JP2025041661A5 - - Google Patents
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- Publication number
- JP2025041661A5 JP2025041661A5 JP2024210915A JP2024210915A JP2025041661A5 JP 2025041661 A5 JP2025041661 A5 JP 2025041661A5 JP 2024210915 A JP2024210915 A JP 2024210915A JP 2024210915 A JP2024210915 A JP 2024210915A JP 2025041661 A5 JP2025041661 A5 JP 2025041661A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- cytidine
- base editor
- cytidine base
- deaminase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962799702P | 2019-01-31 | 2019-01-31 | |
| US62/799,702 | 2019-01-31 | ||
| US201962835456P | 2019-04-17 | 2019-04-17 | |
| US62/835,456 | 2019-04-17 | ||
| US201962941569P | 2019-11-27 | 2019-11-27 | |
| US62/941,569 | 2019-11-27 | ||
| PCT/US2020/016288 WO2020160517A1 (en) | 2019-01-31 | 2020-01-31 | Nucleobase editors having reduced off-target deamination and methods of using same to modify a nucleobase target sequence |
| JP2021544720A JP7600122B2 (ja) | 2019-01-31 | 2020-01-31 | 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544720A Division JP7600122B2 (ja) | 2019-01-31 | 2020-01-31 | 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2025041661A JP2025041661A (ja) | 2025-03-26 |
| JP2025041661A5 true JP2025041661A5 (https=) | 2025-06-16 |
| JP7779988B2 JP7779988B2 (ja) | 2025-12-03 |
Family
ID=71842357
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544720A Active JP7600122B2 (ja) | 2019-01-31 | 2020-01-31 | 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法 |
| JP2024210915A Active JP7779988B2 (ja) | 2019-01-31 | 2024-12-04 | 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544720A Active JP7600122B2 (ja) | 2019-01-31 | 2020-01-31 | 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220136012A1 (https=) |
| EP (1) | EP3918077A4 (https=) |
| JP (2) | JP7600122B2 (https=) |
| KR (1) | KR20210124280A (https=) |
| CN (2) | CN114072509B (https=) |
| AU (1) | AU2020216484A1 (https=) |
| CA (1) | CA3127494A1 (https=) |
| WO (1) | WO2020160517A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| AU2019265019B2 (en) | 2018-05-11 | 2025-11-06 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| AU2020215730A1 (en) | 2019-01-31 | 2021-07-29 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
| CN120174005A (zh) | 2019-02-13 | 2025-06-20 | 比姆医疗股份有限公司 | 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞 |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US12416001B2 (en) * | 2020-02-14 | 2025-09-16 | Ohio State Innovation Foundation | Nucleobase editors and methods of use thereof |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CA3196831A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| EP4313118A4 (en) * | 2021-03-26 | 2025-06-18 | Beam Therapeutics Inc. | ADENOSINE DEAMINASE VARIANTS AND THEIR USES |
| KR20240007651A (ko) * | 2021-04-16 | 2024-01-16 | 빔 테라퓨틱스, 인크. | 간세포의 유전적 변형 |
| WO2022261509A1 (en) * | 2021-06-11 | 2022-12-15 | The Broad Institute, Inc. | Improved cytosine to guanine base editors |
| US20240352439A1 (en) * | 2021-09-03 | 2024-10-24 | The University Of Chicago | Polypeptides and methods for modifying nucleic acids |
| WO2023086953A1 (en) * | 2021-11-11 | 2023-05-19 | Beam Therapeutics Inc. | Compositions and methods for the treatment of hereditary angioedema (hae) |
| CN114686456B (zh) * | 2022-05-10 | 2023-02-17 | 中山大学 | 基于双分子脱氨酶互补的碱基编辑系统及其应用 |
| EP4540378A1 (en) * | 2022-06-20 | 2025-04-23 | CRISPR Therapeutics AG | Base editing proteins and uses thereof |
| EP4605542A1 (en) * | 2022-10-19 | 2025-08-27 | DNA Script | Methods and products for removal of uracil containing polynucleotides |
| CN117384885B (zh) | 2022-12-15 | 2025-06-10 | 中国科学院遗传与发育生物学研究所 | 一种碱基编辑器及其应用 |
| CN118475691B (zh) * | 2023-02-28 | 2025-07-22 | 锐正基因(苏州)有限公司 | 用于碱基编辑的脱氨酶 |
| WO2024240223A1 (en) | 2023-05-24 | 2024-11-28 | Accuredit Therapeutics (Suzhou) Co., Ltd. | Deaminases and variants thereof for use in base editing |
| CN117210445A (zh) * | 2023-08-29 | 2023-12-12 | 苏州湃芮生物科技有限公司 | 一种基于rna特异性脱氨酶突变体及其应用 |
| CN120813698A (zh) * | 2023-09-22 | 2025-10-17 | 北京大学现代农业研究院 | 改进的基因组编辑方法 |
| WO2025119306A1 (zh) * | 2023-12-06 | 2025-06-12 | 北京齐禾生科生物科技有限公司 | 优化工程化t细胞的碱基编辑系统及其应用 |
| WO2025202473A1 (en) * | 2024-03-28 | 2025-10-02 | Revvity Discovery Limited | A nucleic acid deaminase, a base editor and uses thereof |
| WO2025240372A1 (en) * | 2024-05-13 | 2025-11-20 | Metagenomi, Inc. | Compositions and methods for editing t cells |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150165054A1 (en) * | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| IL310721B2 (en) * | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN110214183A (zh) * | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| KR20240116572A (ko) * | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| WO2018213726A1 (en) * | 2017-05-18 | 2018-11-22 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| EP3630849A4 (en) * | 2017-05-25 | 2021-01-13 | The General Hospital Corporation | BIPARTITE BASIC EDITOR (BBE) AND TYPE II-C-CAS9 ZINC FINGER EDITOR ARCHITECTURES |
| WO2019084062A1 (en) * | 2017-10-23 | 2019-05-02 | The Broad Institute, Inc. | SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITION |
| CN119570787A (zh) * | 2018-05-11 | 2025-03-07 | 比姆医疗股份有限公司 | 使用可编程碱基编辑器系统遏止病原性突变的方法 |
| US12157760B2 (en) * | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| CA3108281A1 (en) * | 2018-08-03 | 2020-02-06 | Beam Therapeutics Inc. | Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence |
| EP3911735A4 (en) * | 2019-01-16 | 2023-07-12 | Beam Therapeutics, Inc. | MODIFIED IMMUNE CELLS WITH INCREASED ANTINEOPLASTIC ACTIVITY AND RESISTANCE TO IMMUNOSUPPRESSION |
-
2020
- 2020-01-31 WO PCT/US2020/016288 patent/WO2020160517A1/en not_active Ceased
- 2020-01-31 JP JP2021544720A patent/JP7600122B2/ja active Active
- 2020-01-31 US US17/427,422 patent/US20220136012A1/en active Pending
- 2020-01-31 CA CA3127494A patent/CA3127494A1/en active Pending
- 2020-01-31 AU AU2020216484A patent/AU2020216484A1/en active Pending
- 2020-01-31 KR KR1020217026727A patent/KR20210124280A/ko active Pending
- 2020-01-31 CN CN202080026310.4A patent/CN114072509B/zh active Active
- 2020-01-31 EP EP20748217.5A patent/EP3918077A4/en active Pending
- 2020-01-31 CN CN202510365522.XA patent/CN120400115A/zh active Pending
-
2024
- 2024-12-04 JP JP2024210915A patent/JP7779988B2/ja active Active
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