JP2855535B2 - Method of manufacturing plastic container for chemical liquid containing chemical liquid inside - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a carbohydrate infusion, an electrolyte infusion, a plasma expander,
Intravenous infusions such as osmotic diuretics, amino acid infusions, fat emulsions, high-calorie infusions and enteral nutritional supplements, high protein nutritional supplements, enteral nutritional supplements, and enteral high calorie nutritional supplements such as liquid foods. The present invention relates to a method of manufacturing a relatively flexible plastic container for a medical solution, which accommodates a medical solution of a so-called natural dropping die, which dispenses a medical solution by deforming a body portion. Things.

[Prior art] Due to its advantages such as being not cracked even when dropped and being lightweight, the chemical solution container has been rapidly plasticized in recent years. In particular, the flexibility of the plastic material is utilized to deform the body. Of these, a natural dropping type that administers a chemical solution is often used.

This is because in the case of spontaneous dripping, administration can be performed without supplying air into the container, and therefore there is no concern about invasion of various bacteria into the container, which has an advantage in hygiene.

As this kind of plastic container for chemicals, Japanese Patent Application Laid-Open
There is one described in JP-A-158955. This is for manufacturing a plastic container for a medical solution having a body portion having an elliptical cross section and a mouth portion whose other end is sealed with a plug.

[Problem to be Solved by the Invention] In the above-mentioned conventional plastic container for a medical solution, the body and the mouth except for the stopper are formed by blow molding, and after filling the solution from the mouth, the mouth is sealed with the stopper. And then place the container in 11
A chemical solution is sterilized in a sterilized bath at 0 ° C. for a certain period of time to produce a chemical solution plastic container containing a chemical solution inside.

Therefore, according to the above manufacturing method, after filling with the chemical solution,
The plug body must be heated at the mouth and welded, increasing the number of steps and causing problems in operation, as well as melting burrs generated during this welding and falling into the container, resulting in sanitary problems. have.

Further, in the above-mentioned production method, since the container is subjected to a sterilization treatment in a sterilization tank pressurized at 110 ° C., the equipment for sterilization is large and expensive, and a relatively long sterilization step is required.

Then, in order to solve the above-mentioned conventional drawbacks, the method for manufacturing a plastic container for a chemical solution of the present invention has the following objects. That is, there is no need to weld the plug that may cause the molten burr to fall inside the container.

Form a plug before containing a chemical solution inside.

Obtaining a plastic container for chemicals containing a sanitary chemical inside.

The drug solution to be filled into the container is sterilized by itself at a high temperature of 100 ° C or higher, and the container can be sterilized at the same time as the drug solution is filled into the container, eliminating the need for a large and expensive pressure sterilization process. .

By filling the chemical solution after the blow molding of the container, blow molding of a plastic material with a relatively low melting temperature like a natural type even if the chemical solution is at a high temperature of 100 ° C or more at which the container can be sterilized. Not only does not hinder the molding of the container, but also the sealing of the container after filling with the chemical solution is performed by pressing and welding the outer peripheral surface of the cylindrical portion projecting outside from the body of the container formed in advance by blow molding. By doing so, there is no danger of foreign matter such as molten burrs falling into the container, and a high degree of hygiene is ensured.

It is.

[Means for Solving the Problems] The present invention is configured as follows in order to achieve the above object. It is because the plug is placed in advance in the cavity of the mold for blow molding, then blow molded and the plug is welded to the body integrally, and the end of the body opposite to the plug is attached to the end of the body. The cross-sectional shape of the cylindrical part and the trunk part forming the hanging part that protrude to the outside where the inside and outside of the body communicate with each other form a relatively flat container, and then after the blow molding, The container is filled with a high-temperature chemical solution of 100 ° C. or higher that can sterilize the container from the cylindrical portion for filling the chemical solution of the container formed in advance by blow molding, and the cylindrical portion is sealed. It is a method of manufacturing a plastic container for chemicals contained in a container.

[Operation] Since a plug is placed in advance in the cavity of the mold for blow molding and then blow molded to form a container in which the body and the plug are welded together, the plug is already filled when the chemical is filled. Therefore, it is possible to obtain a sanitary plastic container for a medical solution without the need for welding a plug body which may cause the molten burr to fall inside. In addition, a cylindrical portion projecting to the outside where the inside and outside of the container communicate with each other is formed in advance at the end of the body opposite to the plug body at the time of blow molding, and the container can be sterilized from the cylindrical portion. Since the sealing of the container after filling it with a high temperature (100 ° C or higher) liquid chemical is performed by pressing and welding the outer peripheral surface of the cylindrical part protruding to the outside, there is a risk that foreign matter such as molten burrs may fall into the container. And a high degree of hygiene is ensured. In addition, the chemical solution filled in the container is sterilized and the container is sterilized simultaneously with the filling of the chemical solution, so a large and expensive autoclaving tank is not required, and the sterilization process is not required. Can be omitted.

Example Next, a method for manufacturing a plastic container for a drug solution containing a drug solution therein according to an embodiment of the present invention will be described with reference to the drawings.

As shown in FIG. 1, a die 3 is provided between a pair of split molds 1 and 2.
The more pressed and hung parison 4 is arranged. The cavity 5 of one of the split molds 1 of the pair of split molds 1 and 2 includes:
Further, a plug body cavity 5c for holding the plug body 12 is formed, and the plug body 12 enclosing a rubber plug 17 is fitted into the plug body cavity 5c. A pair of split molds 1,2
Are provided with body cavities 5a, 6a and cylindrical cavities 5b, 6b, respectively.

Next, the split molds 1 and 2 are closed, and a pressurized fluid is injected into the parison 4 from the blow nozzle 7 to expand the parison 4 so that the parison 4 comes into contact with the cavities 5 and 6. The parison 4 is welded to the stopper 12 to obtain the chemical liquid plastic container 10 shown in FIG. In the chemical liquid plastic container 10, a cylindrical portion 13 for filling a chemical liquid protruding to the outside where the inside and the outside of the body portion 11 communicate with each other is integrally formed, and a hanging portion 14 is integrally formed. I have.

As shown in detail in FIG. 2, the plug 12 is constituted by a plug main body 16 and a rubber plug 17 wrapped inside the plug main body 16, and the plug main body 16 has a flange portion 16a extending outward. It is welded to the trunk wall of the trunk 11. 18 is a pull ring,
The top plate portion 16b of the plug body 16 can be opened by a pull ring 18. The pull ring 18 is integrally formed integrally with the plug body 16, a score 16c composed of a thin portion is formed on the top plate portion 16b, and by pulling the pull ring 18, the thin portion is cut off from the score 16c to remove the rubber plug. 17 is exposed. Here, the rubber stopper 17 which has a problem of hygiene when it comes into direct contact with the chemical is sanitary because it is isolated from the chemical by the body wall of the body 11.

After blow molding, as shown in FIGS. 3 to 5,
A chemical liquid filling step and a sealing step are performed.

The chemical liquid plastic container 10 holds the cylindrical part 13 with the filling gripper 19 with the cylindrical part 13 for filling the chemical liquid facing upward. Then, the chemical liquid injection nozzle 20 is
Is inserted into the chemical liquid plastic container 10 from the chemical liquid injection nozzle 20. After the predetermined amount of the chemical is filled, the cylindrical portion 13 is pressed from the outer peripheral surface thereof by the cut seal 21 to be welded and sealed, and the burr above the sealed portion of the cylindrical portion 13 is cut off, so that the chemical is filled inside. The chemical plastic container 10 housed in the container is completed, but since the sealing process is performed by pressing and welding the outer peripheral surface of the cylindrical portion 13 protruding to the outside, there is a possibility that foreign matters such as molten burrs fall into the container. Therefore, a high degree of hygiene is ensured.

In order to stabilize the chemical liquid plastic container 10 during the steps from filling of the chemical solution to sealing as shown in FIGS. 3 to 5, a rod-shaped holding bar (not shown) is provided in the hanging hole 15 of the hanging portion 14. These steps can be performed stably by using the hanging portion 14 such as inserting

The filling of the chemical solution in the plastic container 10 for chemicals performed as described above is performed at a high temperature (100 ° C. or higher) at which the container can be sterilized. It is possible to omit the sterilization process which has been performed after the filling with the chemical solution.

When using the chemical liquid plastic container 10 containing a chemical liquid inside, a hanging tool (not shown) is inserted into the hanging hole 15 of the hanging part 14 to hold the stopper 12 so as to be downward, and then The rubber stopper 17 is exposed by pulling the pull ring 18, and the injection needle of the syringe is made to penetrate the rubber stopper 17 and the body wall of the body part 11 to administer the liquid medicine inside.

[Effects of the Invention] As described above, according to the present invention, since the plug is already formed at the time of filling the chemical solution, welding of the plug that may cause the molten burr to fall inside can be omitted, A sanitary plastic container for chemicals can be obtained. Moreover,
The container can be sterilized from the cylindrical part for filling the chemical
The container is directly filled with a high-temperature chemical solution of 100 ° C or higher and sealed, so that the container is sterilized at the same time as the chemical solution is filled, eliminating the need for a large and expensive autoclaving tank as in the past. Can be omitted. Furthermore, by filling the chemical after the container is blow-molded, even if the chemical is at a high temperature of 100 ° C or higher at which the container can be sterilized, a plastic material with a relatively low melting temperature such as a natural dropping type is blown. Not only does not hinder the molding of the container to be molded, but also the sealing of the container after filling with the chemical solution is performed by pressing and welding the outer peripheral surface of the cylindrical portion that protrudes outward from the body of the container formed in advance by blow molding. By doing so, there is no risk of foreign matter such as molten burrs falling into the container, and a high degree of hygiene can be ensured.

[Brief description of the drawings]

1 to 7 show a method for manufacturing a plastic container for a chemical solution according to an embodiment of the present invention. FIG. 1 is a cross-sectional view showing a blow molding mode, and FIG. 2 is a diagram for a chemical solution obtained by blow molding. FIG. 3 is an enlarged cross-sectional view of a main part of a plug portion of a plastic container, FIG. 3 is a partially cutaway front view illustrating a step of filling a chemical solution, FIG. 4 is an upper side view thereof, and FIG. FIG. 6 is a front view of a chemical solution plastic container containing a chemical solution therein, and FIG. 7 is an upper side view of the same. 1,2… Dividing mold, 5,6 …… Cavity, 5b, 6b …… Cylinder cavity, 5c… Plug cavity, 10… Plastic container for chemicals, 11… Body, 12… Stopper, 13 ... Cylindrical part for filling chemical solution, 14 ... Hanging part, 19 ... Grip for filling, 20 ... Chemical liquid injection nozzle, 21 ... Cut seal.

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. ⁶ , DB name) B29C 49/00-49/80 A61J 1/00 300-353 B65D 1/08 B22L 22:00

Claims (1)

(57) [Claims] 1. A mold cavity for blow molding,
The plug is placed in advance and then blow molded to fuse the plug integrally with the body, and project to the outside where the inside and outside of the body communicate with the end of the body opposite to the plug. To form a container having a relatively flat cross-sectional shape of a body portion formed with a cylindrical portion and a hanging portion for filling a chemical solution, and then, after the blow molding, for filling the container with a liquid solution previously formed at the time of blow molding. A method for manufacturing a plastic container for a drug solution containing a drug solution therein, characterized in that the tube portion is filled with a drug solution at a high temperature of 100 ° C. or higher that can sterilize the container from the cylindrical portion.