JP2025514763A5 - - Google Patents
Info
- Publication number
- JP2025514763A5 JP2025514763A5 JP2024561852A JP2024561852A JP2025514763A5 JP 2025514763 A5 JP2025514763 A5 JP 2025514763A5 JP 2024561852 A JP2024561852 A JP 2024561852A JP 2024561852 A JP2024561852 A JP 2024561852A JP 2025514763 A5 JP2025514763 A5 JP 2025514763A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- multispecific antibody
- amino acid
- antibody according
- constant domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263333293P | 2022-04-21 | 2022-04-21 | |
| US63/333,293 | 2022-04-21 | ||
| PCT/US2023/066036 WO2023205753A1 (en) | 2022-04-21 | 2023-04-20 | Chimeric heavy chain constant domains with reduced binding to fc gamma receptors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025514763A JP2025514763A (ja) | 2025-05-09 |
| JP2025514763A5 true JP2025514763A5 (enExample) | 2026-04-28 |
Family
ID=86425985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024561852A Pending JP2025514763A (ja) | 2022-04-21 | 2023-04-20 | Ｆｃガンマ受容体への結合が低減されたキメラ重鎖定常ドメイン及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250109207A1 (enExample) |
| EP (1) | EP4511398A1 (enExample) |
| JP (1) | JP2025514763A (enExample) |
| KR (1) | KR20250007564A (enExample) |
| CN (2) | CN117597365A (enExample) |
| AU (1) | AU2023255761A1 (enExample) |
| CA (1) | CA3249454A1 (enExample) |
| WO (1) | WO2023205753A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4638729A1 (en) | 2022-12-23 | 2025-10-29 | Regeneron Pharmaceuticals, Inc. | Ace2 fusion proteins and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5582996A (en) | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
| US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| CA2128511C (en) | 1992-01-23 | 2006-11-07 | Andreas Pluckthun | Monomeric and dimeric antibody-fragment fusion proteins |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| GB9824437D0 (en) | 1998-11-06 | 1999-01-06 | Ylo Herttuala Seppo | Gene therapy |
| US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
| WO2005049094A1 (en) | 2003-11-13 | 2005-06-02 | Advantagene, Inc. | A mixed complementary viral vector for gene therapy |
| WO2006028936A2 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Heteromultimeric molecules |
| KR101374454B1 (ko) | 2005-03-31 | 2014-03-17 | 추가이 세이야쿠 가부시키가이샤 | 회합제어에 의한 폴리펩티드 제조방법 |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| EP3663318A1 (en) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| US8703132B2 (en) * | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| TWI507525B (zh) * | 2009-06-26 | 2015-11-11 | Regeneron Pharma | 具天然免疫球蛋白形式之易分離的雙專一性抗體 |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| SG191233A1 (en) * | 2010-12-23 | 2013-07-31 | Janssen Biotech Inc | Active protease-resistant antibody fc mutants |
| MX385344B (es) | 2012-11-28 | 2025-03-18 | Zymeworks Bc Inc | Pares de cadena pesada-cadena ligera de inmunoglobulina modificados genéticamente y usos de estos. |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| US10047167B2 (en) | 2013-03-15 | 2018-08-14 | Eli Lilly And Company | Methods for producing fabs and bi-specific antibodies |
| DK3277725T3 (da) | 2015-03-30 | 2021-01-11 | Regeneron Pharma | Konstante tungkædeområder med reduceret binding til FC-gammareceptorer |
| AU2020379735A1 (en) | 2019-11-05 | 2022-05-26 | Regeneron Pharmaceuticals, Inc. | N-terminal SCFV multispecific binding molecules |
| WO2021150266A1 (en) * | 2020-01-21 | 2021-07-29 | Tavotek Biotherapeutics (Hong Kong) Limited | Agents that interfere with il-1beta receptor signalling |
-
2022
- 2022-05-03 CN CN202280047414.2A patent/CN117597365A/zh active Pending
-
2023
- 2023-04-20 KR KR1020247038245A patent/KR20250007564A/ko active Pending
- 2023-04-20 CA CA3249454A patent/CA3249454A1/en active Pending
- 2023-04-20 WO PCT/US2023/066036 patent/WO2023205753A1/en not_active Ceased
- 2023-04-20 EP EP23725348.9A patent/EP4511398A1/en active Pending
- 2023-04-20 JP JP2024561852A patent/JP2025514763A/ja active Pending
- 2023-04-20 US US18/857,898 patent/US20250109207A1/en active Pending
- 2023-04-20 CN CN202380048565.4A patent/CN119546637A/zh active Pending
- 2023-04-20 AU AU2023255761A patent/AU2023255761A1/en active Pending
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