CN119365202A - 包含结合cd33的t细胞接合抗体分子的结合cd70的car-t细胞 - Google Patents

包含结合cd33的t细胞接合抗体分子的结合cd70的car-t细胞 Download PDF

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CN119365202A
CN119365202A CN202380047510.1A CN202380047510A CN119365202A CN 119365202 A CN119365202 A CN 119365202A CN 202380047510 A CN202380047510 A CN 202380047510A CN 119365202 A CN119365202 A CN 119365202A
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cell
cells
car
domain
acid sequence
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M·V·毛斯
M·莱克
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General Hospital Corp
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General Hospital Corp
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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CN202380047510.1A 2022-04-15 2023-04-13 包含结合cd33的t细胞接合抗体分子的结合cd70的car-t细胞 Pending CN119365202A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263331758P 2022-04-15 2022-04-15
US63/331,758 2022-04-15
US202263341995P 2022-05-13 2022-05-13
US63/341,995 2022-05-13
PCT/US2023/065710 WO2023201288A1 (en) 2022-04-15 2023-04-13 Cd70 binding car-t cells comprising cd33 binding t-cell engaging antibody molecules

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CN119365202A true CN119365202A (zh) 2025-01-24

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CN202380047510.1A Pending CN119365202A (zh) 2022-04-15 2023-04-13 包含结合cd33的t细胞接合抗体分子的结合cd70的car-t细胞

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US (1) US20250249037A1 (enExample)
EP (1) EP4507706A4 (enExample)
JP (1) JP2025515995A (enExample)
CN (1) CN119365202A (enExample)
AU (1) AU2023254840A1 (enExample)
CA (1) CA3248652A1 (enExample)
WO (1) WO2023201288A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3568466A4 (en) 2017-01-10 2020-07-15 The General Hospital Corporation TARGETED T CELLS WITH CYTOTOXICITY TO IMMUNOSUPPRESSIVE CELLS
US12378297B2 (en) 2017-04-14 2025-08-05 The General Hospital Corporation Chimeric antigen receptor T cells targeting the tumor microenvironment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10875919B2 (en) * 2016-04-26 2020-12-29 Alector Llc Chimeric receptors and methods of use thereof
CA3048648A1 (en) * 2017-01-10 2018-07-19 The General Hospital Corporation T cells expressing a chimeric antigen receptor
US20190153096A1 (en) * 2017-10-02 2019-05-23 Covagen Ag Cd3/cd33 bispecific binding molecules
MX2020012028A (es) * 2018-05-11 2021-03-29 Crispr Therapeutics Ag Metodos y composiciones para tratar el cancer.
EP4031150A4 (en) * 2019-09-16 2023-11-01 The General Hospital Corporation CD70-DIRECTED CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AND USES THEREOF

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EP4507706A1 (en) 2025-02-19
JP2025515995A (ja) 2025-05-23
WO2023201288A1 (en) 2023-10-19
EP4507706A4 (en) 2026-04-01
WO2023201288A9 (en) 2026-04-02
CA3248652A1 (en) 2023-10-19
US20250249037A1 (en) 2025-08-07
AU2023254840A1 (en) 2024-11-07

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