JP2798272B2 - Interface for iontophoresis - Google Patents

Description

Description: The present invention relates to an interface (skin / mucosa abutment) for iontophoresis.

The interface in iontophoresis has a structure in which a reservoir for holding a chemical solution and an electrode for current distribution are combined.

The structure of this reservoir must ensure that the drug solution reaches a predetermined amount over time up to the biological skin interface, but since the reservoir itself is three-dimensional and passes through water, dilution of the drug occurs. For example, a sufficient structure has not yet been proposed.

In view of the above, an object of the present invention is to provide an interface having a structure suitable for iontophoresis, that is, an interface having a structure capable of performing efficient and appropriate administration by maintaining a local high concentration of a small amount of a drug such as a peptide.

That is, particularly peptide-based drugs such as calcitonin, insulin, and growth hormone are effective in small doses, but in order to effectively administer them transdermally or transadhesively by iontophoresis, their concentrations must be sufficiently high. Must be maintained.

The present invention effectively proposes an interface in which a drug is attached or stuck to the living body contacting surface of a drug-impermeable and water-permeable semipermeable membrane by spray-drying, spraying, or the like. It is a solution.

During treatment, the water (electrolyte solution, buffer solution, etc.) from the water retention unit passes through the semi-permeable membrane, causing the drug, which has adhered to the outer surface of the semi-permeable membrane in a solid state such as powder, to the skin. It dissolves and maintains local high concentration for a long time.

In another embodiment of the present invention, a drug-adhered form of a drug-containing water-soluble layer can be exemplified as another embodiment of the mode of sticking / adhering a drug.

That is, the drug-containing water-soluble layer is formed of a water-soluble polymer that retains, adheres to, and contains a predetermined drug,
As the water-soluble polymer, any water-soluble polymer such as soluble starch (oblate), sodium polyacrylate, polyvinyl alcohol and the like can be used, and is usually formed into a thin film. Further, the degree of water solubility can be appropriately adjusted according to the purpose of use.

Here, the moisture retaining portion is a container structure or a layered body, and is exemplified by a layer made of moisture permeable fibers such as cotton, PVA sponge, and cellulose triacetate, a swelling gel retaining water, a porous ceramic material, and the like. If necessary, a structure in which the periphery is covered with a cup made of a hard resin to prevent evaporation to the outside, or a structure in which the solution is introduced only at the time of use, may be appropriately adopted.

Examples of the semipermeable membrane include those made of semipermeable cellulose acetate, polyvinyl chloride, or regenerated cellulose, but are not particularly limited.

Next, embodiments of the present invention will be described in detail with reference to the drawings.

In FIG. 1, reference numeral 1 denotes a water holding unit, which is a porous body impregnated with water or an electrolyte solution as described above, a swollen gel-like body described above, or a simple container structure.

2 is a semipermeable membrane (for example, Spectrum medical industrie
Spectra-Por 3 manufactured by s-inc (Spectrum Medical Industries, Inc.) or
Spectra-Por 6), 3 is the drug located on one side. On the inner surface side of the semipermeable membrane 2, conductive rubber, conductive polymer, carbon film, aluminum foil, etc.
A porous or mesh-shaped electrode 4 made of metal foil is arranged. The whole of these structures is covered and supported and fixed by the flexible support member 6.

The support member 6 further extends to the living skin surface 01, and various adhesives and adhesives 11 are provided on the contact surface with the living skin surface 01.

Although the drug used is not limited to its molecular weight, etc., the interface of the present invention maintains the highest possible concentration and maintains a sufficient concentration on the efficiency of iontophoresis, even though the dose is particularly small. It is mainly useful for peptide drugs such as insulin which require the presence of water.

Antitussive expectorant Sodium cromoglycate, Ketotifen fumarate Bronchodilator Formoterol fumarate Analgesic Nalbuphine hydrochloride, Pentazocine lactate, Diclofenac sodium Cardiotonic agent Dopamine hydrochloride Psychiatric nerve stabilizer Perphenazine, Phenothiazine Antibiotics Cefotetan disodium sulfate, Dibecacin sulfate, Amino acid Netilmycin, sisomicin sulfate Antineoplastic agent Adriamycin, Mitomycin C, Bleomycin hydrochloride, Lentinan, Picibanil, Vincristine sulfate, Cisplatin Circulating function improver Nicametate citrate, Meclofenoxate hydrochloride,
Lisulide maleate, Calcium hopantenate Gout treatment Allopurinol Other peptides LHRH, Enkephalin, Endorphin, Interferon, Insulin, Calcitonin, TRH, Oxytocin, Ripressin, Vasopressin, Glucagon, Pituitary hormone (HGH, HMG, HCG, Desmopressin acetate) As described in detail above, the present invention can provide an appropriate water supply without diluting a drug held on the outer surface thereof by the interposition of a semipermeable membrane, and furthermore, the drug penetrates from the surface of a living body or outside. This has the effect of preventing cells from infiltrating into the water holding portion and enabling efficient and accurate administration for a long period of time.

[Brief description of the drawings]

 FIG. 1 is a diagram showing an embodiment of the present invention. DESCRIPTION OF SYMBOLS 1 ... Moisture holding | maintenance part, 2 ... Semi-permeable membrane, 3 ... Drug arrangement | positioning, 4 ... Electrode, 6 ... Support member, 01 ... Body skin surface.

Claims (1)

(57) [Claims] 1. An interface for iontophoresis, comprising a semipermeable membrane on which a drug is stuck or adhered on the living body contacting surface.