JP2025500321A - 多脚型セロトニン作動性化合物ならびにセロトニン受容体アゴニスト及びアンタゴニストのプロドラッグ - Google Patents
多脚型セロトニン作動性化合物ならびにセロトニン受容体アゴニスト及びアンタゴニストのプロドラッグ Download PDFInfo
- Publication number
- JP2025500321A JP2025500321A JP2024537118A JP2024537118A JP2025500321A JP 2025500321 A JP2025500321 A JP 2025500321A JP 2024537118 A JP2024537118 A JP 2024537118A JP 2024537118 A JP2024537118 A JP 2024537118A JP 2025500321 A JP2025500321 A JP 2025500321A
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- JP
- Japan
- Prior art keywords
- compound
- formula
- independently selected
- optionally substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163293730P | 2021-12-24 | 2021-12-24 | |
| US63/293,730 | 2021-12-24 | ||
| US202263299817P | 2022-01-14 | 2022-01-14 | |
| US63/299,817 | 2022-01-14 | ||
| US202263338994P | 2022-05-06 | 2022-05-06 | |
| US63/338,994 | 2022-05-06 | ||
| PCT/US2022/053910 WO2023122320A1 (en) | 2021-12-24 | 2022-12-23 | Polypodal serotonergic compounds and prodrugs of serotonin receptor agonists and antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025500321A true JP2025500321A (ja) | 2025-01-09 |
| JP2025500321A5 JP2025500321A5 (https=) | 2026-01-06 |
Family
ID=86903690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024537118A Pending JP2025500321A (ja) | 2021-12-24 | 2022-12-23 | 多脚型セロトニン作動性化合物ならびにセロトニン受容体アゴニスト及びアンタゴニストのプロドラッグ |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4452939A4 (https=) |
| JP (1) | JP2025500321A (https=) |
| WO (1) | WO2023122320A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023168023A1 (en) | 2022-03-04 | 2023-09-07 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| AU2023319280A1 (en) * | 2022-08-05 | 2025-03-20 | Mindset Pharma Inc. | 3-ethylamino-indole dimers as serotonergic agents useful for the treatment of disorders related thereto |
| WO2024081961A2 (en) * | 2022-10-14 | 2024-04-18 | Invyxis, Inc. | Ester analogs of psilocin, processes for the preparation thereof, and methods of use |
| WO2025045773A1 (en) * | 2023-08-25 | 2025-03-06 | Compass Pathfinder Limited | 3-(2-(dimethylamino)ethyl)-1h-indol-4-yl oligomeric derivatives |
| WO2025122513A1 (en) * | 2023-12-04 | 2025-06-12 | Delix Therapeutics, Inc. | Methods of treating neuropsychiatric disorders with non-hallucinogenic tryptamines |
| US20260021070A1 (en) * | 2024-07-19 | 2026-01-22 | Compass Pathfinder Limited | Subcutaneous formulations comprising psilocybin derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2731223A1 (fr) * | 1995-03-02 | 1996-09-06 | Pf Medicament | Nouveaux derives bi-tryptaminiques, leur procede de preparation et leur utilisation a titre de medicaments |
| EP2771341A4 (en) * | 2011-10-28 | 2015-09-23 | Univ Texas | NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER |
| JP2016521683A (ja) * | 2013-05-24 | 2016-07-25 | ネステク ソシエテ アノニム | 過敏性腸症候群の診断を予測するための経路特異的なアッセイ |
| CA3052974A1 (en) * | 2017-02-09 | 2018-08-16 | CaaMTech, LLC | Compositions and methods comprising a psilocybin derivative |
| BR112022015379A2 (pt) * | 2020-02-04 | 2022-09-27 | Mindset Pharma Inc | Derivados de 3-pirrolidino-indol como agentes psicodélicos serotonérgicos para o tratamento de distúrbios do snc |
| CA3188636A1 (en) * | 2020-08-21 | 2022-02-24 | Matthias GRILL | Novel psilocin derivatives having prodrug properties |
| AU2023234202A1 (en) * | 2022-03-18 | 2024-11-07 | Enveric Biosciences Canada Inc. | Salts of c4-carboxylic acid- and c4-carbonothioate-substituted tryptamine derivatives and methods of using |
| AU2023319280A1 (en) * | 2022-08-05 | 2025-03-20 | Mindset Pharma Inc. | 3-ethylamino-indole dimers as serotonergic agents useful for the treatment of disorders related thereto |
| CN120091999A (zh) * | 2022-08-05 | 2025-06-03 | 思维模式制药公司 | 作为血清素能剂用于治疗相关病症的3-吡咯烷-吲哚二聚体 |
| WO2024081961A2 (en) * | 2022-10-14 | 2024-04-18 | Invyxis, Inc. | Ester analogs of psilocin, processes for the preparation thereof, and methods of use |
-
2022
- 2022-12-23 EP EP22912515.8A patent/EP4452939A4/en active Pending
- 2022-12-23 JP JP2024537118A patent/JP2025500321A/ja active Pending
- 2022-12-23 WO PCT/US2022/053910 patent/WO2023122320A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP4452939A4 (en) | 2025-12-10 |
| EP4452939A1 (en) | 2024-10-30 |
| WO2023122320A1 (en) | 2023-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20251222 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20251222 |