JP2876411B2 - Automatic analyzer - Google Patents

Description

Description: FIELD OF THE INVENTION The present invention relates to an automatic analyzer for performing biochemical analysis and immunological analysis, and particularly to whether the analysis state of the automatic analyzer is set normally. The present invention relates to an automatic analyzer having a function of automatically checking whether or not the automatic analyzer is activated when the automatic analyzer is started.

[Conventional technology and its problems]

As is well known, in this type of conventional automatic analyzer, after starting the automatic analyzer, a reagent blank value or a cell blank is used in order to determine whether or not the analysis state of the automatic analyzer is set normally. In most cases, the value is measured, and the measured value of the general sample is corrected based on the blank value. Therefore, such a correction operation is an extremely important operation that must be performed at the time of starting the automatic analyzer because it varies depending on the daily environment, the degree of cleaning of the reaction tube, and the like.

However, in the conventional automatic analyzer configured as described above, since the correction operation is very complicated and complicated, it is actually necessary to measure a reagent blank value and a cell blank value. At present, they are conducting analysis work.

When the analysis work is performed without such correction work, for example, the reagent has deteriorated, the reagent container has been set incorrectly, the reaction can has become dirty, or the reaction tube has been set. If a defective item is found in the measured items, such as when the item is defective, the analysis work must be performed again from the beginning. There was a problem that the emergency response would be delayed if the work was performed each time.

The present invention has been made in view of the above situation, and an object thereof is to automatically measure a reagent blank value or a cell blank value at the time of starting an automatic analyzer, and to measure the reagent blank value or the cell blank value. When the value is within the allowable range, analysis can be performed, and when the reagent blank value or cell blank value is outside the allowable range, a warning is issued to greatly reduce the daily correction work. An object of the present invention is to provide an automatic analyzer that can be simplified and can promptly respond to an emergency.

[Means for solving the problem]

In order to achieve this object, according to the present invention, a reactor for dispensing and reacting a plurality of reagents corresponding to a predetermined measurement item to a specimen sample contained in a reaction tube, A measurement device for optically colorimetrically measuring the state of the reaction in the reactor, a substance analyzer for analyzing the quantitative amount of the substance colorimetrically measured by the measurement device, and an analysis judgment controller; Is the cell blank value in the reaction tube,
The reagent blank value is automatically measured at the time of start-up, and if the measured value is within a predetermined range, it is regarded as normal, and the material analyzer is instructed to perform quantitative analysis of the material, and the measured value is measured. Is outside the predetermined range, it is regarded as abnormal, and a message to that effect is displayed, and an alarm is issued so as to prompt the user to issue a warning.

[Action]

Therefore, in the automatic analyzer according to the present invention, when the automatic analyzer is started, the blank value of the reagent or the reaction tube is automatically measured, and the blank value falls within the range of the preset allowable value. When the blank value is out of the range of the allowable value, the general sample sample can be directly analyzed, and when the blank value is out of the allowable range, the fact is displayed on a display device, or an alarm is issued. By issuing an alarm, it is configured not to be able to perform an analysis operation on a general specimen sample.

〔Example〕

Hereinafter, the present invention will be described in detail based on an embodiment shown in the accompanying drawings.

Although not particularly shown, the automatic analyzer according to this embodiment is housed in a reaction tube by a sampling pipette as in a known automatic analyzer such as Japanese Patent Application No. 62-505623 or Japanese Patent Application Laid-Open No. 56-168553. The first and second reagents corresponding to the measurement items are dispensed and reacted with the sample specimen thus obtained, and the reaction state is optically colorimetrically measured to perform quantitative analysis of the measurement substance. ing.

In the automatic analyzer configured as described above, when the start switch 1 is turned on as shown in FIG. 1, the automatic analyzer is set in a start-up state (step S1). The measuring device measures the cell blank value of the reaction tube (not shown) containing water and the blank values of the first and second reagents set in the reagent device (step).
S2). When the blank value is measured in this manner, the control device (CPU) of the automatic analyzer converts the blank value X into
As shown in FIG. 2, it is checked whether or not it is within a range of a preset allowable value R to R '(step S3). Next, a calibration curve Y for each measurement item of the standard substance is Check whether the third is in the predetermined allowable range R ₁ to R ₁ ', as shown in FIG. (step S4).

The measurement of the cell blank value is mainly performed to check the washing state of the reaction tube, and the measurement of the reagent blank value is performed to check the deterioration of the reagent, the failure of the dispenser, and the like. Further, the measurement of the calibration curve is mainly performed to check the performance of the optical measurement device.

Therefore, the allowable value R～R 'and R ₁ to R _1' each setting is set as appropriate based on pre-calculated data from the performance of the machine, as shown in FIG. 1 step S5, the blank the value X and the calibration curve Y in the range of acceptable values R～R 'and _{R 1 ~R 1' (R,} R 1 <X, Y <R ', R 1') when in the above control device, the automatic The operation state of the analyzer is regarded as "normal", and the automatic analyzer is set to the state of starting the analysis work (step S6).

On the other hand, as shown in FIG. 1 step S7, the outside of the blank value X tolerance R～R 'or _{R 1 ~R 1' (X,} Y <R, R
₁ ; R ′, R ₁ ′ <X, Y), the control device:
The operation state of the automatic analyzer is regarded as "abnormal" and a warning is issued (step S8).

This warning can be configured to simply issue a warning using a warning device having a known configuration. However, when a display device such as a CRT is provided, as shown in FIG. Examine the container. ], "Check the deterioration of the reagent. ], "Check the dispenser. Check the reaction tube. Is preferably displayed on the display device so that an artificial check can be performed.

When the above check is completed and it is determined that all the check items are normal, the control device measures the blank value X and the calibration curve Y again. Although checked, still is outside the range of the blank value X or calibration curve Y permissible values _{R~R ', R 1 ~R 1'} , if the failure site not known, the control device, The automatic analyzer is set to the state where the analysis work is stopped (step S9). When such an analysis work stop state is set, repair due to a dedicated maintenance factor or reset of an allowable value is performed.

〔The invention's effect〕

Since the automatic analyzer according to the present invention is configured as described above, a reagent blank value or a cell blank value is automatically measured when the automatic analyzer is started, and the reagent blank value or the cell blank value is allowed. When the value is within the range, the analysis operation can be performed.When the reagent blank value or the cell blank value is out of the allowable value range, a warning is issued, thereby largely correcting the daily measurement value. This simplifies and eliminates the necessity of performing the correction work in an emergency, so that an effect such as an emergency inspection can be promptly performed.

[Brief description of the drawings]

FIG. 1 is a flowchart showing the configuration of a main part of an automatic analyzer according to an embodiment of the present invention. FIG. 2 is a graph showing the range of allowable values of cell blank values or reagent blank values.
The figure is a graph showing the range of allowable values of the calibration curve. [EXPLANATION OF SYMBOLS] X ... blank value, Y ... calibration R~R range ...... calibration curve tolerance '... Range R ₁ to R ₁ blank tolerance'

Claims (1)

(57) [Claims] A reactor for dispensing and reacting a plurality of reagents corresponding to predetermined measurement items with respect to a specimen sample contained in a reaction tube, and an optically reacting state in the reactor. A measuring instrument for colorimetric measurement, a substance analyzer for analyzing the quantitative determination of the substance colorimetrically measured by the measuring instrument, and an analysis judgment controller, the analysis judgment controller is a cell blank value in the reaction tube, The reagent blank value is automatically measured at the time of start-up, and if the measured value is within a predetermined range, it is regarded as normal, and the material analyzer is instructed to perform quantitative analysis of the material, and the measured value is measured. An automatic analyzer that, when the value is out of a predetermined range, is regarded as abnormal, the fact is displayed, an alarm is issued, and control is performed so as to prompt the user to warn.