JP2792660B2 - Interface for iontophoresis - Google Patents

Description

The present invention relates to an interface (skin abutment) for iontophoresis.

The interface in iontophoresis has a structure in which a reservoir for holding a chemical solution and an electrode for current distribution are combined.

The structure of this reservoir must ensure that the drug solution reaches a predetermined amount over time up to the biological skin interface, but since the reservoir itself is three-dimensional and passes through water, dilution of the drug occurs. For example, a sufficient structure has not yet been proposed.

In view of the above, an object of the present invention is to provide an interface having a structure suitable for iontophoresis, that is, a structure capable of performing accurate and safe medication.

 The features of the present invention are as follows.

The present invention provides a drug layer containing a drug in a porous body mainly made of ceramics, a water supply reservoir layer holding water, and a semipermeable membrane between the drug layer and the water supply reservoir layer. By passing the water, water is passed from the water supply reservoir layer to the drug layer, but in order to maintain a high drug concentration, a function of preventing leaching of the drug and various bacteria from the drug layer to the water supply reservoir layer is performed. .

Examples of the porous body forming the drug layer include unfired ceramics, ceramic porous bodies such as alumina and zirconia, and synthetic resin materials. Generally, the average pore size is preferably several μm to several hundred μm, and the porosity is usually preferably about 30 to 90%. The pore size and porosity are both selected as appropriate according to the number of sweat glands in the applicable skin, the dose of the drug used, and are not particularly limited.

In addition, a material obtained by laser processing a ceramic material, a synthetic resin material, or the like to form a capillary structure can also be suitably used. The thickness of these materials is not particularly limited, but usually 0.1 mm ~ 10 mm
Good degree.

In addition, although a hard material is preferably used for these interface forming means, a soft fill or sheet material may be used in some cases (that is, if the capillary or the like is non-deformable).

The reservoir layer for water replenishment is exemplified by a container structure, one impregnated with water storage fibers such as cotton, PVA sponge, cellulose triacetate, or a swollen gel holding water. If necessary, a structure in which the periphery is covered with a cup formed of a hard resin to prevent evaporation to the outside can be adopted.

Examples of the semipermeable membrane include semipermeable cellulose acetate, polyvinyl chloride, and regenerated cellulose.

The water shown in the present invention is not limited to this, and may be an electrolyte solution such as sodium chloride.

Next, embodiments of the present invention will be described in detail with reference to the drawings.

In FIG. 1, 1 is a reservoir layer for hydration,
As described above, a porous body impregnated with water or an electrolyte solution, or a swollen gel-like body described above is used.

Reference numeral 2 denotes a semipermeable membrane, and reference numeral 3 denotes a hard porous material containing a drug. The hydration reservoir layer 1, the semi-permeable membrane 2, and the hard porous body 3 are laminated as shown in the figure, and a conductive rubber, a conductive polymer, a carbon film, aluminum An electrode 4 made of a metal foil or the like is laminated. These laminated structures are covered and supported and fixed by the flexible support member 6.

The support member 6 further extends to the living skin surface 01, and various adhesives and adhesives 11 are provided on the contact surface with the living skin surface 01.

Next, another structure is shown in FIG. The embodiment shown in FIG. 2 is provided with a pair of electrodes and a power supply unit.

The hydration reservoir layer 1 forms a sealed space by mounting a rigid cup member 5 and a laminate of the semipermeable membrane 2 and the rigid porous body 3 at the opening of the cup member 5. The electrolyte solution or water is drawn into this space. Further, the surface of the cup member 5 is covered with a flexible support member 6. The electrode 4 is provided on the inner upper surface of the cup member 5.
Is installed.

The support member 6 extends to the surface of the living skin, and a counter electrode 9 made of the same material as the electrode 4 is attached to a contact surface with the surface of the living skin, and the surface of the counter electrode 9 has further adhesiveness. Conductive gel layer 7 (eg, used for biological electrodes)
Is attached and fixed.

On the upper surface of the cup member 5, a power supply unit 8 that includes a battery and an IC and performs electric output is mounted. The power supply unit 8 is connected to the electrode 4 and the counter electrode 9 by conductive wires (conductive wires are not shown).

It is preferable that the extraction port for extracting water into the cup member 5 has an opening / closing mechanism (for example, see Japanese Patent Application Laid-Open No. Sho 49-7747).
No. 9).

When the embodiment shown in FIG. 2 is used, the conductive gel layer 7
Is adhered to the living skin surface 01, the hard porous layer 3 is also in good contact with the living skin surface 01, and the electrode 4 and the counter electrode 9
In the meantime, a closed circuit is obtained via the living skin tissue, and preparation for administration is completed.

The chemical solution contained in the hard porous layer 3 is not limited to its molecular weight and other various amounts. However, the interface of the present invention is suitable for the efficiency of iontophoresis, even though the dose is particularly small. It is useful mainly for peptide-based drugs such as insulin, which maintain the highest possible concentrations and require the presence of sufficient water.

Antitussive expectorant sodium cromoglycate, ketotifen fumarate bronchodilator formoterol fumarate analgesic narbuphine hydrochloride, pentazocine lactate, diclofenac sodium cardiotonic agent dopamine hydrochloride psychoneuric stabilizer perphenazine, phenothiazine antibiotic cefotetan disodium sulfate, dibecacin sulfate Netilmycin, sisomicin sulfate Antineoplastic agent Adriamycin, Mitomycin C, Bleomycin hydrochloride, Lentinan, Picibanil, Vincristine sulfate, Cisplatin Circulating function improver Nicametate citrate, Meclofenoxate hydrochloride,
Lisulide maleate, Calcium hopantenate Gout treatment Allopurinol Other peptides LHRH, Enkephalin, Endorphin, Interferon, Insulin, Calcitonin, TRH, Oxytocin, Ripressin, Vasopressin, Glucagon, Pituitary hormone (HGH, HMG, HCG, Desmopressin acetate) As described in detail above, the present invention can provide an appropriate water supply without diluting the drug solution contained in the hard porous layer 3 by interposing a semi-permeable membrane, This has the effect of preventing bacteria entering from the outside from entering the water replenishing layer and allowing accurate administration for a long period of time.

[Brief description of the drawings]

 1 and 2 are views showing an embodiment of the present invention. DESCRIPTION OF SYMBOLS 1 ... Water supply reservoir layer, 2 ... Semi-permeable membrane, 3 ... Hard porous material (drug layer), 4 ... Electrode, 6 ... Support member, 01 ... Living skin surface.

Claims (1)

(57) [Claims] 1. An interface for iontophoresis, comprising a reservoir layer for water supply, a hard porous layer made of a ceramic material, and a semipermeable membrane interposed between the two layers.