JP2524783B2 - Liver function improver for livestock and poultry - Google Patents

Description

TECHNICAL FIELD The present invention relates to a liver function improving agent for livestock and poultry.

[Conventional technology]

In recent years, diseases caused by liver diseases of livestock and poultry and their economic losses have become a problem in the livestock industry.

For example, in high-lactation cows in the early stage of lactation, milk production surpasses appetite, and in order to compensate for the lack of energy, mobilization of body fat becomes active, resulting in the development of fatty liver and various metabolic disorders and infections. Is causing the disease.

Furthermore, it is known that cattle that are obese at the end of pregnancy are prone to hepatic dysfunction such as fatty liver after calving, and as a result, the onset of ovarian activity and ovulation are delayed, and estrus and conception are delayed. ing.

Also, in poultry such as chickens, by feeding concentrated feed,
It puts a heavy burden on the liver and causes hepatic dysfunction, resulting in economic loss such as a decrease in egg laying rate and yellowing due to fat accumulation in the liver.

Various devises and drugs have been applied to improve these liver dysfunctions, but it is still difficult to say that they are complete, and there is a strong demand for a highly effective drug.

[Problems to be solved by the invention]

In view of the above situation, the present inventors intend to provide a liver function improving agent for livestock and poultry, which contains plant sterol as an active ingredient.

[Means for solving problems]

The plant sterol, which is an active ingredient of the liver function improving agent for livestock and poultry provided by the present invention, is a sterol obtained from various plants such as stigmasterol, ergosterol, 5,6-dihydrosterol, brassicasterol, campesterol. , Α-spinasterol, β-spinasterol, γ-spinasterol, δ-spinasterol, β-sitosterol, γ-sitosterol,
Fucosterol, dimosterol, ascosterol,
Examples include cerevisterol, episterol, γ-sitostanol, fecosterol, anasterol, hyposterol, chondrilasterol, stigmasteranol, and the like, but particularly β-sitosterol, stigmasterol, campesterol, γ-sitosterol, brassica. Sterols and the like are preferred. These are used alone or in appropriate combination of two or more. Further, these plant sterols may be used in the form of a purified product or a crude product.

Among plant sterols, for example, stigmasterol is soybean, palm, cottonseed, kidney beans, odaka, and the like, campesterol is rapeseed, wheat, soybean, rye, and the like, β-sitosterol is a bark of cereals and higher plants, and leaves. It is widely contained in free state, glycosides, fatty acid esters, etc., and γ-sitosterol is obtained from peas, caraval beans, rice, soybean, etc., but obtained when fractionating oil from these plants. The crude plant sterols may be used, or the crude plant sterols obtained by fractionating natural Vitamin E, which is used as a health food, from these oils can be provided at a low price and is economically large. It is also an advantage.

The liver function improving agent for livestock and poultry of the present invention is a powder, a powder, a tablet, a capsule, or a granule, with or without mixing a plant sterol or a crude plant sterol with a physiologically harmless solid or liquid diluent. Although it may be formulated into a suspension, oil, etc., it is usually used by directly mixing it with a conventional feed ingredient or by adding it dispersed in a diluent to the feed ingredient.

Other appropriate auxiliary agents or additives, bactericides, preservatives, enzyme agents, antibiotics, lactic acid bacterium preparations and the like can also be mixed.

The amount of active ingredient used in the liver function improving agent for livestock / poultry of the present invention varies depending on the type of livestock / poultry, breed, weight, age, sex, dosing period, type of plant sterol, condition of liver dysfunction, etc. , For example, 1 to 200 g / day, preferably 5 to 100 g / day, per adult cow, and 1.0 / day / chicken
-2000 mg, preferably 10-700 mg, can improve liver dysfunction, and further, 0.1-50 g / day, preferably 0.5-25 g / day / adult, and 1 / chicken.
Administration of 0.1 to 400 mg, preferably 0.5 to 100 mg daily can prevent liver dysfunction.

In addition, the liver function improving agent in the present invention means a liver function improving agent having a disorder and also a preventive agent for liver function disorder.

The livestock / poultry liver function-improving agent of the present invention is further characterized by low toxicity.

 Hereinafter, the present invention will be described with reference to Examples and Test Examples.

Example 1 β-sitosterol 22.9 parts by weight Campesterol 14.1 parts by weight Brush casterol 7.9 parts by weight Stigmasterol 5.1 parts by weight Oatme meal 50.0 parts by weight was uniformly mixed and prepared.

Example 2 β-sitosterol 51.6 parts by weight Stigmasterol 11.6 parts by weight Campesterol 31.8 parts by weight Brush casterol 5.0 parts by weight were uniformly mixed and prepared.

Example 3 2 parts by weight of campesterol 1 part by weight of stigmasterol 65 parts by weight of corn cob meal 32 parts by weight of defatted soybean flour were uniformly mixed and prepared.

Example 4 20 parts by weight of crude plant sterol (obtained during production of cottonseed oil) 60 parts by weight of defatted soybean flour 20 parts by weight of fermented mother were uniformly mixed to prepare a pill.

Example 5 20 parts by weight of crude plant sterol (obtained during soybean oil production, containing about 15% of plant sterol) 60 parts by weight of corn flour 20 parts by weight of talc were uniformly mixed to prepare granules.

Example 6 Crude plant sterols (obtained during the separation of vitamin E from the crude plant sterols used in Example 4. Approximately 60% content as plant sterols) 5 parts by weight Concovmeal 80 parts by weight Starch 15 parts by weight uniformly It was mixed and prepared.

Test Example 1 10 cows with symptoms such as anorexia and milk loss after calving, and as a result of blood test and liver biopsy, diagnosed as hepatic dysfunction due to fatty liver (average of 4.6 births, average weight of 650 kg) , The feeds shown in Table 1 were fed, and the formulation prepared in Example 1 was supplemented with plant sterols of 15 g and 3 respectively.
Oral administration was carried out once a day for 4 consecutive weeks to give 0 g.
As a control, a normal cow that did not exhibit symptoms such as postpartum fatty liver was used.

Blood tests were performed weekly, and the results are shown in Table 2.

Test Example 2 A 50-day 7-day-old broiler-specific male and female was tested and tested.
The formulation of Example 1 was further added to the compounded feeds shown in the table so that plant sterols were added at 0.01, 0.05, and 0.25%, respectively, and fed ad libitum until the age of 8 weeks. After the completion of the test, all the birds were slaughtered, the lipid content in the liver was measured, and the results are shown in Table 4.

[Effect] As is clear from the results in Table 2, all of the test cows with liver dysfunction showed the same blood image as normal cows by the administration of plant sterol for 2 to 4 weeks, and the liver function was improved. Came to In addition, an increase in milk production and a decrease in somatic cell count were also observed by the administration of plant sterols.

Also, as shown in Table 4, by administering plant sterols in chickens, there was no difference in body weight and feed intake, but a decrease in liver lipid content, liver triglyceride content, fatty liver score could be confirmed, It was possible to suppress the development of fatty liver in chicken.

From these findings, it was confirmed that plant sterol has a therapeutic and preventive effect on liver dysfunction as a liver function improving agent for livestock and poultry.

Claims (1)

(57) [Claims] 1. A hepatic function improving agent for livestock and poultry, which comprises a plant sterol as an active ingredient.