JP2025501457A5 - - Google Patents
Info
- Publication number
- JP2025501457A5 JP2025501457A5 JP2024533884A JP2024533884A JP2025501457A5 JP 2025501457 A5 JP2025501457 A5 JP 2025501457A5 JP 2024533884 A JP2024533884 A JP 2024533884A JP 2024533884 A JP2024533884 A JP 2024533884A JP 2025501457 A5 JP2025501457 A5 JP 2025501457A5
- Authority
- JP
- Japan
- Prior art keywords
- antisense oligonucleotide
- sequence
- splice modulator
- actl6b
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21212904 | 2021-12-07 | ||
| EP21212904.3 | 2021-12-07 | ||
| PCT/EP2022/084365 WO2023104693A1 (en) | 2021-12-07 | 2022-12-05 | Antisense oligonucleotides targeting actl6b |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025501457A JP2025501457A (ja) | 2025-01-22 |
| JP2025501457A5 true JP2025501457A5 (OSRAM) | 2025-12-11 |
Family
ID=78824743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024533884A Pending JP2025501457A (ja) | 2021-12-07 | 2022-12-05 | Ａｃｔｌ６ｂを標的とするアンチセンスオリゴヌクレオチド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240318180A1 (OSRAM) |
| EP (1) | EP4444882A1 (OSRAM) |
| JP (1) | JP2025501457A (OSRAM) |
| CN (1) | CN118434858A (OSRAM) |
| WO (1) | WO2023104693A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250011958A (ko) * | 2022-05-18 | 2025-01-22 | 에프. 호프만-라 로슈 아게 | Rna 결합 단백질 부위를 표적으로 하는 개선된 올리고뉴클레오티드 |
| WO2024126654A1 (en) * | 2022-12-14 | 2024-06-20 | F. Hoffmann-La Roche Ag | Antisense oligonucleotides targeting actl6b |
| CN122055620A (zh) * | 2023-09-29 | 2026-05-15 | 豪夫迈·罗氏有限公司 | 肽生物标志物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| CA2303299C (en) | 1997-09-12 | 2016-02-23 | Exiqon A/S | Oligonucleotide analogues |
| PT1152009E (pt) | 1999-02-12 | 2005-03-31 | Sankyo Co | Novos analogos de nucleosidos e oligonucleotidos |
| NZ514348A (en) | 1999-05-04 | 2004-05-28 | Exiqon As | L-ribo-LNA analogues |
| US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
| US9045518B2 (en) | 2002-11-18 | 2015-06-02 | Santaris Pharma A/S | Amino-LNA, thio-LNA and alpha-L-oxy-LN |
| ES2351674T3 (es) | 2006-01-27 | 2011-02-09 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos modificados en la posición 6. |
| US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
| CA2651453C (en) | 2006-05-11 | 2014-10-14 | Isis Pharmaceuticals, Inc. | 5'-modified bicyclic nucleic acid analogs |
| EP2170917B1 (en) | 2007-05-30 | 2012-06-27 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| EP2176280B2 (en) | 2007-07-05 | 2015-06-24 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| WO2009067647A1 (en) | 2007-11-21 | 2009-05-28 | Isis Pharmaceuticals, Inc. | Carbocyclic alpha-l-bicyclic nucleic acid analogs |
| US8501805B2 (en) | 2008-09-24 | 2013-08-06 | Isis Pharmaceuticals, Inc. | Substituted alpha-L-bicyclic nucleosides |
| US9012421B2 (en) | 2009-08-06 | 2015-04-21 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
| WO2011156202A1 (en) | 2010-06-08 | 2011-12-15 | Isis Pharmaceuticals, Inc. | Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom |
| EP2850092B1 (en) | 2012-04-09 | 2017-03-01 | Ionis Pharmaceuticals, Inc. | Tricyclic nucleic acid analogs |
| SG10201804331TA (en) | 2012-11-15 | 2018-07-30 | Roche Innovation Ct Copenhagen As | Oligonucleotide conjugates |
| JP2016534035A (ja) * | 2013-10-04 | 2016-11-04 | ラナ セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症を治療するための組成物及び方法 |
| JP2017505623A (ja) | 2014-01-30 | 2017-02-23 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 生物切断性コンジュゲートを有するポリオリゴマー化合物 |
| EP4104867A3 (en) * | 2015-12-14 | 2023-03-01 | Cold Spring Harbor Laboratory | Compositions and methods for treatment of central nervous system diseases |
| WO2017106370A1 (en) * | 2015-12-14 | 2017-06-22 | Cold Spring Harbor Laboratory | Compositions and methods for treatment of eye diseases |
-
2022
- 2022-12-05 CN CN202280080863.7A patent/CN118434858A/zh active Pending
- 2022-12-05 EP EP22830207.1A patent/EP4444882A1/en active Pending
- 2022-12-05 JP JP2024533884A patent/JP2025501457A/ja active Pending
- 2022-12-05 WO PCT/EP2022/084365 patent/WO2023104693A1/en not_active Ceased
-
2024
- 2024-06-06 US US18/735,668 patent/US20240318180A1/en active Pending
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