JP2025023942A5 - - Google Patents
Info
- Publication number
- JP2025023942A5 JP2025023942A5 JP2024186312A JP2024186312A JP2025023942A5 JP 2025023942 A5 JP2025023942 A5 JP 2025023942A5 JP 2024186312 A JP2024186312 A JP 2024186312A JP 2024186312 A JP2024186312 A JP 2024186312A JP 2025023942 A5 JP2025023942 A5 JP 2025023942A5
- Authority
- JP
- Japan
- Prior art keywords
- pylrs
- trna synthetase
- mbpylrs
- mutations
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1817444.1 | 2018-10-26 | ||
| GBGB1817444.1A GB201817444D0 (en) | 2018-10-26 | 2018-10-26 | Methods and compositions |
| PCT/GB2019/053023 WO2020084307A1 (en) | 2018-10-26 | 2019-10-24 | Methods and compositions |
| JP2021521504A JP7633156B2 (ja) | 2018-10-26 | 2019-10-24 | 方法及び組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521504A Division JP7633156B2 (ja) | 2018-10-26 | 2019-10-24 | 方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025023942A JP2025023942A (ja) | 2025-02-19 |
| JP2025023942A5 true JP2025023942A5 (enExample) | 2025-10-21 |
Family
ID=64560429
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521504A Active JP7633156B2 (ja) | 2018-10-26 | 2019-10-24 | 方法及び組成物 |
| JP2024186312A Pending JP2025023942A (ja) | 2018-10-26 | 2024-10-23 | 方法及び組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021521504A Active JP7633156B2 (ja) | 2018-10-26 | 2019-10-24 | 方法及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12286657B2 (enExample) |
| EP (1) | EP3870224A1 (enExample) |
| JP (2) | JP7633156B2 (enExample) |
| CN (2) | CN120607506A (enExample) |
| AU (2) | AU2019369192B2 (enExample) |
| CA (1) | CA3116567A1 (enExample) |
| GB (1) | GB201817444D0 (enExample) |
| WO (1) | WO2020084307A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2873793C (en) | 2012-05-18 | 2022-02-22 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| GB201906775D0 (en) | 2019-05-14 | 2019-06-26 | Res & Innovation Uk | Synthetic genome |
| CN114195665A (zh) * | 2021-12-14 | 2022-03-18 | 武汉世吉药业有限公司 | 一种高纯度ncaa的中和酸化工艺及设备 |
| EP4328308A1 (en) * | 2022-08-22 | 2024-02-28 | Technische Universität Berlin | Modified trna-synthetase for the incorporation of non-canonical amino acids |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2410331B1 (en) | 2003-06-18 | 2015-09-23 | The Scripps Research Institute | Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids |
| EP1649004A4 (en) | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US7741071B2 (en) | 2003-12-18 | 2010-06-22 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| AU2005286722B2 (en) | 2004-09-21 | 2010-12-02 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| CN101048506B (zh) | 2004-10-27 | 2013-06-26 | 斯克利普斯研究院 | 体内掺入非天然氨基酸的正交翻译组分 |
| US8431558B2 (en) | 2004-11-01 | 2013-04-30 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| JP2007037445A (ja) | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | ｔＲＮＡ合成方法、核酸、アミノアシルｔＲＮＡ合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法 |
| WO2007090198A2 (en) | 2006-02-01 | 2007-08-09 | Encode Bio, Inc. | Fluorescent assays using orthogonal trna - aminoacyl synthetase pairs |
| US20080096819A1 (en) | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| JP2010526091A (ja) | 2007-04-30 | 2010-07-29 | インテザイン テクノロジーズ， インコーポレイテッド | 癌の処置のための生物学的な標的基の改変 |
| JP5590649B2 (ja) | 2007-09-20 | 2014-09-17 | 独立行政法人理化学研究所 | 変異体ピロリジル−ｔＲＮＡ合成酵素及びこれを用いる非天然アミノ酸組み込みタンパク質の製造方法 |
| GB0721291D0 (en) | 2007-10-30 | 2007-12-12 | Medical Res Council | Methods and compositions |
| GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| GB0917242D0 (en) | 2009-10-01 | 2009-11-18 | Medical Res Council | Acetyl lysine incorporation with tRNA synthetase |
| GB0917240D0 (en) | 2009-10-01 | 2009-11-18 | Medical Res Council | Incorporation of methyl lysine into poiypeptide |
| JP5875083B2 (ja) | 2010-04-15 | 2016-03-02 | メディミューン リミテッド | 増殖性疾患治療用ピロロベンゾジアゼピン |
| EP2563753B9 (en) | 2010-04-27 | 2016-07-06 | SynAffix B.V. | Fused cyclooctyne compounds and their use in metal-free click reactions |
| US20120077186A1 (en) | 2010-05-07 | 2012-03-29 | Oregon Health & Science University | Use of cysteine-derived suppressor trnas for non-native amino acid incorporation |
| WO2011156686A2 (en) | 2010-06-11 | 2011-12-15 | The Regents Of The University Of Colorado, A Body Corporate | Method for synthesizing a cyclic multivalent peptide using a thiol-mediated reaction |
| ES2661095T3 (es) | 2011-02-03 | 2018-03-27 | European Molecular Biology Laboratory | Aminoácidos no naturales que comprenden un grupo análogo de ciclooctinilo o trans-ciclooctenilo y usos de los mismos |
| GB201110815D0 (en) | 2011-06-24 | 2011-08-10 | Medical Res Council | Incorporation of subtituted lysines into polypeptides |
| WO2013036748A1 (en) | 2011-09-09 | 2013-03-14 | Berry, Lana, L. | Bicyclo[6.1.0]non-4-yne reagents for chemical modification of oligonucleotides |
| GB201201100D0 (en) | 2012-01-20 | 2012-03-07 | Medical Res Council | Polypeptides and methods |
| CA2873793C (en) | 2012-05-18 | 2022-02-22 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
| EP2890402B1 (en) * | 2012-08-31 | 2019-04-17 | Sutro Biopharma, Inc. | Modified amino acids comprising an azido group |
| EP2898085B1 (en) | 2012-09-24 | 2019-01-23 | MedImmune Limited | Cell lines |
| EP4122945A1 (en) * | 2013-12-23 | 2023-01-25 | University of Rochester | Methods and compositions for ribosomal synthesis of macrocyclic peptides |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| GB201419109D0 (en) | 2014-10-27 | 2014-12-10 | Medical Res Council | Incorporation of unnatural amino acids into proteins |
| GB201613135D0 (en) | 2016-07-29 | 2016-09-14 | Medical Res Council | Genome editing |
| KR20240141853A (ko) * | 2017-08-03 | 2024-09-27 | 신톡스, 인크. | 자가면역 질환의 치료를 위한 사이토카인 접합체 |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| GB201906775D0 (en) | 2019-05-14 | 2019-06-26 | Res & Innovation Uk | Synthetic genome |
| AU2021447219A1 (en) | 2021-05-28 | 2023-11-09 | United Kingdom Research And Innovation | Microorganisms and uses thereof |
-
2018
- 2018-10-26 GB GBGB1817444.1A patent/GB201817444D0/en not_active Ceased
-
2019
- 2019-10-24 US US17/288,798 patent/US12286657B2/en active Active
- 2019-10-24 AU AU2019369192A patent/AU2019369192B2/en active Active
- 2019-10-24 WO PCT/GB2019/053023 patent/WO2020084307A1/en not_active Ceased
- 2019-10-24 EP EP19806312.5A patent/EP3870224A1/en active Pending
- 2019-10-24 CA CA3116567A patent/CA3116567A1/en active Pending
- 2019-10-24 JP JP2021521504A patent/JP7633156B2/ja active Active
- 2019-10-24 CN CN202510576255.0A patent/CN120607506A/zh active Pending
- 2019-10-24 CN CN201980086289.4A patent/CN113226375B/zh active Active
-
2024
- 2024-10-23 JP JP2024186312A patent/JP2025023942A/ja active Pending
-
2025
- 2025-03-21 US US19/086,998 patent/US20250283066A1/en active Pending
- 2025-07-18 AU AU2025205622A patent/AU2025205622A1/en active Pending
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