JP2025515995A - Ｃｄ３３結合ｔ細胞エンゲージ抗体分子を含むｃｄ７０結合ｃａｒ－ｔ細胞 - Google Patents

Ｃｄ３３結合ｔ細胞エンゲージ抗体分子を含むｃｄ７０結合ｃａｒ－ｔ細胞 Download PDF

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JP2025515995A
JP2025515995A JP2024560356A JP2024560356A JP2025515995A JP 2025515995 A JP2025515995 A JP 2025515995A JP 2024560356 A JP2024560356 A JP 2024560356A JP 2024560356 A JP2024560356 A JP 2024560356A JP 2025515995 A JP2025515995 A JP 2025515995A
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cells
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マルセラ ヴィー． マウス，
マーク レイク，
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ザ ジェネラル ホスピタル コーポレイション
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    • A—HUMAN NECESSITIES
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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JP2024560356A 2022-04-15 2023-04-13 Ｃｄ３３結合ｔ細胞エンゲージ抗体分子を含むｃｄ７０結合ｃａｒ－ｔ細胞 Pending JP2025515995A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263331758P 2022-04-15 2022-04-15
US63/331,758 2022-04-15
US202263341995P 2022-05-13 2022-05-13
US63/341,995 2022-05-13
PCT/US2023/065710 WO2023201288A1 (en) 2022-04-15 2023-04-13 Cd70 binding car-t cells comprising cd33 binding t-cell engaging antibody molecules

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JP2025515995A true JP2025515995A (ja) 2025-05-23
JP2025515995A5 JP2025515995A5 (enExample) 2026-04-21

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JP2024560356A Pending JP2025515995A (ja) 2022-04-15 2023-04-13 Ｃｄ３３結合ｔ細胞エンゲージ抗体分子を含むｃｄ７０結合ｃａｒ－ｔ細胞

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US (1) US20250249037A1 (enExample)
EP (1) EP4507706A4 (enExample)
JP (1) JP2025515995A (enExample)
CN (1) CN119365202A (enExample)
AU (1) AU2023254840A1 (enExample)
CA (1) CA3248652A1 (enExample)
WO (1) WO2023201288A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3568466A4 (en) 2017-01-10 2020-07-15 The General Hospital Corporation TARGETED T CELLS WITH CYTOTOXICITY TO IMMUNOSUPPRESSIVE CELLS
US12378297B2 (en) 2017-04-14 2025-08-05 The General Hospital Corporation Chimeric antigen receptor T cells targeting the tumor microenvironment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10875919B2 (en) * 2016-04-26 2020-12-29 Alector Llc Chimeric receptors and methods of use thereof
CA3048648A1 (en) * 2017-01-10 2018-07-19 The General Hospital Corporation T cells expressing a chimeric antigen receptor
US20190153096A1 (en) * 2017-10-02 2019-05-23 Covagen Ag Cd3/cd33 bispecific binding molecules
MX2020012028A (es) * 2018-05-11 2021-03-29 Crispr Therapeutics Ag Metodos y composiciones para tratar el cancer.
EP4031150A4 (en) * 2019-09-16 2023-11-01 The General Hospital Corporation CD70-DIRECTED CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AND USES THEREOF

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EP4507706A1 (en) 2025-02-19
CN119365202A (zh) 2025-01-24
WO2023201288A1 (en) 2023-10-19
EP4507706A4 (en) 2026-04-01
WO2023201288A9 (en) 2026-04-02
CA3248652A1 (en) 2023-10-19
US20250249037A1 (en) 2025-08-07
AU2023254840A1 (en) 2024-11-07

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