JP2699281B2 - Immersion type urinary stone inhibitor and method for preventing adhesion of urine stone - Google Patents

Description

Description: BACKGROUND OF THE INVENTION The present invention relates to an anti-urinic agent, and more particularly, to an immersion type containing a poorly water-soluble solid acid as a main component and immersed in a toilet trap. It relates to a urinary stone inhibitor.

The immersion type urinary stone inhibitor of the present invention is extremely effective in preventing urine stones from adhering to drainage pipes of various flush toilets, particularly to traps.

[Conventional technology]

The scale of the mixture of calcium-based compounds and organic matter, the so-called urolith, formed by the decomposition of urine adheres to the urinals of toilets, especially men's urinals and drains from toilets, impeding the flow of urine and washing water. In severe cases, block the drain pipe. In addition, organic substances in urine and urinary stones are putrefied and decomposed by bacteria to generate a bad smell.

For the purpose of preventing these urine stones from adhering to toilet bowls and drainage pipes, the present applicant has proposed a scale inhibitor for toilet drainage pipes using solid acid as an active ingredient for preventing urine stones from being generated (Japanese Unexamined Patent Publication (Kokai) No. 2002-157572). Japanese Unexamined Patent Publication (KOKAI) Showa No. 62-38299) and a urinary stone inhibitor which is put into a men's urinal molded using sulfamic acid as an active ingredient and using a sublimable substance and a water-soluble organic substance as base materials are put on the market.

Also, a mixture of a detergent, a detergent such as an ion-sequestering agent, a fragrance, an aromatic substance such as paradichlorobenzene, a bactericide, etc., is formed using a water-soluble substance such as polyethylene glycol as a base material. A fragrance cleaner for toilets which is put into a toilet and used (Japanese Patent Publication No. 45-30)
706, JP-A-57-168688, etc.).

[Problems to be solved by the invention]

In the above-mentioned aroma cleaner, although the effect of preventing urine stones from adhering to the toilet bowl is recognized, the effect of preventing urine stones from adhering to the drainage pipe from the toilet bowl is insufficient. In the case of those containing an ion-sequestering agent, an expensive ion-sequestering agent must be applied to urine in an amount of 0.3 to 1 to completely prevent urine stones from adhering to the toilet.
Since it must be dissolved by weight percent, it is hardly used.

On the other hand, the scale inhibitor for drainage pipes proposed by the present applicant not only has an extremely excellent effect of preventing urine stones from adhering to toilet bowls and drainage pipes, but also has a solid acid in which ammonia generated by the decomposition of urine is dissolved. And produce water-soluble ammonium salts, so that the deodorizing effect is extremely excellent. However, since this urinary stone inhibitor is used by installing it in a flow path where urine flushes and / or urine intermittently flows, the flush water is periodically used irrespective of use. Although it is effective for toilets that discharge water during use, manual toilets that discharge flush water only at the time of use are not used for a long time at night or on holidays. Prevention of generation is insufficient.

An object of the present invention is to provide a urinary stone inhibitor which prevents rot of urine even in a toilet which is not used for a long time and has an effect of preventing adhesion of urine stone.

[Means for solving the problem]

The present inventors have conducted intensive studies to achieve the above object, and found that a molded product containing a solid acid having a saturated solubility in water at 20 ° C. which is equal to or lower than a certain level is put into a urinal trap and used. Thus, even when not used for a long time, rot of urine stones is prevented, the effect of preventing adhesion of urine stones is sufficiently obtained, and it is found that excessive dissolution does not adversely affect drainage pipes or septic tanks. completed.

The present invention has a saturation solubility in water at 20 ° C. of 1 g / 100 g.
An immersion type urinary stone inhibitor comprising a molded article containing 70% by weight or more of a solid acid of water or less.

In the present invention, the solid acid is dissolved in water and can lower the pH of water to 7 or less. The saturated solubility in water at 20 ° C. is 1 g / 100 g water or less, preferably 0.3 to 0.0005 g / 100 g. Substance. As these solid acids, for example, i-
Phthalic acid, o-phthalic acid, terephthalic acid, benzoic acid, fumaric acid, salicylic acid, cyanuric acid and the like and their 2
Mixtures of more than one species.

The immersion type urinary stone inhibitor of the present invention (hereinafter, simply referred to as “agent”) is a molded article obtained by molding the solid acid into an arbitrary dosage form, and includes urine and urine in a toilet, particularly in a trap of a male urinal. It is put directly into the stagnant of washing water or stored and used in a specific container.

These dosage forms are not particularly limited, and may be in the form of granules, granules, spheres, cylinders, discs, perforated discs (donuts), cubes, cones, pyramids, etc., depending on the mode of use. Any dosage form can be selected.

The agent may be a molded product of the solid acid alone, or may contain 70% by weight or more of the solid acid, and may contain a binder and various additives.

The binder is used to improve the moldability of the agent when molding the agent.
It is used to adjust the dissolution rate of the acid from the agent.

As these binders, water-soluble polymers that are solid at room temperature,
For example, bases used for ordinary pharmaceutical preparations such as polyvinylpyrrolidone, hydroxypropylcellulose, methylcellulose, polyethylene glycol, polyvinyl alcohol, polyacrylic acid and salts thereof, various surfactants, ion-sequestering agents and the like, and mixtures thereof. used.

This agent includes various additives, for example, a solid acid having a saturated solubility in water at 20 ° C. of more than 1 g / 100 g water, a disinfectant, a fungicide,
An enzyme inhibitor, a dissolution rate regulator, a surfactant, a fragrance, a deodorant, a colorant, a corrosion inhibitor, an ion sequestering agent, and the like can be added as desired.

Solid acids having a saturation solubility in water at 20 ° C. of more than 1 g / 100 g water can also be used as additives. These solid acids include inorganic acids such as sulfamic acid, sodium hydrogen sulfate, potassium hydrogen sulfate, boric acid, and metaphosphoric acid, succinic acid, adipic acid, tartaric acid, citric acid, oxalic acid, maleic acid, gallic acid, and sorbic acid. And organic acids such as malic acid and ascorbic acid, which can be used alone or as a mixture of two or more.

Sterilization and fungicides are intended to suppress the action of bacteria and fungi that promote the decomposition of urine, and to prevent the decay of urine.
It is preferably added. As these disinfectants and fungicides, boric acid, quaternary ammonium salts, and various oxidants that do not have selectivity for various bacteria in urine are preferably used. In particular, halogen-based oxidizing agents such as trichloroisocyanuric acid, dichloroisocyanuric acid, 1,3-bromo-5,5-dimethylhydantoin, 1-bromo-3-chloro-5,5-dimethylhydantoin, etc. It is most preferably used because it is strong and also rapidly decomposes organic matter in urine and also acts as a part of an acidic substance that lowers the pH of urine.

Enzyme inhibitors are added for the purpose of suppressing the action of urease, which is a urea-degrading enzyme that is secreted by bacteria and fungi and induces an increase in pH that causes the formation of uroliths. As these enzyme inhibitors, known urease inhibitors, the above-mentioned halogen-based oxidizing agents, hydroquinone, gallic acid and the like are used.

The dissolution rate regulator is added mainly for the purpose of delaying the dissolution rate of the agent, for example, higher alcohols,
Poorly water-soluble substances such as higher fatty acids, calcium silicate and calcium stearate are used.

The fragrance can be added for the purpose of masking the odor of the toilet, and it is sufficient if it gives the user a favorable impression. Natural fragrances, synthetic fragrances, compounded fragrances and the like can be used without particular limitation.

The deodorant can be added for the purpose of preventing the generation of offensive odor due to the decomposition of urine, ferrous sulfate, glyoxal,
Glutaraldehyde and the like are preferably used.

Surfactants, ion-sequestering agents, and the like are preferably used because they are effective as cleaning components for drainage pipes and traps and can also be used as base materials.

The corrosion inhibitor is added for the purpose of preventing corrosion of piping by acid. Known corrosion inhibitors such as alkylthiourea-based and triazole-based agents are used as these corrosion inhibitors.

This agent is a method of tablet-forming, a method of extrusion-compression molding, a method of heat-melting and casting a powder mixture, a method of extrusion-granulating and granulating, It can be produced by molding by a known method such as a method of granulating using an apparatus or the like.

[Action]

As described above, the immersion type urinary stone inhibitor of the present invention is characterized by comprising a molded article containing a solid acid having solubility in specific water.

The pH of urine immediately after excretion is usually in the acidic range of 5.5 to 6.5, but as time passes, it is decomposed into ammonia and carbon dioxide by the influence of urease, a urea-degrading enzyme, and the pH rises rapidly. The tendency is even greater in a mixture of urine and washing water, and when the pH rises to 7.5 or higher, calcium ions and phosphate ions contained in the urine react with carbon dioxide gas generated by the decomposition of urine, resulting in poor solubility in water. , Calcium apatite and calcium carbonate are generated, and organic matter in urine is adsorbed to these, and adheres to urine-contacting parts such as toilet bowls, toilet drain pipes, traps and the like to form urinary stones.

In the present invention, the selected solid acid has a low solubility in a neutral or acidic region, but has a high dissolution rate in a basic region, and is disposed in a trap portion or a drain pipe of a toilet bowl in which urine and / or washing water is retained. When the pH of the retained water rises due to the decomposition of urine by using it immersed, it dissolves in the retained water and suppresses the rise in pH. Prevents adhesion.
On the other hand, if the pH of the retained water is lowered, the dissolution rate is reduced. If the pH is further lowered, the dissolution is stopped, and the consumption of the drug more than necessary is suppressed. As a result, unlike conventional urinary stone inhibitors, the amount of medicine consumption is not affected by the frequency of use of the toilet and the amount of flush water,
The amount of drug consumed is automatically controlled according to the urine stone generation conditions, thereby preventing urine stones from adhering to the drain pipe and trap portion and generating odor. In addition, the dissolution of excess chemical does not adversely affect the corrosion of drain pipes or the septic tank.

Also, the rise in pH of urine or a mixture of urine and washing water is
It can be prevented by the use of disinfectants, fungicides, and enzyme inhibitors.However, the use of a large amount thereof has a large adverse effect on the septic tank. Reacts with ammonia
These sterilizers, to produce reactants with pungent odor,
Although it is difficult to control the dissolution rate by using a fungicide or an enzyme inhibitor alone as an urinary stone inhibitor, it is possible to effectively use a minimum amount of a drug by using the selected solid acid in combination. Can be dissolved.

On the other hand, a solid acid having a large saturation solubility can be added in a small amount for the purpose of supplementing the amount of the selected solid acid to be dissolved, but the use of only these is effective when the unused time of the toilet becomes excessive. Of retained urine or a mixture of urine and washing water
It is not preferable because the pH drops excessively and causes corrosion of the piping.

On the other hand, the binder not only improves the moldability in the production of the agent, but also adjusts the dissolution rate of the solid acid when used, and prevents the agent from swelling or losing its shape.

〔Example〕

The present invention will be described in more detail with reference to Examples and Comparative Examples.

However, the scope of the present invention is not limited by the following examples.

In the following examples, "parts" and "%"
Unless otherwise specified, it is based on weight.

(1) Manufacture of immersion type urinary stone inhibitor Sample A-1 A mixture of 100 parts of benzoic acid flakes and 1 part of an alkylthiourea-based corrosion inhibitor was press-molded to form a square prism having a length of 25 mm × 80 mm. Immersion type uric acid inhibitor consisting of: Sample: A-
1 was produced.

Comparative sample CA-1 30 parts of parachlorobenzene, 20 parts of polyethylene glycol having an average molecular weight of 6,000 were heated and melted, and a slurry to which 50 parts of sulfamic acid fine powder was added was poured into a mold, cooled and solidified to obtain a spherical shape having a diameter of 40 mm. A urinary stone inhibitor composed of a molded article was manufactured and used as Comparative Sample CA-1.

Comparative Sample CA-2 A mixture of 50 parts of sulfamic acid fine powder and 50 parts of benzoic acid fine powder was tablet-molded to produce a disc-shaped molded body having a diameter of 45 mm and a thickness of 20 mm, which was used as Comparative Sample CA-2. .

Comparative sample CA-3 A mixture of 100 parts of trichloroisocyanuric acid and 1 part of calcium stearate was molded under pressure to a diameter of 45 mm and a thickness of 20 parts.
mm shaped disc-shaped product: Comparative sample CA-4 was produced.

(2) Urinary stone adhesion prevention test Primary test The flush water timer of 10 men urinals where three urinals with almost the same number of users are connected by a pipe to a 12-liter flush water tank is set to 8:00. From 1 to 19 o'clock, washing was performed once an hour, and washing was stopped at night. The trap section of each urinal was washed with hydrochloric acid to which a corrosion inhibitor was added to remove attached urine stone.

A stainless steel wire mesh cylinder having a diameter of 30 mm and a length of 30 mm was installed in the trap of each urinal. Immersion-type urinary stone inhibitor manufactured in the above item (1): As for sample A-1, one toilet was placed in a plastic container and placed in a trap. As for the comparative sample CA-1, one sample per toilet was placed on the plate of the toilet, and the comparison sample CA-
Regarding 2 and CA-3, one toilet was placed in a plastic container and placed at the trap entrance.

Use the toilet as usual, and perform sensory tests for
After a lapse of months, the stainless steel wire mesh cylinder was collected, dried, weighed, and the amount of attached urine stone was calculated.

A new drug was added when the drug weight fell below the initial 20%.

Secondary test After the completion of the primary test, the trap portion of each toilet was washed with hydrochloric acid, and then the washing timer was set to wash once every 30 minutes day and night, and thereafter, in the same manner as in the primary test. The test was performed.

 The test results are shown in Table 1 together with the composition of each agent.

In addition, the urinary stone adhesion amount and the drug effective days in Table 1 are:
This is the average value of three toilets.

 The following abbreviations in Table 1 were used.

〔component〕

BEZA: Benzoic acid TCCA: Trichloroisocyanuric acid SUPA: Sulfamic acid PEG6: Polypropylene glycol (Mn = 6,000) PDCB: Paradichlorobenzene ATUA: Alkylthiourea-based corrosion inhibitor STCa: Calcium stearate [Judgment of bad odor] ○: No odor : Slight odor ×: Smell is intense The product of the present invention is extremely excellent in both the effect of preventing urinary stone adhesion and the effect of removing bad smell through the primary test and the secondary test. Further, in the secondary test in which a large amount of washing water is used and the amount of urinary stones is small, the amount of washing water is small and urinary stones are easily generated.
Compared to the next study, drug consumption is reduced and drug effective days are extended.

Further, as shown in Table 1, in the system using only trichlorisocyanuric acid, which is a bactericidal fungicide, (see Comparative Example 3), the effect of preventing adhesion of urolith was excellent, but trichlorisocyanuric acid was excellent. The reaction between chlorine generated by the decomposition of urine and ammonia generated by the decomposition of urine generates products having a pungent odor such as nitrogen trichloride, thereby increasing the malodor in the toilet.

[Effect of the Invention] The immersion type urinary stone inhibitor of the present invention was used by being immersed in a toilet drain pipe or a trap portion of a manual flush toilet where cleaning is irregular, as shown in the above examples. In this case, the effect of preventing urine stones from adhering to a trap portion or the like is extremely excellent as compared with a conventional urinary stone preventive agent that is provided in a channel for washing water and urine. In addition, in toilets where the amount of flushing water is large compared to the frequency of use of the toilet and it is difficult for urine to be generated, the increase in pH of the water remaining in the trap is small and the dissolution of the drug is suppressed, so there is no need to dissolve the drug more than necessary. Even without the use of special equipment, the amount of drug dissolved is automatically controlled according to the required amount, preventing the adhesion of urine stones and the generation of offensive odor over a long period of time, as well as the corrosion of drain pipes and septic tanks. There is no adverse effect on

The present invention provides an immersion type urine arrest agent which is suitable for preventing urine stones from adhering to urinal drain pipes and traps of a manually-washed flush toilet. The significance is extremely large.

Claims (4)

(57) [Claims] Claims: 1. A benzoic acid is contained as an essential component, and
An immersion type urinary stone inhibitor comprising a molded product containing a solid acid having a saturation solubility in water at 20 ° C. of 1 g / 100 g water or less, together with benzoic acid, in an amount of 70% by weight or more. 2. An immersion-type urinary stone inhibitor comprising a bactericidal and fungicidal agent as an additive component of the immersion-type urinary stone inhibitor according to claim 1. 3. The immersion type uric acid inhibitor according to claim 2, wherein the disinfectant and the fungicide are halogen-based oxidants. 4. A method for preventing urinary stone adhesion, comprising immersing the immersion type urinary stone inhibitor according to claim 1 or 2 in a trap of a male urinal.