JPH06308131A - Data processing apparatus - Google Patents

Abstract

PURPOSE:To make measuring values of a plurality of apparatus agree thereby to provide highly reliable measuring data, by connecting a plurality of automatic analyzing devices, calculating a correcting coefficient for each device from the measuring values of calibration samples obtained from the analyzing devices, and calibrating the difference of measuring values of the devices automatically. CONSTITUTION:Several samples are measured for each analysis item in each automatic analyzing device. The data are sent to a data processing device 31 through an interface. The data are correlatively processed to the data of a reference device at an operating part 29 of the processing device 31. The result is stored as a correcting coefficient in a memory part 30 of the processing device 31. The correcting coefficient is multiplied by a measuring value obtained from a general sample, and output from an output device connected to the processing device 31.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a data processing device for an automatic analyzer.

[0002]

2. Description of the Related Art In the field of clinical tests, the spread of biochemical automatic analyzers has increased with the increase in the number of specimens. In order to further improve efficiency, large hospitals, test centers, and the like have been able to process a large number of samples for the same analysis item in a short time by using a plurality of automatic analyzers. Moreover, in the analysis of the same item, it is often the case that a backup device for equipment failure, an emergency equipment for nighttime, and a routine equipment for daytime are provided separately. Is important in. Therefore, the performance of each device has been improved in order to ensure the reliability of the inspection data, and the functions such as the accuracy management of each device and the reduction of human error due to the data management by the host computer have been developed. However, although the quality control of each device is performed, the difference in the measured values between the devices is not managed at all, and there is a possibility that the measured values may differ for each device in the same facility. In this way, the measured values may differ even within the same facility, so it is not possible to simply compare and compare the same items if the facilities are different. Therefore, the same examination must be performed every time the patient is transferred to the hospital, which imposes a time and financial burden on the patient.

[0003]

The above-mentioned prior art does not consider the difference in measured values among a plurality of devices, and in order to calibrate the difference in measured values between devices, a calibration sample is measured for each device,
The results were inefficient because the calibration coefficient had to be corrected after totaling and calculating manually. Therefore, an object of the present invention is to automatically calibrate the difference in measured values of a plurality of automatic analyzers so as to match the measured values in a plurality of devices and improve the reliability of inspection.

The present invention is applicable not only to the same facility but also to data management between facilities.

[0005]

According to the present invention, a data processing device to which a plurality of automatic analyzers are connected collects measurement results of calibration samples in each device, and automatically calculates and corrects the calibration coefficient. It is achieved by doing.

[0006]

According to the present invention, a difference in measured value between devices which has not been calibrated up to now can be simply and quickly corrected, and the measured values of a plurality of devices can be matched. This not only improves the reliability of the test, but also because the measurement results are compatible, the same test need not be repeated each time the patient is transferred to the hospital, which saves time and money.

[0007]

Embodiment 1 Hereinafter, Embodiment 1 used for carrying out the present invention will be described with reference to FIGS. 1 and 2a. First, the automatic analyzer 32-
An example of operation of 32 ″ will be described with reference to FIG.

A plurality of sample cups 1 containing the sample are set on the sample disk 2. The sample disc 2 is controlled by the computer 3 via the interface 4. The sample disc 2 is rotationally moved to the bottom of the sample dispensing probe 5 according to a pre-registered order, and a predetermined amount of the sample is dispensed into the reaction container 6 by the sample pump 7 connected to the sample dispensing probe 5. It The reaction container 6 into which the sample has been dispensed moves to the first reagent addition position in the reaction tank 9 connected to the constant temperature tank 8. To the reaction container 6 that has moved to the first reagent addition position, a predetermined first reagent sucked from the reagent bottle 12 is added by the reagent pump 11 connected to the sample dispensing probe 10. After the addition of the first reagent, the reaction container 6 moves to the position of the stirring device 13 and the first stirring is performed. The reaction container 6 in which the contents are stirred passes through the light flux emitted from the light source 14, and the absorbance at this time is detected by the multi-wavelength photometer 15. The detected absorbance signal is analog / digital (A
/ D) via the converter, the computer 3 enters through the interface 4 and is converted into the concentration to be measured in the sample. Although this concentration conversion method varies depending on the measurement item, for example, the enzyme item is converted by the following formula.

[0009]

[Equation 1]

Here, ΔA is the change in absorbance, ε is the molar extinction coefficient, L is the optical path length of the cell, Vs is the sample volume, and Vr is the reagent volume. Of these, the value in parentheses is called K factor, which is a calibration coefficient of enzyme activity. In the automatic analyzer, K
The factor is set in advance and the activity value is obtained by multiplying the measured change in absorbance. The K factor has an F value that is calculated by using each physical parameter constituting the K factor as a theoretical value. However, the F value does not match the reality because it does not consider the variation of the device itself. Therefore, recently, an actually measured K value has been used in which the K factor is calibrated by measuring a plurality of concentrations of reaction indicator substances. The measured K value is more realistic than the F value, but there are many factors that cause measurement errors in devices other than the device, such as changes over time of samples, differences between lots of reagents, and deterioration in the measurement of enzyme activity. In some cases, it may not be possible to correct all by itself. Therefore, in the present invention, each automatic analyzer 32-3
At 2 ″, several kinds of the same sample were measured for each analysis item.
The data processing device 31 through the interface 4
Send to. The calculation unit 29 of the data processing device 31 performs a correlation process with respect to a reference device. The linear linear regression obtained at this time is represented by y = a _i x + b _i , and is stored in the storage unit 30 of the data processing device 31 as a correction coefficient in data processing of each device. The measurement value of the general sample is multiplied by this correction coefficient, and the output device 33 connected to the data processing device 31 outputs and produces a report.
An example of measurement using this method is shown in FIG. 4 using ALP as an example. Generally, the ALP is an item with a large difference between the devices, but by using the present invention, the difference between the devices can be easily corrected. After the measurement, the reaction container 6 is moved to the position of the cleaning mechanism 19, and the container cleaning pump 20 discharges the liquid inside and cleans it with water for the next analysis.

As a second embodiment, in FIG. 2B, several kinds of the same sample are measured for each analysis item in each automatic analysis device 32-32 ″ and are transmitted to the data processing device 31 through the interface 4. The calculation unit 29 of the data processing device 31 performs a correlation process with respect to the reference device, and stores this as a correction coefficient in the storage unit 30 of the data processing device 31. This correction coefficient is stored in each automatic analyzer 32-32 ″. The K factor of each measurement item in the computer 3 is multiplied through the interface 4 to calibrate the K factor itself, and the normal sample is measured and the result is printed out from the printer 17 or displayed on the CRT screen 18. .

[0012]

According to the present invention, it is possible to easily correct a difference in measured values between a plurality of devices which has not been calibrated up to now, supply more versatile measurement data, and increase the reliability of the measurement result. is there. In addition, since the measurement results are compatible, the same test need not be repeated each time the patient is transferred to the hospital, which saves time and money.

[Brief description of drawings]

FIG. 1 is an internal structural diagram of a data processing device.

FIG. 2 is a diagram showing system configuration examples 1 and 2 using a plurality of automatic analyzers.

FIG. 3 is a diagram showing an example of an automatic analyzer.

FIG. 4 is a diagram showing an example of ALP measurement when the present invention is actually used.

[Explanation of symbols]

1 ... Sample cup, 2 ... Sample disk, 3 ... Computer, 4 ... Interface, 5 ... Sample dispensing probe, 6
... Reaction container, 7 ... Sample pump, 8 ... Constant temperature tank, 9 ... Reaction tank, 10 ... Reagent dispensing probe, 11 ... Reagent pump, 12
... Reagent bottle, 13 ... Stirrer, 14 ... Light source, 15 ... Multi-wavelength photometer, 17 ... Printer, 18 ... CRT screen, 19 ...
Washing mechanism, 20 ... Washing pump, 29 ... Data processor processing unit, 30 ... Data processor storage unit, 31 ... Data processor, 32-32 ″ ... Automatic analyzer, 33 ... Output device.

Claims (1)

[Claims] 1. A test substance in a biological sample and a test substance
An automatic analyzer for quantifying a test substance by mixing a reagent containing a substance that can be detected regardless of indirectness and irradiating the reaction substance with light to measure the absorbance, turbidity, or reflectance. In (1), the correction coefficient of each device is calculated from the measurement result of an arbitrary calibration sample obtained from each of the plurality of automatic analyzers, and the difference in the measured values between the devices is automatically calibrated. Data processing device.