JP2025514327A5 - - Google Patents
Info
- Publication number
- JP2025514327A5 JP2025514327A5 JP2024563634A JP2024563634A JP2025514327A5 JP 2025514327 A5 JP2025514327 A5 JP 2025514327A5 JP 2024563634 A JP2024563634 A JP 2024563634A JP 2024563634 A JP2024563634 A JP 2024563634A JP 2025514327 A5 JP2025514327 A5 JP 2025514327A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- crrna
- protective
- group
- double
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263336340P | 2022-04-29 | 2022-04-29 | |
| US63/336,340 | 2022-04-29 | ||
| US202363438842P | 2023-01-13 | 2023-01-13 | |
| US63/438,842 | 2023-01-13 | ||
| PCT/US2023/020418 WO2023212327A1 (en) | 2022-04-29 | 2023-04-28 | Protecting oligonucleotides for crispr guide rna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025514327A JP2025514327A (ja) | 2025-05-02 |
| JP2025514327A5 true JP2025514327A5 (enExample) | 2026-05-08 |
Family
ID=88519734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024563634A Pending JP2025514327A (ja) | 2022-04-29 | 2023-04-28 | Ｃｒｉｓｐｒガイドｒｎａのための保護オリゴヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230407295A1 (enExample) |
| EP (1) | EP4514972A1 (enExample) |
| JP (1) | JP2025514327A (enExample) |
| CN (1) | CN119563023A (enExample) |
| AU (1) | AU2023262033A1 (enExample) |
| CA (1) | CA3250967A1 (enExample) |
| WO (1) | WO2023212327A1 (enExample) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6312894B1 (en) * | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
| US9340799B2 (en) * | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| EP3835419A1 (en) * | 2013-12-12 | 2021-06-16 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
| EP3985115A1 (en) * | 2014-12-12 | 2022-04-20 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| WO2016130943A1 (en) * | 2015-02-13 | 2016-08-18 | Rana Therapeutics, Inc. | Hybrid oligonucleotides and uses thereof |
| US11845929B2 (en) * | 2016-07-08 | 2023-12-19 | Ohio State Innovation Foundation | Modified nucleic acids, hybrid guide RNAs, and uses thereof |
| EP3781677A4 (en) * | 2018-04-16 | 2022-01-19 | University of Massachusetts | COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING |
-
2023
- 2023-04-28 WO PCT/US2023/020418 patent/WO2023212327A1/en not_active Ceased
- 2023-04-28 US US18/141,166 patent/US20230407295A1/en active Pending
- 2023-04-28 CA CA3250967A patent/CA3250967A1/en active Pending
- 2023-04-28 EP EP23797358.1A patent/EP4514972A1/en active Pending
- 2023-04-28 JP JP2024563634A patent/JP2025514327A/ja active Pending
- 2023-04-28 AU AU2023262033A patent/AU2023262033A1/en active Pending
- 2023-04-28 CN CN202380043499.1A patent/CN119563023A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022528487A5 (enExample) | ||
| JP2023550485A5 (enExample) | ||
| JP2022523467A5 (enExample) | ||
| JP7308309B2 (ja) | オリゴヌクレオチド組成物及びその作製方法 | |
| JP2021533804A5 (enExample) | ||
| JP2008504840A (ja) | 非リン酸骨格結合を含むオリゴヌクレオチド | |
| JP2021533762A5 (enExample) | ||
| EP3359523A2 (en) | Oligonucleotide compositions and methods thereof | |
| JP2016216468A (ja) | 新規オリゴヌクレオチド接合体およびその用途 | |
| EP3018208A1 (en) | Improved nanoparticle type oligonucleotide structure having high efficiency and method for preparing same | |
| KR20140109927A (ko) | 고효율 나노입자형 이중나선 올리고 rna 구조체 및 그의 제조방법 | |
| JP2022551269A (ja) | 最小フッ素含有量を用いた低分子干渉ｒｎａの化学修飾 | |
| CN104011209A (zh) | 病毒基因表达的抑制 | |
| CN104244928A (zh) | 磁性纳米颗粒-SAMiRNA复合物及其制备方法 | |
| ES2798270T3 (es) | Métodos de preparación de polinucleótidos usando composiciones de sales de catiónicas multivalentes | |
| CN110997918A (zh) | 单链寡核苷酸 | |
| WO2025165891A1 (en) | Translation enhancing nucleic acid compounds: aso coupled translation - upregulation 1 (act-up1) and uses thereof | |
| Brzezinska et al. | Synthesis of 2′-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus | |
| JP2023526057A5 (enExample) | ||
| JP2026082999A (ja) | Ｗｆｄｃ２の発現を調節するアンチセンス化合物 | |
| JP2024516377A (ja) | 核酸ナノ粒子を含有する組成物、およびその物理化学的性質の改変に関するプロセス | |
| JP2024509906A5 (enExample) | ||
| HK40102389A (en) | Oligonucleotide compositions and methods of making the same | |
| WO2024006672A2 (en) | Modified guide rnas for crispr genome editing | |
| TW202606729A (zh) | 靶向inhbe之聚核酸分子及其用途 |