JP2025512805A - Ｉｋｚｆ２分解剤及びその使用 - Google Patents
Ｉｋｚｆ２分解剤及びその使用 Download PDFInfo
- Publication number
- JP2025512805A JP2025512805A JP2024556604A JP2024556604A JP2025512805A JP 2025512805 A JP2025512805 A JP 2025512805A JP 2024556604 A JP2024556604 A JP 2024556604A JP 2024556604 A JP2024556604 A JP 2024556604A JP 2025512805 A JP2025512805 A JP 2025512805A
- Authority
- JP
- Japan
- Prior art keywords
- carbocyclyl
- alkyl
- heterocyclyl
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263323792P | 2022-03-25 | 2022-03-25 | |
| US63/323,792 | 2022-03-25 | ||
| US202363446105P | 2023-02-16 | 2023-02-16 | |
| US63/446,105 | 2023-02-16 | ||
| PCT/US2023/016177 WO2023183540A1 (en) | 2022-03-25 | 2023-03-24 | Ikzf2 degraders and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025512805A true JP2025512805A (ja) | 2025-04-22 |
| JP2025512805A5 JP2025512805A5 (https=) | 2026-03-31 |
Family
ID=86185384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024556604A Pending JP2025512805A (ja) | 2022-03-25 | 2023-03-24 | Ｉｋｚｆ２分解剤及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250215012A1 (https=) |
| EP (1) | EP4499649A1 (https=) |
| JP (1) | JP2025512805A (https=) |
| KR (1) | KR20250026153A (https=) |
| CN (1) | CN119731179A (https=) |
| TW (1) | TW202341988A (https=) |
| WO (1) | WO2023183540A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2024008868A (es) | 2022-01-18 | 2024-09-23 | Maze Therapeutics Inc | Inhibidores de la apolipoproteína l1 (apol1) y métodos de uso. |
| US20250129088A1 (en) * | 2022-01-29 | 2025-04-24 | Gan & Lee Pharmaceuticals Co., Ltd. | Cereblon e3 ubiquitin ligase inhibitor |
| WO2025261456A1 (zh) * | 2024-06-19 | 2025-12-26 | 甘李药业股份有限公司 | 一种雌激素受体蛋白降解靶向嵌合体化合物及其应用 |
| US12565492B2 (en) | 2024-08-09 | 2026-03-03 | Triana Biomedicines, Inc. | Anaplastic Lymphoma Kinase (ALK) degraders and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI793151B (zh) * | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| CA3123519A1 (en) * | 2019-02-15 | 2020-08-20 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| KR20220092920A (ko) * | 2019-10-30 | 2022-07-04 | 다나-파버 캔서 인스티튜트 인크. | 헬리오스의 소분자 분해제 및 사용 방법 |
| KR20230027056A (ko) * | 2020-06-23 | 2023-02-27 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 |
| JP7819176B2 (ja) * | 2020-08-03 | 2026-02-24 | ノバルティス アーゲー | ヘテロアリール置換３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
-
2023
- 2023-03-24 CN CN202380041783.5A patent/CN119731179A/zh active Pending
- 2023-03-24 KR KR1020247035795A patent/KR20250026153A/ko active Pending
- 2023-03-24 EP EP23719521.9A patent/EP4499649A1/en active Pending
- 2023-03-24 JP JP2024556604A patent/JP2025512805A/ja active Pending
- 2023-03-24 US US18/849,594 patent/US20250215012A1/en active Pending
- 2023-03-24 WO PCT/US2023/016177 patent/WO2023183540A1/en not_active Ceased
- 2023-03-24 TW TW112111194A patent/TW202341988A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20250215012A1 (en) | 2025-07-03 |
| WO2023183540A1 (en) | 2023-09-28 |
| CN119731179A (zh) | 2025-03-28 |
| KR20250026153A (ko) | 2025-02-25 |
| TW202341988A (zh) | 2023-11-01 |
| EP4499649A1 (en) | 2025-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20260323 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20260323 |