JP2782562B2 - Salicylic acid preparation - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a container for a preparation containing salicylic acid. More specifically, the present invention relates to a salicylic acid preparation container that prevents a plastic container that is in direct contact with the contents from being discolored by a reaction with a preparation containing salicylic acid and significantly impairing commercial value.

[0002]

2. Description of the Related Art Salicylic acid has antibacterial properties against microorganisms and has a softening effect on keratin, so that psoriasis, tinea (small vesicle, sweaty tinea, shallow head tinea), It is used as a preparation such as ointment or solution for skin diseases such as versicolor, eczema and keratosis, and is usually filled in a glass container and a colored plastic container.

As materials for plastic containers, high-density polyethylene and polypropylene are widely used. Conventional polyethylene is produced by low density polyethylene (high pressure method, specific gravity 0.91 to 0.93), linear low density polyethylene (medium and low pressure method, specific gravity 0.91 to 0.9) depending on the production method and specific gravity.
3), high density polyethylene (medium and low pressure method, specific gravity 0.93 ~
0.96), and high-density polyethylene is often used as a material for plastic containers.

[0004]

Generally, plastic materials used as containers are made of high-density polyethylene (medium-low pressure method, specific gravity of 0.9) in consideration of safety, processability, usability, and the like.
3-0.96) and polypropylene are widely used,
For example, the above-mentioned salicylic acid-containing preparation has a problem that the plastic is discolored and the commercial value is significantly impaired.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, as a container material (hereinafter, referred to as the material of the present invention) directly in contact with a preparation containing salicylic acid, By using low-density polyethylene, acrylic-styrene copolymer resin, polyester resin such as polyethylene terephthalate and polybutylene terephthalate, polycarbonate resin and nylon, it was found that discoloration of the container could be prevented. Completed the invention.

The low-density polyethylene used for the container material of the present invention is produced by a high-pressure method and has a specific gravity of 0.91 to 0.93, for example, Sumikasen G201 (manufactured by Sumitomo Chemical Co., Ltd.). The coalescing resin is, for example, Denka ASSF312 (manufactured by Denki Kagaku Kogyo KK), and the polyethylene terephthalate is, for example, Mitsui Pet J
125 [manufactured by Mitsui Toatsu Chemicals, Inc.], and polybutylene terephthalate is, for example, Duranex 2000
[Polyplastics Co., Ltd.]. Polycarbonate resin is, for example, Idemitsu PCI2500 [Idemitsu Petrochemical Co., Ltd.].
013NW2500 [manufactured by Ube Industries, Ltd.].

The container of the present invention is not only a container formed of the material of the present invention, but also a glass or metal container in which the material of the present invention is laminated, and a cap made of the material of the present invention used for these containers. Packing etc. are also mentioned. Specifically, a squeeze container for a liquid agent and its cap, an ointment jar, a laminate tube for an ointment, a tube for an ointment, and a cap thereof can be exemplified.

The salicylic acid-containing preparations of the present invention include ointments, solutions, hand lotions, dandruff tonics, toothpastes, etc. Depending on the purpose, antibacterial agents such as tolnaftate, clotrimazole, sorbitol, glycerin, urea, etc. Moisturizer, sodium ascorbate,
Vitamins such as tocopherol acetate, tocopherol, pyridoxine hydrochloride, glycyrrhetinic acid as an anti-inflammatory agent,
Pharmaceutical ingredients such as lidocaine and dibucaine hydrochloride as local anesthetics, diphenhydramine hydrochloride, diphenylpyramine hydrochloride and diphenhydramine as antihistamines, crotamiton as an antipruritic, emulsifiers such as polyoxyethylene cetyl ether and polyoxyethylene lauryl ether, and hydrogen phosphate for toothpaste Calcium, precipitated calcium carbonate, toothpaste additives such as silicic anhydride, propylene glycol, sodium edetate, carboxymethylcellulose, polyvinylpyrrolidone, stabilizers such as polyvinyl alcohol, solvents such as ethanol, methyl ethyl ketone,
Paraffin, cetanol, isopropyl palmitate,
Bases such as stearyl alcohol and myristyl myristate, cooling agents such as menthol and borneol, and additives such as fragrances can also be added.

[0009]

The present invention will be described in more detail with reference to the following Examples, Comparative Examples and Comparative Examples, which by no means limit the scope of the present invention. The comparative example shows a conventional salicylic acid preparation container, and the control example shows an example in which a preparation containing no salicylic acid was filled in a conventional container.

Example 1 Salicylic acid 5 g, tolnaftate 1 g, glycyrrhetinic acid 1 g, crotamiton 10 g, polyoxyethylene cetyl ether 6 g, cetanol 10 g, solid paraffin 8
g and 3 g of light liquid paraffin are heated and dissolved uniformly, and hot water is added to make 100 g. The mixture is stirred, emulsified and then cooled to obtain a uniform cream. The inner surface is filled in a container made of low-density polyethylene (Sumikacene G201). The cap with polyethylene (Sumikasen G201) packing was fastened.

Example 2 Salicylic acid (10 g), glycyrrhetinic acid (1 g), lidocaine (2 g), diphenhydramine hydrochloride (1 g), polyoxyethylene nonylphenyl ether (3 g), polyethylene glycol (20 g), purified water (10 g) and methyl ethyl ketone were added to make a total amount of 100 g. Then, a cap filled with a low-density polyethylene (Sumikasen G201) packing in a glass bottle was fastened.

Example 3 0.2 g of salicylic acid, 2 g of d-α-tocopherol acetate,
1 g of pyridoxine hydrochloride, 5 g of polyoxyethylene cetyl ether, 9 g of cetanol, 8 g of solid paraffin, 3.5 g of lanolin, 0.5 g of sodium edetate and 2.5 g of light liquid paraffin were uniformly dissolved, and hot water was added thereto.
After stirring and emulsifying, the mixture was cooled to obtain a uniform cream, and polyethylene terephthalate (Mitsui Pet J12
5), and the cap made of acrylic-styrene copolymer resin (DENKA ASSF312) was closed.

Example 4 2 g of salicylic acid, 8 g of zinc oxide, 7.5 g of talc, and 2.5 g of bentonite were mixed with a small amount of purified water, and purified water was added to make a total amount of 100 g to make a uniform lotion. 6 nylon 1013NW2500) and filled with polybutylene terephthalate (Duranex 2000) cap.

Example 5 1 g of salicylic acid, calcium hydrogen phosphate 40 for toothpaste
g, precipitated calcium carbonate 5 g, polyoxyethylene cetyl ether 3 g, carboxymethyl cellulose 1 g, sorbitol solution (70%) 25 g, liquid paraffin 1 g, purified water was added to make the total amount 100 g, and the mixture was emulsified with stirring to obtain a dentifrice. ) And filled with low-density polyethylene (Sumikacene G20).
1) The cap with the packing made was tightened.

Comparative Example 1 The cream prepared in Example 1 was treated with a high-density polyethylene (H
The container was filled with DPE2300 (manufactured by Union Polymer Co., Ltd.), and the cap fitted with packing made of high-density polyethylene (HDPE2300) was closed.

Comparative Example 2 The liquid preparation prepared in Example 2 was filled in a glass bottle, and a high-density polyethylene (HDPE2300) cap was closed.

Comparative Example 3 The cream prepared in Example 3 was filled in a container made of polypropylene (Show Allomer MA710, manufactured by Showa Denko KK), and a high-density polyethylene (HDPE2300) cap was closed.

Comparative Example 4 The lotion prepared in Example 4 was filled in a polypropylene (shaw aroma) container, and a high-density polyethylene (HDPE2300) cap was closed.

Comparative Example 5 The dentifrice prepared in Example 5 was replaced with a high-density polyethylene (H
(DPE2300), and the cap made of polypropylene (Showaromer MA710) was closed.

Control Example 1 g of tolnaftate, 1 g of glycyrrhetinic acid, 10 g of crotamiton, 6 g of polyoxyethylene cetyl ether,
10 g of cetanol, 8 g of solid paraffin and 3 g of light liquid paraffin are uniformly heated and dissolved, and hot water is added to add 100 g.
After stirring and emulsifying, the mixture was cooled to obtain a uniform cream, filled into a polypropylene (SHAROMER MA710) container, and closed with a high-density polyethylene (HDPE2300) cap.

[0021]

The ointment, the liquid for external use, the lotion and the dentifrice of each Example, Comparative Example and Control Example were placed in a falling state for 60 minutes.
C., 40.degree. C.-relative humidity 75% and room temperature, and the container, cap and packing were observed for discoloration over time. The results are shown in Tables 1 to 3.

[0022]

[Table 1]

[0023]

[Table 2]

[0024]

[Table 3]

As described above, in the comparative example, discoloration of the container due to salicylic acid over time was observed, but in any of the examples of the present invention, discoloration of the container over time due to salicylic acid was not observed.

[0026]

The container of the present invention is extremely useful as a container for a preparation containing salicylic acid without discoloration over time and without impairing the commercial value.

──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Hiroaki Takahashi 2512 Numagami, Oshikiri, Onan-gun, Osato-gun, Saitama Prefecture -1 Zeria Shinyaku Kogyo Co., Ltd., Central Research Laboratory (72) Inventor, Takayoko Baba Oshikiri, Konan-cho, Osato-gun, Saitama 2512-1 Numakami, Zeria Shinyaku Kogyo Co., Ltd. (72) Inventor Katsuhiro Fukabori 2512-1, Nishigami, Nishigami, Konan-cho, Osato-gun, Saitama Pref. JP-A-36867 (JP, A) JP-A-52-98389 (JP, A) JP-A-59-181164 (JP, A) JP-B-49-11190 (JP, B1) (58) Fields investigated (Int. . ^6, DB name) A61J 1/10

Claims (1)

(57) [Claims] 1. A drug for skin diseases containing salicylic acid, and a container filled with the drug, wherein at least a portion of the container which comes into contact with the drug is low-density polyethylene, an acrylic-styrene copolymer resin, a polyester resin, a polycarbonate resin, A salicylic acid preparation comprising one or more materials selected from nylon.