JP2025517656A5 - - Google Patents

Info

Publication number
JP2025517656A5
JP2025517656A5 JP2024566198A JP2024566198A JP2025517656A5 JP 2025517656 A5 JP2025517656 A5 JP 2025517656A5 JP 2024566198 A JP2024566198 A JP 2024566198A JP 2024566198 A JP2024566198 A JP 2024566198A JP 2025517656 A5 JP2025517656 A5 JP 2025517656A5
Authority
JP
Japan
Prior art keywords
antibody
drug
linker
pharmaceutical composition
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024566198A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025517656A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2023/054841 external-priority patent/WO2023218378A1/en
Publication of JP2025517656A publication Critical patent/JP2025517656A/ja
Publication of JP2025517656A5 publication Critical patent/JP2025517656A5/ja
Pending legal-status Critical Current

Links

JP2024566198A 2022-05-11 2023-05-10 腫瘍抗原に特異的である抗体と、cd47阻害剤との組合せ Pending JP2025517656A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263340745P 2022-05-11 2022-05-11
US63/340,745 2022-05-11
PCT/IB2023/054841 WO2023218378A1 (en) 2022-05-11 2023-05-10 Combination of an antibody specific for a tumor antigen and a cd47 inhibitor

Publications (2)

Publication Number Publication Date
JP2025517656A JP2025517656A (ja) 2025-06-10
JP2025517656A5 true JP2025517656A5 (OSRAM) 2026-05-18

Family

ID=86851891

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024566198A Pending JP2025517656A (ja) 2022-05-11 2023-05-10 腫瘍抗原に特異的である抗体と、cd47阻害剤との組合せ

Country Status (6)

Country Link
US (1) US20250296966A1 (OSRAM)
EP (1) EP4522658A1 (OSRAM)
JP (1) JP2025517656A (OSRAM)
CN (1) CN119403829A (OSRAM)
TW (1) TW202400650A (OSRAM)
WO (1) WO2023218378A1 (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118767148B (zh) * 2024-06-24 2025-09-05 武汉科技大学 一种提高红细胞载体实体肿瘤富集能力的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
ATE255131T1 (de) 1991-06-14 2003-12-15 Genentech Inc Humanisierter heregulin antikörper
AU3657899A (en) 1998-04-20 1999-11-08 James E. Bailey Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
PT1176195E (pt) 1999-04-09 2013-07-18 Kyowa Hakko Kirin Co Ltd Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico
AT500848B1 (de) 1999-06-25 2008-01-15 Genentech Inc Humanisierte anti-erbb2-antikörper
DK2314686T4 (da) 2000-10-06 2023-08-21 Kyowa Kirin Co Ltd Celler, der danner antistofsammensætninger
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
CA2647632C (en) 2006-03-27 2017-06-27 University Of Maryland Biotechnology Institute Glycoprotein synthesis and remodeling by enzymatic transglycosylation
SG178789A1 (en) 2007-02-16 2012-03-29 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof
EP2812442B9 (en) 2012-02-10 2023-02-15 University of Maryland, Baltimore Chemoenzymatic glycoengineering of antibodies and fc fragments thereof
JP6081125B2 (ja) 2012-10-09 2017-02-15 株式会社日立製作所 太陽光発電装置および電力管理システム、並びに、そのための電力負荷と計測装置
WO2014057687A1 (ja) 2012-10-11 2014-04-17 第一三共株式会社 抗体-薬物コンジュゲート
WO2014061277A1 (ja) 2012-10-19 2014-04-24 第一三共株式会社 親水性構造を含むリンカーで結合させた抗体-薬物コンジュゲート
HRP20192013T1 (hr) 2012-12-17 2020-02-07 Trillium Therapeutics Inc. Liječenje cd47+ oboljelih stanica sa sirp alfa-fc fuzijama
PT3088419T (pt) 2013-12-25 2019-01-11 Daiichi Sankyo Co Ltd Conjugado de anticorpo anti-trop2-fármaco
HRP20190431T1 (hr) 2014-01-31 2019-04-19 Daiichi Sankyo Company, Limited Anti-her2 antitijelo-lijek konjugat
JP2017114763A (ja) 2014-03-26 2017-06-29 第一三共株式会社 抗cd98抗体−薬物コンジュゲート
ES2754348T3 (es) 2014-04-10 2020-04-17 Daiichi Sankyo Co Ltd Conjugado de (anticuerpo anti-HER2)-fármaco
CN111228511B (zh) 2014-04-10 2024-06-18 第一三共株式会社 抗her3抗体-药物偶联物
CN116059395A (zh) 2015-06-29 2023-05-05 第一三共株式会社 用于选择性制造抗体-药物缀合物的方法
WO2017027422A1 (en) 2015-08-07 2017-02-16 Alexo Therapeutics Inc. Constructs having a sirp-alpha domain or variant thereof
PL3565828T3 (pl) 2017-01-05 2022-04-04 Kahr Medical Ltd. Białko fuzyjne SIRP1 ALFA-41BBL i sposoby jego zastosowania
EP3572428A4 (en) 2017-01-17 2020-12-30 Daiichi Sankyo Company, Limited ANTI-BODY ANTI-GPR20 AND ANTI-BODY-DRUG CONJUGATE ANTI-GPR20
TWI855528B (zh) 2017-05-15 2024-09-11 日商第一三共股份有限公司 抗體-藥物結合物之製造方法
WO2018236904A1 (en) 2017-06-19 2018-12-27 Surface Oncology, Inc. COMBINATION OF ANTI-CD47 ANTIBODIES AND CELL DEATH INDUCING AGENTS, AND USES THEREOF
KR20250084239A (ko) 2017-08-31 2025-06-10 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 개량 제조 방법
WO2020198370A2 (en) 2019-03-25 2020-10-01 Arch Oncology, Inc. Therapeutic cd47 antibodies
KR20220044904A (ko) * 2019-05-31 2022-04-12 알렉소 온콜로지 인크. 면역 관문 억제제와 병용하는 sirp 알파 fc 융합으로 암을 치료하는 방법

Similar Documents

Publication Publication Date Title
JP7553504B2 (ja) 操作された抗体化合物およびこれらの抱合体
TWI843705B (zh) 結晶及其改良製造方法、以及抗體-藥物結合物之改良製造方法
JP6585600B2 (ja) C末端軽鎖ポリペプチド伸長を含有する抗体、ならびにその複合体及びその使用方法
JPWO2022102634A5 (OSRAM)
TWI822740B (zh) 抗her2雙互補位抗體-藥物結合物及使用方法
CN116271079B (zh) 一种抗dll3抗体及其制备方法、其药物偶联物和应用
JP2020531469A (ja) 三環式基を有するトル様受容体7(tlr7)アゴニスト、そのコンジュゲート、ならびにそれらの方法および使用
WO2015165413A1 (zh) 一种新型的稳定型抗体药物耦联物及其制备方法和用途
JP2015526435A (ja) 抗体成分と血液脳関門を通過するポリペプチドと細胞毒とを含むコンジュゲート
JP2020521478A5 (OSRAM)
TWI845724B (zh) 用於偶聯的多肽複合物及其應用
JP2020532523A (ja) 抗egfr抗体薬物コンジュゲート(adc)及びその使用
AU2015340370A9 (en) Materials and methods relating to linkers for use in protein drug conjugates
TW202330040A (zh) 抗her2抗體藥物偶聯物和酪胺酸激酶抑制劑聯合在製備治療腫瘤的藥物中的用途
JP2025129192A (ja) 胆道癌の治療のための、her2を標的とする二重特異性抗原結合構築物の使用方法
JP2020532543A (ja) 抗egfr抗体薬物コンジュゲート(adc)及びその使用
Kim et al. Bispecific anti-mPDGFRβ x cotinine scFv-Cκ-scFv fusion protein and cotinine-duocarmycin can form antibody-drug conjugate-like complexes that exert cytotoxicity against mPDGFRβ expressing cells
WO2025119257A1 (zh) 间皮素靶向结合蛋白、其编码核酸以及用途
JPWO2023219072A5 (OSRAM)
WO2016059057A1 (en) Vegfr-2 binding polypeptides
WO2025021073A1 (zh) 抗Nectin4抗体药物偶联物和抗PD-1抗体的药物组合以及其用途
WO2026082091A1 (zh) 一种包含特异性结合egfr和muc1的抗体药物偶联物的药物组合物
US8597655B2 (en) Recombinant fusion protein and polynucleotide construct for immunotoxin production
김수현 Bispecific anti-mPDGFRβ/cotinine fusion protein can form antibody-drug conjugate-like complexes with cotinine-duocarmycin and exert cytotoxicity against mPDGFRβ expressing cells
CN119462950A (zh) 结合trop2和/或prlr的双特异性抗原结合分子、其缀合物和用途