JP2025505410A - サイトメトリーのための機械学習法 - Google Patents

サイトメトリーのための機械学習法 Download PDF

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JP2025505410A
JP2025505410A JP2024544733A JP2024544733A JP2025505410A JP 2025505410 A JP2025505410 A JP 2025505410A JP 2024544733 A JP2024544733 A JP 2024544733A JP 2024544733 A JP2024544733 A JP 2024544733A JP 2025505410 A JP2025505410 A JP 2025505410A
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cell
machine learning
type
cells
determining
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JP2025505410A5 (https=
Inventor
ザイツェフ，アレクサンドル
ファストヴェッツ，ドミトリー
ボウブ，アナトリー
ゴールドバーグ，マイケル，エフ．
アタウラクハノフ，ラヴシャン
カミシェヴァ，アンナ
ヴォロニナ，マリア
コマロワ，マリア
クラウズ，イリア
キリナ，アナスタシア
ピチュギン，アレクセイ
ウシャコワ，エカテリーナ
ディカノフ，ダニアル
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BostonGene Corp
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BostonGene Corp
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Publication of JP2025505410A publication Critical patent/JP2025505410A/ja
Publication of JP2025505410A5 publication Critical patent/JP2025505410A5/ja
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G06N20/20—Ensemble learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/045—Combinations of networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/09—Supervised learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/01—Dynamic search techniques; Heuristics; Dynamic trees; Branch-and-bound
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/77—Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
    • G06V10/774—Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
    • G06V10/7747—Organisation of the process, e.g. bagging or boosting
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/82—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/87—Arrangements for image or video recognition or understanding using pattern recognition or machine learning using selection of the recognition techniques, e.g. of a classifier in a multiple classifier system
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

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  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Evolutionary Computation (AREA)
  • Software Systems (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Artificial Intelligence (AREA)
  • Computing Systems (AREA)
  • Biomedical Technology (AREA)
  • Multimedia (AREA)
  • Pathology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Mathematical Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Computational Linguistics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Biophysics (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2024544733A 2022-01-31 2023-01-31 サイトメトリーのための機械学習法 Pending JP2025505410A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263304990P 2022-01-31 2022-01-31
US63/304,990 2022-01-31
PCT/US2023/012003 WO2023147177A1 (en) 2022-01-31 2023-01-31 Machine learning techniques for cytometry

Publications (2)

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JP2025505410A true JP2025505410A (ja) 2025-02-26
JP2025505410A5 JP2025505410A5 (https=) 2026-01-26

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JP2024544733A Pending JP2025505410A (ja) 2022-01-31 2023-01-31 サイトメトリーのための機械学習法

Country Status (6)

Country Link
US (1) US20230245479A1 (https=)
EP (1) EP4473288B1 (https=)
JP (1) JP2025505410A (https=)
AU (1) AU2023213817A1 (https=)
CA (1) CA3249858A1 (https=)
WO (1) WO2023147177A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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US20240177803A1 (en) 2022-11-17 2024-05-30 Bostongene Corporation Comprehensive immunoprofiling of peripheral blood
EP4695425A1 (en) 2023-04-13 2026-02-18 BostonGene Corporation Pan-cancer tumor microenvironment classification based on immune escape mechanisms and immune infiltration
WO2025072692A1 (en) * 2023-09-29 2025-04-03 Dana-Farber Cancer Institute, Inc. Compositions for treating hematological conditions and methods of making and using the same
WO2025096308A1 (en) * 2023-10-30 2025-05-08 Beckman Coulter, Inc. Classification of events in flow cytometry data
WO2025258375A1 (ja) * 2024-06-12 2025-12-18 ソニーグループ株式会社 情報処理方法及び情報処理システム

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JP2018505392A (ja) * 2014-12-10 2018-02-22 ネオゲノミクス ラボラトリーズ， インコーポレイテッド 自動化されたフローサイトメトリ分析方法及びシステム
KR20210082469A (ko) * 2018-10-31 2021-07-05 다케다 야쿠힝 고교 가부시키가이샤 정량적 유세포 분석법

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JP2011515655A (ja) * 2008-02-08 2011-05-19 ヘルス ディスカバリー コーポレイション サポートベクタマシンを用いてフローサイトメトリーデータを分析するための方法及びシステム
JP2018505392A (ja) * 2014-12-10 2018-02-22 ネオゲノミクス ラボラトリーズ， インコーポレイテッド 自動化されたフローサイトメトリ分析方法及びシステム
KR20210082469A (ko) * 2018-10-31 2021-07-05 다케다 야쿠힝 고교 가부시키가이샤 정량적 유세포 분석법

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AU2023213817A1 (en) 2024-08-01
US20230245479A1 (en) 2023-08-03
CA3249858A1 (en) 2023-08-03
WO2023147177A1 (en) 2023-08-03
EP4473288A1 (en) 2024-12-11
EP4473288B1 (en) 2025-10-29
WO2023147177A9 (en) 2023-11-02

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