JP2994594B2 - Health food for constipation - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a health food which is effective in alleviating constipation by utilizing crude drugs without side effects.

[0002]

2. Description of the Prior Art Constipation refers to a condition in which a person has not been bowed for more than 3 to 4 days, and treatment becomes necessary when he / she suffers from unpleasant symptoms such as a stomach swelling or abdominal pain. Laxatives resolve this constipation, and can be broadly classified into two types, irritative laxatives and mechanical laxatives, depending on the way of action. Irritant laxatives have the effect of stimulating intestinal mucosa, activating intestinal motility and promoting defecation, and include large bowel irritants and small bowel irritants. In general, irritating laxatives are strongly irritating and have a great effect, but have a drawback that they become ineffective unless the dose is increased if they continue to be used, and that they tend to become dependent on medicine (dependency). Mechanical laxatives act on intestinal contents (feces) to collect water, swell and swell, and stimulate irritation by stimulation. There is a disadvantage that requires. Disadvantages are also disadvantageous, as are irritating laxatives. In addition, irritating laxatives tend to cause symptoms such as abdominal pain, nausea / vomiting, and wheezing, and mechanical laxatives may cause thirst, nausea, abdominal pain, abdominal bloating, and ringing. In addition, there are occasions when irritability symptoms occur, and it is necessary to take precautions for use such that it is necessary to immediately stop taking the drug and consult a doctor. Conventional laxatives, including irritative laxatives and mechanical laxatives, must be used in accordance with the instructions of a physician or pharmacist, and the amount and period of use must be accurately maintained due to the above-mentioned drawbacks.

[0003]

The conventional laxative has a sharp effect and its self-control is difficult. Also, if you continue to use it, it will not work unless you increase the amount, and it became easy to become a bowel habit that relied on drugs. In addition to the hypersensitivity symptoms, there was a high risk of causing various side effects accompanying changes in gastrointestinal symptoms. These drawbacks are considered to be due to the strong pharmacological effect of the drug and the limited site of action. Therefore, the applicant has a prescription combining two or more types of crude drugs which have a mild pharmacological action, the action site is not limited, and exerts an effect on two or more action sites, and the above-mentioned disadvantages of conventional constipation drugs Is to be solved.

[0004]

In order to solve the above-mentioned drawbacks, as a result of various experiments and examinations using Chinese herbal medicines, folklore medicines, etc., it was concluded that the combined prescription of Tulna and plum is most suitable for constipation. I got the conclusion. The crane is New Zealand
nd Spinach, scientific name Tetragon-iaex
pansa Murr, aka Hamajisha, Hamana,
It is also a perennial beach plant called Hamaakaza. Minerals such as calcium, iron and potassium and vitamins A, B ₁ ,
It contains a large amount of B ₂ , C and the like, and its nutritional value is said to be equal to or higher than spinach. A dried and dried plum meat or a dried plum meat is cut or pulverized to an appropriate size. Plum is a fruit of the family Rosaceae, and has the highest nutrient content among fruits. It is noted that calcium, phosphorus, iron content and protein are very high. Umeboshi made from plums is a favorite product unique to Japan and is a representative of health foods.It has antipyretic and analgesic effects, and it has a lot of organic acids such as citric acid, succinic acid, malic acid and tartaric acid, so it has a refreshing feeling and appetite. It promotes the secretion of saliva and gastric juice. The dried material of Tulna whole plant and dried plum meat as above are usually decocted in the same weight ratio in a pot, etc., and the decoction is drunk. It is convenient to pack them in a cloth bag or paper bag which is convenient for hot water bathing, and the mixing ratio of the two dried products is not limited to 1: 1. Good.

[0005] Next, a concentrated extract is prepared from the dried whole cruciferous plant in accordance with the general rules of preparation (extract) of the Japanese Pharmacopoeia,
A concentrated extract is similarly produced for plum meat or dried plum meat. Drinking water such as purified water is added as an excipient to the mixture of the two concentrated extracts in an appropriate amount, and the mixture is swallowed, or an appropriate excipient and a binder are added to form a tablet or granule, and the mixture is drunk. Down. As described above, the present invention provides a method for cutting or pulverizing dried whole tuna plants and dried plum meat and mixing and mixing them, and then directly boiling them in water or drinking them, or packing them in a suitable amount in a packaging bag (packing agent) and baking them. Drink, or add an appropriate amount of concentrated extract manufactured according to the Japanese Pharmacopoeia General Rules (extract) and increase with water (in this case, a sweetener may be added) and drink as a drink,
The problem was solved by adding excipients and binders to the mixture of the two extracts to obtain tablets or granules of health food.

[0006]

[Example 1] A mixture of dried and finely cut or pulverized dried plum meat, which was thoroughly washed with water and thoroughly dried or cut into powdered plum meat, was mixed at a mixing weight ratio of 1: 1. Pack in suitable paper bags or cloth bags as appropriate. The amount is 20 g to 25 g per bag. When not packed in a bag that can be bathed in hot water, it may be packed in a container such as a can, taken out of a suitable amount each time it is used, and bathed in hot water to drink. The mixing amount of the above-mentioned dessicant and plum desiccant is usually used as 1: 1. Particularly, those with gastrointestinal weakness may increase the plum desiccant,
The mixing ratio of the two agents does not need to be particularly specified, and since it is a so-called crude drug use, there are no side effects or the like, so it can be freely selected according to the physical condition. When used as the above-mentioned decoction beverage, constipation constitution is suitable for use by mild persons and drinking tea instead of tea has the effect of preventing or alleviating constipation.

[0007]

[Example 2] The whole plant of Tulna is thoroughly washed with water, dried and cut into fine pieces or powdered.
To produce a 50% concentrated extract. That is, 1 liter of purified water was added to 50 g of dried turuna powder and concentrated to 500 ml. Then, a 50% concentrated extract was produced using plum meat in accordance with the general rules of preparation (extract) of the Japanese Pharmacopoeia. In addition, the plum meat extract can be obtained from a RO device (Reverse Osmos).
50% concentrated plum juice may be produced using is). R
The O device is a state-of-the-art non-heat concentration device that selectively removes and concentrates only water in plum juice using a synthetic membrane and high reverse osmosis pressure. To facilitate the adjustment, sugar was added as a pretreatment for concentration, and then concentrated plum juice was obtained using a RO apparatus. The concentrated extract of the crucian carp and the concentrated fruit juice were mixed and stirred at a ratio of 1: 1 to obtain an extract stock solution for constipation. Dilute 250 g of each of the above 50% concentrated stock solutions with 50 l of water, and add 200 ml
Dispense into cans to obtain 248 cans. That is, equal amounts of the two concentrated stock solutions are combined, and 500 g is added to 50 l of water, and 200 ml is used as a unit to obtain canned constipation health food in drink form.

[0008]

Example 3 A mixture of 250 g of a 50% concentrated extract of Tulna and 250 g of a 50% concentrated juice of a plum meat extract, and 200 ml of a liquid diluted with 50 l of water suitable for beverages such as purified water as an excipient
Is a unit component amount, and a constipation effective health food in the form of a drink is prepared by adding 1 or 2 or 3 of sugar, lactose or honey as a sweetener in an appropriate amount.

[0009]

EXAMPLE 4 250 g of a 50% concentrated extract of Tulna and 250 g of a 50% concentrated juice of plum meat extract were mixed as a unit component amount of 248 molded tablets, and dried by warm drying, hot air drying or freeze drying to obtain a powder. Then, calcium and lactose are added as excipients, and 1 or 2 of starch or apple fiber is added as a binder in an appropriate amount to form tablets or granules.

[0010]

The plant mucilage contained in the crucian carp stimulates the gastric mucosa to relax and assists in the initiation of intestinal peristalsis.
Stimulates the large intestinal mucosa to assist intestinal peristalsis. In addition, it absorbs the water in the intestinal tract and promotes an increase in stool volume and softening of the stool, which helps the stool to smoothly pass through the large intestine. In addition, the mucous protects the gastric mucosa by mildly coating the gastrointestinal tract and alleviates excessive irritation to the stomach, and reduces excessive intestinal irritation by suppressing excessive secretion of gastric acid. Suppresses the absorption of fat in the intestinal tract, softens stool and assists movement in the intestinal tract. Pectin contained in plums has the effect of suppressing the absorption of intestinal water and keeping stool in a normal shape, and catechinic acid promotes intestinal peristalsis and at the same time sterilizes the intestine, resulting in protein. Increase the decomposition. By these actions, the function of the gastrointestinal tract is promoted in human physiology, and the passage of stool is improved. By combining trunas and plums with these characteristics, individual effects are alleviated,
In addition, it is possible to eliminate constipation without any side effects and without habit (dependency) by showing it accurately.

Next, an experimental example will be described. 250g of 50% concentrated vine extract and 50% concentrated plum juice extract 25
0 g was calculated and 50 l of test drinking water was prepared using purified water. This liquid was dispensed into 200 ml cans to prepare a total of 248 test drinking waters. Using this canned drinking water, the following clinical test was carried out using a conventional laxative containing 40 mg (68 sennoside units) of Senna extract in one tablet as a control drug. 1. Test subjects 20 patients without bowel movement for more than 3-4 days (4 males)
(16 women, average age 32.5 years) However, patients who corresponded to any of the following items were excluded from the subjects. 1) Patients with acute abdominal disease 2) Elderly patients with poor physiological function 3) Pregnant women, women who may be pregnant and lactating women 4) Other patients judged by doctors to be inappropriate 2. Patient consent In principle, prior to the start of the study, the content of the study was explained to the patient and the patient's consent was obtained. 3. Experimental Method Subjects were divided into two groups of 10 persons per group, one group containing the constipation health food (drink) shown in Example 2 of the present invention, and the other group containing a senna extract preparation as an experimental control drug. 1 each
Administered for 0 days, with a 14-day drug holiday,
A bar test was performed. 1) Dosage / Dose Method One dose of the drinking water of the present invention once (200
ml), Senna extract preparation 2 tablets (Senna extract 80m
g) In principle, once daily before bedtime. 2) Experimental items Constipation (subjective symptoms) 3) Diagnostic criteria Each symptom was classified into the following four stages. 3: Severe symptoms (unbearable) 2: Moderate symptoms (predominant) 1: Slight symptoms (somewhat slight) 0: No symptoms or improvement 4) Effect criteria Symptoms The degree of improvement of symptoms was determined in five stages according to the following criteria in principle. Prominent improvement (…): 3 → 0, 2 → 0 Moderate improvement (…): 3 → 1, 1 → 0 Mild improvement (+): 3 → 2, 2 → 1 Invariant (±): No change in symptoms Things worse (-): worsened symptoms 5) Safety The side effects that occurred during the test were determined in the following three stages, and the details of the side effects were recorded in detail. No side effects were observed. Mild side effects were observed but continued taking was possible. Administration was discontinued due to serious side effects. 6) Subjective symptoms and safety were comprehensively evaluated to determine the usefulness of the present invention in the following five stages. Extremely useful Very useful Somewhat useful Not considered useful Experimental Results The degree of improvement in subjective symptoms of the constipation health food (drink) of the present invention is shown in FIG.
It was shown to. The drink-type constipation health food of the present invention showed a remarkable 55% improvement in constipation symptoms, a moderate improvement of 75% or more, and a mild improvement or more of 87% for constipation symptoms when taken for 10 days. The control drug, Senna extract granules, also showed almost the same improvement effect as the health food of the present invention, but slightly less. FIG. 2 shows the results of successively evaluating and examining changes in the intensity of subjective symptoms (constipation). The present invention constipation health food (beverage)
Showed a slow and sustained symptom-improving effect, whereas the senna extract formulation exhibited a sharp effect immediately after the start of administration, but the effect was reduced from around the 5th day of administration, and from 9 days after administration.
On the 10th day, a decrease in the effect was evident when taking the same dose. This tendency was similarly observed during the first and second 10 days of the dosing period. Adverse effects such as nausea, vomiting, wheezing, and abdominal bloating were observed in patients who took Senna extract granules during the first 10 days and the last 10 days, taking a total of 20 days after the 14-day drug holiday. However, when the food of the present invention was taken, no side effects occurred. See FIG. FIG. 4 shows the results of determining usefulness obtained by integrating the subjective symptoms and safety. The food of the present invention is extremely useful 60%, considerably useful 90%, slightly useful 95%, and has a high usefulness compared to the very useful 30%, fairly useful 50%, slightly useful 70% of Senna extract. Was done. From the above results, the beverage as a health food for constipation according to the present invention does not appear to be effective without increasing the dose seen in conventional constipation drugs represented by senna extract. Since no side effects are observed at all, it is considered to be highly evaluated as a health drink aimed at treating and preventing constipation symptoms.

Next, an experiment was carried out on the constipated health food of the present invention in the form of a tablet as shown in Example 4, but as a result, substantially the same results as those of the drink-shaped health food of the present invention were obtained. However, when using the health food of the present invention in the form of tablets or granules, at least one full cup (180 ml to 200 ml) is used.
ml) of water. The health food of the present invention in the form of a decoction was effective in preventing constipation by regularly using it in place of tea.

[0013]

The requirements for relieving constipation are to promote intestinal peristalsis and to suppress water absorption from the stomach and intestinal walls to promote loose stool. The health food for constipation of the present invention is mainly composed of luna and plum or an extract thereof, and minerals such as calcium, iron and potassium contained in the luna extract and vitamins A, B ₁ , B ₂ and C etc. Vegetable mucous consisting of vitamins and the like has the effect of stimulating the gastric mucosa in relaxation and assisting intestinal peristalsis. In addition, the vegetable mucilage has the effect of suppressing the absorption of water in the intestinal tract, increasing the amount of stool and promoting loosening, and helps the stool to pass smoothly through the large intestine. In addition, the mucous protects the gastric mucosa by gently coating the gastrointestinal tract and alleviating excessive irritation to the stomach,
In addition, by suppressing excessive secretion of gastric acid, it has the effect of alleviating excessive irritation of the intestinal tract, suppressing absorption of fat in the intestinal tract, softening stool, and assisting movement in the intestinal tract. That is, the component of the crucian carp acts on two places in the stomach and intestine, and has both the above-mentioned action of relieving constipation and the effect.

Next, pectin contained in ume has an action and an effect of suppressing water absorption in the intestinal tract and keeping stool in a normal form, and catechinic acid contained in ume has an effect on the intestinal wall (mucosa).
It stimulates the peristalsis by stimulating it, and at the same time, sterilizes the intestine, enhances the degradation of proteins, and by these actions, enhances the function of the gastrointestinal tract and exerts the effect of bowel movements.

Next, the tablet or granular health food for constipation of the present invention uses an excipient and a binder. Calcium as an excipient absorbs water in the intestine and lactose itself. Since it has the property of not being absorbed from the gastrointestinal tract, it has the effect of absorbing only the water in the intestinal tract and softening the stool, further enhancing the action and effect of the above-mentioned luna and plum, and the starch as a binder is (Starch is a nutrient that is digested only by the saliva in the oral cavity and absorbed by the intestine, so that it is not in a state of digestion and absorption when swallowed with water as tablets or granules). As a fiber food along with fiber and swelling with water to soften the stool and pass through the gastrointestinal tract, the effect of relieving constipation is further enhanced.

As described above, the health food for constipation according to the present invention is a tablet containing not only the main ingredients of trunna and plum but also relaxes the stomach and intestine, which are the body organs essential for relieving constipation. A health food that is extremely effective in relieving constipation by adopting two agents, Tulna and Ume, in addition to the effect of the main agent in foods in the form of granules, in addition to the effect of the main agent in excipients and binders Could be provided.

By the way, the improvement of subjective symptoms is more effective than the conventional constipation drug (senna extract preparation) as shown in FIG. 1, and the temporal change in the intensity of the constipation symptoms is as shown in FIG. However, there is a remarkable difference between the drink-like health food of the present invention and the conventional senna extract preparations on the market.
It shows the effectiveness of 0% against%. Therefore, even if the effectiveness is comprehensively observed, the health food for constipation of the present invention is extremely effective for constipation as shown in FIG.

[Brief description of the drawings]

FIG. 1 is a comparison diagram of the degree of improvement in awareness of constipation when a health food for constipation of the present invention is used and when a conventional senna extract preparation is administered.

FIG. 2 is a graph showing the change over time in the intensity of constipation symptoms when the health food for constipation of the present invention is used and when a conventional senna extract preparation is administered.

FIG. 3 is a comparison diagram of the incidence of side effects between the constipation health food of the present invention and a constipation drug using a conventional senna extract preparation.

FIG. 4 is a diagram for comprehensively determining the usefulness of the constipation food of the present invention and the conventional constipation drug Senna extract.

──────────────────────────────────────────────────の Continuation of the front page (51) Int.Cl. ⁶ Identification code FI A61K 31/00 601 A61K 35/78 W 35/78 A23L 2 / 00F (56) References JP-A-58-162526 (JP, A) Lebensm Wiss Technology, Vol. 18 [4] (1985) p. 233-237, edited by Yasaburo Sugi, "Encyclopedia of Health and Nutrition" (Toyo Medical School) (1996.3.8) P. 186-187, 465-466 (58) (Int.Cl. ⁶ , DB name) A23L 1/29-1/308 A23L 1/212 A23L 2/38-2/68 A61K 35/87 JICST file (JOIS)

Claims (3)

(57) [Claims] 1. A 50% concentrated solution of trunna extract and a plum extract 50
% Condensed juice and 50% by weight, respectively, further comprising water as an excipient and lactose as a sweetener, a drink-type constipation health food. 2. A 50% concentrated solution of trunna extract and plum meat extract 50
% Concentrated solution, mixed with each other, and dried and powdered, and then kneaded using calcium and lactose as excipients and starch or apple fiber as a binder, followed by molding. A tablet-shaped health food for constipation characterized by the following. 3. A 50% concentrated extract of tuna and plum meat extract 50.
% Concentrated solution, mixed with each other, and dried and powdered, and then kneaded using calcium and lactose as excipients and starch or apple fiber as a binder, followed by molding. A granular health food for constipation, characterized in that: