JPH02180808A - Hair-tonic and hair-growing agent - Google Patents

Abstract

PURPOSE:To obtain a hair-tonic and hair-growing agent effective in promoting the metabolic activity of hair root by the synergistic effect of the components and having improved durability of the effect by compounding oxygen gas to a hair-tonic and hair-growing agent containing a compound active to promote the metabolic activity of hair root. CONSTITUTION:The objective hair-tonic and hair-growing composition exhibiting improved effect to suppress alopecia, promote the growth of hair and keep the activity compared with conventional agent is produced by adding preferably >=10ppm of oxygen gas to a hair-tonic and hair-growing agent containing 0.1-30.0wt.% (preferably 0.5-5wt.%) of a compound active to promote the metabolic activity of hair root, preferably a fatty acid, an alcohol or their derivative having a chain of odd carbon number, preferably >=9, more preferably 11-25 and sealing the mixture in a pressure bottle. The compounding amount of oxygen gas can be adjusted by the injection pressure and the pressure in the bottle is generally adjusted to 1.1-8kg/cm<2> (gauge) at 35 deg.C preferably by compounding a propellant such as nitrogen gas.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a hair nourishing and restoring composition, and more particularly to a hair nourishing and restoring composition that exhibits a sustained hair nourishing and hair restoring effect.

BACKGROUND ART [0003] Hair nourishing and hair growth products using certain fatty acids or derivatives thereof as compounds that promote the metabolic activity of hair roots have been proposed, for example, in Japanese Patent Application Laid-Open No. 59-27809. Another example of a compound that promotes the metabolic activity of hair roots is Oriental japonica extract.

Vitamin E (derivative), vitamin B2 (derivative).

Vitamin B (derivative), vitamin B 1 biotin (derivative) 1 female hormone, adrenal cortical hormone.

Pantothenic acid (derivative), vitamin D (derivative).

Carpronium chloride, garlic extract, nicotinic acid (derivative), amino acids, glycyrrhetinic acid (derivative), hinokitiol, toki extract, usable extract, chinpi extract 2
Carrot extract, minoxidil (derivatives), chamomile extract, tolazoline chloride, etc. are known.

[Problems to be Solved by the Invention] However, conventional hair nourishing and hair restoring agents are not necessarily sufficient in their hair nourishing and hair restoring effects, and are particularly insufficient in terms of sustainability of their effects.

The present invention was made in view of the above circumstances, and the present invention has been made in view of the above circumstances.
An object of the present invention is to provide a hair nourishing/growth composition that can promote and sustain metabolic activity, suppress hair loss, and promote hair growth.

[Means for Solving the Problems] The present inventor has developed a product that has even better hair-nourishing and hair-growth effects than conventional products,
As a result of intensive research to develop a hair nourishing and hair growth product that has excellent long-lasting effects, we found that by incorporating oxygen gas, the synergistic effect promotes the metabolic activity of the hair roots, and the effect is particularly enhanced. The present inventors have discovered that the present invention can be sustained.

That is, the hair nourishing and hair restoring composition of the present invention is characterized in that oxygen gas is blended into the hair nourishing and hair restoring composition containing a compound having an action of promoting hair root metabolic activity, and the mixture is sealed in a pressure-resistant container.

As the compound having the action of promoting hair root metabolic activity used in the present invention, fatty acids or derivatives thereof having an odd carbon chain length and alcohols or derivatives thereof having an odd carbon chain length are preferable. As long as the number of atoms is odd, the carbon chain may be saturated or unsaturated, and in the case of an unsaturated chain, it may contain multiple double bonds. The number of carbon atoms in the carbon chain is preferably 9 or more, more preferably 11 to 2.
There are 5 pieces. Examples of such fatty acids include nonanoic acid, undecanoic acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, nonadecanoic acid, heneicosanoic acid, tricosanoic acid, and bentacic acid.

Examples of fatty acid derivatives having an odd carbon chain length that can be incorporated into the hair nourishing/growth preparation of the present invention include those shown below.

b) The monoglyceride shown below - Exfoliation [II] or [■], [II] [III] (However, R6
represents a straight-chain organic group having an even carbon chain length. an organic group, at least one of which has an even carbon chain length; when the other is a chain organic group with an odd carbon chain length, it is particularly preferably a diglyceride of a fatty acid with an odd chain length; ) C) Triglycerides shown below - Extinction [VI], [■C (However, at least one of R, R4, and R5 is a linear organic group having an even carbon chain length, and the other The compound may be a chain organic group having an odd carbon chain length. In that case, triglycerides of fatty acids with odd chain lengths are particularly preferred.) 2) The following - Fatty acid salts represented by , [■Co(R6COO)nM (where R6 is a linear organic group having an even carbon chain length,
M represents ammonia, an organic amine, or a metal atom, and n represents an integer corresponding to the valence of M. For example, RCOONa, R
COOK, and RCOOL i. ) E) Below - Extinction [■ Ester represented by C, [■] RCOOR7 (However, R6 is a linear organic group having an even number of carbon chain lengths,
R7 represents a monohydric or dihydric alcohol residue, a polyoxyethylene residue, a sorbitan residue, or a sucrose residue. Typical examples of monohydric alcohols are methanol and ethanol. ) to) Below - primary amide represented by []X], [I
[ A secondary amide represented by Any organic group may be used as long as it does not give a The 37th, represented by logging [XI]
(However, R9 represents a linear organic group having an odd carbon chain length, and M is Same as above) nu) Below - Exhaustion [X
A sterol ester represented by I[I], [XDI] (However, at least one of RSR4 and R5 is a linear organic group with an even carbon chain length, and the others have no adverse effect on the human body. Any organic group may be used as long as it does not give any carbon chain length.It is particularly preferable that all three of these groups are linear organic groups with an even number chain length.) (However, R6 has an even number carbon chain length. (represents a linear organic group having
IV] [Xv] (However, R and R4 represent a linear organic group, and at least one of them, particularly preferably both, represents a linear organic group having an even carbon chain length. It represents a choline residue, an ethanolamine residue, a serine residue, or an inositol residue. When it is phosphatidylserine, when it is inositol it becomes phosphatidylinositol.) wo) Below - Radiation [XV
] Phosphatidic acid, (wherein R and R4 are chain organic groups, and at least one of them, particularly preferably both, represents a straight chain organic group having an even carbon chain length. ) W) The following - Sphingolipids represented by [XVI], [XVI] C O (where R6 is a linear organic group with an even carbon chain length
X I represents a sugar residue, a phosphate residue, or an amine base residue such as choline or ethanolamine. ) The aliphatic alcohol used in the present invention may have an odd number of carbon atoms constituting the carbon chain, and the carbon chain may be saturated or unsaturated; , if unsaturated, may contain multiple double bonds.

Further, the alcohol may be a lower alcohol or a higher alcohol, and may be any of primary, secondary, and tertiary alcohols.

Examples of preferable odd chain length aliphatic alcohols include n-propyl alcohol, n-amyl alcohol, n-hebutyl alcohol, n-nonyl alcohol, n-undecyl alcohol, n-tridecyl alcohol, n-pentadecyl alcohol, n-heptadecyl alcohol, n-nonadecyl alcohol, n-raneicosyl alcohol,
Mention may be made of n-tridecyl alcohol and n-bentacocyl alcohol.

Further, derivatives of such odd chain length fatty acid alcohols can also be used in the hair nourishing and restoring composition of the present invention. Typical derivatives are esters and ethers of odd chain length alcohols. Preferred esterification products include the above-mentioned odd-number chain length alcohols, aliphatic carboxylic acids (especially preferred are those having 2 to 24 carbon atoms), succinic acid, citric acid, fumaric acid, lactic acid, pyruvic acid, malic acid, and oxaloacetic acid. It includes esters with organic acids such as organic acids, and inorganic acids such as phosphoric acid.

A preferred etherified product is the above-mentioned odd chain length alcohol;
Aliphatic alcohols (especially preferred are those with 2 to 24 carbon atoms); polyhydric alcohols such as glycerin, polyglycerin, ethylene glycol, propylene glycol, butanediol: glucose, ribose, galactose, arabinose, mannose, xylose, sorbitol , including etherification products with sugars such as mannitol. Further, the etherified product may contain two or more odd-numbered chain length alcohol residues in one molecule, such as di- or tri-odd-numbered chain length alkoxide of glycerin.

Note that the odd-number chain length alcohol derivative used in the hair nourishing/growth preparation of the present invention need only contain the residue of the above-mentioned odd-number chain length alcohol, as long as it does not have an adverse effect on the human body.

Therefore, the acid residues in the above-mentioned esterified products and the alcohol residues and sugar residues in the etherified products may be substituted with various substituents.

The amount of the fatty acid having an odd carbon chain length or a derivative thereof in the hair nourishing/growth preparation of the present invention is 0.1 to 30.0% by weight, preferably 0.5 to 5% by weight. If the blending amount is less than 0.1% by weight, the hair nourishing and hair growth effect will decrease.
Even if it exceeds 0.0% by weight, the hair growth effect does not change much, which is uneconomical and undesirable.

Other metabolism-promoting active substances used in the present invention include l)-R: C-C, 2 straight-chain or branched saturated or unsaturated hydrocarbon groups R-R: C-C5 straight-chain or branched saturated or unsaturated hydrocarbon group n: 1 to 10
(C112) 3N'' (CI+3) 3CΩ- carpronium chloride is preferred.

2) Minoxidil and its derivatives represented by R, R; H or C-C5 linear or branched saturated or unsaturated hydrocarbon group.

3) Vitamin preparations (vitamin E and vitamin E acetate, vitamins A, B, B, B, D, biotin and their derivatives).

4) Herbal medicine extracts (Japanese cabbage, garlic, carrot, aloe,
Chamomile, Yokuinin (Related Patent Patent Publication No. 1747-1988)
013), Angelica sativa, Japanese gentian, Japanese daisy, cephalanthine, hinokitiol, etc.), and preferred are Oriental japonica, ginseng extract, cephalanthine, and hinokitiol.

5) Female hormones (estradiol, ethinylestradiol).

6) Local irritants (capsicum tincture, nonylic acid bata-based nirylamide, Hatsukaji, g-menthol, camphor,
benzyl nicotinate, etc.).

Among the above metabolism promoting substances, l) to 2) are 0.01 to 30
%, 3> to B) is preferably blended in an amount of 10 ppm to 10%.

Various methods can be considered for blending oxygen gas into the hair nourishing/hair growing agent, but a method in which the hair nourishing/hair growing agent is placed in a pressure-resistant container and high-pressure gas is sealed is particularly preferred. By doing so, a part of the oxygen gas is dissolved and blended into the hair nourishing/hair growth agent, and the rest is present in the container as a gas.

In the present invention, it is most important that oxygen gas is blended into the hair nourishing/growth preparation. This amount is 10pp
It is preferable that the amount is at least m. If it is less than this, a sufficient scalp metabolism enhancing effect cannot be expected and the effects of the present invention cannot be obtained. The amount of oxygen gas blended can be adjusted by adjusting the injection pressure, and it is generally preferable to adjust the pressure in the container to 1.1 to 8 kg/cd (gauge pressure) at a temperature of 35°C.

For this purpose, it is preferable to blend at least one of fluorocarbon, liquefied natural gas, dimethyl ether, nitrogen, argon, helium, and carbon dioxide gas as a propellant component.

In addition, the pressure-resistant container used in the present invention must be able to withstand the above-mentioned pressure and hold the hair growth agent in a sealed state until it is used after preparation, and for example, aluminum,
Metal containers such as tinplate, synthetic resin containers such as acetal resin, polycarbonate resin, and glass containers are used.

On the other hand, if the diameter of the discharge nozzle is small, the filling liquid is sprayed in a mist form, and if the diameter is large, the filling liquid is sprayed in the form of foam or liquid. Although the spray form differs depending on the internal pressure of the can, in general, if the diameter of the discharge nozzle of the aerosol spray container is 1.5 mm or less, the oxygen gas will be sprayed in the form of a mist and the oxygen gas will quickly scatter, so a sufficient effect will not be obtained. do not have.

In order to further enhance the effects of the present invention, it is necessary to lengthen the residence time of oxygen gas in the hair nourishing/growth agent, so the hair nourishing/hair growing agent of the present invention may be applied directly to the scalp in foam or liquid form. , preferably foamed on the scalp. For this reason, the diameter of the discharge nozzle should be 0.3 to 1.5 cm, and the length should be 0.3 to 15 cm.
It is preferable to

In addition to the above-mentioned components, various optional components can be added to the hair nourishing/growth preparation of the present invention depending on the purpose of use and the like.

For example, distilled water, alcohols, polyhydric alcohols, surfactants, oils and fats, etc. can be used as the base.
Further, fragrances, preservatives such as parahydroxybenzoic acid esters, cooling agents such as butylated hydroxyannisole, and humectants such as propylene glycol, 3-butylene glycol, and the like can be added and blended.

[Effects of the Invention] The hair nourishing/hair growing agent of the present invention has a hair nourishing/hair growing agent that contains a compound that promotes hair root metabolic activity and further contains oxygen, thereby preventing hair loss and hair growth better than conventional products. It is highly effective in promoting growth and sustaining these effects.

Furthermore, from the effect of inhibiting hair loss and promoting hair growth, the hair growth agent of the present invention is considered to be effective in promoting and sustaining cell activation (metabolism of fatty acids and the like and activation of the TCA cycle) in the scalp.

[Examples] Examples and comparative examples of the present invention will be shown below to explain the present invention more specifically. In addition, prior to the explanation of the 6 cases, the evaluation method of the hair growth/hair growth effect test method adopted in the 6 cases will be explained.

[Hair growth/hair growth effect test method] Six to eight New Sealant White rabbits weighing 2.5 kg were used as a part, the hair on the back was removed, and only those in the resting phase were subjected to the experiment. 0.2 ml of each test sample was applied twice a week for 30 to 60 days to the hair-removed backs of hairs in the telogen phase, and the number of days required for the upper telogen hairs to convert into anagen hairs was determined. The "days of promotion" used as an index of hair growth and hair growth effects refers to the number of days that the conversion from the resting phase to anagen hair is promoted compared to when ethanol that does not contain the test substance is applied. It shows. The hair growth effect was evaluated based on the criteria shown in Table 1 below.

Examples 1 to 5 11 tili test samples shown in Table 2 below were prepared, and the characteristics of each were evaluated. The results are shown in the same table.

From Table 2, it can be seen that the test samples (Examples 1 to 5) containing predetermined amounts of the two types of active ingredients within the scope of the present invention all showed excellent properties in terms of hair nourishing effect and refreshing feeling. It can be seen that none of the test samples outside the scope of the present invention (Comparative Examples 1 to 6) exhibited excellent properties. Test samples that do not contain fatty acids with odd carbon chain lengths and derivatives thereof (Comparative Example 5.6), and test samples that do not contain fatty acids and derivatives thereof with odd carbon chain lengths but do not contain oxygen gas or those according to the present invention Test samples with blending amounts outside the range (Comparative Examples 1 to 4)
There is a problem with the refreshing feeling, which is the basic performance of aerosol tonics.

Example 6 A test sample having the composition shown in Table 3 below was prepared and a trial test was conducted.

Trial subjects were selected from those who had a predisposition to androgenetic alopecia, and who currently had symptoms of increasing telogen phase and symptoms of progression of alopecia. In addition, the trial test was conducted after using the hair nourishing agent having the composition shown in Table 3 every day for 6 months. The rate was measured. The results are shown in Table 4.

As is clear from Table 4, when the test sample (Example 6) containing a compound that promotes hair root metabolic activity and oxygen is used, the increase in the rate of hair breakage is suppressed, or the rate of hair breakage is suppressed. has been reduced. However, in the test sample that did not contain oxygen (Comparative Example 7), the percentage of hair cut at rest was increased.

Example 7 A test sample having the composition shown in Table 5 below was prepared and a trial test was conducted. The evaluation was based on Example 6.

As shown in Table 5, a decrease in the percentage of resting feathers was observed by using the hair nourishing and restoring composition of the present invention containing oxygen gas.

Prescription Example Next, a prescription example will be shown in which the hair nourishing/growth agent of the present invention is applied to an actual product. It has been confirmed that all examples exhibit excellent properties. Note that the units in the following examples are % by weight.

Prescription example 1 (hair growth agent spray) (undiluted solution) (Diluent for filling) Prescription example 2 (aerosol tonic) (undiluted solution) Prescription example 3 (aerosol hair growth liquid) (undiluted solution) (Diluent for filling)

Claims (1)

[Claims] (1) A hair-growth/hair-growth composition comprising a hair-growth/hair-growth composition containing a compound that promotes hair root metabolic activity, mixed with oxygen gas, and sealed in a pressure-resistant container.