and the drug solution is poured into a syringe or the like for administration. The conventional vial container has the following problems. (A) The vial container is composed of four types of glass, aluminum, synthetic resin, and rubber material, and it is necessary to separate the respective materials at the time of waste incineration, which requires a lot of time and labor. (B) retaining the aluminum protector in the hopper,
In the process of inflating the protector on the vial via the feeder, aluminum chips may be generated during stagnation rolling in the hopper, and the aluminum chips may contaminate the flip-off cap. (C) During transportation to the freeze-drying device, there is a possibility that the rubber stopper rises and falls off. (D) Since the vial opening corresponding to the tightened portion of the aluminum protector is opaque, it is difficult to inspect the opening of the vial. (E) When the lid is removed to expose the fractured portion, a shearing portion of aluminum is formed around the fractured portion, and absorbent cotton for sterilization remains on the portion, which hinders sterilization of the exposed portion of the rubber stopper upper surface. You.

[0003] An object of the present invention is to provide a vial container in which separation by material is extremely easy at the time of waste incineration treatment, while there is no danger of floating or falling off of the plug during transportation, and ventilation during freeze-drying can be ensured. It is to provide at low cost.

[0004]

Means for Solving the Problems As means for solving the problems of the prior art, the vial container of the present invention employs the following means.

[0005] The object of the present invention is to provide a bottle container between a synthetic resin protector that forms an opening or a needle passage window closed by a sealing means that allows easy passage of needles on the top wall, and a bottle container to which the protector is fitted. A vent is provided to allow the inside and the outside of the protector to communicate with each other.On the other hand, a plug that seals between the top wall of the protector and the bottle opening is fitted on the inner surface of the top wall of the protector, and the inner surface of the cylinder that constitutes the protector is provided. In a vial container provided with a locking means that engages with the lower edge of the bottle mouth flange and retains the entire stopper sealing posture of the corresponding protector after freeze-drying, the venting means is provided on the inner surface of the cylindrical part of the protector. This is achieved by the configuration with the directional grooves.

The object of the present invention is to provide a bottle container between a synthetic resin protector in which an opening or a needle-passing window portion closed by a sealing means for easy passage of needles is formed in a top wall, and a bottle container to which the protector is fitted. A vent is provided to allow the inside and the outside of the protector to communicate with each other.On the other hand, a plug that seals between the top wall of the protector and the bottle opening is fitted on the inner surface of the top wall of the protector, and the inner surface of the cylinder that constitutes the protector is provided. In a vial container provided with a locking means that engages with the lower edge of the bottle mouth flange and retains the entire stopper sealing posture of the corresponding protector after freeze-drying, the ventilation means is provided in the vertical direction of the outer circumference of the bottle mouth flange. This is achieved by having a ventilation groove or a cut-off surface penetrating through.

[0007] The object of the present invention is to provide a bottle container between a synthetic resin protector which forms an opening or a needle passage window closed by a sealing means for easy needle passage in a top wall, and a bottle container to which the protector is fitted. A vent is provided to allow the inside and the outside of the protector to communicate with each other.On the other hand, a plug that seals between the top wall of the protector and the bottle opening is fitted on the inner surface of the top wall of the protector, and the inner surface of the cylinder that constitutes the protector is provided. In a vial container provided with locking means that engages with the lower edge of the bottle mouth flange and retains the entire stopper sealing posture of the corresponding protector after freeze-drying, the ventilation means is provided with an outer end on the outer periphery of the bottle mouth collar. This is achieved by forming at least three projections in contact with the inner surface of the protector at appropriate intervals.

[0008] The object of the present invention is to provide a vial container according to any one of claims 1 to 3, wherein the half-stopper freezing of the protector is engaged with the inner surface of the cylindrical portion constituting the protector, at the lower edge of the bottle mouth flange. This is achieved by providing locking means for maintaining the drying posture.

[0009] The object of the present invention is to provide a bottle container between a synthetic resin protector that forms an opening or a needle passage window closed by a sealing means that allows easy passage of needles in a top wall, and a bottle container to which the protector is fitted. A vent is provided to allow the inside and the outside of the protector to communicate with each other.On the other hand, a plug that seals between the top wall of the protector and the bottle opening is fitted on the inner surface of the top wall of the protector, and the inner surface of the cylinder that constitutes the protector is provided. In a vial container provided with locking means for engaging the lower edge of the bottle mouth flange to maintain the entire stopper sealing posture of the corresponding protector after freeze-drying, the bottle mouth flange is provided on the inner surface of the cylindrical portion constituting the protector. Along with the locking means for engaging the lower peripheral edge of the part and holding the half-plug freeze-drying posture of the protector, and the ventilation means,
Locking means for forming the outer diameter of the bottle mouth flange smaller than the inner diameter of the cylindrical part of the protector, and for holding the half-stopper freeze-drying posture of the protector, and locking means for holding the entire stopper-sealing posture of the protector Can be attained by constructing each having an intermittent structure.

[0010]

With the locking means having the ridge structure, it is possible to prevent the protector corresponding to the middle of the transportation to the freeze-drying means from rising and falling off, and to secure the seal after the freeze-drying. Freeze-drying of the drug can be effectively performed by means of the communication between the groove provided on the inner surface of the cylindrical body constituting the protector or the protrusion, groove, or notch provided on the outer peripheral portion of the bottle mouth and the inside of the vial container. Since non-combustible metals such as aluminum are not used at all, material separation work is omitted in waste incineration.

[0011]

Next, details of an embodiment of the present invention will be described with reference to the drawings. FIGS. 1, 2 and 5 show the first embodiment, FIGS. 3, 4 and 5 show the second embodiment, FIGS. 6 to 9 show another embodiment of the protector, and FIGS. In the third embodiment,
13 and 14 show the fourth embodiment, and FIGS. 15 to 17 show the fifth embodiment.
18 and 19 show the sixth embodiment, FIGS. 20 to 22 show the seventh embodiment, and FIGS. 23 and 24 show the eighth embodiment.
25 and 26 show the ninth embodiment, and FIGS. 27 and 28 show the first embodiment.
0 shows an example.

The first embodiment shown in FIGS. 1 and 2 will be described in detail. 11 is a protector made of synthetic resin,
A needle passing window 12 is formed at the center of the top wall of the protector 11, and a seal 13 for closing the needle passing window 12 is attached to an upper surface of the top wall of the protector 11. On the surface of the seal 13, a display (not shown) for identifying a medicine name, a content and the like is printed. A plug 15 made of a rubber or synthetic resin material integrally formed with a plug portion 15a provided with a ventilation notch 14 so as to contact the inner surface of the top wall of the protector 11 is fitted therein.
The periphery of the lower part of the collar 15b formed in the protector 1
1 and is engaged with a small ridge 16 integrally formed on the inner surface thereof, and the thickness of the flange 15b is a. In the figure, reference numeral 17 denotes a ventilation groove formed on the inner surface of the protector 11. Also,
On the inner surface of the protector 11, two parallel ridges 18, 19 are integrally formed at appropriate intervals below the ridges 16, and between the ridges 18, 19, a bottle opening 20a of a vial bottle 20 is formed. By interposing and sandwiching the flange portion 20b formed in the portion, the protector 11 is maintained in the freeze-dried posture as shown in FIG. That is, the lower end of the plug portion 15a of the plug 15 slightly intervenes in the bottle opening 20a in a half-plugged state, and the ventilation groove 17 provided in the protector 11 and the ventilation notch 14 provided in the plug portion 15a of the plug 15 are electrically connected. In state. The lowermost ridge 19 prevents the protector 11 from rising and falling, and the next ridge 18 prevents the protector 11 from lowering inadvertently, so that the freeze-drying posture is reliably maintained. It is.
The interval b between the ridge 16 and the ridge 18 is substantially the same as the outer peripheral thickness of the flange 20b of the bottle opening 20a. The collar 1 of the plug 15
The sum of the thickness a of 5b and the distance b between the ridges 16 and 18 is slightly larger than the distance L between the inner surface of the top wall of the protector 11 and the upper edge of the next ridge 18. According to these dimensional conditions, as shown in FIG. 2, after freeze-drying the medicine, the upper surface of the protector 11 is pressed by a top plate (not shown) provided in the freeze-drying chamber, and the stopper 15 is placed in a sealed posture, that is, the flange of the stopper 15. 15b is compressed and brought into close contact with the upper surface of the bottle opening 20a to improve the sealing performance when both are sandwiched and supported between the top wall of the protector 11 and the next ridge 18. As shown in FIG. 2 and FIG.
b It is also possible to intervene in the step 21 formed on the outer periphery of the upper surface.

Next, the second embodiment shown in FIGS. 3 to 5 will be described in detail. In this embodiment, the plug 15 having the plug 15a shown in FIG. 1 and FIG. For the purpose of further improving the sealing property, the sheet-like packing 22 is
A plurality of ring-shaped sealing projections 23 may be integrally formed on the lower surface of the peripheral edge that abuts on the upper surface of the periphery. Instead of the seal ridge 23, a plurality of ring-shaped seal ridges 24 can be integrally formed on the upper surface of the bottle opening 20a as shown by a virtual line in FIG. The other configuration is the same as that of the embodiment shown in FIGS. 1 and 2 described above, and the detailed description is omitted by attaching the same reference numerals to the same components. The seal ridges 23 and 24 can be applied to the embodiment shown in FIG.

Referring to FIGS. 6 to 9, the protector 11
Another embodiment will be described in detail. In this embodiment, instead of the seal 13 shown in FIGS. 1 and 3 described above, a thin seal film 25 for easily piercing a thin syringe needle is formed integrally with the needle passing window portion 12, as shown in FIG. As shown in FIG. 8, the seal film 25 is formed at the uppermost portion of the needle window portion 12 to make the upper surface of the protector 11 flat, or as shown in FIG. Alternatively, as shown in FIG. 9, the seal film 25 is formed integrally with the intermediate portion of the needle window 12. In order to facilitate the breakage of the seal film 25, an easy opening means such as a score (not shown) is provided on the seal film 25 in contact with the periphery of the needle passing window portion 12, and the seal film 25 is pressed with a fingertip. It is also possible to cleanly and easily break the score part.

The details of the third to seventh embodiments will be described with reference to FIGS. These embodiments correspond to the first and second embodiments described above.
In the embodiment, the ventilation means is provided on the outer periphery of the vial of the vial while the ventilation means is provided on the protector. FIGS. 10 to 12 show a third embodiment. As shown in FIG. 10, at least three projections 28 are integrally formed on the outer periphery of the flange 20b of the bottle opening 20a, and as shown in FIG. The cylindrical portion 1 of the protector 11 is
The protector 11 is fitted to the bottle opening 20a so that the inner surface of the bottle 1a contacts the bottle opening 20a.
The flange 20b of FIG. The protector 11
A plurality of ventilation gaps 29 corresponding to the thickness of the projections 28 are formed between the surface of the cylindrical portion 11a and the outer peripheral surface of the flange portion 20b, so that the inside of the vial 20 communicates with the outside. The posture is maintained. After freeze-drying, as shown in FIG. 12, the vent gap 29 is sealed by the stopper 15 by completely stoppering the protector 11, and the flange 20b is closed.
The projection 15 engages with the lower surface of the plug 15 and the protector 11.
Are kept in a sealed position.

In the fourth embodiment shown in FIGS. 13 and 14, the plug 15 having the plug portion 15a of the third embodiment is replaced by a sheet-like packing 22, and the other structure is the same as that of the third embodiment. Therefore, detailed description is omitted. However, in the case of the sheet-like packing 22, since there is no floating phenomenon of the plug itself, the ridge 19 for maintaining the freeze-drying posture is not particularly required as shown by the imaginary line.

The fifth embodiment shown in FIGS.
As shown in FIG. 5, a ventilation groove 30 penetrating vertically is provided on the outer periphery of the flange portion 20b of the bottle opening 20a. Then, as shown in FIG. 16, the stopper portion 15 a of the stopper 15 is half-plugged with respect to the bottle opening 20 a of the vial bottle 20, and the lower ridge 19 provided on the cylindrical portion 11 a of the protector 11 is connected to the bottle opening 20 a. The freeze-drying posture engaged with the lower surface of the flange 20b is maintained, and the inside of the vial
It communicates with the outside through 0. After freeze-drying, as shown in FIG. 17, the vent groove 30 is sealed by the stopper 15 by completely stoppering the protector 11,
The ridge 18 is engaged with the lower surface of the flange portion 20b to hold the stopper 15 and the protector 11 in a sealed posture.

In the sixth embodiment shown in FIGS. 18 and 19, the plug 15 having the plug portion 15a of the fifth embodiment is replaced by a sheet-like packing 22, and the other structure is the same as that of the fifth embodiment. Therefore, detailed description is omitted. However, in the case of the sheet-shaped packing 22, since the floating phenomenon of the plug itself does not occur, the ridge 19 for maintaining the freeze-drying posture does not need to be particularly provided unlike the virtual plug.

FIGS. 20 to 22 show a seventh embodiment. In this embodiment, as shown in FIG. 20, a cut-off surface 31 obtained by cutting the flange portion 20b in the vertical direction is provided at a symmetrical portion of the flange portion 20b of the bottle mouth 20a, and as shown in FIG. Plug the stopper 15a into the vial 20a of the vial 20
And the lower ridge 19 provided on the inner surface of the cylindrical portion 11a of the protector 11 is held in a freeze-drying posture in which the lower ridge 19 is engaged with the lower surface of the flange portion 20b, and the inside of the vial bottle 20 is cut off. It communicates with the outside through a ventilation gap 32 formed between the drop surface 31 and the inner surface of the cylindrical portion 11a. After freeze-drying, as shown in FIG.
The protrusion 18 engages with the lower surface of the flange portion 20b to hold the stopper 15 and the protector 11 in a sealed posture.

FIGS. 23 and 24 show an eighth embodiment. In this embodiment, the stopper 15 having the stopper 15a shown in the seventh embodiment is replaced with a sheet-like packing 22, and other structures are shown. Are the same as those in the seventh embodiment, and a detailed description thereof will be omitted. However, when the sheet-like packing 22 is used, since the floating phenomenon of the plug itself does not occur, the ridge 19 for maintaining the freeze-drying posture is not particularly required as shown by a virtual line.

In the ninth embodiment shown in FIGS. 25 and 26, the outer diameter of the vial 20a of the vial 20,
The outer diameter of b is formed smaller than the inner diameter of the cylindrical portion 11a of the protector 11, and a ventilation gap 33 corresponding to the difference in diameter between the outer periphery of the flange portion 20b and the inner surface of the cylindrical portion 11a is formed. . In this embodiment, as shown in FIG. 25, the stopper 15 is half-plugged into the vial 20a of the vial 20 of the stopper 15a, and the lower ridge 19 provided on the inner surface of the cylindrical portion 11a of the protector 11 is fitted with the flange. The freeze-drying posture engaged with the lower surface of the portion 20b is maintained. At this time, since the ventilation gap 33 may be closed by the ridge 19, this ridge 1
Reference numeral 9 denotes an intermittent structure having a ventilation portion 34. The ridge 18 has the same structure. After freeze-drying, FIG.
As shown in (1), by completely plugging the protector 11, the ventilation gap 33 is sealed by the plug 15, the ridge 18 is engaged with the lower surface of the flange portion 20b, and the plug 15 and the protector 11 are held in a sealed posture. .

The tenth embodiment shown in FIGS. 27 and 28 uses a sheet-like packing 22 in place of the plug 15 having the plug portion 15a shown in the ninth embodiment. Therefore, detailed description is omitted. However, when this sheet-like packing 22 is used, since the floating phenomenon of the plug itself does not occur, the ridge 19 for maintaining the freeze-drying posture is not particularly required as shown by the imaginary line.

[0023]

According to the configuration of the present invention as described above,
The following effects can be obtained. (A) With a simple configuration, the freeze-drying posture and the sealing posture of the protector can be ensured, and the protector can be completely prevented from floating and falling off during transportation to the freeze-drying cabinet, thereby improving work processing efficiency. (B) Since the vial container is made of three materials of glass, synthetic resin, and rubber, the waste incineration becomes extremely easy as compared with the conventional case. (C) Since the protector is made of a synthetic resin material as compared with the conventional technology using an aluminum protector, there is no generation of debris while staying in a hopper or the like, and the management of the protector is easy. (D) Ventilation between the vial and the outside air during freeze-drying can be completely ensured, and freeze-drying can be performed accurately and uniformly.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view of a freeze-drying posture in a first embodiment using a stopper having a stopper as a projection and a stopper.

FIG. 2 is a cross-sectional view of the embodiment shown in FIG. 1 in a sealed position.

FIG. 3 is a sectional view of a freeze-drying posture in a second embodiment in which a locking means of the protector is a projection and a sheet-like packing is used.

4 is a cross-sectional view of the embodiment shown in FIG. 3 in a sealed position.

FIG. 5 is an enlarged sectional view of a main part.

FIG. 6 is a partially cutaway perspective view of an embodiment in which the needle passage window is closed by a seal means that is easy to open and integrated with the protector, and the ventilation means has a groove structure.

FIG. 7 is a cross-sectional view showing another example of the protector provided on the upper part of the needle window portion of the sealing means shown in FIG.

FIG. 8 is a cross-sectional view showing another example of a protector provided at a lower part of a needle window portion of the sealing means shown in FIG.

9 is a cross-sectional view showing another example of a protector provided at an intermediate portion of a needle window portion of the sealing means shown in FIG.

FIG. 10 is a plan view showing a third embodiment in which ventilation means is formed in a bottle mouth.

FIG. 11 is a sectional view showing a freeze-drying posture of the embodiment using a stopper having a stopper portion.

FIG. 12 is a cross-sectional view showing the sealing posture of FIG.

FIG. 13 is a sectional view showing a freeze-drying posture of a fourth embodiment using a sheet-like packing.

FIG. 14 is a cross-sectional view showing the sealing posture of FIG.

FIG. 15 is a plan view of a fifth embodiment in which ventilation means is formed in a bottle opening.

FIG. 16 is a sectional view showing a freeze-drying posture of the embodiment using a stopper having a stopper portion.

FIG. 17 is a cross-sectional view showing the sealing posture of FIG.

FIG. 18 is a sectional view showing a freeze-drying posture of a sixth embodiment using a sheet-like packing.

FIG. 19 is a cross-sectional view showing the sealing posture of FIG.

FIG. 20 is a plan view of a seventh embodiment in which ventilation means is formed in a bottle opening.

FIG. 21 is a sectional view showing a freeze-drying posture of the embodiment using a stopper having a stopper portion.

FIG. 22 is a cross-sectional view showing the sealing posture of FIG.

FIG. 23 is a sectional view showing a freeze-drying posture of an eighth embodiment using a sheet packing.

FIG. 24 is a cross-sectional view showing the sealing posture of FIG.

FIG. 25 is a cross-sectional view of a freeze-drying posture using a stopper having a stopper according to a ninth embodiment in which the difference between the outer diameter of the bottle opening and the inner diameter of the protector cylinder is used as the ventilation means.

FIG. 26 is a cross-sectional view showing the sealing posture of FIG.

FIG. 27 is a sectional view showing a freeze-drying posture of a tenth embodiment using a sheet packing.

FIG. 28 is a cross-sectional view showing the sealing posture of FIG. 27.

FIG. 29 is an exploded vertical sectional front view of a conventional vial container.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 11 Protector 12 Penetration window part 13 Seal 14 Vent notch 15 Plug 15a Plug part 15b Flange 16 Ridge 17 Vent groove 18 Ridge 19 Ridge 20 Vial bottle 20a Bottle opening 20b Flange part 21 Step part 22 Sheet packing 23 Seal Ridge 24 seal ridge 25 seal film 28 protrusion 29 ventilation gap 30 ventilation groove 31 cut-off surface 32 ventilation gap 33 ventilation gap 34 ventilation section

 ────────────────────────────────────────────────── ─── Continued on the front page (72) Inventor Kenji Araki 2-7-12 Ginza, Chuo-ku, Tokyo Inside Sankyo Co., Ltd.

Claims (5)

[Claims] An inside of a bottle container is provided between a synthetic resin protector that forms an opening or a needle passage window closed by a sealing means for easy passage of needles on a top wall, and a bottle container to which the protector is fitted. Provide ventilation means to communicate with the outside,
On the other hand, a plug that seals between the top wall and the bottle mouth is fitted on the inner surface of the top wall of the protector, and the inner surface of the cylinder that constitutes the protector engages with the lower edge of the bottle mouth flange to freeze. In a vial container provided with locking means for holding the entire stopper sealing position of the corresponding protector after drying, the vial means is constituted by a vertical groove provided on the inner surface of the cylindrical portion of the protector. . 2. The interior of a bottle container between a synthetic resin protector that forms an opening or a needle passage window closed by a sealing means that allows easy passage of needles on a top wall, and a bottle container to which the protector is fitted. Provide ventilation means to communicate with the outside,
On the other hand, a plug that seals between the top wall and the bottle mouth is fitted on the inner surface of the top wall of the protector, and the inner surface of the cylinder that constitutes the protector engages with the lower edge of the bottle mouth flange to freeze. In a vial container provided with locking means for maintaining the entire stopper sealing posture of the corresponding protector after drying, the ventilation means is constituted by a ventilation groove or a cut-off surface which penetrates in the vertical direction on the outer periphery of the flange of the bottle mouth. A vial container, characterized in that: 3. The interior of a bottle container between a synthetic resin protector that forms an opening or a needle passage window closed by a sealing means that allows easy passage of needles on a top wall, and a bottle container to which the protector is fitted. Provide ventilation means to communicate with the outside,
On the other hand, a plug that seals between the top wall and the bottle mouth is fitted on the inner surface of the top wall of the protector, and the inner surface of the cylinder that constitutes the protector engages with the lower edge of the bottle mouth flange to freeze. In a vial container provided with locking means for maintaining the entire stopper sealing position of the corresponding protector after drying, the ventilation means is provided with at least three protrusions whose outer end is in contact with the inner surface of the protector on the outer periphery of the bottle mouth flange. A vial container formed integrally at intervals. 4. The vial container according to claim 1, wherein:
A vial container provided with a locking means which engages with a lower peripheral edge of a bottle mouth flange to maintain a half stoppered freeze-drying posture of the protector. 5. The interior of a bottle container between a synthetic resin protector that forms an opening or a needle passing window portion closed by a sealing means for easy needle passing in a top wall, and a bottle container to which the protector is fitted. Provide ventilation means to communicate with the outside,
On the other hand, a plug that seals between the top wall and the bottle mouth is fitted on the inner surface of the top wall of the protector, and the inner surface of the cylinder that constitutes the protector engages with the lower edge of the bottle mouth flange to freeze. In a vial container provided with locking means for maintaining the entire stopper sealing position of the corresponding protector after drying, the protector is half-pressed by engaging the lower edge of the bottle mouth flange with the inner periphery of the cylindrical portion constituting the protector. A locking means for holding the stopper freeze-drying position is provided, and the ventilation means is formed such that the outer diameter of the bottle mouth flange is smaller than the inner diameter of the protector cylinder, and the protector holds the stopper half-plug freeze-drying posture. A vial container characterized in that the stopper means and the locking means for holding the stopper in a completely stoppered sealing position are each provided with an intermittent structure.