JPH0312173A - Interface for iontophoresis - Google Patents

Abstract

PURPOSE:To exactly and safely give medicine to iontophoresis by arranging the medicine on the surface of a porous material. CONSTITUTION:On the side surface of a ceramics porous body 1, the dries medicine is applied by spraying and a medicine grain sticking surface 2 is formed. A conductive member 3 is composed of conductive rubber, conductive polymer, carbon film, aluminum leaf and metal leaf, etc. At the time of electrification, a current flows through the porous body 1, medicine grain sticking surface 2, organ skin 00 and conductive adhesive layer between the conductive member 3 and a counter electrode layer 24 and the medicine of a medicine layer is liquified by mixing conveying liquid. Further, the medicine is loaded on the conveying liquid and immersed into the organ skin. Although the required capacity of this interface is fine, high concentration is maintained as much as possible on the efficiency of the iontophoresis and the existence of enough water is required. Then, this interface is mainly effective used for the peptide medicine such as insulin, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an interface (skin contacting body) for iontophoresis.

The interface in iontophoresis has a structure that combines a reservoir 7 for holding a chemical solution and an electrode for current dispersion.

The structure of this reservoir must ensure that a predetermined amount of drug solution reaches the biological skin interface over time, but since the reservoir itself is three-dimensional and water passes through it, the drug becomes diluted. etc., a sufficient structure has not yet been proposed.

In view of the above, the present invention provides a method suitable for iontophoresis.
That is, the purpose is to provide an interface having a structure that allows accurate and safe administration of medication.

The features of the present invention are as follows.

In the present invention, a solid or dry drug is placed on one side of a porous material by applying, adhering, coating, etc., and when used, by applying electricity and supplying a carrier liquid from the other side. Only at the time of use, the carrier liquid and drug are mixed to form a local high concentration drug solution, and the drug solution is maintained at a high concentration without being diffused and diluted by electric force, facilitating transdermal administration of the drug solution.

Furthermore, the present invention is suitable for long-term storage of drugs because the drugs are in a solid state, ie, dry, before use.

Examples of the porous material include ceramic porous bodies such as unglazed ceramics, alumina, and zirconia, and synthetic resin materials. Generally, the average pore diameter is preferably several μm to several hundred μm, and the porosity is generally preferably about 30 to 90%. In addition, both pore size and porosity,
It is appropriately selected depending on the number of sweat glands in the skin, the dose of the drug used, etc., and is not particularly limited.

Note that a capillary structure formed by laser processing a ceramic material, a synthetic resin material, or the like may also be suitably used. Moreover, the thickness of these materials is not particularly limited, but is usually 0.1 nv-
Approximately 10mm is good.

In some cases, a flexible film or sheet material may be used as long as the capillary tube is non-deformable.

Furthermore, examples of the carrier liquid used in the present invention include, but are not limited to, water and electrolyte liquids such as sodium chloride.

Next, the structure and operation of an embodiment of the present invention will be described in detail with reference to the drawings.

In Figure 1, (1) is a ceramic porous body,
The material is not particularly limited.

The porosity is set within the range described above. One side of the porous body (1) is spray coated with a dried drug to form a drug particle adhesion surface (2).

(3) is a conductive member made of conductive rubber, conductive polymer carbon film, aluminum foil, metal foil, etc. The conductive member (3) may be made of a porous member. The porosity etc. may be selected as appropriate, but it is sufficient that the porosity is sufficient to allow the carrier liquid to penetrate when the carrier liquid is injected.

The laminated structure of the porous body (1), the drug particle adhesion surface (2), and the conductive member (3) is covered and supported and fixed by a flexible support member (6).

An adhesive layer (7) is formed on the support member (6).
7) is for fixing the laminated structure to the surface of the skin of a living body.

Before use, it is placed on silicone-coated paper or the like and stored in the above-mentioned state. In use, the drug particle adhesion surface (2) and the biological skin are brought into contact. A hollow needle (4) provided in the reservoir (4) is inserted into the reservoir (4) containing the carrier liquid (5) from above the support member (6).
8) to communicate with the hollow needle (8), and transfer the carrier liquid (5) to the hollow needle (8).
Then, it is supplied to the porous body (1) via the conductive member (3).

Next, electricity is applied to the conductive member (3). The carrier liquid (5) permeates through the conductive member (3) and the porous body (1), and reaches the drug particle adhesion surface (2). The carrier liquid (5) mixes with the drug particle adhesion surface (2) and becomes liquid. A liquefied drug layer is formed on the surface of the living body's skin, and the drug solution further penetrates into the living body due to electric force.

Since the liquid drug particle adhesion surface (2) is allowed to move only in the direction of the living body due to electric force, it does not diffuse and maintains a high concentration.

FIG. 2 is a schematic diagram of the case where it is actually attached to the skin of a living body (00).

The support member (22) covers the laminate (21) of the porous body, the conductive member, and the drug layer, and the adhesive layer provided on the support member (22) allows these to adhere to the skin (OO). There is.

(4) is a reservoir, and shows the state of insertion and connection with the porous body. (23) is a power supply unit consisting of a battery and a chip type electronic circuit.

In addition to the adhesive layer, a counter electrode layer (24) made of a conductive material is formed on the outermost periphery of the support member (22).

A conductive adhesive layer is laminated on the surface of the counter electrode layer (24). This counter electrode layer (24) is connected to the counter electrode output terminal of the power supply unit (23).

When electricity is applied, a porous body (1), a drug particle adhesion surface (2), a biological skin (00), An electric current flows through the conductive adhesive layer, and the drug in the drug layer is liquefied by mixing with the carrier liquid, and further permeates the skin of the living body on the carrier liquid.

The electrical output used in the present invention is a depolarized pulse that allows stable medication without irritation or pain even if the energization state deteriorates to some extent.

Specifically, it is as shown in Japanese Unexamined Patent Publication No. 156475/1983.

However, in addition to the above-mentioned output, either alternating current or direct current can be used depending on the mode of use, and the present invention is not limited thereto.

Further, although the embodiment shown in Fig. 2 shows a structure in which the power supply unit is integrally mounted, the structure is not limited to this, and the opposite electrode may be separated and connected with a lead wire. , the shape may be changed as appropriate depending on the manner of use.

Although the drug layer is not limited to its molecular weight or other various amounts, the interface of the present invention maintains a concentration as high as possible in terms of the efficiency of iontophorenos, especially despite the small amount of the drug layer. It is mainly useful for peptide drugs such as insulin, which require the presence of sufficient water. Examples of drugs are shown below.

Antitussive expectorant Sodium cromoglycate, Ketotifen fumarate Bronchodilator Formotyrol fumarate Analgesic Nalbuphine hydrochloride, Pentazone lactate, Noclofenac sodium Cardiac agent Dopamine hydrochloride Neurol stabilizer Berphenazine, Phenothiazine antibiotic Cefotetan disodium, Dibekacin sulfate, Sulfuric acid Amikacin, netilmicin sulfate, sisomicin sulfate Adriamycin, mitomine c, m-bleomycin salt, lentinan, vinvanil, vincristine sulfate, cisplatin for improving circulatory function, dimethate citrate, meclofenoxate hydrochloride, lisuride maleate, calcium fovantate Gout treatment agent Allopurinol Other peptides LHRH, enkephalin, endorphin, interferon, insulin, calcitonin, TRH, oxytonon, lippressin, vasoprene, glucagon, pituitary hormones (HGH, HMG, HC, G, desmoprene acetate), follicular progestin There are various methods for forming the dried drug layer, such as spray coating and dipping followed by drying, and these methods are not particularly limited and may be selected as appropriate.

As described in detail above, the present invention enables the drug solution to be used without being diluted.
Appropriate moisture can be supplied, and since the drug is in a dry state when used, it can be stored for a long time without deterioration or decay.Moreover, the drug exists only on the surface that comes into contact with the skin, and it is absorbed by the living body by electrical force. Since diffusion in directions other than directions is prevented, the drug solution can be effectively administered without wasting it.

[Brief explanation of drawings]

FIG. 1 and FIG. 2 are diagrams showing an embodiment of the present invention. l... Porous body (porous material), 2...Drug particle adhesion surface, 3... Conductive member, 4...Reservoir 5...Carrier liquid, 6...Supporting member, 7...Adhesive, 00...Biological skin.

Claims (1)

[Claims] (1) An interface for iontophoresis characterized by disposing a drug on the surface of a porous material.