JP2746737B2 - External preparation for acne skin - Google Patents
External preparation for acne skinInfo
- Publication number
- JP2746737B2 JP2746737B2 JP2193030A JP19303090A JP2746737B2 JP 2746737 B2 JP2746737 B2 JP 2746737B2 JP 2193030 A JP2193030 A JP 2193030A JP 19303090 A JP19303090 A JP 19303090A JP 2746737 B2 JP2746737 B2 JP 2746737B2
- Authority
- JP
- Japan
- Prior art keywords
- external preparation
- acne
- magnolia
- magnolol
- bark
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は抗菌性に優れ且つ安全なニキビ用皮膚外用剤
に関する。Description: TECHNICAL FIELD The present invention relates to an external preparation for acne excellent in antibacterial properties and safe.
抗菌性を有するニキビ用皮膚外用剤については、サル
ファ剤、抗生物質、各種の化学合成物質など、多種のも
のが知られている。As the skin external preparation for acne having antibacterial properties, various kinds are known, such as sulfa drugs, antibiotics, and various chemically synthesized substances.
しかし長期的な安全性については、必ずしも保証され
ていない。However, long-term safety is not always guaranteed.
安全が保証され、更に抗菌性に優れたニキビ用皮膚外
用剤が求められている。There is a need for a skin external preparation for acne that is safe and has excellent antibacterial properties.
一方、朴の木の樹皮の乾燥物である厚朴は局方記載の
生薬で鎮静、筋弛緩、抗けいれん、脊髄反射抑制作用等
があり、特にマグノロール、ホオノキオールは中枢性筋
弛緩作用が報告され、腹痛、かぜ等の病状に用いられて
いる。On the other hand, the dried bark of Park's bark is a crude drug described in the Japanese Pharmacopoeia, which has sedative, muscle relaxation, anticonvulsant, and spinal cord reflex inhibitory effects. It is used for medical conditions such as abdominal pain and cold.
しかし、一般的に抗菌性を有することは知られている
が、ニキビ菌に有効でかつ実際にニキビに有効であると
の報告はない。However, although it is generally known to have antibacterial properties, there is no report that it is effective against acne bacteria and actually effective against acne.
本発明の目的は皮膚に対する長期的安全性が保証さ
れ、しかも抗菌性に優れたニキビ用皮膚外用剤を提供す
ることである。An object of the present invention is to provide a skin external preparation for acne, which guarantees long-term safety on the skin and has excellent antibacterial properties.
本発明者らは、永年にわたり生薬として使用されて来
た各種植物について、その抗菌性を鋭意研究した結果、
朴の木の樹皮に含まれるマグノロール、ホオノキオール
にニキビに関係する菌を抑制する作用があることを見い
だし、本発明を完成した。The present inventors have studied the antibacterial properties of various plants that have been used as crude drugs for many years,
The present inventors have found that magnolol and honokiol contained in the bark of a magnolia tree have an action of suppressing bacteria related to acne, and completed the present invention.
即ち本発明は （１）マグノロール及び／又はホオノキオールを含むニ
キビ用皮膚外用剤であり、 （２）モクレン科ホオノキ属の樹皮を有機溶媒で抽出し
た液を含むニキビ用皮膚外用剤であり、 （３）有機溶媒がメタノール、エタノール、エーテル、
アセトンよりなる群より選んだ少なくとも１種である前
記（２）記載のニキビ用皮膚外用剤であり、 （４）モクレン科ホオノキ属の樹皮が、朴木（Magnolia
obovata）である前記（２）記載のニキビ用皮膚外用剤
である。That is, the present invention is (1) a skin external preparation for acne containing magnolol and / or honokiol, and (2) an external preparation for acne containing a liquid obtained by extracting the bark of the Magnolia genus Magnolia with an organic solvent, (3) The organic solvent is methanol, ethanol, ether,
The skin external preparation for acne according to the above (2), which is at least one selected from the group consisting of acetone.
obovata) according to the above (2).
朴の木の樹皮の乾燥物である厚朴は神農本草経中品に
収載された古くから用いられてきた漢方薬であり、また
局方記載の原料でもあり、安全性に関してはなんら問題
はない。Koboku, which is a dried product of the bark of the Pak tree, is a Chinese herbal medicine that has been used for a long time and is listed in the Shinryo herbal medicinal products, and is also a raw material described in the local government. There is no problem with safety.
しかしながら、該厚朴は、もっばら経口より用いら
れ、腹痛、かぜ等の病状に用いられているにすぎない。However, the magnolia is only used orally, and is only used for medical conditions such as abdominal pain and cold.
モクレン科ホオノキ属の樹皮から、有効成分を抽出す
るには、抽出方法には種々あるが、有機溶媒、特にメタ
ノール、エタノール、エーテル、アセトンより選んだ少
なくとも１種の溶媒を用いて抽出する方法が有効であ
る。抽出物から、マグノロールまたはホウノキオールま
で単離する必要はなく、これらの物質が含有されている
状態であればかまわない。There are various extraction methods for extracting the active ingredient from the bark of the Magnolia genus Magnolia. It is valid. It is not necessary to isolate magnolol or honokiol from the extract, as long as these substances are contained.
マグノロールとホオノキオールの化学構造は マグノロール、ホオノキオール、ホオノキのメタノー
ル抽出物（乾燥物）について、抗菌性を調べるため、下
記の細菌について、最小発育阻止濃度（MIC）を測定し
た。The chemical structures of magnolol and honokiol are In order to examine the antibacterial properties of magnolol, honokiol, and methanol extract (dried matter) of honoki, the minimum growth inhibitory concentration (MIC) of the following bacteria was measured.
方法としては液体培養法を用いた。液体培養法では検
体が分散状態のものは、培養時、振とうを加えた。The liquid culture method was used as the method. In the liquid culture method, when the sample was in a dispersed state, shaking was added during the culture.
その結果を第１表に示す。 Table 1 shows the results.
この結果から、これらの物質が何れも毛襄内細菌に有
効であることが分かった。 From these results, it was found that all of these substances are effective against bacteria in the hairy pills.
本発明を実施例により、更に具体的に説明するが、本
発明はこの実施例によって何等限定されるものではな
い。The present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples.
（実施例１） ニキビ用皮膚外用剤 エタノール 10重量％ 1,3ブチレングリコール ４重量％ マグノロール １重量％ 水 85重量％ （実施例２） 実施例１のマグノロールをホオノキオールに置き換え
たニキビ用皮膚外用剤。(Example 1) Skin external preparation for acne Ethanol 10% by weight 1,3 butylene glycol 4% by weight Magnolol 1% by weight Water 85% by weight (Example 2) For acne obtained by replacing magnolol in Example 1 with honokiol External preparation for skin.
（実施例３） 実施例１のマグノロールをホオノキのメタノール抽出
液（乾燥物）に置き換えたニキビ用皮膚外用剤。(Example 3) A skin external preparation for acne obtained by replacing the magnolol of Example 1 with a methanol extract (dried product) of Pleurotus japonicus.
（比較例１） 実施例１のマグノロールを水に置き換えたもの。(Comparative Example 1) Magnolol in Example 1 was replaced with water.
（評価方法） 二重盲検法を用いて、女性16名で実験した。各検体８
名づつで顔面を左右に分けて行った。(Evaluation method) An experiment was conducted on 16 women using a double-blind method. Each sample 8
The face was divided into left and right by name.
実施期間は２ケ月間行った。結果を第２表に示す。 The implementation period was two months. The results are shown in Table 2.
〔発明の効果〕 モクレン科ホオノキ属の樹皮のメタノール、エタノー
ル、エーテル、アセトン等の溶媒の少なくとも１種を使
用して抽出した液又はこの抽出液中の有効成分であるマ
グノロールまたはホオノキオールを含むニキビ用皮膚外
用剤はニキビに著効があることがわかった。 [Effect of the Invention] A liquid extracted from the bark of Magnolia genus Magnolia using at least one solvent such as methanol, ethanol, ether, and acetone, or contains magnolol or honokiol as an active ingredient in the extract. The skin external preparation for acne was found to have a remarkable effect on acne.
Claims (4)
含むニキビ用皮膚外用剤。1. A skin external preparation for acne comprising magnolol and / or honokiol.
抽出した液を含むニキビ用皮膚外用剤。2. A skin external preparation for acne, comprising a liquid obtained by extracting the bark of Magnolia genus Magnolia with an organic solvent.
テル、アセトンよりなる群より選んだ少なくとも１種で
ある請求項２記載のニキビ用皮膚外用剤。3. The external preparation for acne according to claim 2, wherein the organic solvent is at least one selected from the group consisting of methanol, ethanol, ether and acetone.
gnolia obovata）である請求項２記載のニキビ用皮膚外
用剤。4. The bark of Magnolia genus Magnolia is magnolia (Ma).
3. The external preparation for acne according to claim 2, which is gnolia obovata).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2193030A JP2746737B2 (en) | 1990-07-23 | 1990-07-23 | External preparation for acne skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2193030A JP2746737B2 (en) | 1990-07-23 | 1990-07-23 | External preparation for acne skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0482830A JPH0482830A (en) | 1992-03-16 |
| JP2746737B2 true JP2746737B2 (en) | 1998-05-06 |
Family
ID=16301001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2193030A Expired - Fee Related JP2746737B2 (en) | 1990-07-23 | 1990-07-23 | External preparation for acne skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2746737B2 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2480331A1 (en) * | 2002-04-15 | 2003-10-23 | Tetsuo Santo | Lotion for therapy of dermatitis |
| JP4515098B2 (en) * | 2002-04-15 | 2010-07-28 | 哲夫 山東 | Dermatitis treatment cream |
| US7608741B2 (en) * | 2005-05-30 | 2009-10-27 | Korea Institute Of Oriental Medicine | Mass separation method of magnolol from Magnoliae cortex radix |
| KR100699538B1 (en) * | 2005-09-14 | 2007-03-23 | 바이오스펙트럼 주식회사 | Composition for improving atopic dermatitis comprising magnolol and honokiol |
| FR2911507B1 (en) * | 2007-01-19 | 2009-05-22 | Europ Finances | USE OF LIGNANS AND / OR FOR OBTAINING A PHARMACEUTICAL, COSMETIC, DERMATOLOGICAL AND / OR NEUTRACEUTICAL COMPOSITION |
| KR100971269B1 (en) * | 2008-02-15 | 2010-07-20 | 주식회사 유니젠 | Processed magnolia extract and anti-microbial composition comprising the same |
| KR101006342B1 (en) * | 2008-06-30 | 2011-01-10 | 주식회사 코리아나화장품 | Cosmetic Composition for Protecting the Skin Comprising the Extract of Magnolia Sieboldii |
| DE102009048044A1 (en) * | 2009-10-02 | 2011-04-21 | Beiersdorf Ag | Use of magnolol or honokiol as antibacterial, antimycotic, antiparasitic or antiviral agents |
| CN102743363B (en) * | 2011-04-20 | 2015-01-21 | 上海邦氏生物科技有限公司 | Application of product for treating skin diseases caused by Malassezia prepared by honokiol and its derivative |
| CN102871989B (en) * | 2011-07-04 | 2015-06-10 | 四川大学 | New application of honokiol or pharmaceutically acceptable salt of honokiol |
| ITUA20162223A1 (en) * | 2016-04-01 | 2017-10-01 | Linnea Sa | Topical composition including plant extracts |
-
1990
- 1990-07-23 JP JP2193030A patent/JP2746737B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| Ｊ．Ｐｈａｒｍ．Ｓｃｉ．，Ｖｏｌ．７０ Ｎｏ．８ （１９８１）ｐ．９５１−９５２ |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0482830A (en) | 1992-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |