JP2025503945A - Ｙａｐ／ｔｅａｄ調節およびそれらの適応症のための化合物および方法 - Google Patents

Ｙａｐ／ｔｅａｄ調節およびそれらの適応症のための化合物および方法 Download PDF

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JP2025503945A
JP2025503945A JP2024543955A JP2024543955A JP2025503945A JP 2025503945 A JP2025503945 A JP 2025503945A JP 2024543955 A JP2024543955 A JP 2024543955A JP 2024543955 A JP2024543955 A JP 2024543955A JP 2025503945 A JP2025503945 A JP 2025503945A
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optionally substituted
cycloalkyl
heterocycloalkyl
haloalkyl
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JP2025503945A5 (cg-RX-API-DMAC10.html
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チョウドリー、サムナス
リー、クオン
ハン、シンピン
アルバース、アーロン
グオ、ズオジュン
－ ファ クァク、スン
ファム、フォンリー
ランク、スティーブン
シー、ソンユエン
スペバック、ウェイン
チャン、ドンユ
チャン、ジァジョン
チャン、イン
ヴァル、マーク ヴァンダー
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オプナ バイオ ソシエテ アノニム
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    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
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JP2024543955A 2022-01-28 2023-01-27 Ｙａｐ／ｔｅａｄ調節およびそれらの適応症のための化合物および方法 Withdrawn JP2025503945A (ja)

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US202263304504P 2022-01-28 2022-01-28
US63/304,504 2022-01-28
US202263309442P 2022-02-11 2022-02-11
US63/309,442 2022-02-11
PCT/US2023/011752 WO2023147063A2 (en) 2022-01-28 2023-01-27 Compounds and methods for yap/tead modulation and indications therefor

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CN119968359A (zh) 2022-09-29 2025-05-09 英矽智能科技知识产权有限公司 Tead抑制剂及其使用方法
AU2024212529A1 (en) * 2023-01-27 2025-06-19 Opna Bio SA Compounds and methods for yap/tead modulation and indications therefor
WO2025209524A1 (en) * 2024-04-03 2025-10-09 Insilico Medicine Ip Limited Crystalline tead inhibitor and uses thereof
WO2026096702A1 (en) * 2024-10-31 2026-05-07 The Trustees Of Indiana University Autosomal dominant polycystic kidney disease therapy

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AU2006307939B2 (en) * 2005-10-26 2012-03-29 Merck Serono Sa Sulfonamide derivatives and use thereof for the modulation of metalloproteinases
WO2012154760A1 (en) * 2011-05-10 2012-11-15 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
US10738026B2 (en) * 2014-02-12 2020-08-11 Purdue Pharma L.P. Isoquinoline derivatives and use thereof
EP3322702B1 (en) * 2015-07-14 2019-11-20 Mission Therapeutics Limited Cyanopyrrolidines as dub inhibitors for the treatment of cancer
JP2019501143A (ja) * 2015-12-04 2019-01-17 ヴィーブ ヘルスケア ユーケー リミテッド テトラヒドロイソキノリン誘導体
AU2020257207B2 (en) * 2019-04-16 2026-06-04 Vivace Therapeutics, Inc. Bicyclic compounds
CN113801060B (zh) * 2020-06-13 2025-06-27 苏州鹏旭医药科技有限公司 一种多取代异喹啉化合物的制备方法
CN117956996A (zh) * 2021-05-11 2024-04-30 Opna 生物公司 用于yap/tead调节的化合物和方法及其适应证

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