JP2507953B2 - Granules for filling bone voids and bone resorption parts - Google Patents
Granules for filling bone voids and bone resorption partsInfo
- Publication number
- JP2507953B2 JP2507953B2 JP2072113A JP7211390A JP2507953B2 JP 2507953 B2 JP2507953 B2 JP 2507953B2 JP 2072113 A JP2072113 A JP 2072113A JP 7211390 A JP7211390 A JP 7211390A JP 2507953 B2 JP2507953 B2 JP 2507953B2
- Authority
- JP
- Japan
- Prior art keywords
- bone
- granules
- filling
- powder
- protrusions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- Materials For Medical Uses (AREA)
Description
【発明の詳細な説明】 〈産業上の利用分野〉 本発明は骨空隙部及び骨吸収部等の骨欠損部に充填
し、充填箇所に固定され、かつ、骨組織及び骨類似組織
を生成させるための骨空隙部及び骨吸収部充填用造粒物
に関する。DETAILED DESCRIPTION OF THE INVENTION <Industrial field of application> The present invention fills bone defects such as bone voids and bone resorption parts, fixes them at the filling points, and generates bone tissue and bone-like tissue. The present invention relates to a granulated material for filling a bone void portion and a bone resorption portion.
〈従来の技術〉 従来、骨欠損部及び骨空隙部に対し、治療を必要とす
る場合、該骨欠損部及び骨空隙部の形状が一定でなく、
しかも複雑な形状を有しているので、例えばその形状に
適合するように加工された焼結体を充填材として使用す
る方法が行なわれていた。しかしながら、該方法では、
実際の手術において、充填材をその形状に合わせて更に
加工する必要があり、手術時間が延長し、術者ならびに
患者に対して、多大な負担を強いらなければならないと
いう欠点がある。そこで近年、このような問題を解決す
るために種々の充填材が提案されている。例えば形状が
球形、不定形、楕円等の単純な形状を有する生体用セラ
ミックスの顆粒等が知られている。しかしながら該生体
用セラミックスの顆粒は、骨欠損部等に充填した後、外
力が作用すると個々の顆粒が容易に移動し、新生骨の生
成が遅延する傾向にある。<Prior Art> Conventionally, when treatment is required for a bone defect portion and a bone void portion, the shapes of the bone defect portion and the bone void portion are not constant,
Moreover, since it has a complicated shape, for example, a method of using a sintered body processed so as to conform to the shape as a filler has been performed. However, in the method,
In the actual surgery, there is a disadvantage that the filler needs to be further processed according to its shape, the operation time is extended, and a great burden is imposed on the operator and the patient. Therefore, in recent years, various fillers have been proposed in order to solve such problems. For example, granules of bio-ceramics having a simple shape such as a sphere, an amorphous shape, an ellipse, etc. are known. However, the granules of the biomedical ceramics tend to be delayed in the generation of new bone when the granules of a bone defect or the like are filled and then an external force acts on the granules.
一方最近セラミックス粉末を有機バインダー及び水と
混合したスラリーを所定の型へ流し込み形成した充填材
や、金型中にセラミックス原料粉末を充填してプレス成
型した充填材、更にはセラミックス原料粉末と有機バイ
ンダー及び水を湿式で練り上げ金型を用いて押出し成型
し、所望の長さに切断して形成した充填材等が開発され
ている（特開昭58-1441号公報）。On the other hand, recently, a filler made by pouring a slurry in which ceramic powder is mixed with an organic binder and water into a predetermined mold, a filler made by pressing a ceramic raw material powder into a mold and press-molding, and further a ceramic raw material powder and an organic binder. Also, a filler and the like have been developed in which water is wet-kneaded and extruded using a mold and cut to a desired length to form (Japanese Patent Laid-Open No. 58-1441).
しかしながら、前記充填材では、工業的に大量生産が
困難であり、突出部がかなり大きいために突出部が相互
に交錯した際に形成される３次元的空隙が著しく広くな
り、従って生体親和性が良好にも拘らず新生骨の生成が
遅延するという欠点がある。However, the above-mentioned filler is industrially difficult to mass-produce, and since the protrusions are quite large, the three-dimensional voids formed when the protrusions intersect with each other are significantly widened, and thus the biocompatibility is high. Although good, it has the drawback of delaying the formation of new bone.
〈発明が解決しようとする課題〉 従って本発明の目的は、生体適合性に優れ、しかも異
物反応を伴わずに特に短期間にて骨組織及び骨類似組織
を形成し、骨組織欠損箇所の構造及び機能を速やかに修
復及び回復させることができる骨空隙部及び骨吸収部充
填用造粒物を提供することにある。<Problems to be Solved by the Invention> Therefore, an object of the present invention is to form a bone tissue and a bone-like tissue in a particularly short period of time with excellent biocompatibility and no foreign body reaction, and to provide a structure of a bone tissue defect site. Another object of the present invention is to provide a granule for filling a bone void portion and a bone resorption portion, which can quickly restore and restore its function.
本発明の他の目的は、骨欠損部へ充填した後に外部か
ら作用を受けても個々の顆粒が移動しない骨空隙部及び
骨吸収部充填用造粒物を提供することにある。Another object of the present invention is to provide a granule for filling a bone void portion and a bone resorption portion, in which individual granules do not move even if they are externally acted upon after filling a bone defect portion.
〈課題を解決するための手段〉 本発明によれば、リン酸カルシウム系セラミックスか
ら成る造粒物であって、該造粒物の表面が、該リン酸カ
ルシウム系セラミックスと同一組成のセラミックス粉末
によりコーティングされ、該セラミックス粉末により複
数の突出部を具備しており、該突出部のコーティング
が、前記造粒物を骨空隙部及び骨吸収部に複数充填した
際に、隣接する造粒物表面の突出部と突出部とが交錯し
て、３次元的空間を形成するようなされていることを特
徴とする骨空隙部及び骨吸収部充填用造粒物が提供され
る。<Means for Solving the Problems> According to the present invention, a granulated product made of calcium phosphate-based ceramics, the surface of the granulated product is coated with a ceramic powder having the same composition as the calcium phosphate-based ceramics, The ceramic powder is provided with a plurality of protrusions, and the coating of the protrusions protrudes from the adjacent protrusions on the surface of the granulated product when a plurality of the granulated products are filled in the bone voids and the bone resorption parts. There is provided a granule for filling a bone void portion and a bone resorption portion, which is characterized by intersecting with a portion to form a three-dimensional space.
以下本発明を更に詳細に説明する。 The present invention will be described in more detail below.
本発明の骨空隙部及び骨吸収部充填用造粒物は、表面
に複数の突出部を有するリン酸カルシウム系セラミック
スの造粒物である。The granules for filling bone voids and bone resorption parts of the present invention are granules of calcium phosphate-based ceramics having a plurality of protrusions on the surface.
本発明の充填用造粒物を形成するリン酸カルシウム系
セラミックスとしては、例えばアルミナ等を含むリン酸
三カルシウム、ヒドロキシアパタイト、リン酸四カルシ
ウム、オキシアパタイト、ピロリン酸カルシウム、フッ
素アパイタト、ヒドロキシアパタイトの水酸基の１部が
フッ素イオンで置換された化合物、ブルッシャイト（Ca
HPO4・2H2O）及びこれらの混合物等を挙げることがで
き、これらのうちで新生骨の生成速度が早いもの、すな
わちリン酸三カルシウム、ヒドロキシアパタイト、フッ
素アパタイト若しくはリン酸四カルシウムのうちから選
ばれた１種若しくは２種以上の混合物等を用いることが
好ましい。中でも、ヒドロキシアパタイトは新生骨生成
速度が最も早いことから、最も好ましい。Examples of the calcium phosphate-based ceramics that form the granulated material for filling of the present invention include tricalcium phosphate containing alumina and the like, hydroxyapatite, tetracalcium phosphate, oxyapatite, calcium pyrophosphate, fluoroapatite, and one of the hydroxyl groups of hydroxyapatite. Compound, whose part is replaced by fluorine ion,
HPO 4・ 2H 2 O) and mixtures thereof, etc., of which the rate of new bone formation is fast, namely tricalcium phosphate, hydroxyapatite, fluoroapatite or tetracalcium phosphate. It is preferable to use one kind or a mixture of two or more kinds selected. Among them, hydroxyapatite is most preferable because it has the fastest new bone formation rate.
本発明の充填用造粒物を製造するには、リン酸カルシ
ウム系セラミックスから成る粒状物の表面に、該粒状物
と同一組成の粉末をコーティングし、該表面に複数の突
出部を形成させることにより得ることができる。前記粒
状物は、例えばコーティング造粒法等により球状に形成
したものが好ましく、その大きさは、粒径2.0〜0.5mmの
範囲であるのが望ましい。また前記粉末は、粒状物の表
面に強固に固定するために、粒状物と同一組成にする必
要がある。粉末の粒径は150μｍ以下であるのが好まし
く、粒末をコーティングした造粒物の粒径は10.0〜1.0m
mの範囲であるのが望ましい。In order to produce the filling granulated product of the present invention, it is obtained by coating the surface of a granular material made of calcium phosphate-based ceramics with a powder having the same composition as the granular material and forming a plurality of protrusions on the surface. be able to. The granules are preferably formed into spheres by, for example, a coating granulation method, and the size thereof is preferably in the range of 2.0 to 0.5 mm. Further, the powder needs to have the same composition as the granular material in order to firmly fix it on the surface of the granular material. The particle size of the powder is preferably 150 μm or less, and the particle size of the granulated product coated with powder ends is 10.0 to 1.0 m.
It is preferably in the range of m.
前記粒状物の表面に前記粉末をコーティングするに
は、例えば粒状物にポリビニルアルコール（以下PVAと
略す）、ポリ酢酸ビニル、デキストリン、アラビアゴム
等を噴霧しながら粉末をコーティングし、好ましくは80
〜50℃にて十分乾燥させた後、1200〜700℃で焼成する
方法等により行うことができる。この際粉末は、必ずし
も粒状物表面全体にコーディングされていなくても良
く、またコーティングされた粉末の上に更にコーティン
グすることもできる。即ち粉末が粒状物表面に強固に固
定され、得られる粒状物の表面が複数の突出部を具備
し、且つ骨欠損部及び骨吸収部に充填した際に、隣接す
る充填用造粒物表面の突出部と突出部とが交錯して、３
次元的空間を形成することが可能であれば、粉末が粉状
体にどのようにコーティングされていても良い。In order to coat the powder on the surface of the granular material, for example, polyvinyl alcohol (hereinafter abbreviated as PVA), polyvinyl acetate, dextrin, gum arabic or the like is sprayed on the granular material, and the powder is preferably coated.
It can be carried out by a method of sufficiently drying at -50 ° C and then firing at 1200-700 ° C. The powder here does not necessarily have to be coded on the entire surface of the granulate, but can also be further coated onto the coated powder. That is, the powder is firmly fixed to the surface of the granular material, the surface of the resulting granular material has a plurality of protrusions, and when filling the bone defect portion and the bone resorption portion, 3 and the protrusion and the protrusion intersect
The powder may be coated on the powder material in any manner as long as the three-dimensional space can be formed.
〈発明の効果〉 本発明の骨空隙部及び骨吸収部充填用造粒物は、リン
酸カルシウム系セラミックスにより形成されるので、生
体親和生に優れており、また表面に複数の突出部を具備
しているので、充填後の安定生に優れ、しかも充填した
際に、該突出部同志が交錯して、３次元的空隙を形成す
るので新生骨が短時間にて速やかに生成し、容易に骨欠
損部及び骨吸収部を修復及び回復させることができる。<Effects of the Invention> The granules for filling the bone void portion and the bone resorption portion of the present invention are formed of calcium phosphate-based ceramics, and thus are excellent in biocompatibility and are provided with a plurality of protrusions on the surface. Since it has excellent stability after filling, and when filling, the protrusions intersect with each other to form a three-dimensional void, so new bone can be rapidly generated in a short time, and bone loss can be easily achieved. The part and the bone resorption part can be repaired and restored.
〈実施例〉 以下本発明を実施例及び比較例により更に詳細に説明
するが、本発明はこれらに限定されるものではない。<Examples> The present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto.
実施例１ ヒドロキシアパタイト（以下、HAPと略す）乾燥物を
粉砕し、粒径0.6mm以下の粒状物と、粒径90μｍ以下の
粉末とを得た。Example 1 A dried product of hydroxyapatite (hereinafter abbreviated as HAP) was pulverized to obtain a granular material having a particle size of 0.6 mm or less and a powder having a particle size of 90 μm or less.
次いでパン型造粒機を用いて、0.6mmの粒状物に、５
重量％のPVA水溶液を噴霧しながら粒径90μｍ以下の粉
末をコーティングし、表面に突出部が具備された3.0〜
2.0mmのぶどうの房状造粒物を形成した。その後80℃に
て十分乾燥させ、900℃で焼成し、充填用造粒物を得
た。得られたぶどうの房状充填用造粒物10の拡大概略図
を第１図に示す。第１図に示されるとおり、得られた充
填用造粒物10の表面には、粉末により突出部11が具備さ
れていた。Then, using a pan-type granulator, make 0.6 mm granules,
While spraying a wt% PVA aqueous solution, a powder having a particle size of 90 μm or less was coated, and a protrusion was provided on the surface.
A 2.0 mm grape tuft granulate was formed. Then, it was sufficiently dried at 80 ° C. and baked at 900 ° C. to obtain a granulated material for filling. FIG. 1 shows an enlarged schematic view of the obtained granules 10 for filling a tuft of grapes. As shown in FIG. 1, the surface of the obtained granulated material for filling 10 was provided with a protrusion 11 made of powder.
次に得られた充填用造粒物を家兎大腿骨々髄内に充填
し、４週間経過後、その組織を観察したところ造粒物の
突出部を結ぶように新生骨の生成が顕著に認められた。Next, the obtained granules for filling were filled in the bones of the femurs of rabbits, and after 4 weeks, the tissue was observed. As a result, the generation of new bone was remarkable as if the protrusions of the granules were connected. Admitted.
実施例２ 粒状物としてHAp乾燥物を粉砕した1.0〜6.0mmの粒状
物を用いた以外は、実施例１と同様に充填用造粒物を製
造した。得られた充填用造粒物は、第２図に示すとお
り、コンペイ糖状の充填用造粒物20であって、その粒径
は2.0〜3.0mmであり、表面には突出部21が具備されてい
た。Example 2 A granulation material for filling was produced in the same manner as in Example 1 except that a granular material of 1.0 to 6.0 mm obtained by pulverizing a dried HAp material was used as the granular material. As shown in FIG. 2, the obtained filling granules were Compay sugar-like filling granules 20 having a particle size of 2.0 to 3.0 mm and provided with protrusions 21 on the surface. It had been.
次に、得られた充填用造粒物を実施例１と同様に家兎
大腿骨々髄内に充填し、４週間経過後の組織を観察した
ところ、突出部を結ぶように新生骨の生成が顕著に認め
られた。Next, the obtained granules for filling were filled in the pulp of the femur of the rabbit in the same manner as in Example 1, and the tissue after 4 weeks was observed. As a result, new bone was formed so as to connect the protrusions. Was remarkably recognized.
比較例1,2 鋳込み整形にて、HApから成るテトラポット型の粒径
3.0〜2.0mmの顆粒（比較例１）及びHAp乾燥物を粉砕
し、3.0〜2.0mmでふるい分けした顆粒（比較例２）を得
た。次いで夫々の顆粒を900℃で焼成した後、実施例１
と同様に家兎大腿骨々髄内に夫々を充填し、４週間経過
後の組織を観察した。その結果比較例１及び２の顆粒は
共に顆粒間周辺に僅かに新生骨の生成が認められたのみ
であって、実施例１及び２の造粒物に比して、新生骨の
生成量は顕著に少ない量であった。Comparative Example 1,2 Tetrapot type particle size consisting of HAp by casting shaping
Granules of 3.0 to 2.0 mm (Comparative Example 1) and HAp dried product were crushed to obtain granules sieved at 3.0 to 2.0 mm (Comparative Example 2). Then each granule was calcined at 900 ° C. and then Example 1
In the same manner as above, the intramedullary femurs were each filled with intramedullary bone, and the tissue was observed 4 weeks later. As a result, in each of the granules of Comparative Examples 1 and 2, only a small amount of new bone was found around the intergranular area, and compared with the granules of Examples 1 and 2, the amount of new bone produced was smaller. The amount was remarkably small.
第１図は実施例１で製造した骨空隙部及び骨吸収部充填
用造粒物の拡大概略図、第２図は実施例２で製造した骨
空隙部及び骨吸収部充填用造粒物の拡大概略図である。 10,20……充填用造粒物、11,21……突出部。FIG. 1 is an enlarged schematic view of the granules for filling a bone void portion and a bone resorption portion produced in Example 1, and FIG. 2 is the granule for filling a bone void portion and a bone resorption portion produced in Example 2. FIG. 10,20 ... Granules for filling, 11,21 ... Projections.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 山本 豊彦 埼玉県秩父郡横瀬町大字横瀬2270番地 三菱鉱業セメント株式会社セラミックス 研究所内 (56)参考文献 特開 昭62−224356（ＪＰ，Ａ) 特開 昭59−171546（ＪＰ，Ａ) ─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Toyohiko Yamamoto 2270 Yokose, Yokose-cho, Chichibu-gun, Saitama Mitsubishi Mining and Cement Co., Ltd. Ceramics Research Laboratory (56) Reference JP-A-62-224356 (JP, A) Sho 59-171546 (JP, A)
Claims (1)
造粒物であって、該造粒物の表面が、該リン酸カルシウ
ム系セラミックスと同一組成のセラミックス粉末により
コーティングされ、該セラミックス粉末により複数の突
出部を具備しており、該突出部のコーティングが、前記
造粒物を骨空隙部及び骨吸収部に複数充填した際に、隣
接する造粒物表面の突出部と突出部とが交錯して、３次
元的空間を形成するようなされていることを特徴とする
骨空隙部及び骨吸収部充填用造粒物。1. A granulated product made of calcium phosphate-based ceramics, the surface of which is coated with a ceramic powder having the same composition as the calcium phosphate-based ceramics, the ceramic powder having a plurality of protrusions. When the plurality of granules are filled in the bone void portion and the bone resorption portion, the protrusions on the surface of the adjacent granules intersect with each other to form a three-dimensional coating. A granule for filling a bone void portion and a bone resorption portion, which is characterized by forming a space.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2072113A JP2507953B2 (en) | 1990-03-23 | 1990-03-23 | Granules for filling bone voids and bone resorption parts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2072113A JP2507953B2 (en) | 1990-03-23 | 1990-03-23 | Granules for filling bone voids and bone resorption parts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03272769A JPH03272769A (en) | 1991-12-04 |
| JP2507953B2 true JP2507953B2 (en) | 1996-06-19 |
Family
ID=13479999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2072113A Expired - Fee Related JP2507953B2 (en) | 1990-03-23 | 1990-03-23 | Granules for filling bone voids and bone resorption parts |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2507953B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002060504A1 (en) * | 2001-02-02 | 2002-08-08 | Technology Finance Corporation (Proprietary) Limited | Bone filler material |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59171546A (en) * | 1983-03-18 | 1984-09-28 | 日本特殊陶業株式会社 | Filler for bone substitute |
| JPS62224356A (en) * | 1986-03-26 | 1987-10-02 | 太平化学産業株式会社 | Living body hard tissue prosthetic material and its production |
-
1990
- 1990-03-23 JP JP2072113A patent/JP2507953B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03272769A (en) | 1991-12-04 |
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