JP2823580B2 - Foaming agent and method for producing the same - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to an effervescent agent and a method for producing the same, and more particularly, to an effervescent agent for bathing, washing or sterilization, and a method for producing the same.

[Conventional technology]

Conventionally, various foaming agents containing a carbonate, a bicarbonate, an organic acid component, and the like in addition to a medicinal component, for bathing, bath water purification, pool water sterilization, and the like are known. These are medicinal ingredients, for example, in the case of effervescent baths, herbal medicines prepared by blending dried extracts of medicinal plants such as dried corn extract, in addition to carbonates, bicarbonates, organic acid components, and others. Some necessary ingredients are mixed into a powder,
It is manufactured by tableting or granulating the obtained powder mixture.

When the above-mentioned foaming agent is put into water or hot water, the components therein react with each other, dissolve quickly while generating carbon dioxide gas, and dissipate the medicinal component. Therefore, especially when used as a foaming agent for baths, in addition to the medicinal effects of the contained medicinal components, the foamed carbon dioxide gas has the effect of promoting blood circulation, and is therefore pleased. In addition, the foaming property gives a comfortable feeling of use to the consumer and therefore has a great effect of increasing the commercial value, and the foaming agent is widely used.

[Problems to be solved by the invention]

By the way, when a carbonate or bicarbonate and an organic acid coexist, they react with each other only in the presence of a very small amount of water such as water in the air, and carbon dioxide is generated from the mixture. Therefore, conventional foaming agents generate carbon dioxide gas during storage, increasing the internal pressure in the packaging bag, swelling and breaking the packaging bag, and eventually losing the foaming power before use in many cases. There was a problem.

Certainly, in order to prevent carbon dioxide from being generated from a mixture of a carbonate or a bicarbonate and an organic acid, it is sufficient to prevent water from being mixed into the foaming agent. However, it is actually impossible to completely prevent the invasion of moisture by completely sealing the foaming agent in the packaging bag.

A situation such as breakage of the packaging bag and further loss of the foaming property not only significantly impairs the commercial value of the foaming agent but also possibly degrades the credibility of consumers.

An object of the present invention is to provide a foaming agent that does not deteriorate foaming properties during storage and a method for producing the same, in view of the above-described conventional problems.

[Means for solving the problem]

Foaming agent according to the present invention, in order to solve the above problems, a core component containing a foaming component and a highly hygroscopic medicinal component,
It is formed by coating with an outer shell component composed of a low hygroscopic component.

The foaming agent according to the present invention is produced as follows.
In the first method, a mixed powder containing a foaming component and a highly hygroscopic medicinal component is prepared as a core component powder, while a low-hygroscopic component powder is prepared as an outer shell component, and a specific amount of the outer shell component is prepared. A predetermined amount of the powder for the core component is deposited in a predetermined range on the upper surface portion of the powder for use, and then the core powder is covered with a required amount of the powder for the shell component and the whole is pressed.

The second method is to prepare a mixed powder containing a foaming component and a highly hygroscopic medicinal component as a core component powder, while preparing a powder for an outer shell component with a low hygroscopic component, The powder is solidified to form a highly hygroscopic solid, and the obtained highly hygroscopic solid is coated with the outer shell component powder and pressed.

A third method is to prepare a mixed powder containing a foaming component and a highly hygroscopic medicinal component as a powder for a core component, while preparing a powder for a shell component with a low hygroscopic component and obtain a specific amount of the shell component. Pre-press the powder for molding to form a low-hygroscopic solid,
A certain amount of the core component powder is solidified to form a highly hygroscopic solid, and the highly hygroscopic solid is layered within a predetermined range on the upper surface portion of the low hygroscopic solid, and a necessary amount of the outer shell component powder is further added. Cover and main press.

[Action]

The foaming agent according to the present invention prevents the outer shell component composed of the low-hygroscopic component from invading moisture into the core component including the high-hygroscopic medicinal component.

In the method for producing a foaming agent according to the present invention, a core component containing a highly hygroscopic medicinal component is coated with a low hygroscopic component.

Hereinafter, the foaming agent and the production method thereof according to the present invention will be described in more detail.

<Foaming Agent> The foaming agent according to the present invention is formed of a core component and an outer shell component, and the core component contains a foaming component and a highly hygroscopic drug component.

The foaming component contained in the core component together with the highly hygroscopic medicinal component is composed of bicarbonate and an organic acid which is solid at room temperature. Specific examples of the organic acid that is solid at room temperature used in the present invention include, for example, succinic acid, citric acid, tartaric acid, fumaric acid, lactic acid, malic acid, and the like. These may be used alone or in combination.
Among them, succinic acid is particularly preferred.

Further, the bicarbonate constituting the foaming component together with the organic acid in the present invention is a bicarbonate solid at room temperature, specifically, sodium hydrogen carbonate, potassium hydrogen carbonate, other alkali metal salts except lithium, And ammonium bicarbonate. These may be used alone or in combination. Among them, sodium hydrogen carbonate is particularly preferred.

Further, in addition to the bicarbonate and the organic acid which is solid at room temperature, a carbonate may be contained to constitute the whole foaming component. When a carbonate is added to one of the foaming component constituents, generation of carbon dioxide due to spontaneous decomposition of bicarbonate is suppressed, and long-term storage is possible, which is preferable. Examples of the carbonate which may be contained as the foaming component include, for example, anhydrous sodium carbonate.

It is preferable that the ratio of each constituent substance in the foaming component composed of the above compound is as follows with respect to the entire foaming component. That is, the ratio of the organic acid is 20 to 80% by weight, and the ratio of the bicarbonate is 20 to 80% by weight. The carbonate is not always necessary, but is preferably contained at a ratio of 5 to 50% by weight.

The core component in the foaming agent according to the present invention contains a highly hygroscopic medicinal component in addition to the above foaming components. The type of the highly hygroscopic medicinal component that may be contained in the core component differs depending on the use of the foaming agent. When the foaming agent is a bath foaming agent, the following components are exemplified. That is, it is said to be a herbal medicine, dried toucan extract, dried chimney extract, dried dry extract, and other dry extracts prepared by blending dry extracts of medicinal plants, for example, peonies, ziowe, licorice, yokuinin, bakuryo, botanpi, japjutsu, Dried extracts such as juniper may also be mentioned. The kind of the highly hygroscopic medicinal component contained in the core component is not limited to such crude drugs. In addition, Obak, Ogon, Tofu Chichinomi, Bofu,
Typhoid, Usbania oyster, Hamamelis, Arnica, Calendula, Aesculus chinensis, St. John's wort, Shazensi, Genoko Shoko and the like.
When the foaming agent is a bath or pool washing foaming agent, for example, sodium peroxide, bleaching powder, parahydroxybenzoic acid esters, alkyldimethylbenzylammonium salt, salicylic acid, benzethonium chloride,
Fungicides such as chlorohexidine gluconate and hexachlorophene, and antibacterial agents are also included.

Further, in addition to the medicinal components, for example, highly hygroscopic components such as polyhydric alcohols such as glycerin and sorbitol, saccharides, amino acids, sodium hyaluronate, caramel and cyclodextrin can be preferably contained.

In the core component in the foaming agent according to the present invention, the low-hygroscopic medicinal component limited to the high-hygroscopic medicinal component as described above is mixed with the high-hygroscopic medicinal component. No problem.

In the core component of the foaming agent according to the present invention, the following substances may be contained in addition to the above compounds. For example, when the foaming agent according to the present invention is used as a cleaning foaming agent, one such example is a surfactant. Surfactants which may be used as a core component of the foaming agent when used as a cleaning foaming agent include, specifically, for example, an alkyl sulfonate alkali salt such as sodium alkyl sulfonate, α
-Olefin sulfonic acid alkali salts such as sodium olefin sulfonate, alkyl sulfate sulfate, acyl amino acid alkali salt, fatty acid soap and the like,
These are used alone or in combination. Among them, alkali salts of alkyl sulfonates, particularly sodium alkyl sulfonates, or sodium α-olefin sulfonates are preferred.

When a foaming agent is used as a cleaning foaming agent, an inorganic powder may be added to the core component in addition to the surfactant described above. Specific examples of such an inorganic powder that may be used in the present invention include kaolin, titanium oxide, zinc oxide, sericite, bentonite, talc, calcium silicate, and the like. These may be used alone or in combination. Among them, kaolin is particularly preferred.
When such an inorganic powder is contained, the foamed countless bubbles cause the powder to collide with the surrounding wall, and physically remove dirt.

The particle size of the inorganic powder that may be contained in such a core component is preferably 50 μm or less, and more preferably 20 to 5 μm.
If the particle size exceeds 20 μm, the colloidal particles tend to settle out in water, which is not preferred.

Also, when the foaming agent is used as a bath foaming agent, the density may increase when the inorganic powder as described above is contained. When the density increases, it is less likely that the foaming agent floats by buoyancy and foams on the water surface when foaming in the bathtub. Further, when the inorganic powder is contained, the hardness of the core portion can be increased to a preferable value, and if the hardness rises to a value close to the preferable value, the foaming property of the foaming agent is suppressed and the floating is further prevented. preferable. It is preferable that the inside of the bathtub be clouded with inorganic powder, since it is possible to enjoy a feeling close to a hot spring.

In addition, it is preferable that a fragrance, a coloring agent, and the like are contained in the core component because the atmosphere during bathing can be improved. Particularly in the case of a fragrance or a coloring agent, it can be preferably contained in the core component. In addition, it is preferable to add a polyhydric alcohol such as polyethylene glycol because a moisturizing effect is produced.

The proportion of the foaming component contained in the core component is preferably 20 to 95% by weight in the entire core component.

The proportion of the highly hygroscopic medicinal component contained in the core component varies depending on the use of the foaming agent. For example, in the case of a bath agent, it is 5 to 80% by weight, preferably 10 to 10% by weight in the whole core component.
60% by weight. When the proportion of the highly hygroscopic medicinal component is less than 5% by weight, the effect as a bath agent may not be exhibited in some cases, which is not preferable. If it exceeds 80% by weight, the amount of carbon dioxide gas generated from the foaming component is small,
Dissolution takes a long time, which is not preferable.

When the use of the foaming agent is a bath or pool cleaning foaming agent, the ratio of the foaming component is 10 to 70 in the entire core component.
%, Preferably 20 to 60% by weight.

In the case of tableting only the core component, the shape of the core component is cylindrical, the diameter is 5 to 60 mm, and the height is 10
If the mass of the core component is set to about 10 g, manufacturing is easy. The hardness of the core component is preferably less than 1 kg in breaking strength. However, for example, 2PO of JIS6301 Olsen hardness tester
If the ND is less than 2 degrees, the effect of pressure bonding with the outer shell component is lost, which is not preferable. Further, the foaming time of the core component may be extremely long, which is not preferable.

In the foaming agent according to the present invention, the outer core component covers the core component formed by the above-described configuration. The outer shell component is composed of a low hygroscopic component.

As the low hygroscopic component constituting the outer shell component, for example,
The same low-hygroscopic medicinal component, foaming component, carbonate added to the foaming component, and inorganic powder as well as the above-described components as components that can be included in the core component together with the highly hygroscopic medical component. , A surfactant, a water-soluble fragrance, a coloring agent, polyethylene glycol, and other low hygroscopic substances. These may be used alone or in combination. In particular, it is preferable to change the kind of the pigment to be contained between the core component and the outer shell component, since the recreational property due to the color change is obtained.

Furthermore, it is particularly preferable that the foam component is contained in the outer shell component composed of the low moisture-absorbing component as in the core component.

The proportion of the foaming component that may be contained in the outer shell component is 20 to 95% by weight in the entire outer shell component, preferably,
30-90% by weight is desirable.

The proportion of the outer shell component is 20 to 98% by weight, preferably 60 to 95% by weight in the total of the outer shell component and the core component.
Is desirable. When the proportion of the outer shell component is 20% by weight or less, the outer shell component cannot cover the core component with a sufficient thickness. Therefore, it is not preferable because the core component absorbs the outside air through the outer shell component to foam the foaming component. When the proportion of the outer shell component exceeds 98% by weight, the proportion of the core component is too small and the component effect cannot be sufficiently exhibited, which is not preferable.

When the total amount of the foaming component increases, the foaming time increases, and the thickness of the obtained foamable tablet also increases.

The foaming agent formed by coating the core component with the outer shell component has a cylindrical shape, a diameter of 10 to 90 mm, and a height of 5 to 50 mm, so that machine manufacture may be facilitated. The mass of only the outer shell component covering the core component is preferably about 5 to 200 g. Also,
The hardness of the outer shell component is 2 measured with a push bull gauge.
It is good to be 10 kg, preferably 3 to 7 kg.

When the hardness is high, the foaming amount per unit weight per unit time decreases, and the foaming time generally increases. When the hardness is low, the foaming amount per unit weight per unit time increases, and the foaming time generally decreases. Therefore,
Except for the presence or absence of a hygroscopic component, even if the component composition and the ratio of the outer shell component and the core component are substantially the same, if the hardness is balanced and different, the foaming amount becomes complicated. It is preferable because it can be controlled and can meet various demands of users.

The core component is preferably located centrally in the outer shell component, especially in the foaming agent, without eccentricity. In addition, the outer shape of the foaming agent does not particularly matter. Characters and other marks may be engraved on the surface. When engraving a mark, the mark may be clearly read if the depth is 0.1 mm or more. If the foaming agent has a square or cylindrical shape, or if characters are engraved on the surface, if the corners are slightly rounded, the corners will be chipped during long-term storage. And the shape at the time of manufacture can be maintained for a long period of time.

Such a foaming agent according to the present invention can be stored for an extremely long time if it is sealed in a bag formed of a moisture-proof sheet made of, for example, polyester, polypropylene, or aluminum.

In the method of using the foaming agent according to the present invention, for example, when the foaming agent is a bath foaming agent, usually 1 to 2 pieces are charged into a bathtub to foam. In the case of the cleaning foaming agent as well, usually 1 to 2 pieces are added to the portion to be cleaned and foamed.

<Production method> The above-mentioned foaming agent may be produced by the following production method.

 The first manufacturing method is as follows.

First, a powder for an outer shell component is prepared from the low hygroscopic component already described in the invention relating to the foaming agent.

Meanwhile, a core component powder to be deposited on the outer shell component powder is prepared. The core component powder is prepared by mixing powders of each component including a foaming component and a highly hygroscopic drug component. As the foaming component and the highly hygroscopic medicinal component to be mixed with each other, the respective components already described in the invention relating to the foaming agent are used. The mixing order of the foaming component and the highly hygroscopic medicinal component does not matter. What is necessary is just to mix each by the above-mentioned predetermined amount each.

Next, a specific amount of the outer shell component powder is taken out of the outer shell component powder, filled into a cavity having a predetermined volume, and a predetermined amount of the core component powder is deposited within a predetermined range on the upper surface thereof. Then, the core component powder is covered with a necessary amount of the shell component powder.

The ratio of the outer shell component powder on which the core component powder is deposited is preferably 2 to 10 parts by weight per 1 part by weight of the core component powder. The thickness of the shell component powder filled in the cavity is preferably 2 to 8 with respect to the thickness 1 of the core component powder.

The predetermined range of the upper surface portion of the outer shell component powder on which the inner core component powder is deposited is within the outline around the outer shell component powder, preferably with a width of at least 2/10 to 8/10 of the diameter or diagonal length. The inside surrounded by is preferred.

The ratio of the necessary amount of the outer shell component powder that covers the deposited core component powder from above is preferably 2 to 10 parts by weight per 1 part by weight of the core component powder. The thickness of the outer shell component powder covering the core component powder may be 2 to 8 with respect to the thickness 1 of the core component powder.

Next, after laminating the outer shell component powder and the core component powder in this manner, the whole is pressed at a predetermined pressure. The pressing force is 2 × 10 ³ to 8 × 10 ³ Kg, preferably 4
× 10 ^{3 to} 5 × 10 ³ Kg is desirable. If the pressing force is less than 2 × 10 ³ Kg, the shape of the obtained foaming agent tends to collapse, which is not preferable. If the pressing force exceeds 10 × 10 ³ Kg, the hardness of the obtained foaming agent is too high, and it is difficult to dissolve in water, which is not preferable. Further, the press machine causes air leakage and the like, which is extremely difficult in practice. By inserting a film made of polypropylene or polyethylene between the press pusher part and the compressed outer shell component powder, the film is peeled between the press pusher part and the outer shell component powder to be compressed. Is preferable because it can be easily performed.

By doing so, a cylindrical foaming agent having a ratio of the shell component of 10% to 90% by weight in the total of the shell component and the core component is obtained.

 FIG. 3 shows a process chart of the first manufacturing method.

 The second manufacturing method is as follows.

By the same method as the first production method, a powder for a core component is prepared from a mixed powder containing a foaming component and a highly hygroscopic medicinal component, while a powder for an outer shell component is prepared from a low hygroscopic component.

Next, a predetermined amount of the core component powder is taken out of the core component powder and solidified by, for example, press tableting to form a highly hygroscopic solid. The shape of the highly hygroscopic solid obtained by press tableting may be any shape, but the size of the highly hygroscopic solid is 0.2 / 10 to that of the effervescent tablet to be manufactured.
It is desirably 7/10% by volume, preferably 0.5 / 10 to 4/10% by volume. If the upper area of the highly hygroscopic solid exceeds 80% by area of the entire area, the highly hygroscopic solid is not preferable because it becomes an obstacle to air escape when pressing the powder for the outer shell component. It also requires, in particular, that the values for the vertical and horizontal dimensions are both smaller than the respective values for the effervescent tablets to be produced.

The pressing force at the time of tableting is 200 to ³ × 10 ³ Kg, preferably 30
0 to 2.5 × 10 ³ Kg is desirable. If the pressing force is less than 200 kg, it is not possible to give sufficient hardness to the highly hygroscopic solid, and it may be broken during the production, so that it is not a good idea. When the pressing force exceeds 3 × 10 ³ Kg, the hardness of the obtained highly hygroscopic solid is too high, and the adhesiveness to the powder for the outer shell component may be too weak later, which is not preferable. In addition, if the hardness is high, the drop strength may be reduced, causing chipping with a small impact, or causing cracking when supplying highly hygroscopic solids to an automatic machine. When the powder for the shell component is pressed, air is difficult to escape, and the pressing time is too long, so that the productivity is remarkably reduced.

Next, the thus obtained highly hygroscopic solid is coated with the powder for the outer shell component and pressed. Specifically, the highly hygroscopic solid obtained above may be placed within a predetermined range of a specific amount of the upper surface of the outer shell component powder, covered with the required amount of outer shell component powder, and pressed again.

That is, first, a specific amount of the outer shell component powder to be loaded with the highly hygroscopic solid is taken out and filled into a cavity having a predetermined volume. The proportion of the outer shell component powder on which the highly hygroscopic solid is placed is preferably 2 to 6 parts by weight per 1 part by weight of the highly hygroscopic solid. The packing thickness of the outer shell component powder on which the highly hygroscopic solids are placed is 40 to 80% compressibility of the outer shell component powder by pressing.
In consideration of the above, the thickness is preferably set to 2 to 6 with respect to the thickness 1 of the highly hygroscopic solid.

Next, the highly hygroscopic solid is superimposed within a predetermined range on the upper surface of the specific amount of the outer shell component powder. The range in which the highly hygroscopic solids are overlapped may be in accordance with the predetermined range of the first manufacturing method.

The ratio of the required amount of the outer shell component powder that covers the highly hygroscopic solid from above is 2 to 1 part by weight of the highly hygroscopic solid.
10 parts by weight is good. The thickness of the portion where the thickness of the outer shell component covering the highly hygroscopic solid is smallest is preferably 0.5 to 1 with respect to the thickness 1 of the highly hygroscopic solid in consideration of the compressibility at the time of pressing.

Next, after the outer shell component powder and the highly hygroscopic solid are laminated on each other in this manner, the whole is pressed at a predetermined pressure. The pressing force is 2 × 10 ³ to 10 × 10 ³ Kg, preferably 2.
5 × 10 ³ to 8 × 10 ³ Kg is good. If the pressing force is less than 2 × 10 ³ Kg, the obtained tablets have low drop strength and are liable to crack, which is not preferable. If the pressing force exceeds 10 × 10 ³ Kg, the foaming time becomes too long, and the foaming amount per unit weight per unit time becomes too small, which is not preferable.

As in the case of the first manufacturing method, a polypropylene or polyethylene film may be interposed between the press piston and the powder for the shell component to be compressed.

By doing so, a foaming agent having a ratio of the outer shell component of 10% by weight to 90% by weight in the total of the outer shell component and the core component is obtained.

In the case of the second production method, when the value of the press pressure of the highly hygroscopic solid and the value of the press pressure after coating the highly hygroscopic solid with the outer shell component powder are changed, The hardness of the fusible solid and the hardness of the outer shell can be made different, and the foaming amount of the obtained foaming agent can be changed in a complicated manner.
The difference between the press pressure of the highly hygroscopic solid and the press pressure after coating the highly hygroscopic solid with the powder for the outer shell component is 50 per cm ^2.
When the weight is Kg or more, a difference in hardness between the two is apparent, which is preferable. If there is a difference in hardness, the foaming time will be different. In particular, it is better that the hardness of the highly hygroscopic solid is small unless it breaks during the production. When the hardness of the highly hygroscopic solid is small, the pressure bonding property with the outer shell is improved.

In the case of the second production method, a two-stage press is performed in which the central portion is pressed once, and then the outer portion is pressed while covering the central portion. As compared with a method that requires the use of a press machine, a small press pressure is sufficient, and the desired foaming agent can be easily manufactured using a small machine as a press machine. In particular, this is extremely advantageous in view of the fact that the production of the foaming agent has conventionally required a relatively large load of, for example, about 8 tons on a large press machine to shorten the life of the press machine.

In addition, once the highly hygroscopic solid material serving as the central portion is tableted, the obtained hygroscopic central solid material is further coated with a plurality of outer shell component powder layers or core component powder layers and pressed each time. You may. In this way, by coating a plurality of layers and changing the pressing pressure at that time, the foaming time can be more complicatedly controlled.

 FIG. 4 shows a process chart of the second manufacturing method.

 The third manufacturing method is as follows.

In the same manner as in the first and second production methods, a powder for a core component is prepared from a mixed powder containing a foaming component and a highly hygroscopic medicinal component, while a powder for an outer shell component is prepared from a low hygroscopic component. I do. Next, a highly hygroscopic solid is produced by a method similar to the second production method.

Next, a specific amount is taken out from the outer shell component powder,
Fill and press into a cavity of predetermined volume to form a low hygroscopic solid. The ratio of the specific amount of the powder for the outer shell component to be taken out is 1 to 5 parts by weight, preferably 1 to 4 parts by weight, per 1 part by weight of the highly hygroscopic solid. The shape of the low-hygroscopic solid obtained by pressing is preferably cylindrical.

Press force 200~2 × 10 ³ Kg, preferably 200 to 1 × 10 ³
Kg is preferred.

Next, the highly hygroscopic solid is layered within a predetermined range on the upper surface of the thus obtained low hygroscopic solid. The predetermined range in which the highly hygroscopic solids are stacked may be in accordance with the first and second manufacturing methods. Next, the high moisture-absorbing solid is stacked on the low moisture-absorbing solid in this manner, and the solid is coated with a required amount of the powder for the outer shell component. The ratio of the required amount of the shell component powder to be coated is 1 to 5 parts by weight, preferably 1 to 1 part by weight of the highly hygroscopic solid.
-4 parts by weight is desirable. In addition, the thickness of the portion where the thickness of the outer shell component covering the highly hygroscopic solid is smallest is preferably 2 to 8 with respect to the thickness 1 of the highly hygroscopic solid in consideration of the compressibility.

Next, after the low-hygroscopic solid, the powder for the shell component, and the high-hygroscopic solid are stacked on each other in this manner, the whole is finally pressed at a predetermined pressure. Pressing force is 2 × 10
³ to 10 × 10 ³ kg, preferably 4 × 10 ³ to 8 × 10 ³ kg.
If the pressing force is less than 2 × 10 ³ Kg, the strength of the obtained tablet when it drops is low, and the tablet tends to break, which is not preferable. Ten
If it exceeds × 10 ³ Kg, the foaming time becomes too long, and the foaming amount per unit weight per unit time becomes too small, which is not preferable.

It is preferable to insert a polypropylene or polyethylene film between the press piston and the powder for the shell component to be compressed as in the first and second manufacturing methods. The use of a vibrator at the time of pressing is also the same as in the first and second manufacturing methods.

By doing so, a foaming agent having a ratio of the outer shell component of 10% by weight to 90% by weight in the total of the outer shell component and the core component is obtained.

In the case of the third manufacturing method, when the pressing pressure at the time of forming the low-hygroscopic solid, the pressing pressure at the time of forming the high-hygroscopic solid, and the pressing pressure at the final stage are respectively changed, the hardness of each other is changed. The difference clearly appears, and the amount of foaming of the foaming agent can be more complicatedly changed than in the second production method, which is preferable. In particular, the difference between the press pressure at the time of forming the low-hygroscopic solid, the press pressure at the time of forming the high-hygroscopic solid, and the press pressure at the final stage is preferably 50 kg or more per 1 cm ² .

In the case of the third production method, since the press is performed three times in this manner, a smaller press pressure is sufficient compared to a method in which the foaming agent must be solidified by one or two presses, As the press machine, the desired foaming agent can be easily manufactured with a smaller machine than in the case of the second manufacturing method.

 FIG. 5 shows a process chart of the third manufacturing method.

〔Example〕

 Hereinafter, embodiments of the present invention will be described.

<Example 1> First, a powder for a shell component and a powder for a core component each composed of a mixture as shown in Table 1 were prepared according to the second production method.

Next, a foaming agent was produced in an environment at a temperature of 20 ° C. and a relative humidity of 50%. That is, 5 g of the core component powder was taken out of the powder, and tableted with a pressing force of 500 kg to obtain a columnar, highly hygroscopic solid having a diameter of 20 mm and a height of 10 mm.

Next, 8 g for loading 5 g of the highly hygroscopic solid thus obtained was taken out of the outer shell component powder, and the diameter was 40 mm.
A 60 mm deep cylindrical cavity was filled.

Next, the above highly hygroscopic solid was overlaid on the center of the upper surface of the 8 g of the outer shell component powder, and the required amount of the outer shell component powder 17 g was covered thereon.

After the outer shell component powder and the highly hygroscopic solid were thus laminated on each other, they were pressed with a pressing force of 2.5 × 10 ³ Kg. By doing so, the diameter is 40 mm and the height is 20 m
m and a mass of 30 g were obtained.

When one of the foaming agents thus obtained was cut in half with a cutter and the inside was confirmed, a cross-sectional view of FIG. 1 and a plan view of FIG. As shown, it was found that the core component 1 including the foaming component and the highly hygroscopic medicinal component was formed by coating the outer shell component 2 composed of the low hygroscopic component.

<Comparative Example> A powder mixture composed of a mixture as shown in Table 2 was prepared.

Next, 30 g of the above powder mixture was taken out and filled in the cavity used in Example 1.

Then, the cavity filled with the powder mixture was
Pressing was performed with a force of × 10 ³ Kg. Thus, a columnar foaming agent having a diameter of 40 mm, a height of 20 mm, and a mass of 30 g was obtained.

<Reference Example> A powder mixture composed of a mixture as shown in Table 3 was prepared.

Next, 30 g of the above powder mixture was taken out and filled in the cavity used in Example 1.

Then, the cavity filled with the powder mixture was
Pressing was performed with a force of × 10 ³ Kg. Thus, a cylindrical foam having a diameter of 40 mm, a height of 20 mm, and a mass of 30 g was obtained.

<Comparative experiment 1> The foaming agents and foams obtained in Example 1, Comparative example and Reference example above were each taken out two by two, and one of each two was made to have a relative humidity of 100% and the other to 65%. Placed under environment. Ambient temperature was maintained at 20 ° C. The appearance changes of the foaming agents and foams after 2, 14, 30, and 90 days were compared and observed.

The results are shown in Table 4. In Table 4, た indicates that no change was observed, △ indicates that discoloration was observed,
Samples in which large cracks were confirmed were indicated by x.

From the above experiment, it was found that the foaming agent manufactured according to Example 1 did not change its shape even when stored under high humidity for a long period of time.

<Comparative Experiment 2> Twenty each of the foaming agents and foams obtained in Example 1, Comparative Example, and Reference Example were taken out, and formed into two aluminum sheets each having a size of 9 cm x 11 cm. Each of them was individually sealed in a packaging bag under an environment of a temperature of 20 ° C. and a relative humidity of 50% to obtain a packaged tablet. The required time from powder preparation to sealing was 2 hours. Next, the volume of the obtained packaged tablet in a sealed state was measured in the packaged state. That is, the sample was immersed in a 300 ml measuring cylinder containing 200 ml of water, and the rise in water level was measured. Next, the packaged tablets whose volume was measured in this manner were lifted from the measuring cylinder, and 10 packaged tablets of each effervescent agent obtained in Example 1, Comparative Example and Reference Example were heated at a temperature.
It was placed in a 20 ° C. environment. In the same manner, each of the remaining 10 wrapped tablets obtained in Example 1, Comparative Example and Reference Example was heated at 40 ° C.
Placed under the environment.

With respect to the packaged tablets placed at 20 ° C. and the packaged tablets placed at 40 ° C., the number of swelling of the package was confirmed after 2, 14, 30, and 90 days, respectively.

 The results are shown in Table 5.

From the above experiment, it was found that the foaming agent manufactured according to Example 1 showed almost no change in foaming even when stored under high humidity for a long period of time.

<Comparative experiment 3> The same as Comparative experiment 2 except that the material of the sheet was aluminum foil (foil) and the number of foams was three each.

 The results are shown in Table 6.

From the above experiment, it was found that the foaming agent produced in Example 1 had no foaming change even if stored under high humidity for a long period of time if it was wrapped in an aluminum sheet.

Furthermore, in the above experiment performed on the foaming agent and the foam obtained in Example 1, the comparative example, and the reference example, the comparative experiment 2 was performed on three foaming agents stored at 40 ° C. for 14 days. The volume was measured in the same manner, and the expansion rate was calculated based on the measured value. The expansion rate was calculated by the following equation.

The results are shown in Table 7.

In addition, indicates an average value of each.

<Example 2> The same powder for the outer shell component and the powder for the core component as in Example 1 were prepared.

Next, a foaming agent was produced according to the first production method according to the present invention. That is, 8 g of the outer shell component powder was taken out and filled in the cavity used in Example 1. Next, 5 g of the core component powder is deposited on the upper surface of the filled outer shell component powder in the center, avoiding the peripheral portion.
5 g of the core component powder was covered with 17 g of the shell component powder and pressed with a force of 2.5 × 10 ³ Kg. Thus, a columnar foaming agent having a diameter of 40 mm, a height of 20 mm, and a mass of 30 g was obtained.

One of the foaming agents thus obtained was cut in half by a cutter, and the inside was confirmed. The manufactured foaming agent includes a core component including a foaming component and a highly hygroscopic medicinal component,
It was found that the shell component composed of the low hygroscopic component was formed by coating.

Next, an experiment was performed on the foaming agent produced as described above according to Comparative Experiments 1 to 3.

 The results are shown in Tables 8 to 10 (2).

From the above experiment, it was found that the foaming agent manufactured in Example 2 did not deteriorate in foaming during storage.

<Example 3> The same powder for the outer shell component and the powder for the core component as in Example 1 were prepared.

Next, a foaming agent was produced according to the third production method according to the present invention. That is, from the above core component powders
5 g of the core component powder was taken out and tableted with a pressing force of 500 kg to obtain a highly hygroscopic solid having a cylindrical shape, a diameter of 20 mm and a height of 10 mm.

Then, 17 g of the powder for the outer shell component was taken out, and Example 1 was obtained.
And pressed with a force of 1 × 10 ³ Kg. In this manner, a columnar low-hygroscopic solid having a diameter of 40 mm, a height of 15 mm, and a mass of 22 g was obtained.

Next, the high moisture-absorbing solid is superimposed on the center of the upper surface of the low moisture-absorbing solid in the cavity thus obtained,
Further, 8 g of the powder for the shell component was taken out, the whole highly hygroscopic solid was covered, and pressed with a pressing force of 2.5 × 10 ³ Kg. By doing so, diameter 40mm, height 20mm, mass
30 g of a columnar foaming agent was obtained.

Next, one of the foaming agents thus obtained was cut in half with a cutter, and the inside was confirmed. It was found that the foaming agent obtained by the production was formed by coating a core component containing a foaming component and a highly hygroscopic medicinal component with an outer shell component composed of a low moisture absorbing component.

Next, an experiment was performed on the foaming agent produced as described above according to Comparative Experiments 1 to 3.

 The results are shown in Tables 8 to 10 (2).

From the above experiment, it was found that the foaming agent manufactured in Example 3 did not deteriorate in foaming during storage.

<Examples 4 to 9> The pressing pressure A for tableting the highly hygroscopic solid and the pressing pressure B for laminating the outer shell component powder and the highly hygroscopic solid to each other were set to 10th. A foaming agent was produced in the same manner as in Example 1 except that the procedure was as shown in the table.

Next, the foaming time of each foaming agent thus obtained was measured.

 The results are shown in Table 11 together with the press pressure.

In the table, “′” represents “minute, second” (hereinafter similarly expressed).

From the above results, the powder for the outer shell component and the highly hygroscopic solid were laminated on each other, and the pressing pressure B at the time of pressing in the final stage was kept constant, while the pressing when compressing the highly hygroscopic solid was performed. It was found that increasing the pressure A can increase the foaming time.

At this time, it was found that the foaming agent formed in Example 9 was easily cracked. Furthermore, it was also found that when a highly hygroscopic solid was formed by compressing it with an extremely high pressure, the adhesion to the outer shell was reduced.

<Examples 10 to 13> The procedure was performed except that the pressing pressure A at the time of tableting the highly hygroscopic solid was set to the value shown in Table 12, and the thickness of the obtained highly hygroscopic solid was measured once in the middle. Flaky effervescent tablets were produced in the same manner as in Example 1.

Next, the thickness of the obtained effervescent tablet, the hardness of the outer shell, the time during which it floated while foaming in water, and the time until foaming in water was completed were measured.

Next, the foaming time of each foaming agent thus obtained was measured.

 The results are shown in Table 12.

From the above results, it can be seen that the thickness of the obtained highly hygroscopic solid can be changed by changing the pressing pressure A when compressing the highly hygroscopic solid. It was also found that the foaming time also changed.

<Reference experiments 1 to 4> A foam was produced in the same manner as in Reference example except that the above-mentioned cavity filled with the powder mixture was pressed at the pressure shown in Table 12.

Next, the foaming time was measured for each of the obtained foams.

 The results are shown in Table 13.

In addition, it turned out that the foam obtained by the reference experiment 1 is easy to be broken by falling. In addition, it was found that the foam obtained in Reference Experiment 4 had small bubbles.

<Reference Experiments 5 and 6> Foams were produced in the same manner as in Reference Experiments 1 to 4 while changing the pressing pressure, and the hardness, thickness, and foaming time were measured.

 The results are shown graphically in FIGS.

In FIG. 8, x represents the time during which the foam is floating while foaming, and * represents the time until foaming ends.

From the above results, when the press pressure is high, the hardness increases,
It was found that the foaming time became longer and the thickness became thinner.

〔The invention's effect〕

Since the foaming agent according to the present invention has the above configuration, the foaming property does not deteriorate during storage. Further, the method for producing a foaming agent according to the present invention can produce a foaming agent having such characteristics.

Further, if the hardness of the outer shell component and the hardness of the core component are made different from each other, the foaming amount can be controlled in a complicated manner, and it is possible to meet the complicated demands of users.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view of the foaming agent obtained in Example 1, FIG. 2 is a plan view of the foaming agent obtained in Example 1 when the inside is seen through, and FIG. FIG. 4 is a process diagram of the second manufacturing method, FIG. 5 is a process diagram of the third manufacturing method, and FIG. 6 is a graph showing the pressure and the hardness of the foam in Reference Experiments 1 to 3. FIG. 7 is a graph showing the relationship, FIG. 7 is a graph showing the relationship between the pressure in Reference Experiments 1 to 3 and the thickness of the foam, and FIG. 8 is the relationship between the pressure in Reference Experiments 1 to 3 and the foaming time of the foam. FIG. 1 core component 2 outer shell component

──────────────────────────────────────────────────続 き Continuation of front page (72) Inventor Shigeaki Nagasaka 648, Yayoi-cho, Shizuoka-shi, Shizuoka Pref. Inside of Polar Chemical Industry Co., Ltd. (56) References JP-A-53-130420 (JP, A) JP-A-2- 142722 (JP, A) JP-A-2-147696 (JP, A) JP-B 1-24127 (JP, B2) JP-B 7-47534 (JP, B2) JP-B 7-29883 (JP, B2) JP-B-60-2035 (JP, B2) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 7/00-7/50 A61K 9/46 A01L 2/16 A23L 2/40

Claims (4)

(57) [Claims] 1. A foaming agent formed by coating a core component containing a foaming component and a highly hygroscopic medicinal component with an outer shell component composed of a low hygroscopic component. 2. A mixed powder containing a foaming component and a highly hygroscopic medicinal component is prepared as a core component powder, while a low-hygroscopic component powder is prepared as an outer shell component, and a specific amount of the outer shell component powder is prepared. A method for producing a foaming agent, comprising depositing a predetermined amount of core component powder in a predetermined range on the upper surface portion of the powder, covering the core component powder with a required amount of outer shell component powder, and pressing the whole. 3. A mixed powder containing a foaming component and a highly hygroscopic medicinal component is prepared as a core component powder, while a low-hygroscopic component is prepared as an outer shell component powder, and a fixed amount of the core component powder is prepared. A method for producing a foaming agent, comprising: forming a highly hygroscopic solid by solidifying the resulting product, coating the obtained highly hygroscopic solid with a powder for an outer shell component, and pressing. 4. A mixed powder containing a foaming component and a highly hygroscopic medicinal component is prepared as a core component powder, while a low-hygroscopic component is prepared as an outer shell component powder, and a specific amount of the outer shell component powder is prepared. The powder is pre-pressed to form a low-hygroscopic solid, and a certain amount of the core component powder is solidified to form a high-hygroscopic solid. A method for producing a foaming agent, in which a hygroscopic solid is layered, further coated with a necessary amount of powder for an outer shell component, and then pressed.