JP3054009B2 - plaster - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a new plaster. More specifically, the present invention relates to a plaster using a polyester elastomer as a substrate.

[0002]

2. Description of the Prior Art Conventionally, plasters have been produced by applying an adhesive, a chemical or the like to a substrate having low elasticity such as woven fabric or paper. However, in recent years, attempts have been made to use a stretchable sheet as a base material so as to follow the expansion and contraction of the human body, to reduce the thickness, and to block the smell of drugs. A series elastomer is used.

However, these base cloths do not yet have sufficient odor blocking properties, and additives such as plasticizers and stabilizers are extracted from the base cloth and come into contact with the skin together with the drug or are originally known as toxic substances. There is a risk that the used vinyl chloride monomer, isocyanates and the like may be extracted by the used chemicals and adhesives.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a plaster using a base cloth which is free from toxic substances, has good barrier properties to odors, and is soft and has little bleeding out of a plasticizer or the like. is there.

[0005]

The inventor of the present invention has conducted various studies to find a method for solving such a problem. As a result, when a polyester / polyester block copolymer is used, a flexible sheet containing no harmful substances as described above is used. This was found to be excellent in odor blocking properties, and the present invention was achieved.

That is, the present invention provides a hard segment mainly composed of terephthalic acid and tetramethylene glycol, and a polyester mainly composed of an aliphatic polyester and / or an aromatic dicarboxylic acid and a glycol having 5 or more carbon atoms. Is a plaster obtained by applying an adhesive and a drug to one surface of a sheet made of a polyester / ester block copolymer comprising a soft segment. In particular, the polyester / polyester block copolymer is composed of a hard segment mainly composed of terephthalic acid and tetramethylene glycol, and a soft segment mainly composed of aromatic dicarboxylic acid and glycol having 5 or more carbon atoms. Ester block copolymers are preferred because they have good odor blocking properties and the like.

A hard segment mainly comprising terephthalic acid and tetramethylene glycol and a soft segment mainly comprising an aliphatic polyester and / or a polyester comprising an aromatic dicarboxylic acid and a glycol having 5 or more carbon atoms. Specifically, the polyester / ester block copolymer is as follows.

[0008] As the aliphatic polyester, a carbon number of 6 to
Polyesters obtained from aliphatic dicarboxylic acids of 12 and aliphatic diols having 2 to 12 carbon atoms, polyesters obtained from oxycarboxylic acid derivatives such as ε-caprolactone, and aromatic dicarboxylic acids and carbon atoms. Polyester containing a glycol having a number of 5 or more as a main component is an aromatic dicarboxylic acid, a dicarboxylic acid other than a glycol having a carbon number of 5 or more, 50 mol% of a diol,
Preferably, polyesters which may be copolymerized in an amount of less than 40 mol% are mentioned. The soft segment is preferably amorphous or low crystalline and has a melting point of 50 ° C. or less. This is necessary because it is flexible when attached to the human body. As the aromatic dicarboxylic acid used here, for example, those in which the carboxyl group such as isophthalic acid and phthalic acid are not located at the point-symmetric position of the aromatic ring are preferably used, and those having a side chain as the diol are used. Is not necessarily particular about this.

[0009] On the other hand, the hard segment comprising terephthalic acid and tetramethylene glycol may contain less than 40 mol% of other dicarboxylic acids other than terephthalic acid or less than 40 mol% of glycols other than tetramethylene glycol. It is.

The ratio of the hard segment to the soft segment is 20:80 to 50:50, preferably 3
0:70 to 40:60. If the content of the hard segment component is larger than this, flexibility becomes insufficient when the sheet is formed, and it becomes difficult to obtain a flexible poultice which is the object of the present invention.

[0011] Such a block copolymer is prepared by melt-mixing a polyester constituting a soft segment produced by a method similar to a usual polyester polymerization method and a polyester constituting a hard segment produced similarly. Then, it is produced by a method of blocking, a method of adding a lactone in a molten state to a polyester composed of terephthalic acid and tetramethylene glycol and performing transesterification simultaneously with ring-opening polymerization, but is not limited to this method. Absent.

This block copolymer has an intrinsic viscosity (35
℃, measured in orthochlorophenol) is 0.8 or more,
Preferably it is 1.0 or more.

In the present invention, the block copolymer needs to be formed into a sheet. This sheeting can be formed by a usual melt extrusion molding method. In other words, a die capable of being melt-extruded into a sheet shape such as a T-die or an I-die is attached to the tip of the extruder, and the molten block copolymer is extruded onto a cooling drum, release paper, or another release film, and cooled and solidified. You can use the method to make it.

The cooling temperature is preferably changed depending on the purpose. If a sheet having good transparency is desired, the cooling temperature is preferably set low, for example, 30 ° C. or lower, preferably 20 ° C. or lower.

On the other hand, when it is desired to form a sheet having low adhesiveness, the cooling temperature is preferably set to be higher, for example, 50 ° C.
As described above, 60 to 100 ° C. is preferably used.

The sheet thus obtained has a thickness of 5 to 5
The thickness may be set to 00 μm, preferably 10 to 200 μm. The reason for this is that a thicker one is stiff and requires too much force to expand and contract, and a thinner one causes a decrease in mechanical strength and makes handling difficult.

This sheet is often sticky,
Further, when the sheet becomes thin, handling may become difficult, and in many cases, it is preferable to use release paper or the like. The release paper is not particularly limited, and for example, paper to which a release agent such as polyethylene or silicone is applied to paper is used. However, since it is an application that comes into contact with the human body, it is of course not preferable to use harmful substances such as toxic substances.

In the present invention, such a sheet is coated with an adhesive and a chemical to form a plaster. Examples of the adhesive include rosin esters and polyacrylates. Examples of the drug include menthol, salicylic acid ester, nonylvanillylamide, and the like, but are not particularly limited thereto.

It is well known that the sheet provided with the pressure-sensitive adhesive or the medicine is put on a release paper or the like on the surface of the pressure-sensitive adhesive and put in a bag for preventing volatilization of the drug or the like and sold. In addition, the plaster of the present invention is not particularly limited to these storage methods, and a generally used method is employed as it is.

[0020]

By implementing the present invention, it is possible to obtain effects such as flexibility and good recoverability and less odor due to permeation of the drug, as compared with the conventionally used plaster. Also, in terms of safety, without containing toxic substances such as vinyl chloride monomer and isocyanate,
Even if it does not contain a phenol-based or amine-based stabilizer, it does not deteriorate, so that there are many advantages such as a small amount of additives.

[0021]

The present invention will be described below in detail with reference to examples. In this example, “parts” means “parts by weight”.

[Example 1] Dimethyl isophthalate 175
Part, 23 parts of dimethyl sebacate and 140 parts of hexamethylene glycol are subjected to a transesterification reaction with a titanium tetrabutoxide catalyst, followed by polycondensation under reduced pressure to give an intrinsic viscosity of 1.0.
6 was obtained. To this polyester, a polybutylene terephthalate chip having an intrinsic viscosity of 0.98, obtained by separately performing polycondensation, was dried, and 107 parts were added.
After further reacting at 250 ° C. for 55 minutes,
The reaction was stopped by adding 5 parts. This block polyester was taken out and made into chips to be used as raw materials. The melting point of this chip was 205 ° C. and the intrinsic viscosity was 1.01.

The chip thus obtained was extruded into a sheet at 240 ° C. by an extruder equipped with a T-die and cooled by a cooling drum cooled to 10 ° C. to obtain a sheet having a thickness of 100 μm.
On one side of this sheet, rosin ester 20 g / m ² , l
Menthol 5 g / m ² , glycol salicylate 5 g /
The mixture was applied at a rate of m ² , and a silicone release paper was layered thereon and wound.

The sheet is cut to a width of 1 cm, and 50% per minute.
The elastic recovery measured at an elongation of 100% at the same pulling speed and immediately returned at the same speed was 88%.

This sheet was stuck on an aluminum foil, and the aluminum foil was bent so as to suppress the leakage of the odor from the edge and left at room temperature for 24 hours. Then, the perception of the odor was increased without informing 20 persons of the content. As a result of the examination, 18 persons answered that they did not smell at all (evaluation 5) and two persons smelled slightly (evaluation 4). For comparison, a commercially available Salon Pas-High (manufactured by Hisamitsu Pharmaceutical Co., Ltd.) was similarly affixed and examined, and as a result, all of them were evaluated to be quite odorous (evaluation 2). (Evaluation 1: Odor on the adhesive side of Salon Pas-High, Evaluation 5: No odor) Regarding safety, there is essentially no heavy metal other than titanium and phosphorus, and no phenols as a stabilizer. As a result of performing a heat resistance test on only the base sheet, 15
Degradation test in air at 0 ° C for 200 hours is 50
%, Indicating that no stabilizer was required.

[Examples 2 to 3] In Example 1, dimethyl isophthalate, dimethyl sebacate and hexamethylene glycol were used in place of the starting materials shown in the table.
Example 1 was repeated using a block copolymer produced in the same manner as in Example 1.
A cataplasm was prepared in the same manner as described above. The test results are as shown in Table 1.

[0027]

[Table 1]

Comparative Example 1 Dimethyl terephthalate 34
Parts, tetramethylene glycol 31 parts, average molecular weight 15
In the same manner as in Example 1, a poultice was prepared by polymerizing 62 parts of polytetramethylene glycol of Example 00 with a titanium tetrabutoxide catalyst and adding 0.5 part of hydroxydibutyltoluene as a stabilizer. As a result of requesting a sensory test for odor to 20 persons in the same manner as in Example 1,
11 smells (evaluation 3), 9 smells (evaluation 4)
People.

Claims (2)

(57) [Claims] 1. A hard segment containing terephthalic acid and tetramethylene glycol as main components, an aliphatic polyester and / or an aromatic dicarboxylic acid, and a carbon number of 5
A polyester comprising a soft segment containing a polyester comprising the above glycol as a main component.
A plaster obtained by applying an adhesive and a drug to one surface of a sheet made of an ester block copolymer. 2. A polyester / polyester block copolymer comprising: a hard segment mainly composed of terephthalic acid and tetramethylene glycol; and a soft segment mainly composed of aromatic dicarboxylic acid and a glycol having 5 or more carbon atoms. The plaster according to claim 1, which is a polyester / ester block copolymer consisting of: