JP2025508122A5 - - Google Patents
Info
- Publication number
- JP2025508122A5 JP2025508122A5 JP2024553758A JP2024553758A JP2025508122A5 JP 2025508122 A5 JP2025508122 A5 JP 2025508122A5 JP 2024553758 A JP2024553758 A JP 2024553758A JP 2024553758 A JP2024553758 A JP 2024553758A JP 2025508122 A5 JP2025508122 A5 JP 2025508122A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- optionally substituted
- piperazine
- methylcarbamoyl
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210260944 | 2022-03-11 | ||
| CN202210260944.7 | 2022-03-11 | ||
| CN202210448803.8 | 2022-04-24 | ||
| CN202210448803 | 2022-04-24 | ||
| CN202211219599.9 | 2022-09-30 | ||
| CN202211219599 | 2022-09-30 | ||
| CN202211505904.0 | 2022-11-28 | ||
| CN202211505904 | 2022-11-28 | ||
| PCT/CN2023/077988 WO2023169226A1 (en) | 2022-03-11 | 2023-02-23 | Substituted tricyclic compounds as parp inhibitors and the use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025508122A JP2025508122A (ja) | 2025-03-21 |
| JP2025508122A5 true JP2025508122A5 (https=) | 2026-03-04 |
Family
ID=87937164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024553758A Pending JP2025508122A (ja) | 2022-03-11 | 2023-02-23 | Ｐａｒｐ阻害剤としての置換三環式化合物およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20250215013A1 (https=) |
| EP (1) | EP4490161A4 (https=) |
| JP (1) | JP2025508122A (https=) |
| KR (1) | KR20240162104A (https=) |
| CN (1) | CN119013279A (https=) |
| AU (1) | AU2023229992A1 (https=) |
| CA (1) | CA3253468A1 (https=) |
| IL (1) | IL315586A (https=) |
| MX (1) | MX2024011086A (https=) |
| TW (1) | TW202400601A (https=) |
| WO (1) | WO2023169226A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120081844A (zh) | 2022-01-21 | 2025-06-03 | 新特拉有限公司 | Parp1抑制剂及其用途 |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| AU2023259236B2 (en) * | 2022-04-28 | 2025-01-09 | Xinthera, Inc. | Tricyclic parp1 inhibitors and uses thereof |
| JP7835895B2 (ja) * | 2022-05-07 | 2026-03-25 | サイブランチ セラピューティクス カンパニー リミテッド | Ｐａｒｐ１を選択的に阻害するフルオロキノキサリノン誘導体 |
| WO2024099416A1 (zh) * | 2022-11-10 | 2024-05-16 | 上海海和药物研究开发股份有限公司 | 一种稠合三环类parp1抑制剂、其制备方法及用途 |
| WO2024179547A1 (en) * | 2023-03-01 | 2024-09-06 | Impact Therapeutics (Shanghai) , Inc. | Substituted nitrogen-containing tricyclic compounds as parp inhibitors and the use thereof |
| WO2024255697A1 (zh) * | 2023-06-13 | 2024-12-19 | 中国医药研究开发中心有限公司 | 含氮杂环类化合物及其医药用途 |
| TW202525808A (zh) * | 2023-09-13 | 2025-07-01 | 大陸商上海瑛派藥業有限公司 | 用作ｐａｒｐ１抑制劑的化合物、其用途及包含其之組合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPS137402A0 (en) * | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| CN101528704B (zh) * | 2006-09-01 | 2014-04-09 | 生华生物科技股份有限公司 | 丝氨酸-苏氨酸蛋白激酶和parp调节剂 |
| CA2672860C (en) * | 2006-12-28 | 2013-01-29 | Abbott Laboratories | Inhibitors of poly(adp-ribose)polymerase |
| CN102341394B (zh) * | 2009-01-23 | 2015-04-15 | 武田药品工业株式会社 | 聚(adp-核糖)聚合酶(parp)抑制剂 |
| EP2459561A1 (en) * | 2009-07-30 | 2012-06-06 | Takeda Pharmaceutical Company Limited | Poly (adp-ribose) polymerase (parp) inhibitors |
| MX375707B (es) * | 2015-06-09 | 2025-03-06 | Onconic Therapeutics Inc | Compuesto derivativo triciclico, metodo para prepararlo y composicion farmaceutica que comprende el mismo. |
| US11591331B2 (en) * | 2021-04-19 | 2023-02-28 | Xinthera, Inc. | PARP1 inhibitors and uses thereof |
| AU2022334408A1 (en) * | 2021-08-27 | 2024-02-15 | Impact Therapeutics (Shanghai), Inc. | Substituted tricyclic compounds as parp inhibitors and use thereof |
| US20250163022A1 (en) * | 2021-12-22 | 2025-05-22 | Synnovation Therapeutics, Inc. | Parp1 inhibitors |
| KR20240134366A (ko) * | 2022-01-13 | 2024-09-09 | 에이스랜드 테라퓨틱스 (홍콩) 리미티드 | 피페라진 고리 함유 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 용도 |
| AU2023259236B2 (en) * | 2022-04-28 | 2025-01-09 | Xinthera, Inc. | Tricyclic parp1 inhibitors and uses thereof |
| JP7835895B2 (ja) * | 2022-05-07 | 2026-03-25 | サイブランチ セラピューティクス カンパニー リミテッド | Ｐａｒｐ１を選択的に阻害するフルオロキノキサリノン誘導体 |
| CN115232129B (zh) * | 2022-08-18 | 2023-12-01 | 上海闻耐医药科技有限公司 | 一种parp1选择性抑制剂及其制备方法和用途 |
| WO2024099416A1 (zh) * | 2022-11-10 | 2024-05-16 | 上海海和药物研究开发股份有限公司 | 一种稠合三环类parp1抑制剂、其制备方法及用途 |
-
2023
- 2023-02-23 CN CN202380026468.5A patent/CN119013279A/zh active Pending
- 2023-02-23 US US18/846,265 patent/US20250215013A1/en active Pending
- 2023-02-23 AU AU2023229992A patent/AU2023229992A1/en active Pending
- 2023-02-23 WO PCT/CN2023/077988 patent/WO2023169226A1/en not_active Ceased
- 2023-02-23 KR KR1020247033867A patent/KR20240162104A/ko active Pending
- 2023-02-23 CA CA3253468A patent/CA3253468A1/en active Pending
- 2023-02-23 IL IL315586A patent/IL315586A/en unknown
- 2023-02-23 EP EP23765804.2A patent/EP4490161A4/en active Pending
- 2023-02-23 JP JP2024553758A patent/JP2025508122A/ja active Pending
- 2023-03-01 TW TW112107292A patent/TW202400601A/zh unknown
-
2024
- 2024-09-10 MX MX2024011086A patent/MX2024011086A/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2025508122A5 (https=) | ||
| JP7311654B2 (ja) | Ｒｅｔキナーゼ阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 | |
| JP7129420B2 (ja) | Ｈｐｋ１阻害剤としてのイソキノリン | |
| JP2024532733A (ja) | 複素環式化合物及び使用方法 | |
| JP2024532735A (ja) | 複素環式化合物及び使用方法 | |
| AU2016365366B2 (en) | Protein kinase inhibitor, preparation method and medical use thereof | |
| EP3846800A1 (en) | Compounds for the degradation of brd9 or mth1 | |
| WO2022221227A9 (en) | Amino-substituted heterocycles for treating cancers with egfr mutations | |
| WO2019183364A1 (en) | Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof | |
| WO2024229442A1 (en) | Pyrido[4,3-d]pyrimidine derivatives as mutant kras g12c inhibitors for the treatment of cancer | |
| KR102659211B1 (ko) | G1t38의 형체 형태 및 그의 제조 방법 | |
| WO2016203404A1 (en) | Compounds and compositions for inhibiting the activity of shp2 | |
| TW201618773A (zh) | Ｂｔｋ抑制劑、ｐｉ３ｋ抑制劑、ｊａｋ－２抑制劑、及／或ｃｄｋ４／６抑制劑的治療組合物 | |
| TW201618772A (zh) | Ｂｔｋ抑制劑、ｐｉ３ｋ抑制劑、ｊａｋ－２抑制劑及／或ｂｃｌ－２抑制劑之治療組合物 | |
| CA2963736A1 (en) | Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof | |
| KR20200108867A (ko) | G1t38 우수한 투여 요법 | |
| WO2016040848A1 (en) | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors | |
| WO2018005863A1 (en) | Pyrimidine-based compounds for the treatment of cancer | |
| JP7628089B2 (ja) | 三環式化合物およびそれらの用途 | |
| WO2021043245A1 (en) | Hydantoin derivative | |
| JP2024513538A5 (https=) | ||
| AU2013318283A1 (en) | Dihydropyrrolidino-pyrimidines as kinase inhibitors | |
| JP6847954B2 (ja) | キナーゼ阻害剤としての三環式化合物および組成物 | |
| CN116940573A (zh) | 三环类化合物及其用途 | |
| RU2024127255A (ru) | Замещенные трициклические соединения в качестве ингибиторов parp и их применение |