JP2683400B2 - Hair restoration / hair restoration - Google Patents

Description

TECHNICAL FIELD The present invention relates to a hair-growth / hair-growth composition, and more particularly to a hair-growth / hair-growth composition having a sustained hair-growth / hair-growth effect.

[Prior Art] Conventionally, a hair nourishing and hair-growing agent using a predetermined fatty acid or a derivative thereof as a compound that promotes the metabolic activity of hair roots,
For example, it is proposed in JP-A-59-27809. In addition, as other examples of the compound that promotes the metabolic activity of hair root, assemblage extract, vitamin E (derivative), vitamin B ₂ (derivative), vitamin B ₆ (derivative), vitamin
B ₁₂ , biotin (derivative), female hormone, adrenocortical hormone, pantothenic acid (derivative), vitamin D (derivative), carpronium chloride, garlic extract, nicotinic acid (derivative), amino acids, glycyrrhetinic acid (derivative), hinokitiol , Toki extract, Chen skin extract, carrot extract, minoxidil compounds (derivatives),
Chamomile extract, tolazoline chloride, etc. are known.

[Problems to be Solved by the Invention] However, it is difficult to say that the conventional hair-growth and hair-growth agents are sufficiently satisfactory in their hair-growth and hair-growth effects, and in particular, the effect sustainability is insufficient.

The present invention has been made in view of the above circumstances, and an object thereof is to provide a hair nourishing / hair-growth composition that can promote and maintain metabolic activity of hair roots, suppress hair loss, and promote hair growth. And

[Means for Solving the Problems] The present invention is more excellent in hair nourishing and hair-growing effects than conventional products,
In particular, as a result of intensive research to develop a hair nourishing and hair-growth agent excellent in the sustainability of the effect, by adding oxygen gas, the synergistic effect promotes the metabolic activity of the hair root, and particularly the effect is obtained. They have found that they can last, and have completed the present invention.

That is, the hair nourishing / hair-growth composition of the present invention is characterized in that the hair-growth / hair-growth material containing the compound having the activity of promoting hair root metabolism is mixed with oxygen gas and sealed in a pressure-resistant container.

The compound having an activity of promoting hair root metabolic activity used in the present invention is preferably a fatty acid having an odd carbon chain length or a derivative thereof and an alcohol having an odd carbon chain length or a derivative thereof, and these are carbons constituting a carbon chain. If the number of atoms is an odd number, the carbon chain may be either saturated or unsaturated, and in the case of an unsaturated chain, it may contain a plurality of double bonds. The number of carbon atoms in the carbon chain is preferably 9 or more, more preferably 11 to 25
Individual. Examples of such fatty acids include nonanoic acid,
Examples thereof include undecanoic acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, nonadecanoic acid, heneicosanoic acid, tricosanoic acid, and pentacoic acid.

Examples of the fatty acid derivative having an odd carbon chain length that can be incorporated in the hair nourishing and hair-restoring agent of the present invention include the following.

A) a monoglyceride represented by the following general formula [II] or [III], (However, R ₆ represents a straight-chain organic group having an even carbon chain length) (b) A diglyceride represented by the following general formula [IV] or [V], (However, R ₃ and R ₄ are linear organic groups, and at least one of them has an even carbon chain length. When the other one is an odd chain organic group, it is an odd number. It is particularly preferable that it is a diglyceride of a fatty acid having a chain length.) C) Triglyceride represented by the following general formula [VI], (However, at least one of R ₃ , R ₄ , and R ₅ is a linear organic group having an even carbon chain length, and the other is a linear organic group having an odd carbon chain length. In that case, triglyceride of an odd-chain-length fatty acid is particularly preferable.) D) A fatty acid salt represented by the following general formula [VII], [VII] (R ₆ COO) _n M (provided that R ₆ Is a linear organic group having an even carbon chain length, M
Represents ammonia, an organic amine, or a metal atom, and n represents an integer corresponding to the valence of M. For example, RCOONa, RCOOK, and RCOOLi. ) E) An ester represented by the following general formula [VIII], [VIII] R ₆ COOR ₇ (wherein R ₆ is a linear organic group having an even carbon chain length, R ₇
Represents a monohydric or dihydric alcohol residue, a polyoxyethylene residue, a sorbitan residue, or a sucrose residue. 1
Typical examples of polyhydric alcohols are methanol and ethanol. ) F) The first amide represented by the following general formula [IX], [IX] R ₆ CONR ₈ R ₉ (wherein R ₆ represents a linear organic group having an even carbon chain length. R ₈ and R ₉ represents hydrogen or an organic group that does not adversely affect the human body.) G) A second amide represented by the following general formula [X], (However, if at least one of R ₃ and R ₄ is a straight-chain organic group having an even carbon chain length and the other and R ₈ are those that do not adversely affect the human body, R ₈ may be hydrogen, and R ₈ may be hydrogen. It is particularly preferable that both are straight chain organic groups having an even chain length.) H) A group represented by the following general formula [XI] 3 amides, (However, if at least one of R ₃ , R ₄ , and R ₅ is a straight-chain organic group having an even carbon chain length and the other ones do not adversely affect the human body, It is particularly preferable that all of these are straight-chain organic groups having an even chain length.) I) Dibasic acids represented by the following general formula [XII] and salts thereof [XII MOOCR ₉ COOM (wherein R ₉ represents a straight-chain organic group having an odd carbon chain length, and M is the same as above.) N) A sterol ester represented by the following general formula [XIII], (However, R ₆ represents a linear organic group having an even carbon chain length.) Le) A phospholipid represented by the following general formula [XIV], (However, R ₃ and R ₄ are chain organic groups, and at least one of them, particularly preferably both are linear organic groups having an even carbon chain length. X is a choline residue. , Ethanolamine residue, serine residue, or inositol residue, phosphatidylcholine when X is a choline residue, phosphatidylethanolamine when X is an ethanolamine residue, and phosphatidylethanolamine when X is a serine residue. In the case of fatidylserine or inositol, it becomes phosphatidylinositol.) Wo) Phosphatidic acid represented by the following general formula [XV], (However, R ₃ and R ₄ are chain organic groups, and at least one of them, particularly preferably both are linear organic groups having an even carbon chain length.) Wa) The following general A sphingolipid represented by the formula [XVI], (However, R ₆ is a linear organic group having an even carbon chain length,
X'represents a sugar residue, a phosphoric acid residue, or an amine base residue such as choline or ethanolamine. ) The aliphatic alcohol used in the present invention may have either a saturated or unsaturated carbon chain as long as it has an odd number of carbon atoms constituting the carbon chain,
When unsaturated, it may contain a plurality of double bonds. Further, the alcohol may be a lower alcohol or a higher alcohol, and may be any of primary, secondary and tertiary alcohols.

As an example of a preferable odd chain length aliphatic alcohol, n-
Propyl alcohol, n-amyl alcohol, n-heptyl alcohol, n-nonyl alcohol, n-undecyl alcohol, n-tridecyl alcohol, n-pentadecyl alcohol, n-heptadecyl alcohol, n-
Mention may be made of nonadecyl alcohol, n-uneicosyl alcohol, n-tricosyl alcohol, and n-pentacosyl alcohol.

Further, such a derivative of an odd chain fatty acid alcohol can be used in the hair nourishing and hair-restoring agent of the present invention. Representative derivatives are esters and ethers of odd chain length alcohols. Preferred esterified products include the above-mentioned odd chain length alcohols, aliphatic carboxylic acids (particularly those having 2 to 24 carbon atoms), succinic acid, citric acid, fumaric acid, lactic acid, pyruvic acid, malic acid and oxaloacetic acid. Organic acids and esterified products with organic acids such as phosphoric acid.

Preferred etherified products are the above-mentioned odd chain length alcohols and aliphatic alcohols (C2 to C24 ones are particularly preferable); polyhydric alcohols such as glycerin, polyglycerin, ethylene glycol, propylene glycol and butanediol; glucose, It includes etherification products with sugars such as ribose, galactose, arabinose, mannose, xylose, sorbitol, mannitol. Further, an etherified product is a di- or tri-odd chain length alkoxide of glycerin, which has 2 units in one molecule.
It may contain the above-mentioned odd-chain alcohol residue.

The odd chain length alcohol derivative used in the hair nourishing / hair-fostering agent of the present invention need only contain the residues of the above-mentioned odd chain length alcohol as long as it does not adversely affect the human body. Therefore, the acid residue in the esterified product and the alcohol residue or sugar residue in the etherified product may be substituted with various substituents.

The blending amount of the fatty acid having an odd carbon chain length or its derivative in the hair nourishing and hair-restoring agent of the present invention is 0.1 to 30.0% by weight, preferably 0.5 to 5% by weight. If the blending amount is less than 0.1% by weight, the hair-growth / hair-growth effect is lowered, and if it exceeds 30.0% by weight, the hair-growth effect does not change so much, which is not economical and not preferable.

Other metabolic promoting active substances used in the present invention include: 1) general formula R ₁ : C _{1 to} C ₂₂ straight or branched chain saturated or unsaturated hydrocarbon group R _{2 to} R ₄ : C _{1 to} C ₅ straight or branched chain saturated or unsaturated hydrocarbon group Groups n: 1 to 10 X: a carpronium derivative represented by a hydrogen group or a halogen group, especially CH ₃ CO ₂ (CH ₂ ) _{3
^{N + (CH 3) 3 Cl}} - of carpronium chloride are preferred.

2) General formula Minoxidil represented by R ₁ , R ₂ ; H or C _{1 to} C ₅ linear or branched, saturated or unsaturated hydrocarbon group and derivatives thereof.

3) vitamins (vitamin E and vitamin E acetate, vitamin _{A, B 2, B 6,} B 12, D, biotin and derivatives thereof).

4) Crude drug extract (Cucumber, garlic, carrot, aloe,
Chamomile, yokinin (related patent JP-A-60-174706),
Sugar beet, gentian, gnat, cepharanthin,
Hinokitiol and the like), preferably Assemblage, ginseng extract, cepharanthin, hinokitiol.

5) Female hormones (estradiol, ethinylestradiol).

6) Topical stimulants (capsicum tincture, vanillyl amide nonylate, peppermint oil, l-menthol, camphor, benzyl nicotinate, etc.).

Of the above metabolism promoting substances, 1) to 2) are 0.01 to 30
%), 3) to 6) are preferably blended in an amount of 10 ppm to 10%.

Various methods can be considered for adding oxygen gas to the hair-growth / hair-growth agent, but a method of putting the hair-growth / hair-growth agent in a pressure resistant container and enclosing high-pressure gas is particularly preferable. By doing so, a part of the oxygen gas is dissolved and blended in the hair nourishing / hair-growth material, and the rest is present as a gas in the container.

In the present invention, it is most important that oxygen gas is mixed in the hair-growth / hair-growth material. This amount is 10ppm
The above is preferable, and if less than this, a sufficient scalp metabolism enhancing action cannot be expected, and the effect of the present invention cannot be obtained. Adjustment of the blending amount of oxygen gas can be performed by injection pressure, and generally, the pressure in the container is 1.
It is preferable that the pressure is 1 to 8 kg / cm ² (gauge pressure).

Therefore, it is preferable to mix at least one of CFC, liquefied natural gas, dimethyl ether, nitrogen, argon, helium, and carbon gas as the propellant component.

Further, the pressure-resistant container used in the present invention needs to be capable of withstanding the above pressure and holding the hair nourishing / hair-growing material in a sealed state until it is used after preparation, such as aluminum and tin. A metal container, a synthetic resin container such as an acetal resin and a polycarbonate resin, and a glass container are used.

On the other hand, when the diameter of the discharge nozzle is small, the filling liquid is atomized, and when it is large, it is foamed or liquid. Although the injection form varies depending on the internal pressure of the can, in general, when the diameter of the discharge nozzle of the aerosol spray container is set to 1.5 mm or less, it is sprayed in a mist form and oxygen gas is immediately scattered, so that a sufficient effect cannot be obtained. To enhance the effect of the present invention,
It is necessary to prolong the residence time of oxygen gas in the hair-growth / hair-growth agent. Therefore, it is preferable to apply the hair-growth / hair-growth agent of the present invention directly to the scalp in the form of foam or liquid to foam on the scalp.
Therefore, the diameter of the discharge nozzle is 0.3 to 1.5 mm and the length is 0.3 to 1 mm.
It is preferably 5 cm.

The hair nourishing and hair-restoring agent of the present invention, depending on the purpose of use,
Various optional components can be blended in addition to the above components. For example, distilled water, alcohols, polyhydric alcohols, surfactants, fats and oils can be used as a base, and also a perfume, a preservative such as parahydroxybenzoic acid ester, butyl hydroxy annisol, etc. A cooling agent, a humectant such as propylene glycol and 1,3-butylene glycol can be added and blended.

[Effects of the Invention] The hair nourishing and hair-restoring agent of the present invention has a hair-restoring and hair-restoring agent containing a compound having an activity of promoting hair root metabolic activity, and oxygen is further added to the hair-restoring and hair-restoring agent. It is highly effective in promoting growth and sustaining these effects.

From the effect of inhibiting hair loss and promoting hair growth, it is considered that the hair nourishing and hair-restoring agent of the present invention is effective for promoting and sustaining cell activation (metabolic acid metabolism and TCA cycle activation) in the scalp.

[Examples] Hereinafter, the present invention will be described more specifically by showing Examples of the present invention and Comparative Examples. Prior to the description of each example, the evaluation method of the hair-growth / hair-growth effect test method adopted in each example will be described.

[Test method for hair growth and hair growth effect] New Zealand White Rabbit 6 weighing about 2.5 kg
Approximately 8 birds were made into a group, their backs were hair-removed, and only those in the resting period were subjected to the experiment. Apply 0.2 ml each of the test sample twice a week for 30 to 60 days to the dorsal part of the hair that was in the resting period,
The number of days required to convert resting hair to growing hair was examined. The term "promoting days" used as an index of the hair-growth / hair-growth effect refers to the number of days in which the conversion from resting hair to anagen hair was promoted as compared with the case where ethanol containing no test substance was applied. It is shown. The hair nourishing / hair-growth effect was evaluated based on the criteria shown in Table 1 below.

Examples 1 to 5 11 kinds of test samples shown in Table 2 below were prepared, and the characteristics of each were evaluated. The results are shown in the same table.

From Table 2, the test samples (Examples 1 to 5) containing the predetermined amounts of the two active ingredients within the scope of the present invention show excellent properties in hair nourishing effect and refreshing feeling. ,
It is understood that none of the test samples (Comparative Examples 1 to 6) outside the scope of the present invention show excellent characteristics. A test sample containing no fatty acid having an odd carbon chain length and its derivative (Comparative Examples 5 and 6), or containing a fatty acid having an odd carbon chain length and its derivative but containing no oxygen gas or the present invention Test samples with compounding amounts outside the range of
4) has a problem in the refreshing feeling which is the basic performance of the aerosol tonic.

Example 6 A test sample having a composition shown in Table 3 below was prepared and a trial test was conducted.

Trials were selected from those with a predisposition to androgenetic alopecia, who currently have increased telogen hairs and currently advanced hair loss. In addition, the trial test is that the hair-restoring and hair-growing agent having the composition shown in Table 3 is used every day for 6 months, and the resting period is the ratio of the number of resting period to total hair before and after use. The rate was measured. Table 4 shows the results.

As is clear from Table 4, when a test sample (Example 6) containing a compound having a hair root metabolic activity promoting action and oxygen is used, an increase in the resting period hair percentage is suppressed or the resting period hair percentage is increased. Was reduced. However, in the test sample containing no oxygen (Comparative Example 7), the quiescent hair ratio was increased.

Example 7 A test sample having the composition shown in Table 5 below was prepared and a trial test was conducted. The evaluation was based on Example 6.

As shown in Table 5, a reduction in the resting period hair ratio was observed by using the hair nourishing and hair-restoring agent of the present invention containing oxygen gas.

Prescription Example Next, a prescription example in which the hair nourishing / hair-growing agent of the present invention is applied to an actual product will be shown. It has been confirmed that all examples show excellent characteristics. The unit of the following examples is% by weight.

Prescription example 1 (hair growth spray) Prescription example 2 (aerosol tonic) Prescription example 3 (aerosol hair growth liquid)

Claims (1)

(57) [Claims] 1. A hair-growth / hair-growth composition comprising a hair-growth / hair-growth material containing a compound having an activity of promoting hair root metabolism and oxygen gas, which is sealed in a pressure-resistant container.