JP3047179B1 - Skin cosmetics - Google Patents
Skin cosmeticsInfo
- Publication number
- JP3047179B1 JP3047179B1 JP11074197A JP7419799A JP3047179B1 JP 3047179 B1 JP3047179 B1 JP 3047179B1 JP 11074197 A JP11074197 A JP 11074197A JP 7419799 A JP7419799 A JP 7419799A JP 3047179 B1 JP3047179 B1 JP 3047179B1
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- skin
- ceramide
- maltose
- effect
- cosmetic
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Abstract
【要約】
【課題】アトピー性皮膚炎の肌の状態を整え、アトピー
症状の改善あるいは予防効果を有する優れた皮膚化粧料
を提供する。
【解決手段】セラミド及び糖セラミドから選ばれる一種
または二種とマルトース・ショ糖縮合物を配合してなる
皮膚化粧料。The present invention provides an excellent skin cosmetic which has a skin condition of atopic dermatitis, and has an effect of improving or preventing atopic symptoms. A skin cosmetic comprising one or two selected from ceramide and sugar ceramide and a maltose / sucrose condensate.
Description
【０００１】[0001]
【発明の属する技術分野】この発明は優れた保湿効果、
荒れ肌改善効果、かゆみ防止効果、皮膚状態改善効果を
持つことにより、アトピー性皮膚炎症状に対する改善効
果を持つ皮膚化粧料に関するものである。TECHNICAL FIELD The present invention provides an excellent moisturizing effect,
The present invention relates to a skin cosmetic having an effect of improving rough skin, an effect of preventing itching, and an effect of improving skin condition, thereby improving an atopic dermatitis condition.
【０００２】[0002]
【従来の技術】環境の変化や食生活の変化に伴いアトピ
ー性皮膚炎はますます増加し、深刻化している。アトピ
ー性皮膚炎の原因については未だ明らかにされていない
が、その症状として肌の乾燥、炎症、かゆみなどが挙げ
られ、かゆみによる掻き壊し、黄色ブドウ球菌などの病
原菌が患部に繁殖することが肌の状態をさらに悪くする
ことが知られている。医学的な治療としては対処的なス
テロイド剤の投与や抗ヒスタミン剤の投与であるが、そ
れらの副作用の面でも問題があった。2. Description of the Related Art Atopic dermatitis is increasing and becoming more serious with changes in the environment and changes in eating habits. Although the cause of atopic dermatitis has not yet been elucidated, its symptoms include dryness, inflammation, and itching of the skin. Is known to make the condition worse. Medical treatment includes the administration of steroids and antihistamines which are coping, but there are also problems in terms of their side effects.
【０００３】一方、セラミドや糖セラミドは角質層の細
胞間脂質を整え、皮膚の水分蒸散を抑え、皮膚のバリヤ
機能を高める作用を有していることは知られており、化
粧料などに使用されている（特開昭６１−２６０００８
号公報、特開昭６２−５６４１４号公報）。[0003] On the other hand, ceramide and sugar ceramide are known to have the effect of regulating intercellular lipids in the stratum corneum, suppressing the evaporation of water from the skin, and enhancing the barrier function of the skin. (JP-A-61-260008)
JP, JP-A-62-56414).
【０００４】[0004]
【発明が解決しようとする課題】しかし、セラミドや糖
セラミドを単独で配合してなる化粧料を皮膚に適用して
も、水分保持機能は高まるが、アトピー症状を改善する
効果は充分でなかった。また、マルトース・ショ糖縮合
物は有益な皮膚の常在菌により選択的に消化され、特異
的に繁殖させることにより、皮膚の常在菌をコントロー
ルし、黄色ブドウ球菌等の病原菌の繁殖を抑えるなど、
菌叢を整える作用があることは知られているが、単独で
配合してもアトピー症状を充分に改善するには至らなか
った。However, even when a cosmetic comprising ceramide or sugar ceramide alone is applied to the skin, the water retention function is enhanced, but the effect of improving atopic symptoms is not sufficient. . In addition, the maltose-sucrose condensate is selectively digested by beneficial resident bacteria of the skin, and controls the resident bacteria of the skin by suppressing the proliferation of pathogenic bacteria such as Staphylococcus aureus by specifically breeding. Such,
Although it is known to have an action of regulating the microflora, even if used alone, it did not sufficiently improve the atopic symptoms.
【０００５】また、これらを組み合わせて使用すると角
質層の水分保持機能やバリヤ機能が高まり、かゆみを発
生する原因である黄色ブドウ球菌の繁殖を抑えることに
より、肌の乾燥やかゆみ、肌荒れなどのアトピー性皮膚
炎の肌状態に対して著しい改善効果や予防効果を有する
ことは全く知られていなかった。[0005] Further, when these are used in combination, the water retention function and barrier function of the stratum corneum are enhanced, and the growth of Staphylococcus aureus, which causes itching, is suppressed. It was not known at all that it had a remarkable improvement or prevention effect on the skin condition of atopic dermatitis.
【０００６】この発明は、アトピー性皮膚炎の肌の状態
を整え、アトピー症状の改善あるいは予防効果を有する
優れた皮膚化粧料を提供することを目的としたものであ
る。SUMMARY OF THE INVENTION An object of the present invention is to provide an excellent skin cosmetic which has a skin condition of atopic dermatitis and has an effect of improving or preventing atopic symptoms.
【０００７】[0007]
【課題を解決するための手段】そこでこの発明者らはこ
うした課題に鑑み、鋭意研究を重ねた結果、セラミド及
び糖セラミドから選ばれる一種または二種とマルトース
・ショ糖縮合物を組み合わせて配合してなる皮膚化粧料
に、安全性が高く、水分保持力を高め、皮膚常在菌をコ
ントロールすることにより、アトピー性皮膚炎症状を持
つ肌の状態を整え、乾燥やかゆみなどの症状を改善ある
いは予防する効果を見出し、この発明を完成するに至っ
た。Means for Solving the Problems In view of these problems, the present inventors have conducted intensive studies and, as a result, have combined maltose / sucrose condensate with one or two selected from ceramide and sugar ceramide. A skin cosmetic that is highly safe, enhances water retention, controls skin resident bacteria, improves the condition of skin with atopic dermatitis, and improves symptoms such as dryness and itching. The present inventors have found the effect of prevention and completed the present invention.
【０００８】すなわち、この発明は、安全性が高く、ア
トピー肌の症状の改善あるいは予防効果の優れた皮膚化
粧料であり、セラミド及び糖セラミドから選ばれる一種
または二種と、マルトース・ショ糖縮合物を組み合わせ
て配合する、皮膚化粧料とした。[0008] That is, the present invention is a skin cosmetic which is highly safe and has an excellent effect of improving or preventing symptoms of atopic skin, and comprising one or two kinds selected from ceramide and sugar ceramide, and a maltose-sucrose condensate. It was made into a skin cosmetic, which was prepared by combining substances.
【０００９】[0009]
【発明の実施の形態例】以下、この発明について詳細に
説明する。この発明に用いられるセラミドは、例えば、
牛、馬等の哺乳動物の組織より抽出されるものや、米糠
から得られる植物由来のもの、または化学合成により得
られるもの等がある。また、糖セラミドはグルコセラミ
ド、ガラクトシルセラミドなどであり、例えば、牛、馬
等の哺乳動物の組織より抽出されるものや、米糠から得
られる植物由来のもの、または化学合成により得られる
もの等がある。DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail. Ceramide used in the present invention, for example,
Examples include those extracted from the tissues of mammals such as cows and horses, those derived from plants obtained from rice bran, and those obtained by chemical synthesis. In addition, sugar ceramide is glucoceramide, galactosylceramide and the like, for example, those extracted from mammalian tissues such as cows and horses, those derived from plants obtained from rice bran, those obtained by chemical synthesis, and the like. is there.
【００１０】マルトース・ショ糖縮合物は天然の糖であ
るマルトース及びショ糖から、固定化酵素法により得ら
れた縮合物であり、その構造は（Ｏ−α−Ｄ−ｇｌｕｃ
ｏｐｙｒａｎｏｓｙｌ−（１→２））−（Ｏ−α−Ｄ−
ｇｌｕｃｏｐｙｒａｎｏｓｙｌ−（１→６））−（Ｏ−
α−Ｄ−ｇｌｕｃｏｐｙｒａｎｏｓｙｌ−（１→４））
−（Ｏ−α−Ｄ−ｇｌｕｃｏｐｙｒａｎｏｓｅ）であ
る。マルトース・ショ糖縮合物として、例えばバイオエ
コリア（日光ケミカル社製）等が好適である。The maltose-sucrose condensate is a condensate obtained from the natural sugars maltose and sucrose by an immobilized enzyme method, and has a structure of (O-α-D-gluc).
opyranosyl- (1 → 2))-(O-α-D-
glucopyranosyl- (1 → 6))-(O-
α-D-glucopyranosyl- (1 → 4))
-(O-α-D-glucopyranose). As the maltose-sucrose condensate, for example, Bioecoria (manufactured by Nikko Chemical Co., Ltd.) is suitable.
【００１１】この発明に用いられるセラミド及び糖セラ
ミドの配合量は皮膚化粧料の総量を基準として０．００
１〜５．０重量％、より好ましくは０．０１〜２．０重
量％であり、マルトース・ショ糖縮合物の配合量は皮膚
化粧料の総量を基準として０．００１〜５．０重量％、
より好ましく０．０１〜２．０重量％である。また、セ
ラミド又は糖セラミドとマルトース・ショ糖縮合物の配
合比率として、セラミド又は糖セラミド／マルトース・
ショ糖縮合物がショ糖縮合物が０．００１〜１０．０が
好ましい。この範囲でセラミドまたは糖セラミドとマル
トース・ショ糖縮合物を組み合わせて配合した皮膚化粧
量はこの発明の目的とする効果が得られる。The amount of ceramide and sugar ceramide used in the present invention is 0.00 based on the total amount of skin cosmetic.
1 to 5.0% by weight, more preferably 0.01 to 2.0% by weight, and the amount of the maltose / sucrose condensate is 0.001 to 5.0% by weight based on the total amount of the skin cosmetic. ,
It is more preferably 0.01 to 2.0% by weight. The mixing ratio of ceramide or sugar ceramide and maltose / sucrose condensate is ceramide or sugar ceramide / maltose.
The sucrose condensate is preferably 0.001 to 10.0. Within this range, a skin cosmetic composition containing a combination of ceramide or sugar ceramide and a maltose / sucrose condensate can achieve the effects intended by the present invention.
【００１２】この発明の皮膚化粧料は例えば洗顔料類、
ローション類、乳液類、クリーム類、パック類等に適用
することができる。尚、この発明の皮膚化粧料には上記
の他に色素、香料、防腐剤、界面活性剤、植物抽出液、
顔料、抗酸化剤等をこの発明の目的を達成する範囲内で
適宜配合することができる。The skin cosmetics of the present invention include, for example, facial cleansers,
It can be applied to lotions, emulsions, creams, packs and the like. In addition, in addition to the above, the skin cosmetic of the present invention includes pigments, fragrances, preservatives, surfactants, plant extracts,
Pigments, antioxidants and the like can be appropriately compounded within a range that achieves the object of the present invention.
【００１３】[0013]
【実施例】以下、実施例及び比較例に基づいてこの発明
を詳説する。また、この発明に使用した荒れ肌改善効果
試験、官能テストは以下の通りである。The present invention will be described below in detail with reference to examples and comparative examples. The rough skin improvement effect test and sensory test used in the present invention are as follows.
【００１４】［荒れ肌改善効果試験］下脚部に荒れ肌を
有する中高年被験者１０名を対象に４週間連続塗布し、
その効果を評価した。すなわち、被験者の左側下脚外側
試験部位に１日１回、約０．５ｇの試料を塗布し、試験
開始前および試験終了後の皮膚の状態を表１の判定基準
により判定した。右側下脚部は試料を塗布せずに対照と
した。[Rough Skin Improving Effect Test] Apply to 10 middle-aged and elderly subjects having rough skin on lower leg for 4 weeks continuously.
The effect was evaluated. That is, about 0.5 g of a sample was applied once a day to the test site on the left lower leg outside of the test subject, and the skin condition before the start of the test and after the test was determined according to the criteria shown in Table 1. The right lower leg was used as a control without applying the sample.
【００１５】[0015]
【表１】 [Table 1]
【００１６】試験前後の試験部位と対照部位の判定結果
を比較し、皮膚乾燥度が２段階以上改善された場合（例
えば＋→−、＋＋→±）を有効、１段階改善された場合
をやや有効、変化がなかった場合を無効とした。試験結
果は有効、やや有効となった被験者の人数で示した。By comparing the judgment results of the test site and the control site before and after the test, it is effective if the degree of dryness of the skin is improved by two or more stages (for example, + → −, ++ → ±), and if the skin dryness is improved by one stage, Valid, no change if not. The test results were indicated by the number of subjects who were effective or slightly effective.
【００１７】［官能テスト（アトピー肌改善効果）］ア
トピー性皮膚炎による肌の乾燥、かゆみ等を訴える女子
被験者（１６〜３０才）２０人に試料を１日２回（朝・
夕）連続４週間塗布して４週間後の効果を評価した。試
験結果は、皮膚のカサカサ感、つっぱり感、かゆみの各
項目に対して、カサカサ感が改善した、皮膚が滑らかに
なった、かゆみが改善したと回答した人数で示した。[Sensory test (effect of improving atopic skin)] Twenty female subjects (16-30 years old) complaining of dryness and itching of skin due to atopic dermatitis twice a day (morning and morning)
Evening) Application was performed for 4 consecutive weeks, and the effect after 4 weeks was evaluated. The test results were expressed by the number of persons who answered that the feeling of dryness was improved, the skin became smoother, and the itching was improved for each item of the feeling of dryness, firmness, and itching of the skin.
【００１８】［比較例１〜４及び実施例１〜１２］表２
記載の組成の化粧液、比較例１〜４及び実施例１〜１２
をそれぞれ常法に従って調製し、前記諸試験を実施し、
結果を表３に記載する。Comparative Examples 1-4 and Examples 1-12 Table 2
Cosmetic liquid of the described composition, Comparative Examples 1 to 4 and Examples 1 to 12
Is prepared according to a conventional method, and the above-described tests are performed.
The results are shown in Table 3.
【００１９】[0019]
【表２】 [Table 2]
【００２０】[0020]
【表３】 [Table 3]
【００２１】結果から基本となる比較例１の化粧液及び
比較例１の化粧液にセラミドまたは糖セラミドとマルト
ース・ショ糖縮合物をそれぞれ単独に配合した化粧液、
比較例２及び比較例３及び比較例４に比べ、セラミドと
マルトース・ショ糖縮合物を組み合わせて配合した化粧
液、実施例１、実施例２、実施例３、実施例４、及び比
較例１の化粧液に糖セラミドとマルトース・ショ糖縮合
物を組み合わせて配合した化粧液、実施例５、実施例
６、実施例７、実施例８が荒れ肌改善効果、アトピー肌
改善効果ともに高いことが示された。また、セラミド及
び糖セラミドとマルトース・ショ糖縮合物を組み合わせ
て配合した化粧液、実施例９、実施例１０、実施例１
１、実施例１２に同様の効果が得られた。From the results, the basic cosmetic liquid of Comparative Example 1 and the cosmetic liquid of Comparative Example 1 in which ceramide or sugar ceramide and maltose / sucrose condensate were individually blended,
Compared with Comparative Example 2, Comparative Example 3, and Comparative Example 4, a cosmetic solution containing a combination of ceramide and a maltose-sucrose condensate, Example 1, Example 2, Example 3, Example 4, and Comparative Example 1 Example 5, Example 6, Example 7, Example 8, and Example 8 in which sugar ceramide and maltose / sucrose condensate were combined with the cosmetic solution of Example 1 showed that both the rough skin improving effect and the atopic skin improving effect were high. Was done. Further, a cosmetic solution containing a combination of ceramide and sugar ceramide and a maltose / sucrose condensate, Examples 9, 10, and 1
1. Similar effects were obtained in Example 12.
【００２２】［比較例５〜８及び実施例１３〜２４］表
４記載の組成のクリーム、比較例５〜８及び実施例１３
〜２４をそれぞれ常法に従って調製し、前記諸試験を実
施し、結果を表５に記載する。[Comparative Examples 5 to 8 and Examples 13 to 24] Creams having the compositions shown in Table 4, Comparative Examples 5 to 8 and Example 13
To 24 were prepared according to a conventional method, and the above tests were carried out. The results are shown in Table 5.
【００２３】[0023]
【表４】 [Table 4]
【００２４】[0024]
【表５】 [Table 5]
【００２５】結果から基本となる比較例５のクリーム及
び比較例５のクリームにセラミド又は糖セラミドとマル
トース・ショ糖縮合物をそれぞれ単独に配合したクリー
ム、比較例６、比較例７、比較例８に比べ、セラミドと
マルトース・ショ糖縮合物を組み合わせて配合したクリ
ーム、実施例１３、実施例１４、実施例１５、実施例１
６、及び糖セラミドとマルトース・ショ糖縮合物を組み
合わせて配合したクリーム、実施例１７、実施例１８、
実施例１９、実施例２０が荒れ肌改善効果、アトピー肌
改善効果ともに高いことが示された。また、セラミド及
び糖セラミドとマルトース・ショ糖縮合物を組み合わせ
て配合したクリーム、実施例２１、実施例２２、実施例
２３、実施例２４に同様の効果が得られた。Based on the results, the creams of Comparative Example 5 and the cream of Comparative Example 5 were prepared by blending ceramide or sugar ceramide and a condensate of maltose and sucrose alone, respectively. Comparative Examples 6, 6, and 8 Cream containing a combination of ceramide and maltose / sucrose condensate, as compared to Example 13, Example 14, Example 14, Example 15, and Example 1
6, and a cream containing a combination of sugar ceramide and maltose / sucrose condensate, Example 17, Example 18,
It was shown that Example 19 and Example 20 had high both the rough skin improving effect and the atopic skin improving effect. In addition, similar effects were obtained in creams prepared by combining ceramide and sugar ceramide with a maltose / sucrose condensate, Examples 21, 22, 23 and 24.
【００２６】[0026]
【発明の効果】以上記載のごとく、この発明は、荒れ肌
改善効果、アトピー肌改善効果の優れた皮膚化粧料を提
供することができる。As described above, the present invention can provide a skin cosmetic excellent in improving rough skin and atopic skin.
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 平８−294395（ＪＰ，Ａ) 特開 平６−219935（ＪＰ，Ａ) 特開 昭61−271205（ＪＰ，Ａ) 特表 平４−502492（ＪＰ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/00 - 7/50 ＣＡＰＬＵＳ（ＳＴＮ) ＲＥＧＩＳＴＲＹ（ＳＴＮ)──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-8-294395 (JP, A) JP-A-6-219935 (JP, A) JP-A-61-271205 (JP, A) 502492 (JP, A) (58) Fields investigated (Int. Cl. 7 , DB name) A61K 7/ 00-7/50 CAPLUS (STN) REGISTRY (STN)
Claims (1)
種または二種とマルトース・ショ糖縮合物を配合してな
ることを特徴とする、皮膚化粧料。1. A skin cosmetic comprising one or two selected from ceramide and sugar ceramide and maltose / sucrose condensate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11074197A JP3047179B1 (en) | 1999-03-18 | 1999-03-18 | Skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11074197A JP3047179B1 (en) | 1999-03-18 | 1999-03-18 | Skin cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP3047179B1 true JP3047179B1 (en) | 2000-05-29 |
| JP2000264832A JP2000264832A (en) | 2000-09-26 |
Family
ID=13540229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11074197A Expired - Lifetime JP3047179B1 (en) | 1999-03-18 | 1999-03-18 | Skin cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3047179B1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4509517B2 (en) * | 2002-09-19 | 2010-07-21 | ロート製薬株式会社 | Agent that inhibits Staphylococcus aureus skin adhesion and promotes Staphylococcus epidermidis skin adhesion |
| JP5465444B2 (en) * | 2008-02-18 | 2014-04-09 | ライオン株式会社 | Itching inhibitor and itch inhibiting composition |
| JP5793307B2 (en) * | 2011-01-12 | 2015-10-14 | 花王株式会社 | Hand sanitizer composition |
| JP5900956B2 (en) * | 2012-03-13 | 2016-04-06 | 株式会社ツツミプランニング | Method for producing gel-like cleaning material |
| JP2014205634A (en) * | 2013-04-12 | 2014-10-30 | ニチモウ株式会社 | External preparation for skin |
-
1999
- 1999-03-18 JP JP11074197A patent/JP3047179B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000264832A (en) | 2000-09-26 |
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