JP2025501358A - Ｔ細胞受容体、その製造方法、及び使用 - Google Patents

Ｔ細胞受容体、その製造方法、及び使用 Download PDF

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JP2025501358A
JP2025501358A JP2024540916A JP2024540916A JP2025501358A JP 2025501358 A JP2025501358 A JP 2025501358A JP 2024540916 A JP2024540916 A JP 2024540916A JP 2024540916 A JP2024540916 A JP 2024540916A JP 2025501358 A JP2025501358 A JP 2025501358A
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tcr
chain
amino acid
acid sequence
constant region
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JP2025501358A5 (https=
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貴登 李
洪成 程
雅静 邱
悦 許
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Suzhou Institute of Systems Medicine
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Suzhou Institute of Systems Medicine
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    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
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    • A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C12N2740/00—Reverse transcribing RNA viruses
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    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2024540916A 2022-01-05 2022-12-29 Ｔ細胞受容体、その製造方法、及び使用 Pending JP2025501358A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202210005890 2022-01-05
CN202210005890.X 2022-01-05
PCT/CN2022/143567 WO2023131053A1 (zh) 2022-01-05 2022-12-29 一种t细胞受体及其制备方法和用途

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JP2025501358A true JP2025501358A (ja) 2025-01-17
JP2025501358A5 JP2025501358A5 (https=) 2025-12-01

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JP2024540916A Pending JP2025501358A (ja) 2022-01-05 2022-12-29 Ｔ細胞受容体、その製造方法、及び使用

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US (1) US20240358832A1 (https=)
EP (1) EP4461366A4 (https=)
JP (1) JP2025501358A (https=)
KR (1) KR20240130120A (https=)
CN (1) CN118475601A (https=)
WO (1) WO2023131053A1 (https=)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2651174A1 (en) * 2006-05-03 2007-11-15 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Chimeric t cell receptors and related materials and methods of use
EA202091977A1 (ru) * 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения
CN110818802B (zh) * 2018-08-08 2022-02-08 华夏英泰（北京）生物技术有限公司 一种嵌合t细胞受体star及其应用
CN110857319B (zh) * 2018-08-24 2023-12-08 杭州康万达医药科技有限公司 一种分离的t细胞受体、其修饰的细胞、编码核酸及其应用
CN113396216A (zh) * 2019-02-04 2021-09-14 Ksq治疗公司 用于改进的免疫疗法的组合基因靶标
CN115776991A (zh) * 2020-05-07 2023-03-10 华夏英泰（北京）生物技术有限公司 改进的t细胞受体-共刺激分子嵌合物
US20240294598A1 (en) * 2020-05-25 2024-09-05 China Immunotech (Beijing) Biotechnology Co., Ltd Enhanced synthetic t-cell receptor and antigen receptor

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KR20240130120A (ko) 2024-08-28
CN118475601A (zh) 2024-08-09
EP4461366A4 (en) 2026-01-21
EP4461366A1 (en) 2024-11-13
WO2023131053A1 (zh) 2023-07-13
US20240358832A1 (en) 2024-10-31

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