JP2025508882A5 - - Google Patents
Info
- Publication number
- JP2025508882A5 JP2025508882A5 JP2024550728A JP2024550728A JP2025508882A5 JP 2025508882 A5 JP2025508882 A5 JP 2025508882A5 JP 2024550728 A JP2024550728 A JP 2024550728A JP 2024550728 A JP2024550728 A JP 2024550728A JP 2025508882 A5 JP2025508882 A5 JP 2025508882A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cytokine
- domain
- mutation
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263314926P | 2022-02-28 | 2022-02-28 | |
| US202263314928P | 2022-02-28 | 2022-02-28 | |
| US63/314,926 | 2022-02-28 | ||
| US63/314,928 | 2022-02-28 | ||
| PCT/US2023/014128 WO2023164288A2 (en) | 2022-02-28 | 2023-02-28 | Targeted cytokines and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025508882A JP2025508882A (ja) | 2025-04-10 |
| JP2025508882A5 true JP2025508882A5 (https=) | 2026-03-05 |
Family
ID=85791876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024550728A Pending JP2025508882A (ja) | 2022-02-28 | 2023-02-28 | 標的化サイトカインおよびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230365641A1 (https=) |
| EP (1) | EP4486460A2 (https=) |
| JP (1) | JP2025508882A (https=) |
| KR (1) | KR20240152853A (https=) |
| CN (1) | CN120248131A (https=) |
| AU (1) | AU2023225803A1 (https=) |
| CA (1) | CA3247112A1 (https=) |
| IL (1) | IL314922A (https=) |
| MX (1) | MX2024010488A (https=) |
| TW (1) | TW202342504A (https=) |
| WO (1) | WO2023164288A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116554344A (zh) * | 2022-01-30 | 2023-08-08 | 中国科学院生物物理研究所 | 一种pd1抗体与白介素2融合的双功能分子 |
| AU2024330564A1 (en) * | 2023-08-30 | 2026-04-02 | Xilio Development, Inc. | Vhh masked cytokines and methods of use thereof |
| WO2025049948A1 (en) * | 2023-08-30 | 2025-03-06 | Xilio Development, Inc. | Masked il-2 cytokines and methods of use thereof |
| WO2025151274A1 (en) * | 2024-01-08 | 2025-07-17 | Adimab, Llc | Inducible il-18 prodrugs |
| US20250250314A1 (en) * | 2024-01-10 | 2025-08-07 | Xilio Development, Inc. | Masked il-2 cytokines and methods of use thereof |
| WO2025242835A1 (en) * | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
| WO2025242836A1 (en) * | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US20140302037A1 (en) | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| US20220002370A1 (en) * | 2018-09-27 | 2022-01-06 | Xilio Development, Inc. | Masked cytokine polypeptides |
| US20220289822A1 (en) * | 2019-08-21 | 2022-09-15 | AskGene Pharma, Inc. | Novel il-21 prodrugs and methods of use thereof |
| EP4126246A4 (en) * | 2020-04-01 | 2024-05-15 | Xilio Development, Inc. | MASKED IL-15 CYTOKINE AND THEIR DECOMPOSITION PRODUCTS |
| TW202204388A (zh) * | 2020-04-01 | 2022-02-01 | 美商艾希利歐發展股份有限公司 | 經遮蔽之il-2細胞激素及其裂解產物 |
| JP7771076B2 (ja) * | 2020-04-01 | 2025-11-17 | エクシリオ デベロップメント， インコーポレイテッド | マスクされたｉｌ－１２サイトカイン及びその切断産物 |
| WO2022115865A2 (en) * | 2020-11-25 | 2022-06-02 | Xilio Development, Inc. | Tumor-specific cleavable linkers |
-
2023
- 2023-02-28 JP JP2024550728A patent/JP2025508882A/ja active Pending
- 2023-02-28 KR KR1020247028140A patent/KR20240152853A/ko active Pending
- 2023-02-28 MX MX2024010488A patent/MX2024010488A/es unknown
- 2023-02-28 AU AU2023225803A patent/AU2023225803A1/en active Pending
- 2023-02-28 CN CN202510242073.XA patent/CN120248131A/zh active Pending
- 2023-02-28 EP EP23714392.0A patent/EP4486460A2/en active Pending
- 2023-02-28 CA CA3247112A patent/CA3247112A1/en active Pending
- 2023-02-28 WO PCT/US2023/014128 patent/WO2023164288A2/en not_active Ceased
- 2023-02-28 IL IL314922A patent/IL314922A/en unknown
- 2023-02-28 US US18/115,527 patent/US20230365641A1/en active Pending
- 2023-03-01 TW TW112107424A patent/TW202342504A/zh unknown
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