JPH01146823A - Liver function improving agent for domestic animal and livestock - Google Patents

Abstract

PURPOSE:To obtain a pharmaceutical for treating and preventing liver functional disease of domestic animal and livestock e. g., capable of lowering liver lipid content, liver triglyceride content and fatty hepatic score and suppressing occurrence of fatty liver of a domestic fowl, by containing a vegetable sterol as an active ingredient. CONSTITUTION:A vegetable sterol is contained as an active ingredient. As the vegetable sterol, e. g., stigmasterol obtained from soybean, coconut, cotton seed, bean, arrowhead, etc.; campesterol obtained from notch, wheat, soybean, rye, etc.; beta-sitosterol contained as glycoside, fatty acid ester, etc., in liberated state in bark, leaf, etc., of cereals or higher plant or gamma-sitosterol obtained from pea, carabal bean, etc., is used. When used, the vegetable sterol may be directly blended with a feed ingredient or the vegetable sterol dispersed in a diluent may be added to the feed ingredient, etc.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a liver function improving agent for livestock and poultry.

[Conventional technology]

In recent years, diseases caused by liver diseases in livestock and poultry and the resulting economic losses have become a problem in the livestock industry.

For example, in high-yielding dairy cows in the early stages of lactation, the degree of emulsification exceeds appetite, and body fat mobilization becomes active to compensate for the resulting energy deficiency.

It develops into fatty liver and causes various metabolic disorders and infections.

Furthermore, it is known that cows that are obese at the end of pregnancy are more likely to develop liver dysfunction such as fatty liver after parturition, which delays the start of ovarian activity and ovulation, resulting in a delay in estrus and conception. ing.

In addition, in poultry such as chickens, feeding concentrated feed places a heavy burden on the liver, leading to liver dysfunction, resulting in economic losses such as reduced egg production and yellowing due to fat accumulation in the liver.

Although various devices and drugs have been used to improve these liver dysfunctions, they are still far from perfect, and highly effective drugs have been desperately needed.

[Problem that the invention seeks to solve]

In view of the above circumstances, the present inventors intend to provide a liver function improving agent for livestock and poultry containing plant styrene as an active ingredient.

[Means for solving problems]

The plant styrene that is an active ingredient of the liver function improving agent for livestock and poultry provided by the present invention includes styrene obtained from various plants, such as stigmastyrol, ergostyrol, 5,6-cyhydrostyrol, brassicastyrol, and campestyrol. Styrol, α-spinastyrol, β-spinasterol, γ-spinastyrol, δ-spinastyrol, β-sitostyrol, γ-sitostyrol,
fucostyrol, zimostyrol, ascostyrol,
Examples include cerevistyrol, evistyrol, γ-sitostanol, fecostyrol, anastyrol, hypostyrol, contrilastyrol, stigmastyrol, but especially β-sitostyrol, stigmastyrol, campestyrol, γ-sitostyrol , Brassica Styrol and the like are preferred, and these are used singly or in an appropriate combination of two or more. Further, these plant styrenes may be used in the form of purified products or crude products.

One of the plant styrols, for example, stigmastyrol comes from soybean, palm, cottonseed, kidney bean, omodaka, etc., and campestyrol comes from rapeseed, wheat, soybean, rye, etc.
β-sitostyrol is widely contained in the bark and leaves of cereals and higher plants in the free state, glycosides, fatty acid esters, etc., and γ-sitostyrol is found in peas, carapal beans, and rice.

It can be obtained from soybeans, etc., but it can also be crude vegetable styrene obtained when oil is separated from these plants, or natural vitamin E, which is touted as a health food, can be obtained from these oils. Crude vegetable styrene and the like can be provided at low prices, which is a great economic advantage.

The liver function improving agent for livestock and poultry of the present invention can be prepared by mixing plant styrene or crude plant styrene with a physiologically harmless solid or liquid diluent, or by mixing it with a physiologically harmless solid or liquid diluent. Although they may be formulated into suspensions, oils, etc., they are usually used by directly mixing them with conventional feed ingredients, or by adding them to feed ingredients after being dispersed in a diluent.

Other appropriate adjuvants or additives, bactericides, preservatives, enzymes, antibiotics, lactic acid bacteria preparations, etc. can also be mixed.

The amount of active ingredient used in the liver function improving agent for livestock and poultry of the present invention varies depending on the type, breed, weight, age, sex, duration of administration, type of phytostyrene, state of liver dysfunction, etc. of the livestock and poultry. , for example by administering 1 to 200 g, preferably 5 to 100 g per adult cow, or 1 to 100 g per chicken per day.
1.0-2000mg per day, preferably 10-700mg
Liver dysfunction can be improved by administration of 0.1 to 50 g per adult cow per day, preferably 0.5 to 25 g per day.
g, and 0.1 to 400 m per chicken per day.
Hepatic dysfunction can be prevented by administering 0.5 to 100 mg, preferably 0.5 to 100 mg.

In addition, the liver function improving agent in the present invention refers to an agent for improving impaired liver function, and also means an agent for preventing liver function disorder.

The liver function improving agent for livestock and poultry of the present invention is further characterized by low toxicity.

The present invention will be explained below with reference to Examples and Test Examples.

Example 1 β-sitostyrol 22.9 parts by weight Campestrol 14.1 parts by weight Brassica styrol 7.9 parts by weight Stigmastyrol 5.1 parts by weight Soybean
It was prepared by uniformly mixing 50.0 parts by weight of lees.

Example 2 β-sitostyrol 51.6 parts by weight stigmastyrol 11.6 parts by weight campestrol 31.8 parts by weight Brassica styrol 5.0 parts by weight were uniformly mixed for preparation.

Example 3 Campestrol 2 parts by weight Stigmastyrol 1 part by weight Corn cob meal 65 parts by weight Defatted soy flour
It was prepared by uniformly mixing 32 parts by weight.

Example 4 20 parts by weight of crude vegetable styrene (obtained during the production of cottonseed oil), 60 parts by weight of defatted soybean flour, and 20 parts by weight of yeast were uniformly mixed and prepared into pills.

Example 5 Crude vegetable styrene (obtained during soybean oil production. Contains approximately 15% as vegetable styrene) 20 parts by weight Corn flour 60 parts by weight Tart
20 parts by weight were uniformly mixed to form one particle.

Example 6 Crude vegetable styrene (obtained when vitamin E was separated from the crude vegetable styrene used in Example 4. Contains about 60% as vegetable styrene) 5 parts by weight Corn cob meal 80 parts by weight Starch
It was prepared by uniformly mixing 15 parts by weight.

Test Example 1 10 dairy cows exhibited symptoms such as loss of appetite and decreased milk production after calving, and were diagnosed with liver dysfunction due to fatty liver as a result of blood tests and liver biopsies (average history of parity 4.6 times, average weight 650
kg) were divided into two groups and fed the feed shown in Table 1, and the formulation prepared in Example 1 was fed once a day for 4 consecutive weeks so that the amount of plant styrene was 15 g and 30 g, respectively. It was administered orally. As a control, normal cows that did not exhibit symptoms such as postpartum fatty liver were used.

Blood tests were conducted every week, and the results are shown in Table 2.

Table 1 Table 2 Test Example 2 50 male and female broiler chickens of 7 days old were tested.
The formulation of Example 1 was further added to the formulated feed shown in the table, and plant styrene was added at a concentration of 0.01, 0.05, and 0.25%, respectively, and fed ad libitum until 8 weeks of age. After the test, the gold feather layer was killed and the lipid content in the liver was measured, and the results are shown in Table 4.

Table 3 Table 4 [Effects] As is clear from the results in Table 2, all of the test subjects with liver dysfunction showed blood images equivalent to those of normal subjects after 2 to 4 weeks of plant styrene administration. , liver function improved. Additionally, an increase in milk yield and a decrease in somatic cell number were observed with the administration of plant styrene.

In addition, as shown in Table 4, there was no difference in body weight or feed intake by administering plant styrene to chickens, but liver lipid content, liver triglyceride content,
A decrease in fatty liver score was confirmed, and the occurrence of fatty liver in chickens could be suppressed.

Based on these findings, it was recognized that plant styrene has therapeutic and preventive effects on liver dysfunction as a liver function improving agent for livestock and poultry.

Patent applicant Kaken Pharmaceutical Co., Ltd.

Claims (1)

[Claims] A liver function improving agent for livestock and poultry that contains plant styrene as an active ingredient.