JP2025502061A5 - - Google Patents

Info

Publication number
JP2025502061A5
JP2025502061A5 JP2024540882A JP2024540882A JP2025502061A5 JP 2025502061 A5 JP2025502061 A5 JP 2025502061A5 JP 2024540882 A JP2024540882 A JP 2024540882A JP 2024540882 A JP2024540882 A JP 2024540882A JP 2025502061 A5 JP2025502061 A5 JP 2025502061A5
Authority
JP
Japan
Prior art keywords
seq
amino acid
acid sequence
muc16
bispecific antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024540882A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025502061A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2023/010326 external-priority patent/WO2023133280A1/en
Publication of JP2025502061A publication Critical patent/JP2025502061A/ja
Publication of JP2025502061A5 publication Critical patent/JP2025502061A5/ja
Pending legal-status Critical Current

Links

JP2024540882A 2022-01-07 2023-01-06 再発性卵巣癌を、二重特異性抗muc16×抗cd3抗体単独で、または抗pd-1抗体と組み合わせて治療する方法 Pending JP2025502061A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202263297333P 2022-01-07 2022-01-07
US63/297,333 2022-01-07
US202263342542P 2022-05-16 2022-05-16
US63/342,542 2022-05-16
US202263394483P 2022-08-02 2022-08-02
US63/394,483 2022-08-02
US202263421541P 2022-11-01 2022-11-01
US63/421,541 2022-11-01
PCT/US2023/010326 WO2023133280A1 (en) 2022-01-07 2023-01-06 Methods of treating recurrent ovarian cancer with bispecific anti-muc16 x anti-cd3 antibodies alone or in combination with anti-pd-1 antibodies

Publications (2)

Publication Number Publication Date
JP2025502061A JP2025502061A (ja) 2025-01-24
JP2025502061A5 true JP2025502061A5 (https=) 2026-01-13

Family

ID=85199214

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024540882A Pending JP2025502061A (ja) 2022-01-07 2023-01-06 再発性卵巣癌を、二重特異性抗muc16×抗cd3抗体単独で、または抗pd-1抗体と組み合わせて治療する方法

Country Status (9)

Country Link
US (1) US20230312718A1 (https=)
EP (1) EP4460520A1 (https=)
JP (1) JP2025502061A (https=)
KR (1) KR20240130137A (https=)
AU (1) AU2023204751A1 (https=)
CA (1) CA3242629A1 (https=)
IL (1) IL313864A (https=)
MX (1) MX2024008055A (https=)
WO (1) WO2023133280A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7066690B2 (ja) * 2016-09-23 2022-05-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗muc16(ムチン16)抗体
TW202542187A (zh) * 2023-12-12 2025-11-01 美商再生元醫藥公司 以雙特異性抗muc16x抗cd3抗體單獨或與抗pd-1抗體組合治療子宮內膜癌之方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL354286A1 (en) 1999-08-23 2003-12-29 Dana-Farber Cancer Institutedana-Farber Cancer Institute Pd-1, a receptor for b7-4, and uses therefor
CN101899114A (zh) 2002-12-23 2010-12-01 惠氏公司 抗pd-1抗体及其用途
DK2439273T3 (da) 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
BR122017025062B8 (pt) 2007-06-18 2021-07-27 Merck Sharp & Dohme anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
AU2009288730B2 (en) 2008-08-25 2013-06-20 Amplimmune, Inc. Compositions of PD-1 antagonists and methods of use
MY192182A (en) 2009-06-26 2022-08-04 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format
CA2840018C (en) 2011-07-24 2019-07-16 Curetech Ltd. Variants of humanized immunomodulatory monoclonal antibodies
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
JP7066690B2 (ja) 2016-09-23 2022-05-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗muc16(ムチン16)抗体
TW202504917A (zh) * 2018-06-21 2025-02-01 美商再生元醫藥公司 用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症之方法

Similar Documents

Publication Publication Date Title
TWI890661B (zh) 用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症的方法
EP3986569A1 (en) Dosing regimen and combination therapies for multispecific antibodies targeting b-cell maturation antigen
JP2023505218A5 (https=)
CN108602889A (zh) 医治急性成淋巴细胞性白血病的双特异性抗cd20/抗cd3抗体
JP2019503361A (ja) がんを治療するための抗pd−1抗体と二重特異性抗cd20/抗cd3抗体の組合せ
CN105377894A (zh) 以il-4r抑制剂治疗过敏症及强化过敏原特异性免疫治疗的方法
JP2021528423A5 (https=)
WO2020063988A1 (zh) Cldn18的抗体和化疗药物的联合治疗
JP2022512851A5 (https=)
JP2025502061A5 (https=)
US20250333522A1 (en) Compositions and methods for treating pain in subjects with rheumatoid arthritis
JP2025509567A5 (https=)
KR20240117655A (ko) 항-cd19 항체 및 베네토클락스 조합 치료에 대한 치료 패러다임
JP2025509567A (ja) 再発性類上皮肉腫を、二重特異性抗MUC16x 抗CD3抗体単独で、または抗PD-1抗体と組み合わせて治療する方法
JP2022520572A5 (https=)
CN118871128A (zh) 抗tim-3抗体与抗pd-l1抗体的药物组合
RU2024122332A (ru) СПОСОБЫ ЛЕЧЕНИЯ РЕЦИДИВИРУЮЩЕГО РАКА ЯИЧНИКА С ПОМОЩЬЮ БИСПЕЦИФИЧНЫХ АНТИТЕЛ К MUC16 x CD3 ОТДЕЛЬНО ИЛИ В КОМБИНАЦИИ С АНТИТЕЛАМИ К PD-1
RU2024129390A (ru) СПОСОБЫ ЛЕЧЕНИЯ РЕЦИДИВИРУЮЩЕЙ ЭПИТЕЛИОИДНОЙ САРКОМЫ С ПОМОЩЬЮ БИСПЕЦИФИЧНЫХАНТИТЕЛ ПРОТИВ MUC16 x CD3 САМИХ ПО СЕБЕ ИЛИ В КОМБИНАЦИИ С АНТИТЕЛАМИ ПРОТИВ PD-1
US20220389088A1 (en) Anti-angiopoietin-like 4 (angptl4) antibodies and methods of use
CN116615238A (zh) 用于治疗癌症和减轻细胞因子释放综合征的抗体组合
JP2025508832A5 (https=)
JP2021518393A5 (https=)
RU2022101756A (ru) Антитела к tigit и их применение
TH2101002581A (th) วิธีการทรีตโรคตาโปนจากไทรอยด์โดยใช้แอนติบอดีชนิด anti-fcrn
TW202608479A (zh) 治療具有類風濕性關節炎的個體中疼痛之組成物及方法