JP2025508046A - 核酸センサーに関連する組成物及び方法 - Google Patents

核酸センサーに関連する組成物及び方法 Download PDF

Info

Publication number
JP2025508046A
JP2025508046A JP2024553342A JP2024553342A JP2025508046A JP 2025508046 A JP2025508046 A JP 2025508046A JP 2024553342 A JP2024553342 A JP 2024553342A JP 2024553342 A JP2024553342 A JP 2024553342A JP 2025508046 A JP2025508046 A JP 2025508046A
Authority
JP
Japan
Prior art keywords
nucleic acid
sensor
domain
toehold
double
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024553342A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025508046A5 (enExample
Inventor
リサール エフ ハリアディ
グデ ビマナンダ マハーディカ ウィスナ
ランジャン サスマル
Original Assignee
アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ filed Critical アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ
Publication of JP2025508046A publication Critical patent/JP2025508046A/ja
Publication of JP2025508046A5 publication Critical patent/JP2025508046A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2024553342A 2022-03-07 2023-03-07 核酸センサーに関連する組成物及び方法 Pending JP2025508046A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263317424P 2022-03-07 2022-03-07
US63/317,424 2022-03-07
PCT/US2023/063860 WO2023172911A2 (en) 2022-03-07 2023-03-07 Compositions and methods related to nucleic acid sensors

Publications (2)

Publication Number Publication Date
JP2025508046A true JP2025508046A (ja) 2025-03-21
JP2025508046A5 JP2025508046A5 (enExample) 2026-03-13

Family

ID=87935960

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024553342A Pending JP2025508046A (ja) 2022-03-07 2023-03-07 核酸センサーに関連する組成物及び方法

Country Status (6)

Country Link
US (1) US20250188517A1 (enExample)
EP (1) EP4490310A4 (enExample)
JP (1) JP2025508046A (enExample)
CN (1) CN119110852A (enExample)
CA (1) CA3245380A1 (enExample)
WO (1) WO2023172911A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026064708A1 (en) * 2024-09-20 2026-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Compositions and methods related to nucleic acid nanopores

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017112941A1 (en) * 2015-12-23 2017-06-29 The Regents Of The University Of California Nano-sensors for nucleic acid detection and discrimination
US11674141B2 (en) * 2018-02-28 2023-06-13 National University Corporation Tokyo Medical And Dental University Ischemic-lesion-site-specific gene therapy
US20230212681A1 (en) * 2020-02-17 2023-07-06 Arizona Board Of Regents On Behalf Of Arizona State University Transmembrane nanosensor arrays for rapid, ultra-sensitive and specific digital quantification of internal micro-rna content of intact exosomes
WO2022081766A1 (en) * 2020-10-13 2022-04-21 Arizona Board Of Regents On Behalf Of Arizona State University Transmembrane sensors and molecular amplifiers for lysis-free detection of intracellular targets

Also Published As

Publication number Publication date
CA3245380A1 (en) 2023-09-14
EP4490310A4 (en) 2026-04-08
WO2023172911A2 (en) 2023-09-14
WO2023172911A3 (en) 2023-10-26
CN119110852A (zh) 2024-12-10
US20250188517A1 (en) 2025-06-12
EP4490310A2 (en) 2025-01-15

Similar Documents

Publication Publication Date Title
US20240052400A1 (en) Unimolecular aptamer-based sensors for pathogen detection
JP7477183B2 (ja) 新規な等温単一反応用プローブセット及びその用途
US20090130650A1 (en) Methods for the production of highly sensitive and specific cell surface probes
JPH09504950A (ja) 核酸検出用ハイブリダイゼーションプローブ、共通ステム、方法およびキット
US20060014191A1 (en) Analog probe complexes
Morris et al. Single-molecule kinetic investigation of cocaine-dependent split-aptamer assembly
US8703734B2 (en) Nanoprobes for detection or modification of molecules
US20200370100A1 (en) Fluorescent nucleic acid nanostructure-graphene biosensor for nucleic acid detection
JP2020503030A (ja) 2パートメディエータプローブ
JP2002526032A (ja) Rna結合化合物の発見のための方法およびキット
BR112021013787A2 (pt) Composições reagentes marcadas com alta densidade e métodos para sequenciamento
Astakhova et al. Perylene attached to 2′-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture
US20220195497A1 (en) HYBRIDIZING all-LNA OLIGONUCLEOTIDES
Napoletano et al. MicroLOCK: Highly stable microgel biosensor using locked nucleic acids as bioreceptors for sensitive and selective detection of let-7a
US20030073091A1 (en) Use of generic oligonucleotide microchips to detect protein-nucleic acid interactions
WO2006065597A2 (en) Id-tag complexes, arrays, and methods of use thereof
Bruno et al. Competitive FRET-aptamer-based detection of methylphosphonic acid, a common nerve agent metabolite
US20250188517A1 (en) Compositions and methods related to nucleic acid sensors
US20090239762A1 (en) Aptamers that bind abnormal cells
Lilley Analysis of global conformational transitions in ribozymes
US20160152656A1 (en) Methods of Using Phosphoramidation Reaction for Conjugation-Labeling Nucleic Acids
US20230175040A1 (en) Epiprinter Technology and Methods of Use for Detecting Biomolecules
Chu et al. A G-quadruplex DNAzyme chemiluminescence aptasensor based on the target triggered DNA recycling for sensitive detection of adenosine
Zatsepin et al. 2'‐Functionalized Nucleic Acids as Structural Tools in Molecular Biology
JPH0275958A (ja) Dna検出法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260305

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20260305