JP2025509853A - ジンクフィンガーデグロン配列 - Google Patents

ジンクフィンガーデグロン配列 Download PDF

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Publication number
JP2025509853A
JP2025509853A JP2024555386A JP2024555386A JP2025509853A JP 2025509853 A JP2025509853 A JP 2025509853A JP 2024555386 A JP2024555386 A JP 2024555386A JP 2024555386 A JP2024555386 A JP 2024555386A JP 2025509853 A JP2025509853 A JP 2025509853A
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JP
Japan
Prior art keywords
zinc finger
finger domain
hybrid
amino acid
cys2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024555386A
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English (en)
Japanese (ja)
Other versions
JP2025509853A5 (enExample
Inventor
キャン サヒルリオグル アリ
ニコラス マリア シューマッハ アントニウス
Original Assignee
スティヒティング ヘット ネーデルランズ カンケル インスティテュート－アントニ ファン レーウェンフーク ジーケンハウス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by スティヒティング ヘット ネーデルランズ カンケル インスティテュート－アントニ ファン レーウェンフーク ジーケンハウス filed Critical スティヒティング ヘット ネーデルランズ カンケル インスティテュート－アントニ ファン レーウェンフーク ジーケンハウス
Publication of JP2025509853A publication Critical patent/JP2025509853A/ja
Publication of JP2025509853A5 publication Critical patent/JP2025509853A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2024555386A 2022-03-18 2023-03-17 ジンクフィンガーデグロン配列 Pending JP2025509853A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2031325 2022-03-18
NL2031325A NL2031325B1 (en) 2022-03-18 2022-03-18 Novel zinc finger degron sequences
PCT/NL2023/050136 WO2023177296A1 (en) 2022-03-18 2023-03-17 Zinc finger degron sequences

Publications (2)

Publication Number Publication Date
JP2025509853A true JP2025509853A (ja) 2025-04-11
JP2025509853A5 JP2025509853A5 (enExample) 2026-02-25

Family

ID=82483007

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024555386A Pending JP2025509853A (ja) 2022-03-18 2023-03-17 ジンクフィンガーデグロン配列

Country Status (9)

Country Link
US (1) US20250206789A1 (enExample)
EP (1) EP4493696A1 (enExample)
JP (1) JP2025509853A (enExample)
CN (1) CN118922547A (enExample)
AU (1) AU2023233426A1 (enExample)
CA (1) CA3255620A1 (enExample)
IL (1) IL315649A (enExample)
NL (1) NL2031325B1 (enExample)
WO (1) WO2023177296A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2033636B1 (en) 2022-11-29 2024-06-04 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Receptor- and drug-dependent regulated on-site production of biologicals.
NL2037809B1 (en) 2024-05-29 2025-12-12 Cell Control Biotherapeutics Inc Loop reinforcement expression system for improved cell therapy products

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201710620D0 (en) 2017-07-03 2017-08-16 Glaxosmithkline Intellectual Property Ltd Targeted protein degradation
US12049482B2 (en) 2017-10-31 2024-07-30 The Brigham And Women's Hospital, Inc. Molecular switch-mediated control of engineered cells
WO2020132039A2 (en) 2018-12-18 2020-06-25 Dana-Farber Cancer Institute, Inc. Peptide tags for ligand induced degradation of fusion proteins
CN111907552B (zh) 2019-07-17 2021-08-13 中车大同电力机车有限公司 机车牵引装置及其调整方法
EP4048301B1 (en) 2019-10-23 2024-09-18 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Chimeric polypeptide for regulating immune cells
US20230151342A1 (en) 2020-02-28 2023-05-18 The Broad Institute, Inc Zinc finger degradation domains

Also Published As

Publication number Publication date
EP4493696A1 (en) 2025-01-22
NL2031325B1 (en) 2023-09-29
US20250206789A1 (en) 2025-06-26
CN118922547A (zh) 2024-11-08
WO2023177296A1 (en) 2023-09-21
AU2023233426A1 (en) 2024-10-31
CA3255620A1 (en) 2023-09-21
IL315649A (en) 2024-11-01

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