JP2542324B2 - Industrial sterilization and antiseptic composition - Google Patents

Description

Detailed Description of the Invention

[0001]

The present invention relates to various industrial waters such as, for example,
The present invention relates to water for papermaking in the paper and pulp industries, or industrial sterilizing and preservative agents such as metalworking oils, fiber oils, aqueous paints, latexes, starch pastes, starch slurries, and clay slurries. In particular, it relates to a bactericide against microorganisms that generate slime in the papermaking process water in the paper and pulp industries.

[0002]

2. Description of the Related Art Conventionally, many industrial products such as metalworking oils, water-based paints, latexes, starch pastes, starch slurries and clay slurries have been seriously damaged by spoilage by bacteria. Further, it is known that slime generated in water in the papermaking process in the paper and pulp industry causes a loss such as a decrease in quality and a decrease in production efficiency due to paper shortage. Occurrence of such slime is caused by bacteria,
A wide variety of microorganisms such as filamentous fungi and yeasts are involved.
As a means for suppressing or sterilizing these putrefaction or slime, industrial sterilization is performed antiseptic sterilization treatment using an antiseptic, and especially for slime generated during the papermaking process, various slime control agents are added. Have been sterilized.

It is known that a cyclic nitrogen-sulfur compound, a bromine compound, a thiocyan compound, a quaternary ammonium compound, or the like, or a mixture thereof is used as a sterilizing and antiseptic agent. However, in recent years, highly toxic drugs cannot be used due to environmental safety problems, and many of these compounds have drawbacks in use. For example, conventional drugs have insufficient drug effects at low concentrations, the drugs are irritating to the human body, or they tend to become resistant when used for a long period of time, and bad odors, etc. adversely affect. It has drawbacks. In particular, a slime control agent that suppresses the generation of slime must take into consideration environmental pollution from the viewpoint of its use.

[0004]

DISCLOSURE OF THE INVENTION In consideration of the above points, the present inventors have developed various industrial sterilization and antiseptic agents having a low concentration and effective sterilization and antiseptic properties without causing environmental pollution. As a result of repeated studies, an industrial sterilizer having a synergistic bactericidal effect by combining dichloroglyoxime and another fungicide, an antiseptic agent was found, and the present invention has been completed. It provides an industrial sterilizing and antiseptic agent having a sufficient drug effect.

[0005]

The gist of the present invention is dichloroglyoxime.

[0006]

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And 2- (4-hydroxyphenyl) -2
-Oxoacetohydroxymoyl chloride

[0008]

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And α-chlorobenzaldoxime acetate

[0010]

[Chemical 6]

Industrial sterilization containing at least one compound selected from the group consisting of compounds as an active ingredient,
It is an antiseptic composition. That is, dichloroglyoxime has a strong bactericidal activity, while the single compounds of the above two compound groups have weak bactericidal activity, but when combined with dichloroglyoxime, they have a synergistic bactericidal activity. The effect was obtained. Moreover, the dichloroglyoxime (hereinafter referred to as DCG) used in the present invention is decomposed into oxalic acid and hydroxylamine via the oxalohydroxamic acid or oxalohydroxymic acid and hydrochloric acid by the following reaction in water, and both of them produce Since it becomes a compound safe to the environment to be decomposed, the industrial sterilization and antiseptic composition of the present invention, especially when used as a slime control agent, as an extremely powerful sterilization and antiseptic agent without causing environmental pollution. To work.

[0012]

[Chemical 7]

Next, the present invention will be described in detail. The two or more compounds of the present invention are usually mixed by various methods and added to each target system for use. As a means for mixing these compounds, these compounds are dissolved in a common organic solvent, and then the respective solutions are mixed. At that time, a formulation can be prepared by adding a surfactant if necessary.

Suitable common organic solvents include ethylene glycol (EG), methoxypolyethylene glycol (M-PEG), diethylene glycol monomethyl ether.
Examples include glycol-based solvents such as Tell (MDG). Further, each compound may be added to the target system separately, and the mixing ratio of DCG and the other compound is 0.1: 9.9 to 9.9: 0 for dichloroglyoxime: other drug. ．
1, preferably 9: 1 to 4: 6. The ratio of the industrial sterilization and preservative added to the target system varies depending on the type of the system, but is usually 0.1 to 30 ppm, preferably 0.5 to 10 ppm as the active ingredient.

[0015]

EXAMPLES Next, the present invention will be described in more detail by way of examples, but the present invention is not limited thereto. In the table, each compound is represented as follows: DCG dichloroglyoxime HPAHCI 2- (4-hydroxyphenyl) -2-
Oxoacetohydroxymoyl chloride CBA α-chlorobenzaldoxime acetate

Example 1 Dichloroglyoxime and other compounds, HPACI and C
BA was mixed in the ratio shown in Table 1, and the minimum bactericidal concentration (MBC) at that ratio was determined. Standard strain E.
E. coli JCM1649 strain was used. As a test method, physiological saline was added to E. coli. E. coli JCM1649 strain was inoculated to about 10 ⁶ cells / ml and placed in an L-shaped culture tube to give a predetermined active ingredient concentration (40, 20, 10,
5,2.5,1.3,0.6,0.3,0.15pp
m) was added with a drug, and the viable cell count after 1 hour of culturing on a mono-shaker at 30 ° C. was measured by a conventional method (SPC method).
The minimum concentration (MBC) sterilized by 9.9% was measured. These results are shown in FIG. 1 and FIG. In FIG. 1, CBA1
00%, 40ppm or more means 1 CBA as an active ingredient
This means that the minimum bactericidal concentration when used at 00% is 40 ppm or more.

As is clear from FIGS. 1 and 2, dichloroglyoxime was considered by combining α-chlorobenzaldoxime acetate and 2- (4-hydroxyphenyl) -2-oxoacetohydroxymoyl chloride. It showed an unbelievably low MBC.

Example 2 A sterilization test was carried out on the chemicals shown in Table 1 using white water (acidic) manufactured by A Paper Manufacturing Company, which produces newspaper.

[0019]

[Table 1]

As a method, a certain amount (20 ppm, 10 ppm) of the drug shown in Table 1 was added to the test white water, and the viable cell count after shaking culture at 30 ° C. for 1 hour was measured by a conventional method (SPC method) and no drug was added. Contrast with. Table 2 shows the results. For comparison, no chemicals added or DCG, HPAHCl, and CBA
The same test as described above was performed when each of the above compounds was used alone. It is clear from Table 2 that dichloroglyoxime synergistically enhanced the bactericidal activity by combining with other drugs.

[0021]

[Table 2]

Example 3 A sterilization test was carried out on the chemicals shown in Table 1 using white water (neutral) of a paper manufacturing company B, which manufactures the base paper for the coat. The results are shown in Table 3. For comparison, no drug added or D
The same test as above was carried out when each of the compounds CG, HPAHCl, and CBA was used alone. It is clear from Table 3 that dichloroglyoxime synergistically enhanced the bactericidal activity by combining with other agents.

[0023]

[Table 3]

[0024]

As described above, the present invention provides dichloroglyoxime and 2- (4-hydroxyphenyl) -2-
By using at least one compound selected from the group consisting of oxoacetohydroxymoyl chloride and α-chlorobenzaldoxime acetate as an active ingredient, an extremely small amount as shown in each Example. Synergistically shows strong bactericidal and antiseptic properties, and since dichloroglyoxime is decomposed into a compound harmless to the environment in water, it is particularly useful for slime control in the papermaking process water in the paper and pulp industry. Effective as an agent.

[Brief description of drawings]

FIG. 1 is a diagram showing the relationship between the ratio of both DCG and CBA mixed drugs of Example 1 and the minimum bactericidal concentration.

FIG. 2 is a diagram showing the relationship between the ratio of both DCG and HPAHCl mixed drugs of Example 1 and the minimum bactericidal concentration.

[Explanation of symbols]

 The horizontal axis represents the compounding ratio of the drug, and the vertical axis represents the minimum bactericidal concentration.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Hideki Sugano 1-6 Omano-cho, Koshigaya-shi, Saitama Pure Chemicals Co., Ltd. Saitama Laboratory (72) Inventor Masayasu Takahashi 1-18-6 Ginza, Chuo-ku, Tokyo Common building (Ginza) within Fuji Sangyo Co., Ltd.

Claims (1)

(57) [Claims] 1. A dichloroglyoxime embedded image And 2- (4-hydroxyphenyl) -2-oxoacetohydroxymoyl chloride And α-chlorobenzaldoxime acetate Industrial bactericidal and antiseptic compositions containing, as an active ingredient, at least one compound selected from the group consisting of: