JP2002294044A - Substrate film for patch and patch comprising the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a substrate film for a patch and a patch not negatively affecting the natural environment. SOLUTION: This substrate film for a patch comprises a biodegradable aliphatic/aromatic copolyester.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a base material film for a patch and a patch, and more particularly, to a natural environment even if it is discarded or buried or incinerated after use. The present invention relates to a base material film for a patch, which does not adversely affect the adhesive, and can be used for a patch and a plaster.

[0002]

2. Description of the Related Art Conventionally, a polyvinyl chloride (hereinafter referred to as PVC) film or the like has been used as a base film for a patch. The adhesive material is usually one in which an adhesive layer is provided on one surface of a base film, and is applied to the skin surface to be applied via the adhesive layer. However, since a large amount of a plasticizer is blended into a PVC film for the purpose of imparting flexibility, the plasticizer bleeds out to the film surface to cause poor adhesion between the film and the pressure-sensitive adhesive layer. In some cases, the adhesive strength decreased due to migration, and the flexibility decreased at low temperatures in some cases. Further, a substrate film containing no chlorine atom is desired from the viewpoint of environmental problems.

In order to solve the problem, Japanese Patent Application Laid-Open No. 9-1
JP-A-87498 discloses a rescue bandage film comprising a copolymer of styrene and a diene-based hydrocarbon, ethylene-propylene rubber and other polyolefin-based resin, and JP-A-11-206869 discloses an ethylene-acetic acid. A base material for a patch made of a vinyl copolymer is disclosed.

[0004] However, the above-mentioned base film does not biodegrade or hydrolyze in a natural environment or has a very low decomposition rate, so that it may remain in the soil when buried after use. If discarded, it may damage the landscape or destroy the living environment of living things. In addition, even if incinerated, there is a problem that toxic gas is generated or the incinerator is deteriorated.

Therefore, Japanese Patent Application Laid-Open No. Hei 10-182442 discloses a skin patch using a stretched polylactic acid film as a coating liner. It is described that it is preferable to employ a degradable aliphatic polyester-based film.

[0006] Polylactic acid-based polymers are biodegradable, transparent,
It has excellent properties such as heat resistance, rigidity and cost, and has been actively developed for various uses. However, due to its molecular structure, it also has so-called hard and brittle properties such as high rigidity, low flex resistance, low impact resistance, etc., in fields where flexibility and elongation are required. There was a desire for improvement.

[0007]

DISCLOSURE OF THE INVENTION The present invention relates to a sticking material having flexibility and elongation that does not adversely affect the natural environment even after being discarded or buried or incinerated after use. An object of the present invention is to provide a base film and a patch comprising the same.

[0008]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that a base film for a patch contains an aliphatic / aromatic copolymer polyester having biodegradability. The inventors have found that the above problems can be solved by using a film, and have reached the present invention. That is, the gist of the present invention is as follows. (1) A base film for a patch containing a biodegradable aliphatic / aromatic copolymerized polyester. (2) The base material film for a patch according to the above (1), which comprises a polylactic acid-based polymer. (3) An adhesive material comprising a pressure-sensitive adhesive layer formed on one surface of the adhesive substrate film according to any one of (1) and (2).

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail. The aliphatic / aromatic copolymer polyester used in the present invention may be any polyester having an aliphatic component and an aromatic component and having biodegradability. Examples of the aliphatic / aromatic copolyester include hydroxycarboxylic acids such as lactic acid, glycolic acid, hydroxybutyric acid, and hydroxycaproic acid, caprolactone, butyrolactone,
Lactides, cyclic lactones such as glycolide, ethylene glycol, butanediol, cyclohexanedimethanol, bis-hydroxymethylbenzene, diols such as toluenediol, succinic acid, adipic acid, suberic acid, sebacic acid, terephthalic acid, isophthalic acid, Copolymers containing dicarboxylic acids such as naphthalenedicarboxylic acid, cyclic anhydrides, oxiranes, and the like, and having an aliphatic component and an aromatic component, include ethylene glycol, butanediol, succinic acid, adipic acid, and sebacine. Copolymers containing an acid, terephthalic acid and isophthalic acid as components are preferred. In addition, a urethane bond, an amide bond, an ether bond, or the like can be introduced into these as long as the biodegradability is not affected.

In the present invention, the aliphatic / aromatic copolymer polyester may contain a polylactic acid-based polymer. As a polylactic acid-based polymer, as long as it has a polylactic acid or a lactic acid component as a main component, polylactic acid, lactic acid or lactide and other hydroxycarboxylic acids,
Dicarboxylic acid, diol, copolymer with cyclic lactone,
Blends may be mentioned. A urethane bond, an amide bond, an ether bond, and the like can be introduced into these to the extent that biodegradability is not affected.

The method for polymerizing the aliphatic / aromatic copolymerized polyester or the polylactic acid polymer is not particularly limited, and examples thereof include a condensation polymerization method and a ring-opening polymerization method. Also,
At the time of or immediately after the polymerization, a method in which one or more kinds of other components such as another polymer, a monomer, and an oligomer component are added to further proceed the polymerization is also possible.

The polymer used in the present invention may be in any stage of polymerization, but for the purpose of increasing the molecular weight,
It is also possible to add small amounts of chain extenders, such as diisocyanate compounds, epoxy compounds, acid anhydrides and the like.

The polymer used in the present invention may contain additives such as plasticizers, lubricants, inorganic fillers, ultraviolet absorbers, etc. for the purpose of adjusting the physical properties and processability of the film within a range not to impair the effects of the present invention. It is also possible to add a bulking agent or another polymer material.

The plasticizer is not particularly limited, but is preferably one having excellent compatibility with the polymer. Specifically, an aliphatic polycarboxylic acid ester derivative, an aliphatic polyhydric alcohol ester derivative, an aliphatic oxyester, and the like. Single or plural mixtures selected from acid ester derivatives, aliphatic polyether derivatives, aliphatic polyether polycarboxylic acid ester derivatives, and the like. As aliphatic polycarboxylic acid ester derivatives, dimethyl adipate, dibutyl adipate, diisobutyl adipate, etc., as aliphatic polyhydric alcohol ester derivatives, triethylene glycol diacetate, polypropylene glycol dibutyrate, etc., as aliphatic oxyacid ester derivatives Are aliphatic polyether derivatives such as methyl acetyl ricinoleate and acetyl tributyl citric acid, and aliphatic polyether derivatives such as polyethylene glycol, polypropylene glycol, copolymerized polyalkylene glycol such as ethylene glycol and butylene glycol, etc. Derivatives include dimethyl diglycol succinate, dibutyl diglycol adipate and the like.

The lubricant is not particularly limited, but is preferably an aliphatic carboxylic acid amide. Examples of such an aliphatic carboxylic acid amide include stearic acid amide, oleic acid amide, erucic acid amide, and behenic acid amide.

The inorganic filler is not particularly limited, but is preferably a natural or synthetic silicate compound, titanium oxide, barium sulfate, calcium phosphate, calcium carbonate, sodium phosphate and the like. Examples of the silicate compound include layered silicates such as kaolinite, halloysite, talc, smectite, vermiculite, and mica. These layered silicates may be swellable or non-swellable, and may be surface-treated.

The thickness of the substrate film of the present invention is preferably from 10 to 300 μm. If it is less than 10 μm, the strength at the time of use is insufficient, and if it exceeds 300 μm, it lacks flexibility,
The texture is not good. Especially practical thickness is 15 ~
100 μm.

The method for producing the substrate film of the present invention is not particularly limited, and examples thereof include a usual T-die method and an inflation method. These films may be substantially unstretched or may be stretched uniaxially or biaxially. Further, if necessary, the heat treatment may be performed by using an arbitrary technique such as a hot air method or a hot roll method. Further, surface treatment such as corona treatment, sandblasting, embossing, or the like may be performed.

The base film of the present invention may be a laminate,
The method of laminating is not particularly limited, but a method of laminating and co-extruding in a die or an earlier feed block after melting with a plurality of extruders, a method of coating an unwound film, a method of rolling a plurality of films Or a method of thermocompression bonding with a press machine or the like, or bonding using an adhesive. The adhesive is not particularly limited, but preferably has biodegradability.

The substrate film of the present invention may be porous or non-porous. Also, for the purpose of increasing moisture permeability,
A moisture permeable hole may be formed by a method using a hot pin, a laser beam, or the like. In addition, the step of forming these moisture-permeable holes may be performed in a state of the base film alone, or may be performed after performing an adhesion process.

An adhesive material can be prepared by forming an adhesive layer on one surface of the substrate film of the present invention. The pressure-sensitive adhesive layer to be formed has a thickness of 10 to 100 μm, preferably 20 to 80 μm from the viewpoint of skin adhesion. The pressure-sensitive adhesive used in the present invention is not particularly limited, as long as it can be used as a medical pressure-sensitive adhesive with little skin irritation. Specific examples include acrylic adhesives, natural rubber adhesives, synthetic rubber adhesives, silicone adhesives, vinyl ether adhesives, starch adhesives, and mixtures thereof. Among them, those having biodegradability are preferable.

The method for applying the pressure-sensitive adhesive to the substrate film is not particularly limited, but includes a method of directly applying the pressure-sensitive adhesive to the substrate, a method of applying the pressure-sensitive adhesive to release paper, and then transferring the pressure-sensitive adhesive to the substrate. Is mentioned. The pressure-sensitive adhesive may be applied to the entire surface of the base film or may be pattern-coated without being applied to the entire surface. The pressure-sensitive adhesive surface is preferably protected by a release sheet or the like until use, in order to prevent contamination, drying, deterioration and the like.

The base material film for a patch of the present invention can be used as a dressing or a wrapper, or can be used as a skin patch by applying an external medicine containing various medicinal ingredients.
A pad for protecting a wound portion, such as a cloth such as gauze or a sponge pad, may be provided in a part of the adhesive layer to be used as a bandage. As the pad to be used, a cellulose-based absorbent, a polyester-based absorbent, or the like is preferable, but any pad having water absorbency may be used, and the pad is not limited thereto. Preferably, a pad having biodegradability is good.

In this way, a base material film for a patch and a patch comprising the same, which do not adversely affect the natural environment even when discarded, buried or incinerated, are subjected to disposal treatment.

[0025]

Next, the present invention will be described in detail with reference to Examples, but it should not be construed that the invention is limited thereto. The evaluation method in the present invention is as follows. 1. Biodegradability evaluation Using a base film with a width of 250 mm and a length of 500 mm,
The composting process was performed at a water content of 65% and a temperature of 80 ° C. The state of the film after 5 days was visually observed. A sample with little change was marked with X, a sample with 50% or more disappearance was marked with △, and a sample with completely disappeared was marked with ○. 2. Tensile elongation A base film was cut out to a width of 10 mm and a length of 100 mm, and measured according to ASTM-D882.

Example 1 Aliphatic / aromatic copolymerized polyester (BASF: E
coflex F), melted at 180 ° C., extruded from an inflation film forming machine having a die diameter of 100 mm, and folded at a take-up speed of 20 m / min.
m, a base film having a thickness of 50 μm was obtained. The biodegradability and elongation of the obtained base film were measured and are shown in Table 1.

Example 2 Polylactic acid (Cargill Dow Polymer Co., Ltd .: D-form = 3.
7%) 70% by mass, aliphatic / aromatic copolymerized polyester (Eastman Chemical Company)
Manufactured by EASTER BIO GP Copies
ter) A composition comprising 30% by mass was melted at 180 ° C. and extruded from a T-die to obtain a base film having a thickness of 50 μm. Table 1 shows the properties of the obtained base film.

Example 3 Polylactic acid (manufactured by Cargill Dow Polymer Co., Ltd .: D-form = 1.
(0%) 30% by mass and a composition comprising 70% by mass of an aliphatic / aromatic copolymerized polyester (manufactured by BASF: Ecoflex F) were melted at 210 ° C to obtain a base film in the same manner as in Example 2. Table 1 shows the properties of the obtained base film.

Example 4 Polylactic acid (manufactured by Cargill Dow Polymer: D-form = 1)
%): Composition 7 consisting of an aliphatic / aromatic copolymerized polyester (Ecoflex F, manufactured by BASF) 5 = 1: 1
Using a composition consisting of 0% by mass, 15% by mass of acetyltributyl citric acid (manufactured by Sanken Kako Co., Ltd .: ATBC) and 15% by mass of talc, the composition was melted at 210 ° C., and the die diameter was 100 mm.
Extruded from an inflation film forming machine at a take-up speed of 2
Folding diameter 350mm, thickness 50μm under the condition of 0m / min
Was obtained. Table 1 shows the properties of the obtained base film.

Comparative Example 1 Polylactic acid (Cargill Dow Polymer Co., Ltd .: D-form = 3.
7%) to obtain a film in the same manner as in Example 2. Table 1 shows the properties of the obtained base film.

Comparative Examples 2-3 The characteristics of a film made of a soft vinyl chloride resin having a thickness of 50 μm and an ethylene-vinyl acetate copolymer are shown in Table 1.

[0032]

[Table 1]

Using the base films obtained in Examples 1 to 4, a patch was prepared. That is, a natural rubber-based pressure-sensitive adhesive having a solid concentration of 30% by mass was coated on a release paper with a thickness of 40 μm.
After drying and drying, the pressure-sensitive adhesive layer was adhered to one side of the base film, transferred and laminated, thereby producing a patch. There was no practical problem with the obtained patch.

[0034]

According to the present invention, it is possible to obtain a base material film for a patch and a patch comprising the same, which do not adversely affect the natural environment even when discarded or buried or incinerated. In particular, a base material film for a patch containing an aliphatic / aromatic copolymerized polyester has flexibility and is suitable as a base material for a patch or a plaster.

Continued on front page F term (reference) 4C081 AA03 BB09 CA161 CC01 4F071 AA43 AF21 AH06 BB09 BC01 4J002 CF03W CF18W CF18X CF19W GG00 4J004 AA04 AA05 AA08 AA10 AA11 AB01 CA06 CC02 CC03 CC07 FA08 FA09

Claims (3)

[Claims] 1. A base film for a patch, comprising an aliphatic / aromatic copolymer polyester having biodegradability. 2. The adhesive base film according to claim 1, further comprising a polylactic acid-based polymer. 3. A patch comprising a pressure-sensitive adhesive layer formed on one surface of the substrate film for a patch according to claim 1.