JP7600122B2 - 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法 - Google Patents

低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法 Download PDF

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JP7600122B2
JP7600122B2 JP2021544720A JP2021544720A JP7600122B2 JP 7600122 B2 JP7600122 B2 JP 7600122B2 JP 2021544720 A JP2021544720 A JP 2021544720A JP 2021544720 A JP2021544720 A JP 2021544720A JP 7600122 B2 JP7600122 B2 JP 7600122B2
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ニコル ゴーデッリ、
イ ユ、
イアン スレイメイカー、
ジェイソン マイケル ゲールケ、
スン―ジュ イ、
デイビッド エー． ボーン、
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ビーム セラピューティクス インク．
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04005—Cytidine deaminase (3.5.4.5)
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)

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JP2021544720A 2019-01-31 2020-01-31 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法 Active JP7600122B2 (ja)

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JP2024210915A JP7779988B2 (ja) 2019-01-31 2024-12-04 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法

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US201962799702P 2019-01-31 2019-01-31
US62/799,702 2019-01-31
US201962835456P 2019-04-17 2019-04-17
US62/835,456 2019-04-17
US201962941569P 2019-11-27 2019-11-27
US62/941,569 2019-11-27
PCT/US2020/016288 WO2020160517A1 (en) 2019-01-31 2020-01-31 Nucleobase editors having reduced off-target deamination and methods of using same to modify a nucleobase target sequence

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JP2024210915A Active JP7779988B2 (ja) 2019-01-31 2024-12-04 低減されたオフターゲット脱アミノ化を有する核酸塩基エディターおよび核酸塩基標的配列を改変するためのその使用方法

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US (1) US20220136012A1 (https=)
EP (1) EP3918077A4 (https=)
JP (2) JP7600122B2 (https=)
KR (1) KR20210124280A (https=)
CN (2) CN114072509B (https=)
AU (1) AU2020216484A1 (https=)
CA (1) CA3127494A1 (https=)
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AU2019265019B2 (en) 2018-05-11 2025-11-06 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
US12157760B2 (en) 2018-05-23 2024-12-03 The Broad Institute, Inc. Base editors and uses thereof
US12522807B2 (en) 2018-07-09 2026-01-13 The Broad Institute, Inc. RNA programmable epigenetic RNA modifiers and uses thereof
EP3847254A4 (en) 2018-09-07 2022-08-10 Beam Therapeutics Inc. COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM
WO2020051562A2 (en) 2018-09-07 2020-03-12 Beam Therapeutics Inc. Compositions and methods for improving base editing
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
AU2020215730A1 (en) 2019-01-31 2021-07-29 Beam Therapeutics Inc. Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors
CN120174005A (zh) 2019-02-13 2025-06-20 比姆医疗股份有限公司 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
WO2020191233A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
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CN120400115A (zh) 2025-08-01
CA3127494A1 (en) 2020-08-06
JP2022521460A (ja) 2022-04-08
KR20210124280A (ko) 2021-10-14
WO2020160517A1 (en) 2020-08-06
EP3918077A1 (en) 2021-12-08
EP3918077A4 (en) 2023-03-29
AU2020216484A1 (en) 2021-07-29
CN114072509A (zh) 2022-02-18
JP2025041661A (ja) 2025-03-26
JP7779988B2 (ja) 2025-12-03
CN114072509B (zh) 2025-04-15
US20220136012A1 (en) 2022-05-05

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